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List of works by Christopher G. Dowson

A Role for Sigma Factor σ(E) in Corynebacterium pseudotuberculosis Resistance to Nitric Oxide/Peroxide Stress

scientific article published on 3 April 2012

A combined approach for comparative exoproteome analysis of Corynebacterium pseudotuberculosis.

scientific article

A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens.

scientific article

Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae

scientific article published on 25 May 2007

Adenosine tetraphosphoadenosine drives a continuous ATP-release assay for aminoacyl-tRNA synthetases and other adenylate-forming enzymes ⬇️

scientific article published on 13 August 2013

Association between hypermutator phenotype, clinical variables, mucoid phenotype, and antimicrobial resistance in Pseudomonas aeruginosa

scientific article published on 06 August 2008

Automated pneumococcal MLST using liquid-handling robotics and a capillary DNA sequencer.

scientific article

Bacterial Lipid II Analogs: Novel In Vitro Substrates for Mammalian Oligosaccharyl Diphosphodolichol Diphosphatase (DLODP) Activities

scientific article published on 06 June 2019

Bacterial cell wall assembly: still an attractive antibacterial target

scientific article published on 12 January 2011

Bayesian modeling of recombination events in bacterial populations

scientific article

Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity

scientific article published on 02 August 2018

Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity

scientific article published on 21 July 2015

Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan

scientific article published on 12 December 2007

Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity.

scientific article published on 30 August 2016

Commercial mushrooms and bean sprouts are a source of Pseudomonas aeruginosa.

scientific article published on November 2005

Data reduction in headspace analysis of blood and urine samples for robust bacterial identification.

scientific article

Deletion analysis of the essentiality of penicillin-binding proteins 1A, 2B and 2X of Streptococcus pneumoniae.

scientific article

Detection of "Hidden" Antimicrobial Drug Resistance

scientific article published on 20 June 2019

Development of a multilocus sequence typing scheme for the opportunistic pathogen Pseudomonas aeruginosa.

scientific article published on December 2004

Development of a multilocus sequence typing scheme for the pig pathogen Streptococcus suis: identification of virulent clones and potential capsular serotype exchange

scientific article published on October 2002

Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis.

scientific article published on 31 December 2016

Distribution and genetic diversity of the ABC transporter lipoproteins PiuA and PiaA within Streptococcus pneumoniae and related streptococci.

scientific article published in February 2006

Distribution of epidemic antibiotic-resistant pneumococcal clones in Scottish pneumococcal isolates analysed by multilocus sequence typing

scientific article published on 01 February 2006

Distribution, genetic diversity, and variable expression of the gene encoding hyaluronate lyase within the Streptococcus suis population.

scientific article published on July 2004

Diversity of the parB and repA genes of the Burkholderia cepacia complex and their utility for rapid identification of Burkholderia cenocepacia

scientific article

Elucidating global epidemiology of Burkholderia multivorans in cases of cystic fibrosis by multilocus sequence typing.

scientific article published on 21 November 2007

Evaluation of a Library of FDA-Approved Drugs for Their Ability To Potentiate Antibiotics against Multidrug-Resistant Gram-Negative Pathogens

scientific article published on 25 July 2019

Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis

scientific article

Expression, purification, crystallization and preliminary characterization of uridine 5'-diphospho-N-acetylmuramoyl L-alanyl-D-glutamate:lysine ligase (MurE) from Streptococcus pneumoniae 110K/70.

scientific article published on 23 January 2004

Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5.

scientific article published on 7 September 2006

Genetic diversity of the tet(M) gene in tetracycline-resistant clonal lineages of Streptococcus pneumoniae.

scientific article

Genetic relationships between clinical isolates of Streptococcus pneumoniae, Streptococcus oralis, and Streptococcus mitis: characterization of "Atypical" pneumococci and organisms allied to S. mitis harboring S. pneumoniae virulence factor-encoding

scientific article published on March 2000

Genetics of high level penicillin resistance in clinical isolates of Streptococcus pneumoniae.

scientific article published in March 1995

Genetics of high level penicillin resistance in clinical isolates ofStreptococcus pneumoniae

article

Horizontal spread of an altered penicillin-binding protein 2B gene between Streptococcus pneumoniae and Streptococcus oralis

scientific article

Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae

scientific article

In silico identification, synthesis and biological evaluation of novel tetrazole inhibitors of MurB.

scientific article published on 24 January 2018

In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA).

scientific article

Incremental Increase in Fitness Cost with Increased β‐Lactam Resistance in Pneumococci Evaluated by Competition in an Infant Rat Nasal Colonization Model

article

Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis

scientific article published on 01 September 2010

Infection With Transmissible Strains of Pseudomonas aeruginosa and Clinical Outcomes in Adults With Cystic Fibrosis

scientific article published in The Journal of the American Medical Association

Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. ⬇️

scientific article published on 5 December 2017

Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors

scientific article

Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae.

scientific article published in June 1990

InvestigatingBurkholderia cepaciacomplex populations recovered from Italian maize rhizosphere by multilocus sequence typing

article

Key role for efflux in the preservative susceptibility and adaptive resistance of Burkholderia cepacia complex bacteria

scientific article published on 15 April 2013

Kinetic characterization of lipid II-Ala:alanyl-tRNA ligase (MurN) from Streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates.

scientific article published on 8 October 2008

Larval therapy for leg ulcers (VenUS II): randomised controlled trial.

scientific article

Localized sex in bacteria

scientific article published in Nature

Meeting the discovery challenge of drug-resistant infections: progress and focusing resources

scientific article published on 23 November 2018

Metal Complexes as a Promising Source for New Antibiotics

scientific article published on 22 October 2019

Metal complexes as a promising source for new antibiotics

scientific article published on 12 February 2020

Molecular evolution of rifampicin resistance in Streptococcus pneumoniae

scientific article published on 01 January 1998

Multilocus Sequence Typing Identifies Evidence for Recombination and Two Distinct Lineages of Corynebacterium diphtheriae ⬇️

scientific article published on September 15, 2010

Multilocus sequence types of invasive Corynebacterium diphtheriae isolated in the Rio de Janeiro urban area, Brazil.

scientific article

Multilocus sequence typing breathes life into a microbial metagenome

scientific article

Multilocus sequence typing for comparison of veterinary and human isolates of Campylobacter jejuni.

scientific article

Multilocus sequence typing of Cronobacter sakazakii and Cronobacter malonaticus reveals stable clonal structures with clinical significance which do not correlate with biotypes

scientific article

Multilocus sequence typing of Staphylococcus aureus isolated from high-somatic-cell-count cows and the environment of an organic dairy farm in the United Kingdom.

scientific article

Multilocus sequence typing scheme that provides both species and strain differentiation for the Burkholderia cepacia complex.

scientific article published on September 2005

Mutational analysis of the substrate specificity of Escherichia coli penicillin binding protein 4.

scientific article

NanA, a neuraminidase from Streptococcus pneumoniae, shows high levels of sequence diversity, at least in part through recombination with Streptococcus oralis.

scientific article published on August 2005

Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing

scientific article

Novel and Improved Crystal Structures of H. influenzae, E. coli and P. aeruginosa Penicillin-Binding Protein 3 (PBP3) and N. gonorrhoeae PBP2: Toward a Better Understanding of β-Lactam Target-Mediated Resistance

scientific article published on 10 July 2019

Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics

scientific article published in October 1994

Oxidation of tertiary amine-derivatized surfaces to control protein adhesion

scientific article published on 22 February 2013

PiuA and PiaA, iron uptake lipoproteins of Streptococcus pneumoniae, elicit serotype independent antibody responses following human pneumococcal septicaemia

scientific article published on 01 January 2005

Profiling interactions of vaborbactam with metallo-β-lactamases

scientific article published on 17 May 2019

Proinflammatory activation of Toll-like receptor-2 during exposure of penicillin-resistant Streptococcus pneumoniae to beta-lactam antibiotics

scientific article published on 31 October 2006

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

scientific article published on 22 May 2019

Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis

scientific article

Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase.

scientific article published on 15 March 2016

Recruitment of a penicillin-binding protein gene from Neisseria flavescens during the emergence of penicillin resistance in Neisseria meningitidis

scientific article

Reliability of multilocus sequence typing of the Burkholderia cepacia complex in cystic fibrosis.

scientific article published in December 2006

Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis

scientific article published on March 2017

Sequence Control as a Powerful Tool for Improving the Selectivity of Antimicrobial Polymers.

scientific article published on 25 October 2017

Site-Directed Mutagenesis to Determine Structure Function Relationships in Streptococcus pneumoniae Penicillin-Binding Protein Genes

scientific article

Specificity Determinants for Lysine Incorporation in Staphylococcus aureus Peptidoglycan as Revealed by the Structure of a MurE Enzyme Ternary Complex

scientific article

Spontaneous sequence duplications within capsule genes cap8E and tts control phase variation in Streptococcus pneumoniae serotypes 8 and 37.

scientific article published in February 2003

Structural studies suggest aggregation as one of the modes of action for teixobactin

scientific article published on 20 September 2018

Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase

scientific article published on 05 November 2019

Structure-based modeling and dynamics of MurM, a Streptococcus pneumoniae penicillin resistance determinant present at the cytoplasmic membrane

scientific article published on 18 March 2021

Substrate and Stereochemical Control of Peptidoglycan Cross-Linking by Transpeptidation by Escherichia coli PBP1B

scientific article published on 02 March 2020

The Molecular Basis of Antibiotic Action and Resistance

scientific article published on 29 June 2019

The Tetracycline Resistance Genetet(M) Exhibits Mosaic Structure

scientific article published on 01 May 1996

The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients

scientific article published on 17 October 2008

The role of the jaw subdomain of peptidoglycan glycosyltransferases for lipid II polymerization

scientific article published on 01 June 2018

The use of microarray technology for the analysis of Streptococcus pneumoniae.

scientific article

Touching proteins with virtual bare hands : Visualizing protein-drug complexes and their dynamics in self-made virtual reality using gaming hardware

scientific article published on 07 June 2018

VenUS II: a randomised controlled trial of larval therapy in the management of leg ulcers.

scientific article

Whole-Genome Sequence of Corynebacterium pseudotuberculosis 262 Biovar equi Isolated from Cow Milk.

scientific article published on 24 March 2016

Whole-genome sequence of Corynebacterium pseudotuberculosis strain Cp162, isolated from camel.

scientific article published on October 2012

β-Lactam Resistance Mediated by Changes in Penicillin-Binding Proteins

scientific article published on January 1, 1998

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