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List of works by Bart De Strooper

A cell biological perspective on Alzheimer's disease

scientific article

A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases

scientific article

A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes

scientific article published on 25 October 2011

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

scientific article

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

scientific article published on 17 October 2003

A protective mutation

journal article; published in Nature on 2012-08-01

A self-organizing miR-132/Ctbp2 circuit regulates bimodal notch signals and glial progenitor fate choice during spinal cord maturation

scientific article published on 14 August 2014

ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase

scientific article published on 11 February 2009

ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein

scientific article published on 28 September 2011

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

scientific article

APLP2 regulates neuronal stem cell differentiation during cortical development

scientific article

APP mouse models for Alzheimer's disease preclinical studies

scientific article published on August 2017

Active gamma-secretase complexes contain only one of each component

scientific article

Alteration of the microRNA network during the progression of Alzheimer's disease

scientific article

Alterations in phosphatidylethanolamine levels affect the generation of Aβ.

scientific article published on 28 November 2011

Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics

scientific article published on 4 April 2016

Alzheimer's dementia by circulation disorders: when trees hide the forest

scientific article

Alzheimer's disease neurons fail the acid test

scientific article published in June 2010

Alzheimer's disease: A breach in the blood-brain barrier

scientific article published on 23 May 2012

Alzheimer's disease: Mental plaque removal

scientific article published in May 2003

Alzheimer's disease: where next for anti-amyloid therapies?

scientific article published in April 2017

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions

scientific article

Amyloid Precursor Protein Accumulation in Lewy Body Dementia and Alzheimers Disease ⬇️

scientific article published on March 1, 1995

Amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer's disease

scientific article published in January 2013

Amyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons

scientific article published on 13 May 2016

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation

scientific article

Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain

scientific article published on 28 July 2005

Amyloid-beta precursor protein processing in neurodegeneration

scientific article published in October 2004

An inflammatory drug prospect ⬇️

scientific article published on November 8, 2001

An overlooked neurotoxic species in Alzheimer's disease

scientific article published on 26 July 2011

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

scientific article published on 18 October 2009

Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse

scientific article

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

scientific article

Assay to probe proteolytic processing of Notch by γ-secretase

scientific article published in January 2014

Attack on amyloid

scientific article published on 25 July 2003

Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

scientific article

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease

scientific article published on 29 January 2016

BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's disease

scientific article

BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid

scientific article published in September 2013

BACE2 distribution in major brain cell types and identification of novel substrates

scientific article published on 01 January 2018

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells

scientific article published on 10 June 2013

Bexarotene treatment does not clear β-Amyloid in an AD mouse model and Beagle dogs

Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling

scientific article published on 20 November 2017

Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency

scientific article (publication date: 6 March 2017)

Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling

scientific article

Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation

scientific article

Characterization of lentiviral vector-mediated gene transfer in adult mouse brain

scientific article

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons ⬇️

scientific article published on May 26, 1998

Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice

scientific article published on 6 March 2013

Close encounter: mitochondria, endoplasmic reticulum and Alzheimer's disease ⬇️

scientific article published on October 9, 2012

Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding

scientific article published on September 2004

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

scientific article published on 08 January 2020

Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex

scientific article published on 14 July 2006

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

scientific journal article

Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation

scientific article (publication date: 4 June 2004)

Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity

scientific article published on 7 July 2017

Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity

scientific article

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein ⬇️

scientific article published on January 22, 1998

Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice

scientific article published on 12 October 2014

Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures

scientific article

Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis ⬇️

scientific article published on October 15, 1998

Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation

scientific article published on 16 December 2012

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

scientific article

Dose-dependent improvements in learning and memory deficits in APPPS1-21 transgenic mice treated with the orally active Aβ toxicity inhibitor SEN1500.

scientific article published on 10 September 2013

Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization

scientific article published on 15 November 2011

Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes ⬇️

scientific article published on July 1, 1998

Drosophila transgenic RNAi screen of genes implicated in human neurological disease

article

Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome

scientific article published in July 2015

Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein

scientific article (publication date: 12 April 2002)

Epigenetic control of aquaporin 1 expression by the amyloid precursor protein

scientific article published on 17 August 2009

European Alzheimer disease funding

scientific article published in July 2006

FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction

scientific article

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds

scientific article published on April 2016

Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex

scientific article

G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease

scientific article published on 20 October 2009

Gamma-secretase and the intramembrane proteolysis of Notch

scientific article published on January 2010

Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models

scientific journal article

Gene dosage effect on gamma-secretase component Aph-1b in a rat model for neurodevelopmental disorders

scientific article

Gene profiling of hippocampal neuronal culture.

scientific article published in June 2003

Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration

scientific article

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

scientific article published on 15 February 2017

High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease

scientific article published on 7 February 2018

In Vitro Comparison of the Activity Requirements and Substrate Specificity of Human and Triboleum castaneum PINK1 Orthologues

scientific article

In vitro studies of Flemish, Dutch, and wild-type beta-amyloid provide evidence for two-staged neurotoxicity

scientific article published in November 2002

Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration

scientific article published on 6 June 2017

Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription

scientific article published on 17 May 2008

Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old AppNL/NL Knock-In Mice

article published in 2018

Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.

scientific article

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

scientific article

LRRK2 expression is enriched in the striosomal compartment of mouse striatum ⬇️

scientific article published on July 29, 2012

LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism

scientific article

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

scientific article

Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond

scientific article published on October 2014

Lessons from a failed γ-secretase Alzheimer trial

scientific article published in November 2014

Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice

scientific article

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models

scientific article published in October 2015

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression

scholarly article

Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease

scientific article

Mitochondria dysfunction and neurodegenerative disorders: cause or consequence

scientific article published on January 2010

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

scientific journal article

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer's disease

scientific article published on 19 October 2020

Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease

scientific article published on 2 May 2012

Modulation of BACE1 Activity by Chemically Modified Aptamers

scientific article published on 11 January 2018

Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer's Disease

scientific article

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

scientific article published on 18 December 2012

Molecular plasticity regulates oligomerization and cytotoxicity of the multipeptide-length amyloid-β peptide pool

scientific article

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore

scientific article

Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy

scientific article published on 16 May 2013

Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model

scientific article (publication date: 2013)

Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer's disease

scientific article published on 04 December 2019

Neurodegeneration: From cellular concepts to clinical applications

scientific article published on November 2016

Neuronal membrane cholesterol loss enhances amyloid peptide generation

scientific article published on December 2004

Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation

scientific article published in March 2010

Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein

scientific article published in July 2003

Neuroscience. Promiscuous Alzheimer's amyloid: yet another partner

scientific article published in September 2013

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

scientific article

Nicastrin: gatekeeper of the gamma-secretase complex

scientific article

No endogenous A beta production in presenilin-deficient fibroblasts

scientific article

Non-coding RNAs with essential roles in neurodegenerative disorders

scientific article published on February 2012

Noncoding RNAs in neurodegeneration

scientific article published on 17 August 2017

Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites

scientific journal article

Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology

scientific article published on 17 January 2020

Novel research horizons for presenilins and γ-secretases in cell biology and disease

scientific article published on January 2010

Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's disease

scientific article

Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation

scientific article published on 11 February 2019

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

scientific article

On the identification of low allele frequency mosaic mutations in the brains of Alzheimer's disease patients

scientific article

P1-457: Neuronal differentiation of APP/APLP1/APLP2 triple knockout (tKO) embryonic stem (ES) cells

PARL: The mitochondrial rhomboid protease

scientific article

PINK1 activation-turning on a promiscuous kinase

scientific article published on April 2015

PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402

scientific article

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling

scientific journal article

PLD3 gene and processing of APP.

scientific article published in January 2017

Parkin interacts with Ambra1 to induce mitophagy

scientific article

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

scientific article

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice

scientific article

Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain

scientific article published in June 2012

Peroxisome proliferator-activated receptor gamma enhances the activity of an insulin degrading enzyme-like metalloprotease for amyloid-beta clearance

scientific article published in January 2010

Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide.

scientific article

Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease

scientific article published on 6 March 2017

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

scientific article published on 29 June 2005

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

scientific article

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

scientific journal article

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

scientific article

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

scientific article (publication date: 20 September 2002)

Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway

scientific article

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

scientific article published in March 2003

Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease

scientific article published on January 2012

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

scientific article

Presenilins in memory, Alzheimer's disease, and therapy

scientific article published on April 2004

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

scientific article published on 28 July 2003

Presenilins: members of the gamma-secretase quartets, but part-time soloists too.

scientific article published on August 2008

Prion protein in Alzheimer's pathogenesis: a hot and controversial issue

scientific article

Probing γ-secretase-substrate interactions at the single amino acid residue level

scientific article published on July 2016

Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence ⬇️

scientific article published on October 16, 1995

Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process

scientific article

Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

scientific article published on 17 March 2021

Qualitative changes in human γ-secretase underlie familial Alzheimer's disease

scientific article

Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.

scientific article

Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease

scientific article published on 8 November 2013

Redundancy and divergence in the amyloid precursor protein family

scientific article published on 23 May 2013

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

scientific article published on 19 May 2006

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase

scientific article published on 16 February 2007

Regulation of amyloid precursor protein processing by serotonin signaling

scientific article (publication date: 2014)

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

scientific article

Response to Shilling et al. (10.1074/jbc.M111.300491).

scientific article published in June 2012

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

scientific article published on 9 June 2016

Role of presenilins in neuronal calcium homeostasis

scientific article

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

scientific article published on 01 May 2019

Secretases: potential and roadblocks on the way to therapy.

scientific article published on 13 September 2013

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

Signature amyloid β profiles are produced by different γ-secretase complexes

scientific article published on 13 December 2013

Small molecules that inhibit Notch signaling

scientific article

Soluble amyloid-β precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans

scientific article published on 28 August 2013

Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in mice.

scientific article published on 19 April 2018

Stem-cell-derived human microglia transplanted in mouse brain to study human disease

scientific article published on 28 October 2019

Structure and function of gamma-secretase

scientific article

Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study

scientific article

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.

scientific article published on 31 January 2018

Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling

scientific article published on 22 September 2003

Tau association with synaptic vesicles causes presynaptic dysfunction

scientific article

Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity

scientific article

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

scientific article published on 10 March 2017

The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation

scientific article

The Cellular Phase of Alzheimer's Disease

scientific article published on February 2016

The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling

scientific article

The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation

scientific article published on 2 April 2014

The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing ⬇️

scientific article published on September 1, 2011

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics ⬇️

scientific article (publication date: 19 August 2011)

The amyloid cascade hypothesis: are we poised for success or failure?

scientific article published on 3 June 2016

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

scientific article published on 24 September 2003

The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex

scientific article

The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation

scientific article published on 16 September 2013

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

scientific article

The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

scientific article

The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons

scientific article

The role of G protein-coupled receptors in the pathology of Alzheimer's disease

scientific article published on February 2011

The secretases: enzymes with therapeutic potential in Alzheimer disease

scientific article

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor

scientific article published on 18 December 2011

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

scientific article published on 29 January 2012

The world of dementia beyond 2020.

scientific article

The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants

scientific article (publication date: 2012)

Transgenic mice expressing an α-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder ⬇️

scientific article published on September 1, 1998

Translating genetic risk of Alzheimer's disease into mechanistic insight and drug targets

scientific article

Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase

scientific article published on 15 May 2008

Tumour necrosis factor-alpha, interleukin-6 and interleukin-8 do not promote adhesion of human endometrial epithelial cells to mesothelial cells in a quantitative in vitro model

scientific article published on 27 October 2005

University education is more than higher education

scientific article published on 01 January 1992

Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: the need of larger datasets

scientific article published on 04 March 2014

Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency

scientific article

When the dust settles: what did we learn from the bexarotene discussion?

scientific article

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

scientific article published on 11 April 2005

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

scientific article published in March 2003

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease

scientific article

gamma-secretases: from cell biology to therapeutic strategies

scientific article published on February 2010

miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain

scientific article published on August 2016

microRNA-132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease

scientific article published on February 2017

α2-macroglobulin and subacute-phase responses in Alzheimer's disease ⬇️

scientific article published on March 1, 1993

α2-macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease ⬇️

scientific article published on May 1, 1993

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease

scientific article published on 2 December 2012

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer’s disease.

scientific article published on 13 September 2013

β‐Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment ⬇️

scientific article published on August 20, 2012

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