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List of works by Howard Feldman

16-Year Survival of the Canadian Collaborative Cohort of Related Dementias.

scientific article published on 7 May 2018

18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery

scientific article published in February 2018

A Canadian Cohort Study of Cognitive Impairment and Related Dementias (ACCORD): Study Methods and Baseline Results

article

A conceptual framework and ethics analysis for prevention trials of Alzheimer Disease.

scientific article published on 21 January 2013

A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17

article

A randomized clinical trial to evaluate home-based assessment of people over 75 years old

scientific article published on 11 March 2019

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

scientific article

Activities of daily living in moderate-to-severe Alzheimer disease: an analysis of the treatment effects of memantine in patients receiving stable donepezil treatment

scientific article published in October 2006

Adaptive crossover designs for assessment of symptomatic treatments targeting behaviour in neurodegenerative disease: a phase 2 clinical trial of intranasal oxytocin for frontotemporal dementia (FOXY)

scholarly article by Elizabeth Finger et al published 27 September 2018 in Alzheimers Research & Therapy

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

scientific article

Alzheimer's disease research and development: a call for a new research roadmap

scientific article published on April 2014

Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup

scientific article

An exploration of cognitive subgroups in Alzheimer's disease

scientific article

Analyses of mortality risk in patients with dementia treated with galantamine.

scientific article

Assessing the validity of deriving clinical dementia rating (CDR) global scores from independently-obtained functional rating scale (FRS) scores in vascular dementia with and without Alzheimer's disease.

scientific article published in October 2009

Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans

scientific article published on 16 February 2012

Behavioural measures in frontotemporal lobar dementia and other dementias: the utility of the frontal behavioural inventory and the neuropsychiatric inventory in a national cohort study.

scientific article published on 20 April 2007

Brain volumetric deficits in MAPT mutation carriers: a multisite study

scientific article published on 28 November 2020

Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease

scientific article published on 12 February 2013

Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease

scientific article

Characterizing neuropsychiatric symptoms in subjects referred to dementia clinics

scientific article

Clinical and pathological features of familial frontotemporal dementia caused by C9ORF72 mutation on chromosome 9p

scientific article published on February 17, 2012

Clinical and radiographic subtypes of vascular cognitive impairment in a clinic-based cohort study

scientific article

Clinical phenotypes of Cerebral Amyloid Angiopathy.

scientific article published on 6 March 2007

Clinical presentation of prodromal frontotemporal dementia.

scientific article published on December 2007

Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

scientific article

Cognition, function, and caregiving time patterns in patients with mild-to-moderate Alzheimer disease: a 12-month analysis

scientific article

Cognitive heterogeneity in probable Alzheimer disease: Clinical and neuropathologic features

scientific article published on 18 July 2019

Cognitive impairment no dementia - neuropsychological and neuroimaging characterization of an amnestic subgroup

scientific article published on 8 February 2008

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

scientific article

Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia

scientific article published on 21 August 2008

Defeating Alzheimer's disease and other dementias: a priority for European science and society

scientific article published on April 2016

Delayed daily activity and reduced NREM slow-wave power in the APPswe/PS1dE9 mouse model of Alzheimer's disease

scientific article published on 14 February 2019

Dementia with Lewy bodies

scientific article published on 01 January 2004

Dependence as a unifying construct in defining Alzheimer's disease severity

scientific article

Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium

scientific article

Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium

scientific article (publication date: 27 December 2005)

Differentiating the frontal variant of Alzheimer's disease

scientific article published in July 2010

Disease progression in vascular cognitive impairment: cognitive, functional and behavioural outcomes in the Consortium to Investigate Vascular Impairment of Cognition (CIVIC) cohort study.

scientific article

Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease

scientific article published on 09 November 2018

Early neuropsychological characteristics of progranulin mutation carriers

scientific article

Editorial: Collaborative Efforts to Prevent Alzheimer's Disease

scientific article published in January 2017

Effect of diesel exhaust inhalation on blood markers of inflammation and neurotoxicity: a controlled, blinded crossover study

scientific article

Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study

scientific article

Effectiveness of donepezil in reducing clinical worsening in patients with mild-to-moderate alzheimer's disease

scientific article

Effects of gender on response to treatment with rivastigmine in mild cognitive impairment: A post hoc statistical modeling approach

scientific article

Efficacy and safety of donepezil in patients with more severe Alzheimer's disease: a subgroup analysis from a randomized, placebo-controlled trial

scientific article published in June 2005

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial.

scientific article

Efficacy of donepezil on behavioral symptoms in patients with moderate to severe Alzheimer's disease.

scientific article published in December 2002

Epidemiology and genetics of frontotemporal dementia/Pick's disease.

scientific article

Evaluation of late-onset Alzheimer disease genetic susceptibility risks in a Canadian population.

scientific article

Executive dysfunction in vascular cognitive impairment in the consortium to investigate vascular impairment of cognition study

scientific article published on 17 October 2009

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

scientific article

Extrapyramidal features in patients with motor neuron disease and dementia; a clinicopathological correlative study.

scientific article published on 24 January 2004

Familial frontotemporal dementia with neuronal intranuclear inclusions is not a polyglutamine expansion disease

scientific article

Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development

scientific article published on 05 October 2012

Generation of an induced pluripotent stem cell line (UBCi001-A) from a presymptomatic individual carrying the R418X progranulin gene mutation

scientific article published on 08 November 2019

Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration

scientific article

Global issues in drug development for Alzheimer's disease.

scientific article published in March 2011

Memantine and Acetylcholinesterase Inhibitor Use in Alzheimer's Disease Clinical Trials: Potential for Confounding by Indication

scientific article published on 01 January 2019

Mild cognitive impairment

scientific article published in The Lancet

Minimizing misdiagnosis: psychometric criteria for possible or probable memory impairment

scientific article published on 28 April 2009

Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder

scientific article

Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration

scientific article

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

scientific article

Neurobehavioral characterization of adult-onset Alexander disease: A family study

scientific article published on 01 October 2017

Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases

scientific article published in January 2004

Neuropsychiatric symptom clusters and functional disability in cognitively-impaired-not-demented individuals

scientific article published on 10 October 2007

Neuropsychological characterization of cognitively-impaired-not-demented (CIND) individuals: clinical comparison data.

scientific article

New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures

scientific article published on 06 January 2020

Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy

scientific article published on 10 September 2010

Outcomes of cognitively impaired not demented at 2 years in the Canadian Cohort Study of Cognitive Impairment and Related Dementias

scientific article published on 11 September 2006

Participant satisfaction with dementia prevention research: Results from Home-Based Assessment trial

scientific article published on 05 October 2018

Periventricular hyperintensities are associated with elevated cerebral amyloid

scientific article published on 8 January 2016

Pharmacodynamics of selective inhibition of γ-secretase by avagacestat.

scientific article published on 28 December 2012

Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative

scientific article published in October 2007

Potential for misclassification of mild cognitive impairment: a study of memory scores on the Wechsler Memory Scale-III in healthy older adults

scientific article published in May 2008

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.

scientific article published in March 2016

Predicting response to acetylcholinesterase inhibitor treatment in Alzheimer disease: has the time come?

scientific article published on 3 February 2009

Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance

scientific article published on 14 December 2010

Prevention trials in Alzheimer's disease: an EU-US task force report.

scientific article published on 10 September 2011

Progranulin expression in the developing and adult murine brain.

scientific article published in October 2010

Protein kinase C activity and protein levels in Alzheimer's disease

scientific article published in August 1997

Rates of cognitive change in Alzheimer disease: observations across a decade of placebo-controlled clinical trials with donepezil

scientific article

Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria

scientific article (publication date: August 2007)

Revised research diagnostic criteria for Alzheimer's disease.

scientific article

Revising the definition of Alzheimer's disease: a new lexicon.

scientific article published on 9 October 2010

Rivastigmine: a placebo controlled trial of twice daily and three times daily regimens in patients with Alzheimer's disease.

scientific article

Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial

scientific article published on 08 July 2019

Safety and tolerability of the γ-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease

scientific article

Serum levels of the iron binding protein p97 are elevated in Alzheimer's disease.

scientific article published in November 1996

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

scientific article

Superficial siderosis: a potential diagnostic marker of cerebral amyloid angiopathy in Alzheimer disease.

scientific article

Synaptic dysfunction in progranulin-deficient mice

scientific article published on 25 October 2011

Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease

scientific article published in April 2008

Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial

scientific article published on 28 September 2015

The "rights" of precision drug development for Alzheimer's disease

scientific article published on 31 August 2019

The 2002 NIMH Provisional Diagnostic Criteria for Depression of Alzheimer's Disease (PDC-dAD): Gauging their Validity over a Decade Later

scientific article

The Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics

scientific article published in March 2008

The Canadian dementia challenge: Ensuring optimal care and services for those at risk or with dementia throughout the country.

scientific article published on 20 April 2017

The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study

scientific article published on 16 July 2019

The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

scientific article

The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene

scientific article published in November 2006

Therapeutic potential of statins in Alzheimer's disease.

scientific article published on 24 March 2009

Therapeutic trial design for frontotemporal dementia and related disorders

scientific article published on 25 October 2018

Transition from cognitively impaired not demented to Alzheimer's disease: an analysis of changes in functional abilities in a dementia clinic cohort.

scientific article

Treatment of Alzheimer's disease: current status and new perspectives.

scientific article

Treatment with galantamine and time to nursing home placement in Alzheimer's disease patients with and without cerebrovascular disease

scientific article

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

scientific article

Will the circle be unbroken: a history of the U.S. National Ambient Air Quality Standards

article

rs5848 polymorphism and serum progranulin level

scientific article published on November 2, 2010