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List of works by Alan Fairlamb

8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases

scientific article published on 01 August 2018

8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase

scientific article published in June 2003

A comparative study of methylglyoxal metabolism in trypanosomatids

scientific article published on 3 December 2008

A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major

scientific article published on 8 October 2007

A new expression vector for Crithidia fasciculata and Leishmania

scientific article published in April 2002

A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article (publication date: 18 June 2015)

A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism

scholarly article by Adam J Roberts published in August 2018

A simple magnetic method for the purification of malarial pigment

scientific article published on July 1984

A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi

scientific article

A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes

scientific article

A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major

scholarly article

ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides

scientific article published in November 2008

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania

scientific article

Active site of trypanothione reductase. A target for rational drug design.

scientific article published on September 1992

Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog

scientific journal article

An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes

scientific article published on 01 April 1998

An improved method for the estimation of suramin in plasma and trypanosome samples.

scientific article published in October 1980

An improved technique for the cultivation of Plasmodium falciparum in vitro without daily medium change

scientific article published on 01 August 1985

Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3-b]thiopen-4,9-quinones

scientific article

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

scientific article published on 27 February 2017

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

scientific article published on 05 June 2017

Antimicrobial drug discovery

scientific article published in June 2011

Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine

scientific article

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals

scholarly article by Richard J Wall et al published August 2018 in Antimicrobial Agents and Chemotherapy

Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism

scientific article published on 6 January 2011

Arsenic exposure and outcomes of antimonial treatment in visceral leishmaniasis patients in Bihar, India: a retrospective cohort study

scientific article

Arsenical-resistant trypanosomes lack an unusual adenosine transporter

scientific article

Assessing the essentiality of Leishmania donovani nitroreductase and its role in nitro drug activation

scientific article published on 3 December 2012

Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

scientific article published on 01 November 2018

Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase

scientific article published in August 2003

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

scientific article

Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

scientific article published on April 2014

Biochemical changes associated with alpha-difluoromethylornithine uptake and resistance in Trypanosoma brucei

scientific article published in October 1987

Biochemistry of trypanosomiasis and rational approaches to chemotherapy

Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata

scientific article

Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi

scientific article

Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro

scientific article

Brave new world of post-genomics!

scientific article published on 01 June 2001

Characterisation of a Putative Glutamate 5- Kinase from Leishmania donovani.

scientific article

Characterisation of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism

scientific article published on July 1992

Characterisation of pentamidine-resistant Trypanosoma brucei brucei

scientific article

Characterization of kinetoplast DNA networks from the insect trypanosome Crithidia luciliae

scientific article published on September 20, 1977

Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata

scientific article published on June 2002

Characterization of the peptide substrate specificity of glutathionylspermidine synthetase from Crithidia fasciculata

scientific article published on 01 January 1997

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

scientific article published on 2 October 2017

Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes

scientific article published on July 2008

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis

scientific article

Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

scientific article

Chemotherapy of human African trypanosomiasis: current and future prospects ⬇️

scientific article published on November 1, 2003

Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis

scientific article published on 28 October 2013

Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata

scientific article published in July 1998

Cloning of a pyruvate phosphate dikinase from Trypanosoma cruzi

scientific article

Cloning, expression and functional characterisation of a peroxiredoxin from the potato cyst nematode Globodera rostochiensis

scientific article

Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata

scientific article published on October 1998

Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi

scientific article

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay

scientific article published on 9 April 2013

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article published on 25 May 2016

Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis

scientific article

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

scientific article

Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I.

scientific article

Crystallization of Recombinant Crithidia fasciculata Tryparedoxin

article

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

scientific article published in Nature

Cytochrome P450 in trypanosomatids

scientific article

Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors

scientific article

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

scientific article

Detailed characterization of a cyclophilin from the human malaria parasite Plasmodium falciparum ⬇️

scientific article (publication date: September 1998)

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

scientific article

Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome

article

Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors

scientific article

Diamine auxotrophy in a eukaryotic parasite

scientific article

Diamine auxotrophy may be a universal feature of Trypanosoma cruzi epimastigotes

scientific article published on January 1997

Differential susceptibility of filarial and human erythrocyte glutathione reductase to inhibition by the trivalent organic arsenical melarsen oxide

scientific article published on May 1995

Differential toxicity of antimonial compounds and their effects on glutathione homeostasis in a human leukaemia monocyte cell line

scientific article published on 28 November 2005

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

scientific article

Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening

scientific article

Discovery of a Novel Class of Orally Active Trypanocidal N -Myristoyltransferase Inhibitors

scientific article

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

scientific article published on 10 September 2016

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

scientific article published on May 1997

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods

scientific article

Dissecting the metabolic roles of pteridine reductase 1 in Trypanosoma brucei and Leishmania major

scientific article published on 14 January 2011

Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: Effect on parasite intracellular survival ⬇️

scientific article published on April 28, 1998

Drug resistance in eukaryotic microorganisms

scientific article

Drug resistance in leishmaniasis

scientific article (publication date: 2006)

Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani

scientific article

Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates

scientific article published on 27 May 2010

Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase

scientific article published on February 2003

Entamoeba histolytica lacks trypanothione metabolism

scientific article

Erratum for De Rycker et al., Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

scholarly article published in Antimicrobial Agents and Chemotherapy

Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus

scientific article

Exploring the potential of xanthene derivatives as trypanothione reductase inhibitors and chloroquine potentiating agents

Extrachromosomal, homologous expression of trypanothione reductase and its complementary mRNA in Trypanosoma cruzi.

scientific article published on August 1996

FC4 glutathionylspermidine synthethase from Crithidia fasciculata: Kinetic properties of glutathione and spermidine analogues

Future prospects for the chemotherapy of human trypanosomiasis. 1. Novel approaches to the chemotherapy of trypanosomiasis

scientific article published on September 1990

Genome sequence of the human malaria parasite Plasmodium falciparum

scientific article

Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

scientific article

Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 1: Substitution of the glycine carboxylic acid group

scientific article published in September 2002

Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: substitution of the glycine part

scientific article published in October 2002

Glutathionylspermidine metabolism in Escherichia coli.

scientific article published on December 1995

High-performance liquid chromatographic method for the separation and quantitative estimation of anti-parasitic melaminophenyl arsenical compounds

scientific article

High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity

scientific article

Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei

scientific article published on 25 November 2014

Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.

scientific article published on December 1994

Identification and characterisation of a functional peroxidoxin from Leishmania major

scientific article published in October 1998

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

scientific article

Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis

scientific article

In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei

scientific article published on 01 June 1987

Inhibition of polyamine biosynthesis in Crithidia fasciculata by D,L-alpha-difluoromethylornithine and D,L-alpha-difluoromethylarginine

scientific article published on May 1991

Initiating a crystallographic study of trypanothione reductase

scientific article published on November 1990

Interactions between immunity and chemotherapy in the treatment of the trypanosomiases and leishmaniases

scientific article

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei

scientific article

Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis

scientific article published on January 2006

Kinetoplastids: related protozoan pathogens, different diseases

scientific article published on April 2008

Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis

scientific article

Leishmania major elongation factor 1B complex has trypanothione S-transferase and peroxidase activity

scientific article

Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities

scientific article

Lipoprotein lipase suppression in 3T3-L1 cells by a haematoprotozoan-induced mediator from peritoneal exudate cells

scientific article published on May 1984

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

scientific article published on 20 March 2019

MYST family histone acetyltransferases in the protozoan parasite Toxoplasma gondii

scientific article

Mapping the functional synthetase domain of trypanothione synthetase from Leishmania major

scientific article

Metabolic pathway analysis in trypanosomes and malaria parasites

scientific article

Metabolism and functions of trypanothione in the Kinetoplastida

scientific article

Methylglyoxal metabolism in trypanosomes and leishmania

scientific article published on 15 February 2011

Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei

scientific article published in September 2001

Molecular characterization and expression of Onchocerca volvulus glutathione reductase.

scientific article published on August 1997

Molecular characterization of the trypanothione reductase gene from Crithidia fasciculata and Trypanosoma brucei: comparison with other flavoprotein disulphide oxidoreductases with respect to substrate specificity and catalytic mechanism

scientific article

Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells

scientific article

Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial

scientific article published on 09 March 2021

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

scientific article

New approach to screening drugs for activity against African trypanosomes

scientific article

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei

scientific article

Norspermidine is not a self-produced trigger for biofilm disassembly

scientific article published on February 2014

Novel 8-nitroquinolin-2(1 H )-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study

scientific article published on 05 June 2018

Novel biochemical pathways in parasitic protozoa

scientific article published on January 1989

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

scientific article

Open Lab as a source of hits and leads against tuberculosis, malaria and kinetoplastid diseases

scientific article published on 29 March 2016

Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488

scientific article

Ovothiol and trypanothione as antioxidants in trypanosomatids

scientific article published in July 2001

Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes

scientific article published on 18 December 2015

Peptoid inhibition of trypanothione reductase as a potential antitrypanosomal and antileishmanial drug lead

scientific article published in June 2002

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

scholarly article by Victoriano Corpas-Lopez et al published 12 November 2018 in ACS Infectious Diseases

Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress.

scientific article published on November 1993

Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome

scientific article

Polyamine and pentamidine metabolism in African trypanosomes

scientific article

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

scientific article published on 08 April 2019

Properties of melarsamine hydrochloride (Cymelarsan) in aqueous solution.

scientific article

Properties of phosphoenolpyruvate mutase, the first enzyme in the aminoethylphosphonate biosynthetic pathway in Trypanosoma cruzi

scientific article published on 2 April 2003

Properties of trypanothione synthetase from Trypanosoma brucei

scientific article published in September 2003

Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases

scientific article

Purification of glutathione reductase from muscle of the adult parasitic nematode Ascaris suum

scientific article published on 01 April 1992

Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata ⬇️

scientific article published on July 1, 1992

Quinol derivatives as potential trypanocidal agents

scientific article published on 27 December 2011

Rational design of peptide-based inhibitors of trypanothione reductase as potential antitrypanosomal drugs

scientific article published on 01 October 1994

Rational design of selective ligands for trypanothione reductase fromtrypanosoma cruzStructural effects on the inhibition by dibenzazepines based on imipramine

scientific article published on 01 August 1997

Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures ⬇️

scientific article published on August 15, 1992

Refinement of techniques for the propagation of Leishmania donovani in hamsters

scientific article published on 7 February 2006

Renewed strategies for drug development against parasitic diseases.

scientific article

Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials

scientific article published on 4 February 2008

Screening a protein kinase inhibitor library against Plasmodium falciparum

scientific article published on 7 November 2017

Separation and quantitation of the polyamine biosynthesis inhibitor D,L-alpha-difluoromethylarginine and other guanidine-containing compounds by high-performance liquid chromatography

scientific article published on November 1990

Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase.

scientific article

Specific peptide inhibitors of trypanothione reductase with backbone structures unrelated to that of substrate: potential rational drug design lead frameworks

scientific article

Specificity of Ethanolamine Transport and Its Further Metabolism in Trypanosoma brucei

scientific article published in Journal of Biological Chemistry

Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme

scientific article

Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases

scientific article

Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate

scientific article published on September 2006

Structure of trypanothione reductase from Crithidia fasciculata at 2.6 A resolution; enzyme-NADP interactions at 2.8 A resolution

scientific article published in March 1994

Subcellular distribution of trypanothione reductase in bloodstream and procyclic forms of Trypanosoma brucei.

scientific article published on September 1991

Substrate interactions between trypanothione reductase and N1-glutathionylspermidine disulphide at 0.28-nm resolution

scientific article

Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata

scientific article published on 01 June 1987

Surface receptors and transporters of Trypanosoma brucei

scientific article published in January 1998

Synthesis and enzymology of modifiedN-benzyloxycarbonyl-L-cysteinylglycyl-3,3-dimethylaminopropylamide disulphides as alternative substrates for trypanothione reductase fromTrypanosoma crud: Part 3

scientific article published on 01 January 1999

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase

scientific article

Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani

scientific article

Synthesis and evaluation of indatraline-based inhibitors for trypanothione reductase

scientific article

Synthesis of N-benzyloxycarbonyl-l-cysteinylglycine 3-dimethylaminopropylamide disulfide: A cheap and convenient new assay for trypanothione reductase

scientific article published on 01 October 1991

Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity

scientific article

Target assessment for antiparasitic drug discovery

scientific article

Target validation: linking target and chemical properties to desired product profile

scientific article

The N-myristoylome of Trypanosoma cruzi

scientific article published on 5 August 2016

The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani

scientific article published on 30 January 2020

The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis

scientific article

The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei

scientific article

The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis

scientific article

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

scientific article published on 24 May 2016

The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes

scientific article

The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of γ-glutamyl-modified substrate analogues

scientific article published on 01 November 1993

The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I

scientific article

The interaction of arsenical drugs with dihydrolipoamide and dihydrolipoamide dehydrogenase from arsenical resistant and sensitive strains of Trypanosoma brucei brucei

scientific article published on July 1992

The interaction of trypanocidal drugs with polyamine and trypanothione metabolism

scientific article published on December 1990

The structure, organization, and expression of the Leishmania donovani gene encoding trypanothione reductase

scientific article published on April 1994

The trypanothione reductase gene of Leishmania donovani

scientific article

Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products

scientific article published on 21 November 2005

Triclosan is minimally effective in rodent malaria models

scientific article published in January 2011

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

scientific article published on 17 June 2016

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

scientific article

Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy

scientific article published on 9 September 2013

Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase

scientific article

Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice

scientific article

Trypanosoma brucei: Maintenance of concentrated suspensions of bloodstream trypomastigotes in vitro using continuous dialysis for measurement of endocytosis

scientific article published on 01 June 1980

Trypanosoma brucei: Suramin and other trypanocidal compounds' effects on sn-glycerol-3-phosphate oxidase

scientific article published on 01 December 1977

Trypanosoma cruzi trypanothione reductase is inactivated by peroxidase-generated phenothiazine cationic radicals

scientific article published in April 2001

Trypanosoma cruzi trypanothione reductase. Crystallization, unit cell dimensions and structure solution.

scientific article

Trypanothione Reductase from Leishmania donovani. Purification, Characterisation and Inhibition by Trivalent Antimonials ⬇️

scientific article published on June 1, 1995

Trypanothione S-transferase activity in a trypanosomatid ribosomal elongation factor 1B.

scientific article

Trypanothione biosynthesis in Leishmania major

scientific article

Trypanothione dependent peroxide metabolism in Crithidia fasciculata and Trypanosoma brucei

scientific article published on 01 May 1987

Trypanothione metabolism and rational approaches to drug design

scientific article published on October 1990

Trypanothione metabolism: a chemotherapeutic target in trypanosomatids

scientific article

Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme.

scientific article

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity

scientific article published on 13 April 2009

Trypanothione-dependent glyoxalase I in Trypanosoma cruzi ⬇️

scientific article

Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function

scientific article (publication date: 11 July 2003)

Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design

scientific article

Uptake of the nitroimidazole drug megazol by African trypanosomes

scientific article published in 2000

Uptake of the trypanocidal drug suramin by bloodstream forms of Trypanosoma brucei and its effect on respiration and growth rate in vivo

scientific article published on October 1980

Visceral leishmaniasis and arsenic: an ancient poison contributing to antimonial treatment failure in the Indian subcontinent?

scientific article

p-(4,6-Diamino-s-triazin-2-yl)aminophenylarsonic Acid Dihydrate

scientific article published on 01 September 1995

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