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List of works by Lars G Fritsche

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Seven new loci associated with age-related macular degeneration

scientific article
Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk

scientific article
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

scientific article published on 21 December 2015
Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA

scientific article
Systemic complement activation in age-related macular degeneration

scientific article
Age-related macular degeneration: genetics and biology coming together

scientific article
An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)

scientific article
Exome-wide association study of plasma lipids in >300,000 individuals

scientific article published on 30 October 2017
CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors

scientific article published on 6 August 2010
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

scientific article published on 14 January 2019
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

scientific article published on 30 October 2017
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

scientific article published on 13 August 2018
Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies

scientific article published on 12 September 2011
Modelling the genetic risk in age-related macular degeneration.

scientific article
Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people

scientific article
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology

scientific article published on 30 July 2018
CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD

scientific article published in 2009
No clinically significant association between CFH and ARMS2 genotypes and response to nutritional supplements: AREDS report number 38

scientific article
Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype

scientific article published on 13 January 2012
A Subgroup of Age-Related Macular Degeneration is Associated With Mono-Allelic Sequence Variants in theABCA4Gene

scientific article published on April 30, 2012
Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency.

scientific article
In Silico Functional Meta-Analysis of 5,962 ABCA4 Variants in 3,928 Retinal Dystrophy Cases

scientific article published on 3 January 2017
Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease

scientific article published on 30 October 2017
Genotype imputation in genome-wide association studies

scientific article published on July 2013
Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative

scientific article published on 17 May 2018
Novel Common Genetic Susceptibility Loci for Colorectal Cancer

scientific article published on 01 February 2019
Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development

scientific article published on 27 December 2017
Assessment of the contribution of CFH and chromosome 10q26 AMD susceptibility loci in a Russian population isolate.

scientific article
Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve

scientific article
A Scalable Bayesian Method for Integrating Functional Information in Genome-wide Association Studies

scientific article
Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration

scientific article published on 11 February 2019
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

scientific article published on 13 June 2018
First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

scientific article published on 25 September 2018
Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene

scientific article published in July 2009
Case-control genetic association study of fibulin-6 (FBLN6 or HMCN1) variants in age-related macular degeneration (AMD)

scientific article
Genome-wide analysis yields new loci associating with aortic valve stenosis

scientific article published on 7 March 2018
Bivariate Analysis of Age-Related Macular Degeneration Progression Using Genetic Risk Scores

scientific article published on 24 March 2017
HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization

scientific article published on 12 September 2017
Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study

scientific article published on 31 January 2019
Genome-wide Analysis of Disease Progression in Age-related Macular Degeneration

scientific article published on 15 January 2018
Expanding the spectrum of PTH1R mutations in patients with primary failure of tooth eruption

scientific article published on June 15, 2013
Improving power of association tests using multiple sets of imputed genotypes from distributed reference panels.

scientific article published on September 2017
UK Biobank Whole-Exome Sequence Binary Phenome Analysis with Robust Region-Based Rare-Variant Test

scientific article published on 19 December 2019
Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

scientific article published on 27 April 2020
Age-related macular degeneration and coronary heart disease: evaluation of genetic and environmental associations

scientific article published on 25 October 2012
Age-related macular degeneration with discordant late stage phenotypes in monozygotic twins.

scientific article
Exploring various polygenic risk scores for skin cancer in the phenomes of the Michigan genomics initiative and the UK Biobank with a visual catalog: PRSWeb

scientific article published on 13 June 2019
Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration

scientific article published on 17 March 2012
Prediction of Ankylosing Spondylitis in the HUNT Study by a Genetic Risk Score Combining 110 Single-nucleotide Polymorphisms of Genome-wide Significance

scientific article published on 01 April 2019
Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts

scientific article published on 18 May 2020

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