List of works - Juan S. Bonifacino

Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments

scientific article

The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain

scientific article published on 05 January 2006

BLOC-3, a protein complex containing the Hermansky-Pudlak syndrome gene products HPS1 and HPS4

scientific article

Clathrin adaptor AP-2 is essential for early embryonal development.

scientific article

EARP is a multisubunit tethering complex involved in endocytic recycling

scientific article

Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variants

scientific article

Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs).

scientific article

Basolateral sorting of the coxsackie and adenovirus receptor through interaction of a canonical YXXPhi motif with the clathrin adaptors AP-1A and AP-1B

scientific article published on 16 February 2012

Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9

scientific journal article

Mutational analysis of the fusion peptide of the human immunodeficiency virus type 1: identification of critical glycine residues.

scientific article published in April 1996

Structural Mechanism for Cargo Recognition by the Retromer Complex.

scientific article

The Vps27/Hse1 Complex Is a GAT Domain-Based Scaffold for Ubiquitin-Dependent Sorting

scientific article

A new variant of Hermansky-Pudlak syndrome due to mutations in a gene responsible for vesicle formation

scientific article published on 01 April 2000

Aggregation as a determinant of protein fate in post-Golgi compartments: role of the luminal domain of furin in lysosomal targeting

scientific article published in December 1997

Assembly and Architecture of Biogenesis of Lysosome-related Organelles Complex-1 (BLOC-1)

scientific article published on December 27, 2011

Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex

scientific article

Polycystic liver disease is a disorder of cotranslational protein processing.

scientific article

Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway.

scientific article published on 29 April 2009

Insights into the biogenesis of lysosome-related organelles from the study of the Hermansky-Pudlak syndrome

scientific article published on 01 December 2004

Structural requirements for function of yeast GGAs in vacuolar protein sorting, alpha-factor maturation, and interactions with clathrin.

scientific article

Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins

scientific article

Definition of the consensus motif recognized by gamma-adaptin ear domains

scientific article published on 9 December 2003

Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex

scientific article

Ultrastructure of long-range transport carriers moving from the trans Golgi network to peripheral endosomes

scientific article published on 19 June 2006

CD1a and MHC class I follow a similar endocytic recycling pathway

scientific article

Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.

scientific article published on 16 November 2011

Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.

scientific article

BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks.

scientific article

CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms

scientific article

Rab5 and its effector FHF contribute to neuronal polarity through dynein-dependent retrieval of somatodendritic proteins from the axon

scientific article published on 24 August 2016

Canonical interaction of cyclin G associated kinase with adaptor protein 1 regulates lysosomal enzyme sorting

scientific article

Sorting of Dendritic and Axonal Vesicles at the Pre-axonal Exclusion Zone.

scientific article

The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting.

scientific article

Recognition of accessory protein motifs by the gamma-adaptin ear domain of GGA3

scientific article

Moving and positioning the endolysosomal system.

scientific article published on 20 February 2017

The adaptor protein-1 μ1B subunit expands the repertoire of basolateral sorting signal recognition in epithelial cells

scientific article

Direct binding to Rsp5p regulates ubiquitination-independent vacuolar transport of Sna3p.

scientific article

A Ragulator-BORC interaction controls lysosome positioning in response to amino acid availability

scientific article

Transient aggregation of major histocompatibility complex class II chains during assembly in normal spleen cells.

scientific article published in May 1995

Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism

scientific article

Functional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogaster

scientific article

Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor.

scientific article

Structural Basis for the Recognition of Tyrosine-based Sorting Signals by the 3A Subunit of the AP-3 Adaptor Complex

scientific article

Reversal of fortune for nascent proteins

scientific article published in Nature

Cloning, expression, and localization of a novel γ‐adaptin‐like molecule

scientific article published on September 18, 1998

Gga2 mediates sequential ubiquitin-independent and ubiquitin-dependent steps in the trafficking of ARN1 from the trans-Golgi network to the vacuole.

scientific article

Anchors aweigh: protein localization and transport mediated by transmembrane domains

scientific article published on 24 June 2013

Molecular characterization of hepatocystin, the protein that is defective in autosomal dominant polycystic liver disease.

scientific article published in June 2004

The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites

scientific article

AP-1A controls secretory granule biogenesis and trafficking of membrane secretory granule proteins

scientific article

List of works by Juan S. Bonifacino

Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments

The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain

BLOC-3, a protein complex containing the Hermansky-Pudlak syndrome gene products HPS1 and HPS4

Clathrin adaptor AP-2 is essential for early embryonal development.

EARP is a multisubunit tethering complex involved in endocytic recycling

Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variants

Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs).

Basolateral sorting of the coxsackie and adenovirus receptor through interaction of a canonical YXXPhi motif with the clathrin adaptors AP-1A and AP-1B

Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9

Mutational analysis of the fusion peptide of the human immunodeficiency virus type 1: identification of critical glycine residues.

Structural Mechanism for Cargo Recognition by the Retromer Complex.

The Vps27/Hse1 Complex Is a GAT Domain-Based Scaffold for Ubiquitin-Dependent Sorting

A new variant of Hermansky-Pudlak syndrome due to mutations in a gene responsible for vesicle formation

Aggregation as a determinant of protein fate in post-Golgi compartments: role of the luminal domain of furin in lysosomal targeting

Assembly and Architecture of Biogenesis of Lysosome-related Organelles Complex-1 (BLOC-1)

Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex

Polycystic liver disease is a disorder of cotranslational protein processing.

Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway.

Insights into the biogenesis of lysosome-related organelles from the study of the Hermansky-Pudlak syndrome

Structural requirements for function of yeast GGAs in vacuolar protein sorting, alpha-factor maturation, and interactions with clathrin.

Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins

Definition of the consensus motif recognized by gamma-adaptin ear domains

Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex

Ultrastructure of long-range transport carriers moving from the trans Golgi network to peripheral endosomes

CD1a and MHC class I follow a similar endocytic recycling pathway

Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.

Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.

BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks.

CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms

Rab5 and its effector FHF contribute to neuronal polarity through dynein-dependent retrieval of somatodendritic proteins from the axon

Canonical interaction of cyclin G associated kinase with adaptor protein 1 regulates lysosomal enzyme sorting

Sorting of Dendritic and Axonal Vesicles at the Pre-axonal Exclusion Zone.

The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting.

Recognition of accessory protein motifs by the gamma-adaptin ear domain of GGA3

Moving and positioning the endolysosomal system.

The adaptor protein-1 μ1B subunit expands the repertoire of basolateral sorting signal recognition in epithelial cells

Direct binding to Rsp5p regulates ubiquitination-independent vacuolar transport of Sna3p.

A Ragulator-BORC interaction controls lysosome positioning in response to amino acid availability

Transient aggregation of major histocompatibility complex class II chains during assembly in normal spleen cells.

Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism

Functional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogaster

Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor.

Structural Basis for the Recognition of Tyrosine-based Sorting Signals by the 3A Subunit of the AP-3 Adaptor Complex

Reversal of fortune for nascent proteins

Cloning, expression, and localization of a novel γ‐adaptin‐like molecule

Gga2 mediates sequential ubiquitin-independent and ubiquitin-dependent steps in the trafficking of ARN1 from the trans-Golgi network to the vacuole.

Anchors aweigh: protein localization and transport mediated by transmembrane domains

Molecular characterization of hepatocystin, the protein that is defective in autosomal dominant polycystic liver disease.

The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites

AP-1A controls secretory granule biogenesis and trafficking of membrane secretory granule proteins