List of works - Tom Vanden Berghe

A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins.

scientific article published on December 2007

A real-time fluorometric method for the simultaneous detection of cell death type and rate

scientific article published on 14 July 2016

An inactivating caspase-11 passenger mutation muddles sepsis research

scientific article published in July 2013

An outline of necrosome triggers

scientific article

Apoptosis and necrosis: detection, discrimination and phagocytosis

scientific article

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

scientific article published in Nature Communications

Autophagy: for better or for worse

scientific article published on 13 September 2011

Beclin1: a role in membrane dynamics and beyond

scientific article published on January 2012

Caspase inhibitors promote alternative cell death pathways

scientific article published on 24 October 2006

Caspase substrates: easily caught in deep waters?

scientific article published on 29 October 2009

Caspase-7 in molar tooth development.

scientific article published in August 2012

Caspase-7 participates in differentiation of cells forming dental hard tissues

scientific article published on 29 May 2013

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.

scientific article

Caspases in cell survival, proliferation and differentiation.

scientific article

Caspases leave the beaten track: caspase-mediated activation of NF-kappaB.

scientific article

Determination of apoptotic and necrotic cell death in vitro and in vivo.

scientific article

Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD.

scientific article published on 10 December 2003

Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy

article

Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

scientific article published on 18 November 2002

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

scientific article

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis

scientific article published on 27 October 2020

Expression of calcium-sensing receptor in quail granulosa explants: a key to survival during folliculogenesis

scientific article published in May 2010

Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris

scientific article published on 3 November 2017

Fine-tuning nucleophosmin in macrophage differentiation and activation.

scientific article

Heavy metal suicide

scientific article published on 31 May 2017

How do we fit ferroptosis in the family of regulated cell death?

scientific article published on 6 October 2017

Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease.

scientific article published on 06 March 2017

Inflammatory mediators in Escherichia coli-induced mastitis in mice

scientific article published on 19 February 2008

Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft-dependent stimulation of Akt.

scientific article published on 13 January 2009

Initiation and execution mechanisms of necroptosis: an overview

scientific article

Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling

scientific article

Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis.

scientific article

MLKL Reveals Its Friendly Face: A Role in Nerve Regeneration

scientific article published on 01 November 2018

Major cell death pathways at a glance

scientific article published on 04 September 2009

Methods for distinguishing apoptotic from necrotic cells and measuring their clearance

scientific article

Mitochondria and NADPH oxidases are the major sources of TNF-α/cycloheximide-induced oxidative stress in murine intestinal epithelial MODE-K cells

scientific article

Molecular crosstalk between apoptosis, necroptosis, and survival signaling

scientific article

Molecular mechanisms and pathophysiology of necrotic cell death

scientific article published on May 2008

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

More than one way to die: methods to determine TNF-induced apoptosis and necrosis.

scientific article published on January 2004

NADPH oxidases: new players in TNF-induced necrotic cell death

scientific article

NLRP3/caspase-1-independent IL-1beta production mediates diesel exhaust particle-induced pulmonary inflammation

scientific article published on 15 August 2011

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

scholarly article by Behrouz Hassannia et al published 1 August 2018 in Journal of Clinical Investigation

Nanoscopic X-ray fluorescence imaging and quantification of intracellular key-elements in cryofrozen Friedreich's ataxia fibroblasts

scientific article published on 17 January 2018

Necroptosis, in vivo detection in experimental disease models

scientific article

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features.

scientific article

Necrosis is associated with IL-6 production but apoptosis is not.

scientific article published on 14 July 2005

Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response

scientific article published on 8 July 2006

Necrotic cell death and 'necrostatins': now we can control cellular explosion

scientific article published on 16 July 2008

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

scientific article

Non-apoptotic functions of caspase-7 during osteogenesis

scientific article published on 14 August 2014

Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue

scientific article published on 8 August 2015

Non-classical proIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent

scientific article

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

scientific article published on 22 December 2015

Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.

scientific article

Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids

scientific article published on 10 September 2018

Preconditioning with Lipopolysaccharide or Lipoteichoic Acid Protects against Staphylococcus aureus Mammary Infection in Mice.

scientific article

Programmed necrosis from molecules to health and disease

scientific article published on January 2011

Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity

scientific journal article

RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

scientific article published in December 2011

RIP kinases at the crossroads of cell death and survival

scientific article published on July 2009

RIPK1 prevents aberrant ZBP1-initiated necroptosis.

scientific article published on 12 December 2016

Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

scientific article

Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD.

scientific article

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock

scientific article

Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB

scholarly article by Louise V Webb et al published 19 February 2019 in Immunity

Synchronized renal tubular cell death involves ferroptosis. ⬇️

scientific article

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

scientific journal article

Take my breath away: necrosis in kidney transplants kills the lungs!

scientific article published in April 2015

Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes

scientific article published on 30 July 2008

The death-fold superfamily of homotypic interaction motifs

scientific article published on 26 July 2011

The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal

scientific article

The role of the kinases RIP1 and RIP3 in TNF-induced necrosis

scientific article published on 30 March 2010

Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA.

scientific article published in September 2002

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.

scientific article published in February 2018

List of works by Tom Vanden Berghe

A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins.

A real-time fluorometric method for the simultaneous detection of cell death type and rate

An inactivating caspase-11 passenger mutation muddles sepsis research

An outline of necrosome triggers

Apoptosis and necrosis: detection, discrimination and phagocytosis

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

Autophagy: for better or for worse

Beclin1: a role in membrane dynamics and beyond

Caspase inhibitors promote alternative cell death pathways

Caspase substrates: easily caught in deep waters?

Caspase-7 in molar tooth development.

Caspase-7 participates in differentiation of cells forming dental hard tissues

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.

Caspases in cell survival, proliferation and differentiation.

Caspases leave the beaten track: caspase-mediated activation of NF-kappaB.

Determination of apoptotic and necrotic cell death in vitro and in vivo.

Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD.

Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy

Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis

Expression of calcium-sensing receptor in quail granulosa explants: a key to survival during folliculogenesis

Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris

Fine-tuning nucleophosmin in macrophage differentiation and activation.

Heavy metal suicide

How do we fit ferroptosis in the family of regulated cell death?

Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease.

Inflammatory mediators in Escherichia coli-induced mastitis in mice

Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft-dependent stimulation of Akt.

Initiation and execution mechanisms of necroptosis: an overview

Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling

Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis.

MLKL Reveals Its Friendly Face: A Role in Nerve Regeneration

Major cell death pathways at a glance

Methods for distinguishing apoptotic from necrotic cells and measuring their clearance

Mitochondria and NADPH oxidases are the major sources of TNF-α/cycloheximide-induced oxidative stress in murine intestinal epithelial MODE-K cells

Molecular crosstalk between apoptosis, necroptosis, and survival signaling

Molecular mechanisms and pathophysiology of necrotic cell death

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

More than one way to die: methods to determine TNF-induced apoptosis and necrosis.

NADPH oxidases: new players in TNF-induced necrotic cell death

NLRP3/caspase-1-independent IL-1beta production mediates diesel exhaust particle-induced pulmonary inflammation

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Nanoscopic X-ray fluorescence imaging and quantification of intracellular key-elements in cryofrozen Friedreich's ataxia fibroblasts

Necroptosis, in vivo detection in experimental disease models

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features.

Necrosis is associated with IL-6 production but apoptosis is not.

Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response

Necrotic cell death and 'necrostatins': now we can control cellular explosion

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

Non-apoptotic functions of caspase-7 during osteogenesis

Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue

Non-classical proIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.

Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids

Preconditioning with Lipopolysaccharide or Lipoteichoic Acid Protects against Staphylococcus aureus Mammary Infection in Mice.

Programmed necrosis from molecules to health and disease

Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity

RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

RIP kinases at the crossroads of cell death and survival

RIPK1 prevents aberrant ZBP1-initiated necroptosis.

Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD.

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock

Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB

Synchronized renal tubular cell death involves ferroptosis. ⬇️

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

Take my breath away: necrosis in kidney transplants kills the lungs!

Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes

The death-fold superfamily of homotypic interaction motifs

The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal

The role of the kinases RIP1 and RIP3 in TNF-induced necrosis

Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA.

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.