List of works - Leila Lo Leggio

A fungal family of lytic polysaccharide monooxygenase-like copper proteins

scientific article published on 13 January 2020

A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis

scientific article published on 13 January 2020

A structural overview of GH61 proteins - fungal cellulose degrading polysaccharide monooxygenases

scientific article

A β1-6/β1-3 galactosidase from Bifidobacterium animalis subsp. lactis Bl-04 gives insight into sub-specificities of β-galactoside catabolism within Bifidobacterium

scientific article

Activity of three β-1,4-galactanases on small chromogenic substrates.

scientific article published on 27 May 2011

An 1,4-α-glucosyltransferase defines a new maltodextrin catabolism scheme in Lactobacillus acidophilus

scientific article published on 22 May 2020

An L-glucitol oxidizing dehydrogenase from Bradyrhizobium japonicum USDA 110 for production of D-sorbose with enzymatic or electrochemical cofactor regeneration.

scientific article published on 6 September 2013

Aspergillus aculeatus beta-1,4-galactanase: substrate recognition and relations to other glycoside hydrolases in clan GH-A

scientific article

Beta-glucosidase, beta-galactosidase, family A cellulases, family F xylanases and two barley glycanases form a superfamily of enzymes with 8-fold beta/alpha architecture and with two conserved glutamates near the carboxy-terminal ends of beta-strand

scientific article

Binding of the N-terminal domain of the lactococcal bacteriophage TP901-1 CI repressor to its target DNA: a crystallography, small angle scattering, and nuclear magnetic resonance study

scientific article

Changes in active-site geometry on X-ray photoreduction of a lytic polysaccharide monooxygenase active-site copper and saccharide binding

scientific article published in 2022

Characterization of different crystal forms of the alpha-glucosidase MalA from Sulfolobus solfataricus

scientific article

Characterization of the genetic switch from phage ɸ13 important for Staphylococcus aureus colonization in humans

scientific article published on 01 October 2021

Chemoenzymatic indican for light-driven denim dyeing

scientific article published on 27 February 2024

Crystal structure of α-galactosidase from Lactobacillus acidophilus NCFM: insight into tetramer formation and substrate binding

scientific article

Crystal structures of A. acidocaldarius endoglucanase Cel9A in complex with cello-oligosaccharides: strong -1 and -2 subsites mimic cellobiohydrolase activity

scientific article

Crystal structures of Val58Ile tryptophan repressor in a domain-swapped array in the presence and absence of L-tryptophan

scientific article published on 30 July 2021

Crystallization and preliminary X-ray analysis of the major endoglucanase from Thermoascus aurantiacus.

scientific article published in September 1997

Crystallization and preliminary X-ray characterization of a thermostable pectate lyase from Thermotoga maritima

scientific article published on 22 March 2002

Crystallization and preliminary crystallographic analysis of an Escherichia coli-selected mutant of the nuclease domain of the metallonuclease colicin E7.

scientific article published on 30 April 2013

DNA binding by the plant-specific NAC transcription factors in crystal and solution: a firm link to WRKY and GCM transcription factors

scientific article

DNA-binding specificity and molecular functions of NAC transcription factors

article

Discovery of α-L-arabinopyranosidases from human gut microbiome expands the diversity within glycoside hydrolase family 42.

scientific article published on 23 October 2017

Effect of mutations on the thermostability of Aspergillus aculeatus β-1,4-galactanase.

scientific article published on 9 April 2015

Engineering the substrate binding site of the hyperthermostable archaeal endo-β-1,4-galactanase from Ignisphaera aggregans

scientific article published on 16 September 2021

Enzymology and Structure of the GH13_31 Glucan 1,6- -Glucosidase That Confers Isomaltooligosaccharide Utilization in the Probiotic Lactobacillus acidophilus NCFM

scientific article

Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis

scientific article published on 28 August 2019

Expression, refolding and spectroscopic characterization of fibronectin type III (FnIII)-homology domains derived from human fibronectin leucine rich transmembrane protein (FLRT)-1, -2, and -3

scientific article published on 7 July 2017

Gene cloning, sequencing, and characterization of a family 9 endoglucanase (CelA) with an unusual pattern of activity from the thermoacidophile Alicyclobacillus acidocaldarius ATCC27009.

scientific article

Identification of Quaternary Structure and Functional Domains of the CI Repressor from Bacteriophage TP901-1

scientific article published on 15 December 2007

Identification of the molecular determinants driving the substrate specificity of fungal lytic polysaccharide monooxygenases (LPMOs)

scientific article published on 16 November 2020

Inhibition of sperm-zona binding by suramin, a potential ‘lead’ compound for design of new anti-fertility agents

article

Insights into an unusual Auxiliary Activity 9 family member lacking the histidine brace motif of lytic polysaccharide monooxygenases

scientific article published on 30 August 2019

Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components

scientific article

Investigating the binding of beta-1,4-galactan to Bacillus licheniformis beta-1,4-galactanase by crystallography and computational modeling

scientific article

Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function

scientific article (publication date: August 2003)

Learning from oligosaccharide soaks of crystals of an AA13 lytic polysaccharide monooxygenase: crystal packing, ligand binding and active-site disorder

scientific article

Lytic polysaccharide monooxygenases: a crystallographer's view on a new class of biomass-degrading enzymes

scientific article

Mapping of an internal protease cleavage site in the Ssy5p component of the amino acid sensor of Saccharomyces cerevisiae and functional characterization of the resulting pro- and protease domains by gain-of-function genetics

scientific article

Mechanism and biomass association of glucuronoyl esterase: an α/β hydrolase with potential in biomass conversion

scientific article published on 18 March 2022

NAC transcription factors: structurally distinct, functionally diverse

scientific article

NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor.

scientific article

Preliminary crystallographic analysis of the NAC domain of ANAC, a member of the plant-specific NAC transcription factor family

scientific article published on 18 December 2003

Purification, crystal structure determination and functional characterization of type III antifreeze proteins from the European eelpout Zoarces viviparus

scientific article

Raffinose family oligosaccharide utilisation by probiotic bacteria: insight into substrate recognition, molecular architecture and diversity of GH36 α-galactosidases

article by Maher Abou Hachem et al published 3 April 2012 in Biocatalysis & Biotransformation

Rational engineering of mannosyl binding in the distal glycone subsites of Cellulomonas fimi endo-beta-1,4-mannanase: mannosyl binding promoted at subsite -2 and demoted at subsite -3

scientific article

Recent insight into oligosaccharide uptake and metabolism in probiotic bacteria

article by Maher Abou Hachem et al published August 2013 in Biocatalysis & Biotransformation

Repression of the lysogenic PR promoter in bacteriophage TP901-1 through binding of a CI-MOR complex to a composite OM-OR operator

scientific article published on 26 May 2020

Revealing the mechanism of repressor inactivation during switching of a temperate bacteriophage

scientific article published on 11 August 2020

Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase

scientific article

Stimulation of lignocellulosic biomass hydrolysis by proteins of glycoside hydrolase family 61: structure and function of a large, enigmatic family

scientific article

Structural and biochemical studies elucidate the mechanism of rhamnogalacturonan lyase from Aspergillus aculeatus

scientific article

Structural and biochemical studies of the glucuronoyl esterase OtCE15A illuminate its interaction with lignocellulosic components

scientific article published on 18 November 2019

Structural and dynamics studies of a truncated variant of CI repressor from bacteriophage TP901-1

scientific article published on 12 July 2016

Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates.

scientific article

Structural characterization of the thermostable Bradyrhizobium japonicumD-sorbitol dehydrogenase.

scientific article published on 27 October 2016

Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase ⬇️

scientific article

Structure of Aspergillus aculeatus β-1,4-galactanase in complex with galactobiose

scientific article published on 10 May 2019

Structure of a hyperthermostable carbonic anhydrase identified from an active hydrothermal vent chimney.

scientific article published on 30 March 2018

Structure of dimeric, recombinant Sulfolobus solfataricus phosphoribosyl diphosphate synthase: a bent dimer defining the adenine specificity of the substrate ATP

scientific article

Structure of the Sulfolobus solfataricus alpha-glucosidase: implications for domain conservation and substrate recognition in GH31.

scientific article

Structure of the conserved domain of ANAC, a member of the NAC family of transcription factors

scientific article

Structure of two fungal β-1,4-galactanases: Searching for the basis for temperature and pH optimum

scientific article (publication date: June 2003)

Structure–function analyses reveal that a glucuronoyl esterase from Teredinibacter turnerae interacts with carbohydrates and aromatic compounds

scientific article published on 27 February 2019

Substrate preference of an ABC importer corresponds to selective growth on β-(1,6)-galactosides in Bifidobacterium animalis subsp. lactis

scientific article published on 11 June 2019

Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016).

scientific article published on 28 September 2017

The 1.62 A structure of Thermoascus aurantiacus endoglucanase: completing the structural picture of subfamilies in glycoside hydrolase family 5

scientific article

The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases.

scientific article

The structure and specificity of Escherichia coli maltose acetyltransferase give new insight into the LacA family of acyltransferases

scientific article (publication date: 13 May 2003)

The structure of endo-beta-1,4-galactanase from Bacillus licheniformis in complex with two oligosaccharide products

scientific article

Unliganded and substrate bound structures of the cellooligosaccharide active lytic polysaccharide monooxygenase Ls AA9A at low pH

scientific article published on 24 March 2017

α-Amylase from mung beans (Vigna radiata) – Correlation of biochemical properties and tertiary structure by homology modelling

scientific article published on 23 May 2007

List of works by Leila Lo Leggio

A fungal family of lytic polysaccharide monooxygenase-like copper proteins

A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis

A structural overview of GH61 proteins - fungal cellulose degrading polysaccharide monooxygenases

A β1-6/β1-3 galactosidase from Bifidobacterium animalis subsp. lactis Bl-04 gives insight into sub-specificities of β-galactoside catabolism within Bifidobacterium

Activity of three β-1,4-galactanases on small chromogenic substrates.

An 1,4-α-glucosyltransferase defines a new maltodextrin catabolism scheme in Lactobacillus acidophilus

An L-glucitol oxidizing dehydrogenase from Bradyrhizobium japonicum USDA 110 for production of D-sorbose with enzymatic or electrochemical cofactor regeneration.

Aspergillus aculeatus beta-1,4-galactanase: substrate recognition and relations to other glycoside hydrolases in clan GH-A

Beta-glucosidase, beta-galactosidase, family A cellulases, family F xylanases and two barley glycanases form a superfamily of enzymes with 8-fold beta/alpha architecture and with two conserved glutamates near the carboxy-terminal ends of beta-strand

Binding of the N-terminal domain of the lactococcal bacteriophage TP901-1 CI repressor to its target DNA: a crystallography, small angle scattering, and nuclear magnetic resonance study

Changes in active-site geometry on X-ray photoreduction of a lytic polysaccharide monooxygenase active-site copper and saccharide binding

Characterization of different crystal forms of the alpha-glucosidase MalA from Sulfolobus solfataricus

Characterization of the genetic switch from phage ɸ13 important for Staphylococcus aureus colonization in humans

Chemoenzymatic indican for light-driven denim dyeing

Crystal structure of α-galactosidase from Lactobacillus acidophilus NCFM: insight into tetramer formation and substrate binding

Crystal structures of A. acidocaldarius endoglucanase Cel9A in complex with cello-oligosaccharides: strong -1 and -2 subsites mimic cellobiohydrolase activity

Crystal structures of Val58Ile tryptophan repressor in a domain-swapped array in the presence and absence of L-tryptophan

Crystallization and preliminary X-ray analysis of the major endoglucanase from Thermoascus aurantiacus.

Crystallization and preliminary X-ray characterization of a thermostable pectate lyase from Thermotoga maritima

Crystallization and preliminary crystallographic analysis of an Escherichia coli-selected mutant of the nuclease domain of the metallonuclease colicin E7.

DNA binding by the plant-specific NAC transcription factors in crystal and solution: a firm link to WRKY and GCM transcription factors

DNA-binding specificity and molecular functions of NAC transcription factors

Discovery of α-L-arabinopyranosidases from human gut microbiome expands the diversity within glycoside hydrolase family 42.

Effect of mutations on the thermostability of Aspergillus aculeatus β-1,4-galactanase.

Engineering the substrate binding site of the hyperthermostable archaeal endo-β-1,4-galactanase from Ignisphaera aggregans

Enzymology and Structure of the GH13_31 Glucan 1,6- -Glucosidase That Confers Isomaltooligosaccharide Utilization in the Probiotic Lactobacillus acidophilus NCFM

Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis

Expression, refolding and spectroscopic characterization of fibronectin type III (FnIII)-homology domains derived from human fibronectin leucine rich transmembrane protein (FLRT)-1, -2, and -3

Gene cloning, sequencing, and characterization of a family 9 endoglucanase (CelA) with an unusual pattern of activity from the thermoacidophile Alicyclobacillus acidocaldarius ATCC27009.

Identification of Quaternary Structure and Functional Domains of the CI Repressor from Bacteriophage TP901-1

Identification of the molecular determinants driving the substrate specificity of fungal lytic polysaccharide monooxygenases (LPMOs)

Inhibition of sperm-zona binding by suramin, a potential ‘lead’ compound for design of new anti-fertility agents

Insights into an unusual Auxiliary Activity 9 family member lacking the histidine brace motif of lytic polysaccharide monooxygenases

Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components

Investigating the binding of beta-1,4-galactan to Bacillus licheniformis beta-1,4-galactanase by crystallography and computational modeling

Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function

Learning from oligosaccharide soaks of crystals of an AA13 lytic polysaccharide monooxygenase: crystal packing, ligand binding and active-site disorder

Lytic polysaccharide monooxygenases: a crystallographer's view on a new class of biomass-degrading enzymes

Mapping of an internal protease cleavage site in the Ssy5p component of the amino acid sensor of Saccharomyces cerevisiae and functional characterization of the resulting pro- and protease domains by gain-of-function genetics

Mechanism and biomass association of glucuronoyl esterase: an α/β hydrolase with potential in biomass conversion

NAC transcription factors: structurally distinct, functionally diverse

NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor.

Preliminary crystallographic analysis of the NAC domain of ANAC, a member of the plant-specific NAC transcription factor family

Purification, crystal structure determination and functional characterization of type III antifreeze proteins from the European eelpout Zoarces viviparus

Raffinose family oligosaccharide utilisation by probiotic bacteria: insight into substrate recognition, molecular architecture and diversity of GH36 α-galactosidases

Rational engineering of mannosyl binding in the distal glycone subsites of Cellulomonas fimi endo-beta-1,4-mannanase: mannosyl binding promoted at subsite -2 and demoted at subsite -3

Recent insight into oligosaccharide uptake and metabolism in probiotic bacteria

Repression of the lysogenic PR promoter in bacteriophage TP901-1 through binding of a CI-MOR complex to a composite OM-OR operator

Revealing the mechanism of repressor inactivation during switching of a temperate bacteriophage

Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase

Stimulation of lignocellulosic biomass hydrolysis by proteins of glycoside hydrolase family 61: structure and function of a large, enigmatic family

Structural and biochemical studies elucidate the mechanism of rhamnogalacturonan lyase from Aspergillus aculeatus

Structural and biochemical studies of the glucuronoyl esterase OtCE15A illuminate its interaction with lignocellulosic components

Structural and dynamics studies of a truncated variant of CI repressor from bacteriophage TP901-1

Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates.

Structural characterization of the thermostable Bradyrhizobium japonicumD-sorbitol dehydrogenase.

Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase ⬇️

Structure of Aspergillus aculeatus β-1,4-galactanase in complex with galactobiose

Structure of a hyperthermostable carbonic anhydrase identified from an active hydrothermal vent chimney.

Structure of dimeric, recombinant Sulfolobus solfataricus phosphoribosyl diphosphate synthase: a bent dimer defining the adenine specificity of the substrate ATP

Structure of the Sulfolobus solfataricus alpha-glucosidase: implications for domain conservation and substrate recognition in GH31.

Structure of the conserved domain of ANAC, a member of the NAC family of transcription factors

Structure of two fungal β-1,4-galactanases: Searching for the basis for temperature and pH optimum

Structure–function analyses reveal that a glucuronoyl esterase from Teredinibacter turnerae interacts with carbohydrates and aromatic compounds

Substrate preference of an ABC importer corresponds to selective growth on β-(1,6)-galactosides in Bifidobacterium animalis subsp. lactis

Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016).

The 1.62 A structure of Thermoascus aurantiacus endoglucanase: completing the structural picture of subfamilies in glycoside hydrolase family 5

The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases.

The structure and specificity of Escherichia coli maltose acetyltransferase give new insight into the LacA family of acyltransferases

The structure of endo-beta-1,4-galactanase from Bacillus licheniformis in complex with two oligosaccharide products

Unliganded and substrate bound structures of the cellooligosaccharide active lytic polysaccharide monooxygenase Ls AA9A at low pH

α-Amylase from mung beans (Vigna radiata) – Correlation of biochemical properties and tertiary structure by homology modelling