List of works - Bart De Strooper

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

scientific article published on January 22, 1998

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

scientific article published on 29 January 2012

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

scientific article (publication date: 19 August 2011)

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

scientific article

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

scientific article published on May 26, 1998

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression

scholarly article

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

scientific article

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

scientific journal article

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

scientific article

The secretases: enzymes with therapeutic potential in Alzheimer disease

scientific article

The Cellular Phase of Alzheimer's Disease

scientific article published on February 2016

Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

scientific article published on October 15, 1998

Alterations of the microRNA network cause neurodegenerative disease.

scientific article published on 04 March 2009

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

scientific article published on 6 October 2010

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

scientific article

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

scientific article

Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process

scientific article

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

scientific article

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression.

scientific article

Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

scientific article

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

scientific article

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

scientific article published on 29 June 2005

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

scientific article published on 11 April 2005

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

scientific article

The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex

scientific article

Neuronal membrane cholesterol loss enhances amyloid peptide generation

scientific article published on December 2004

Alteration of the microRNA network during the progression of Alzheimer's disease

scientific article

Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease

scientific article

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

scientific article published on 24 September 2003

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

scientific article

Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration

scientific article

Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease

scientific article published on January 2012

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

scientific article

Novel research horizons for presenilins and γ-secretases in cell biology and disease

scientific article published on January 2010

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

scientific article (publication date: 20 September 2002)

Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice

scientific article

Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency

scientific article

Parkin interacts with Ambra1 to induce mitophagy

scientific article

Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation

scientific article

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

scientific article

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

scientific article published on 17 October 2003

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling

scientific journal article

The amyloid-beta precursor protein: integrating structure with biological function

scientific article

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

scientific article

Non-coding RNAs with essential roles in neurodegenerative disorders

scientific article published on February 2012

The role of G protein-coupled receptors in the pathology of Alzheimer's disease

scientific article published on February 2011

A cell biological perspective on Alzheimer's disease

scientific article

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease

scientific article

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

scientific article published in March 2003

APP mouse models for Alzheimer's disease preclinical studies

scientific article published on August 2017

List of works by Bart De Strooper

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

The secretases: enzymes with therapeutic potential in Alzheimer disease

The Cellular Phase of Alzheimer's Disease

Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

Alterations of the microRNA network cause neurodegenerative disease.

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression.

Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex

Neuronal membrane cholesterol loss enhances amyloid peptide generation

Alteration of the microRNA network during the progression of Alzheimer's disease

Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration

Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

Novel research horizons for presenilins and γ-secretases in cell biology and disease

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice

Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency

Parkin interacts with Ambra1 to induce mitophagy

Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling

The amyloid-beta precursor protein: integrating structure with biological function

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

Non-coding RNAs with essential roles in neurodegenerative disorders

The role of G protein-coupled receptors in the pathology of Alzheimer's disease

A cell biological perspective on Alzheimer's disease

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

APP mouse models for Alzheimer's disease preclinical studies