List of works - Junxian Lim

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats

scientific article

Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity.

scientific article published on 17 December 2015

Biased Signaling by Agonists of Protease Activated Receptor 2.

scientific article published on 7 February 2017

Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl-1 Proteins.

scientific article published on 27 March 2018

C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

scientific article

Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism

scientific article

Downsizing a human inflammatory protein to a small molecule with equal potency and functionality.

scientific article

Electrophilic Helical Peptides That Bond Covalently, Irreversibly, and Selectively in a Protein-Protein Interaction Site

scientific article published on 15 November 2016

Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor

scientific article

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

scientific article published on 24 August 2017

Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.

scientific article published on 16 September 2013

Mapping transmembrane residues of proteinase activated receptor 2 (PAR2) that influence ligand-modulated calcium signaling.

scientific article

PAR2 Modulators Derived from GB88.

scientific article

Pathway-selective antagonism of proteinase activated receptor 2.

scientific article

Potent Small Agonists of Protease Activated Receptor 2.

scientific article published on 30 November 2015

Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity

scientific article published on 07 January 2020

Potent heterocyclic ligands for human complement c3a receptor

scientific article published on 8 October 2014

Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).

scientific article published on 3 March 2016

Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition

scientific article published on 17 December 2020

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.

scientific article

Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2.

scientific article published on 7 October 2015

Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides.

scientific article

Structure-activity relationships for substrate-based inhibitors of human complement factor B.

scientific article published in October 2009

Three Homology Models of PAR2 Derived from Different Templates: Application to Antagonist Discovery.

scientific article published on 22 May 2015

List of works by Junxian Lim

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats

Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity.

Biased Signaling by Agonists of Protease Activated Receptor 2.

Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl-1 Proteins.

C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism

Downsizing a human inflammatory protein to a small molecule with equal potency and functionality.

Electrophilic Helical Peptides That Bond Covalently, Irreversibly, and Selectively in a Protein-Protein Interaction Site

Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.

Mapping transmembrane residues of proteinase activated receptor 2 (PAR2) that influence ligand-modulated calcium signaling.

PAR2 Modulators Derived from GB88.

Pathway-selective antagonism of proteinase activated receptor 2.

Potent Small Agonists of Protease Activated Receptor 2.

Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity

Potent heterocyclic ligands for human complement c3a receptor

Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).

Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.

Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2.

Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides.

Structure-activity relationships for substrate-based inhibitors of human complement factor B.

Three Homology Models of PAR2 Derived from Different Templates: Application to Antagonist Discovery.