List of works - Randy A. Albrecht

1918 and 2009 H1N1 influenza viruses are not pathogenic in birds

scientific article

A Live-Attenuated Prime, Inactivated Boost Vaccination Strategy with Chimeric Hemagglutinin-Based Universal Influenza Virus Vaccines Provides Protection in Ferrets: A Confirmatory Study

scholarly article by Raffael Nachbagauer et al published 25 July 2018 in Vaccines

A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective Inactivated SARS-CoV-2 Vaccine

scientific article published on 17 December 2020

A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine

scientific article published on 31 July 2020

A dual vaccine against influenza & Alzheimer's disease failed to enhance anti-β-amyloid antibody responses in mice with pre-existing virus specific memory

scientific article

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

scientific article published on 03 May 2021

A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.

scientific article published on 10 July 2018

A negative regulatory element (base pairs -204 to -177) of the EICP0 promoter of equine herpesvirus 1 abolishes the EICP0 protein's trans-activation of its own promoter

scientific article

A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses

scientific article (publication date: 9 March 2017)

A point mutation in the polymerase protein PB2 allows a reassortant H9N2 influenza isolate of wild-bird origin to replicate in human cells

scientific article

A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies

scientific article published on 14 September 2017

Accumulation of CD11b⁺Gr-1⁺ cells in the lung, blood and bone marrow of mice infected with highly pathogenic H5N1 and H1N1 influenza viruses

scientific article

Active opioid use does not attenuate the humoral responses to inactivated influenza vaccine

scientific article published on 6 February 2016

An In Vitro Microneutralization Assay for SARS-CoV-2 Serology and Drug Screening

scientific article published on 01 September 2020

Analyses of Cellular Immune Responses in Ferrets Following Influenza Virus Infection

article

Animal models for COVID-19

scientific article published on 23 September 2020

Antigenic sites in influenza H1 hemagglutinin display species-specific immunodominance

Assessment of Influenza Virus Hemagglutinin Stalk-Specific Antibody Responses

article

Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets.

scientific article

Author Correction: Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection

scientific article published on 16 June 2020

Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection

scientific article

Clinical and Serologic Responses After a Two-dose Series of High-dose Influenza Vaccine in Plasma Cell Disorders: A Prospective, Single-arm Trial

scientific article published on 7 March 2017

Complete-proteome mapping of human influenza A adaptive mutations: implications for human transmissibility of zoonotic strains.

scientific article

Constitutive resistance to viral infection in human CD141+ dendritic cells.

scientific article published on July 2017

Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins

scientific article

Differences in antibody responses between trivalent inactivated influenza vaccine and live attenuated influenza vaccine correlate with the kinetics and magnitude of interferon signaling in children

scientific article

Differential requirement for the IKKβ/NF-κB signaling module in regulating TLR- versus RLR-induced type 1 IFN expression in dendritic cells

scientific article published on 23 July 2014

Diminished B-Cell Response After Repeat Influenza Vaccination

scientific article published on 01 April 2019

Direct interaction of TFIIB and the IE protein of equine herpesvirus 1 is required for maximal trans-activation function

scientific journal article

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

scientific article published on 24 July 2020

Distinct cross-reactive B-cell responses to live attenuated and inactivated influenza vaccines

scientific article

Distinct patterns of B-cell activation and priming by natural influenza virus infection versus inactivated influenza vaccination.

scientific article

Divergent H7 immunogens offer protection from H7N9 virus challenge.

scientific article

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus

scientific article

Effect of cholecalciferol supplementation on inflammation and cellular alloimmunity in hemodialysis patients: data from a randomized controlled pilot trial

scientific article

Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species

scientific article published on 10 March 2017

Experimental infection of pigs with the human 1918 pandemic influenza virus

scientific article

Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus.

scientific article

Flow Cytometric and Cytokine ELISpot Approaches To Characterize the Cell-Mediated Immune Response in Ferrets following Influenza Virus Infection

scientific article published on 29 June 2016

Functional Effects of Cardiomyocyte Injury in COVID-19

scientific article published on 20 October 2021

Glycosylations in the globular head of the hemagglutinin protein modulate the virulence and antigenic properties of the H1N1 influenza viruses

scientific article

H3N2 influenza virus infection induces broadly reactive hemagglutinin stalk antibodies in humans and mice

scientific article published on 13 February 2013

H7N9 influenza virus neutralizing antibodies that possess few somatic mutations

scientific article

Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets

scientific article published on 30 December 2015

Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses.

scientific article published on 31 July 2013

Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins

scientific article

Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism

scientific article published on 28 June 2019

Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses.

scientific article

Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses

scientific article

Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements

scientific article

ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination

scientific article

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

scientific article published on 15 May 2020

Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial

scientific article published on 17 October 2019

Immunologic characterization of a rhesus macaque H1N1 challenge model for candidate influenza virus vaccine assessment.

scientific article

Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination

scientific article published on March 2013

Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency

scientific article

Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I

scientific article

Influenza A virus transmission bottlenecks are defined by infection route and recipient host.

scientific article

Influenza virus infection causes global RNAPII termination defects

Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypes

scientific article

Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1

scientific article published on 30 September 2019

Innate immune evasion strategies of influenza viruses

scientific article

Interaction of the equine herpesvirus 1 EICP0 protein with the immediate-early (IE) protein, TFIIB, and TBP may mediate the antagonism between the IE and EICP0 proteins

scientific article

Interactive Big Data Resource to Elucidate Human Immune Pathways and Diseases

scientific article

Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza

scientific article

Macaque proteome response to highly pathogenic avian influenza and 1918 reassortant influenza virus infections

scientific article

Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses.

scientific article published on 20 April 2016

Major histocompatibility complex class II expression and hemagglutinin subtype influence the infectivity of type A influenza virus for respiratory dendritic cells

scientific article

Mapping the sequences that mediate interaction of the equine herpesvirus 1 immediate-early protein and human TFIIB.

scientific article

Mass Cytometry Defines Virus-Specific CD4<sup>+</sup> T Cells in Influenza Vaccination

scientific article published on 11 December 2020

Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes.

scientific article

Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.

scientific article

MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies

scientific article published on 11 August 2013

Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection

scientific article published on 21 May 2020

Microbiome disturbance and resilience dynamics of the upper respiratory tract in response to influenza A virus infection in analog hosts

article

Model of influenza A virus infection: dynamics of viral antagonism and innate immune response.

scientific article

Mouse dendritic cell (DC) influenza virus infectivity is much lower than that for human DCs and is hemagglutinin subtype dependent

scientific article published on 28 November 2012

Moving Forward: Recent Developments for the Ferret Biomedical Research Model

scientific article published on 17 July 2018

Mucosal polyinosinic-polycytidylic acid improves protection elicited by replicating influenza vaccines via enhanced dendritic cell function and T cell immunity.

scientific article published on 23 June 2014

NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication

scientific article published on 7 July 2010

One-shot vaccination with an insect cell-derived low-dose influenza A H7 virus-like particle preparation protects mice against H7N9 challenge.

scientific article

Oseltamivir-resistant variants of the 2009 pandemic H1N1 influenza A virus are not attenuated in the guinea pig and ferret transmission models.

scientific article

Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death.

scientific article

Pandemic influenza virus vaccines boost hemagglutinin stalk-specific antibody responses in primed adult and pediatric cohorts

scientific article published on 06 December 2019

Pathophysiology of SARS-CoV-2: targeting of endothelial cells renders a complex disease with thrombotic microangiopathy and aberrant immune response. The Mount Sinai COVID-19 autopsy experience

scientific article published on 22 May 2020

Programming the magnitude and persistence of antibody responses with innate immunity

scientific article

Protection against lethal influenza with a viral mimic

scientific article published on 29 May 2013

Real Time Investigation of a large Nosocomial Influenza A Outbreak Informed by Genomic Epidemiology

scientific article published on 15 May 2020

Real-Time Investigation of a Large Nosocomial Influenza A Outbreak Informed by Genomic Epidemiology

scientific article published on 30 November 2020

Recombinant IgA is sufficient to prevent influenza virus transmission in guinea pigs

scientific article published on 22 May 2013

Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy

scientific article published on 23 September 2021

SARS-CoV-2 launches a unique transcriptional signature from in vitro, ex vivo, and in vivo systems

scientific article (preprint)

Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model

scientific article published on 10 April 2019

Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein

scientific article

Substitutions T200A and E227A in the hemagglutinin of pandemic 2009 influenza A virus increase lethality but decrease transmission

scientific article

Suppression of the antiviral response by an influenza histone mimic

scientific article

The EICP27 protein of equine herpesvirus 1 is recruited to viral promoters by its interaction with the immediate-early protein.

scientific article published on March 2005

The M segment of the 2009 new pandemic H1N1 influenza virus is critical for its high transmission efficiency in the guinea pig model

scientific article

The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways

scientific article

The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity

scientific article published on May 2017

The equine herpesvirus 1 EICP27 protein enhances gene expression via an interaction with TATA box-binding protein

scientific journal article

The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease

scientific article

The nucleoprotein of newly emerged H7N9 influenza A virus harbors a unique motif conferring resistance to antiviral human MxA.

scientific article

The origin of the PB1 segment of swine influenza A virus subtype H1N2 determines viral pathogenicity in mice

scientific article

The unique IR2 protein of equine herpesvirus 1 negatively regulates viral gene expression

scientific journal article

Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models

scientific article published on 01 December 2020

Transcription Elongation Can Affect Genome 3D Structure

scientific article published on 23 August 2018

Turkey versus guinea pig red blood cells: hemagglutination differences alter hemagglutination inhibition responses against influenza A/H1N1.

scientific article

Vaccination With Viral Vectors Expressing Chimeric Hemagglutinin, NP and M1 Antigens Protects Ferrets Against Influenza Virus Challenge

scientific article published on 21 August 2019

Viral Determinants in H5N1 Influenza A Virus Enable Productive Infection of HeLa Cells

scientific article published on 31 January 2020

List of works by Randy A. Albrecht

1918 and 2009 H1N1 influenza viruses are not pathogenic in birds

A Live-Attenuated Prime, Inactivated Boost Vaccination Strategy with Chimeric Hemagglutinin-Based Universal Influenza Virus Vaccines Provides Protection in Ferrets: A Confirmatory Study

A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective Inactivated SARS-CoV-2 Vaccine

A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine

A dual vaccine against influenza & Alzheimer's disease failed to enhance anti-β-amyloid antibody responses in mice with pre-existing virus specific memory

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.

A negative regulatory element (base pairs -204 to -177) of the EICP0 promoter of equine herpesvirus 1 abolishes the EICP0 protein's trans-activation of its own promoter

A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses

A point mutation in the polymerase protein PB2 allows a reassortant H9N2 influenza isolate of wild-bird origin to replicate in human cells

A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies

Accumulation of CD11b⁺Gr-1⁺ cells in the lung, blood and bone marrow of mice infected with highly pathogenic H5N1 and H1N1 influenza viruses

Active opioid use does not attenuate the humoral responses to inactivated influenza vaccine

An In Vitro Microneutralization Assay for SARS-CoV-2 Serology and Drug Screening

Analyses of Cellular Immune Responses in Ferrets Following Influenza Virus Infection

Animal models for COVID-19

Antigenic sites in influenza H1 hemagglutinin display species-specific immunodominance

Assessment of Influenza Virus Hemagglutinin Stalk-Specific Antibody Responses

Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets.

Author Correction: Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection

Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection

Clinical and Serologic Responses After a Two-dose Series of High-dose Influenza Vaccine in Plasma Cell Disorders: A Prospective, Single-arm Trial

Complete-proteome mapping of human influenza A adaptive mutations: implications for human transmissibility of zoonotic strains.

Constitutive resistance to viral infection in human CD141+ dendritic cells.

Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins

Differences in antibody responses between trivalent inactivated influenza vaccine and live attenuated influenza vaccine correlate with the kinetics and magnitude of interferon signaling in children

Differential requirement for the IKKβ/NF-κB signaling module in regulating TLR- versus RLR-induced type 1 IFN expression in dendritic cells

Diminished B-Cell Response After Repeat Influenza Vaccination

Direct interaction of TFIIB and the IE protein of equine herpesvirus 1 is required for maximal trans-activation function

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

Distinct cross-reactive B-cell responses to live attenuated and inactivated influenza vaccines

Distinct patterns of B-cell activation and priming by natural influenza virus infection versus inactivated influenza vaccination.

Divergent H7 immunogens offer protection from H7N9 virus challenge.

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus

Effect of cholecalciferol supplementation on inflammation and cellular alloimmunity in hemodialysis patients: data from a randomized controlled pilot trial

Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species

Experimental infection of pigs with the human 1918 pandemic influenza virus

Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus.

Flow Cytometric and Cytokine ELISpot Approaches To Characterize the Cell-Mediated Immune Response in Ferrets following Influenza Virus Infection

Functional Effects of Cardiomyocyte Injury in COVID-19

Glycosylations in the globular head of the hemagglutinin protein modulate the virulence and antigenic properties of the H1N1 influenza viruses

H3N2 influenza virus infection induces broadly reactive hemagglutinin stalk antibodies in humans and mice

H7N9 influenza virus neutralizing antibodies that possess few somatic mutations

Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets

Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses.

Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins

Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism

Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses.

Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses

Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements

ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial

Immunologic characterization of a rhesus macaque H1N1 challenge model for candidate influenza virus vaccine assessment.

Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination

Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency

Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I

Influenza A virus transmission bottlenecks are defined by infection route and recipient host.

Influenza virus infection causes global RNAPII termination defects

Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypes

Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1

Innate immune evasion strategies of influenza viruses

Interaction of the equine herpesvirus 1 EICP0 protein with the immediate-early (IE) protein, TFIIB, and TBP may mediate the antagonism between the IE and EICP0 proteins

Interactive Big Data Resource to Elucidate Human Immune Pathways and Diseases

Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza

Macaque proteome response to highly pathogenic avian influenza and 1918 reassortant influenza virus infections

Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses.

Major histocompatibility complex class II expression and hemagglutinin subtype influence the infectivity of type A influenza virus for respiratory dendritic cells

Mapping the sequences that mediate interaction of the equine herpesvirus 1 immediate-early protein and human TFIIB.

Mass Cytometry Defines Virus-Specific CD4<sup>+</sup> T Cells in Influenza Vaccination

Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes.

Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.

MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies

Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection

Microbiome disturbance and resilience dynamics of the upper respiratory tract in response to influenza A virus infection in analog hosts

Model of influenza A virus infection: dynamics of viral antagonism and innate immune response.

Mouse dendritic cell (DC) influenza virus infectivity is much lower than that for human DCs and is hemagglutinin subtype dependent

Moving Forward: Recent Developments for the Ferret Biomedical Research Model

Mucosal polyinosinic-polycytidylic acid improves protection elicited by replicating influenza vaccines via enhanced dendritic cell function and T cell immunity.