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List of works by Bart De Strooper

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Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain

scientific article published on 28 July 2005
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

scientific journal article
Role of presenilins in neuronal calcium homeostasis

scientific article
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

scientific article published on 19 May 2006
The amyloid cascade hypothesis: are we poised for success or failure?

scientific article published on 3 June 2016
Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

scientific article (publication date: 23 May 2013)
Lessons from a Failed γ-Secretase Alzheimer Trial

scientific article published on November 6, 2014
Amyloid-beta precursor protein processing in neurodegeneration

scientific article published in October 2004
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor

scientific article published on 18 December 2011
Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation.

scientific article
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

scientific article
A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases

scientific article
Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

scientific journal article
Active gamma-secretase complexes contain only one of each component

scientific article
Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex

scientific article published on 14 July 2006
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase

scientific article published on 11 February 2009
Comparison and meta-analysis of microarray data: from the bench to the computer desk.

scientific article published in October 2003
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

scientific article
Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model.

scientific article published in June 2012
Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase

scientific article published on 16 February 2007
gamma-secretases: from cell biology to therapeutic strategies

scientific article published on February 2010
Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

scientific article published on 15 February 2017
Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway

scientific article
FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction

scientific article
The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons

scientific article
Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

scientific article published on 9 June 2016
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease

scientific article published on 2 December 2012
Presenilins: members of the gamma-secretase quartets, but part-time soloists too.

scientific article published on August 2008
Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

scientific article published in March 2003
β‐Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

scientific article published on August 20, 2012
Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide.

scientific article
Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

scientific article published on 18 October 2009
BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells

scientific article published on 10 June 2013
Characterization of lentiviral vector-mediated gene transfer in adult mouse brain

scientific article
Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

scientific article published on 28 July 2003
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism

scientific article
Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling

scientific article published on 22 September 2003
Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites

scientific journal article
The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation

scientific article
Molecular biology. miRNAs in neurodegeneration

scientific article published on 01 August 2007
A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals.

scientific article published on 5 October 2016
Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease

scientific article published on 8 November 2013
Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

Tau association with synaptic vesicles causes presynaptic dysfunction

scientific article
Epigenetically regulated microRNAs in Alzheimer's disease.

scientific article published on 18 October 2013
Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence

scientific article published on October 16, 1995
Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy

scientific article published on 16 May 2013
Qualitative changes in human γ-secretase underlie familial Alzheimer's disease

scientific article
Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

scientific article
Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein

scientific article (publication date: 12 April 2002)

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