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List of works by Sebastian Polak

A four-compartment PBPK heart model accounting for cardiac metabolism - model development and application

scientific article published on 04 January 2017

Age and gender dependent heart rate circadian model development and performance verification on the proarrhythmic drug case study

scientific article published on 9 February 2013

Am I or am I not proarrhythmic? Comparison of various classifications of drug TdP propensity.

scientific article

An Open-Access Dataset of Thorough QT Studies Results

scientific article published on 25 January 2020

Analysis of non-hospital antibacterial pharmacotherapy in Poland

scientific article published on 15 April 2008

Antibacterial drug prescription for outpatients: age, seasonal and pulmonary disease dependency.

scientific article published in May 2008

Artificial intelligence technology as a tool for initial GDM screening

scientific article published in May 2004

Artificial neural network in pharmacoeconomics

scientific article published on 01 January 2004

Artificial neural networks as an engine of Internet based hypertension prediction tool.

scientific article

Artificial neural networks based Internet hypertension prediction tool development and validation

scientific article published in January 2008

Artificial neural networks based modeling for pharmacoeconomics application

scientific article published in September 2008

Assessment of inter-individual variability in predicted phenytoin clearance

scientific article published in December 2009

BDTcomparator: a program for comparing binary classifiers.

scientific article published on 13 October 2011

Better prediction of the local concentration-effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the evolution of model-informed drug discovery and development

scientific article published on 24 May 2019

CardiacPBPK: A tool for the prediction and visualization of time-concentration profiles of drugs in heart tissue

scientific article published on 07 October 2019

Characterization of In Vitro and In Vivo Metabolism of Antazoline Using Liquid Chromatography-Tandem Mass Spectrometry

scientific article published on 18 December 2020

Circadian models of serum potassium, sodium, and calcium concentrations in healthy individuals and their application to cardiac electrophysiology simulations at individual level

scientific article published on 03 September 2013

Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties

scientific article

Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay

scientific article published on 23 January 2020

Comment on "In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically-Based Absorption Models"

scientific article published on 16 December 2016

Computer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challenges

scientific article

Development and Performance Verification of the PBPK Model for Antazoline and Its Metabolite and Its Utilization for Pharmacological Hypotheses Formulating

scientific article published on 20 March 2022

Development of In Vitro-In Vivo Correlation/Relationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from "Golem": A Novel Apparatus.

scientific article

Development of physiologically based pharmacokinetic model for the immediate release ropinirole tablets

scientific article published on 27 August 2021

Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models

scientific article published on 16 November 2017

Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials

scientific article

Drug-physiology interaction and its influence on the QT prolongation-mechanistic modeling study

scientific article published on 15 March 2018

Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates

scientific article published on 5 May 2015

Early assessment of proarrhythmic risk of drugs using the in vitro data and single-cell-based in silico models: proof of concept.

scientific article

Electrophysiologically inactive drugs – Can we predict their cardiotoxicity?

scientific article published in June 2012

Enhanced QSAR models for drug-triggered inhibition of the main cardiac ion currents

scientific article published on 05 January 2015

From Heuristic to Mathematical Modeling of Drugs Dissolution Profiles: Application of Artificial Neural Networks and Genetic Programming

scientific article published on 26 May 2015

From in vitro-in vivo relationship (IVIVR) towards in vitro-in vivo extrapolation (IVIVE): A case study of pulmonary delivery systems

scientific article published in 2017

Generalized in vitro-in vivo relationship (IVIVR) model based on artificial neural networks

scientific article published on 27 March 2013

How circadian variability of the heart rate and plasma electrolytes concentration influence the cardiac electrophysiology - model-based case study

scientific article published in June 2021

How in vitro influences in silico utilized for the prediction of in vivo - pilot study of the drug-induced pro-arrhythmic potency prediction

scientific article

Humans Vary, So Cardiac Models Should Account for That Too!

scientific article

In Silico Assessment of Nifedipine Effects on Human Heart Cells: Pharmacokinetic-Pharmacodynamic Analyses at the Population Level

scientific article published on 14 September 2017

In Vitro-In Vivo Correlation (IVIVC): From Current Achievements Towards the Future

scientific article published in 2018

In vitro to human in vivo translation – pharmacokinetics and pharmacodynamics of quinidine ⬇️

scientific article published on 01 January 2013

In vitro-in vivo extrapolation of drug-induced proarrhythmia predictions at the population level.

scientific article published on 16 October 2013

Inter-individual Variability in the Pre-clinical Drug Cardiotoxic Safety Assessment—Analysis of the Age–Cardiomyocytes Electric Capacitance Dependence ⬇️

scientific article published on March 13, 2012

Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information

scientific article

Magnetic Core-Shell Molecularly Imprinted Nano-Conjugates for Extraction of Antazoline and Hydroxyantazoline from Human Plasma-Material Characterization, Theoretical Analysis and Pharmacokinetics

scientific article published in April 2021

Mechanistic Physiologically Based Pharmacokinetic (PBPK) Model of the Heart Accounting for Inter-individual Variability: Development and Performance Verification

scientific article published on 23 November 2017

Model of the distribution of diastolic left ventricular posterior wall thickness in healthy adults and its impact on the behavior of a string of virtual cardiomyocytes

scientific article

Open-access database of literature derived drug-related Torsade de Pointes cases

scientific article published on 10 January 2022

Optimizing drug discovery by Investigative Toxicology: Current and future trends

scientific article published on 20 December 2018

Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations

scientific article published on 30 September 2020

Physiologically based pharmacokinetic modelling to guide drug delivery in older people

scientific article published on 04 September 2018

Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals

scientific article published on 25 June 2018

Plasma vs heart tissue concentration in humans - literature data analysis of drugs distribution

scientific article

Population-based mechanistic prediction of oral drug absorption

scientific article published on 21 April 2009

Prediction of concentration-time profile and its inter-individual variability following the dermal drug absorption

scientific article published on 19 April 2012

Prediction of the hERG potassium channel inhibition potential with use of artificial neural networks

scientific article published in March 2011

Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.

scientific article

QTc modification after risperidone administration--insight into the mechanism of action with use of the modeling and simulation at the population level approach.

scientific article published on 8 May 2015

Quality Control Dissolution Data Is Biopredictive for a Modified Release Ropinirole Formulation: Virtual Experiment with the Use of Re-Developed and Verified PBPK Model

scientific article published in 2022

Quantitative Assessment of the Physiological Parameters Influencing QT Interval Response to Medication: Application of Computational Intelligence Tools

scientific article published on 4 January 2018

Quantitative approach for cardiac risk assessment and interpretation in tuberculosis drug development.

scientific article published on 8 March 2018

Quantitative prediction of formulation-specific food effects and their population variability from in vitro data with the physiologically-based ADAM model: a case study using the BCS/BDDCS Class II drug nifedipine

scientific article

Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram.

scientific article published on 27 November 2017

Selective laser sintering (SLS) technique for pharmaceutical applications—Development of high dose controlled release printlets

scientific article published in February 2021

Serum potassium, sodium and calcium levels in healthy individuals - literature review and data analysis

scientific article

Slow delayed rectifying potassium current (IKs ) - analysis of the in vitro inhibition data and predictive model development.

scientific article

The Role of Interaction Model in Simulation of Drug Interactions and QT Prolongation

scientific article

The effects of six antipsychotic agents on QTc--an attempt to mimic clinical trial through simulation including variability in the population

scientific article published on 28 January 2014

The impact of pharmaceutical care on patients with hypertension and their pharmacists.

scientific article published on April 2011

The open-access dataset for insilico cardiotoxicity prediction system

scientific article

Thorough QT (TQT) studies: concordance with torsadogenesis and an evolving cardiac safety testing paradigm

scientific article published on 13 May 2017

Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations

scientific article

Towards Bridging Translational Gap in Cardiotoxicity Prediction: an Application of Progressive Cardiac Risk Assessment Strategy in TdP Risk Assessment of Moxifloxacin.

scientific article published on 14 March 2018

Tox-Database.net—Knowledge for drug development

scientific article published in June 2012

Tox-database.net: a curated resource for data describing chemical triggered in vitro cardiac ion channels inhibition

scientific article

Using Artificial Neural Network as a Tool for Epidemiological Data Analysis

scientific article published in 2003

Utilizing postmortem drug concentrations in mechanistic modeling and simulation of cardiac effects: a proof of concept study with methadone

scientific article published on 13 June 2018

Virtual Clinical Trial Toward Polytherapy Safety Assessment: Combination of Physiologically Based Pharmacokinetic/Pharmacodynamic-Based Modeling and Simulation Approach With Drug-Drug Interactions Involving Terfenadine as an Example

scientific article published on 15 September 2016

Virtual Thorough QT (TQT) Trial-Extrapolation of In Vitro Cardiac Safety Data to In Vivo Situation Using Multi-Scale Physiologically Based Ventricular Cell-wall Model Exemplified with Tolterodine and Fesoterodine

scientific article published on 11 July 2018

Virtual population generator for human cardiomyocytes parameters: in silico drug cardiotoxicity assessment.

scientific article published in January 2012

What it takes to understand and cure a living system: computational systems biology and a systems biology-driven pharmacokinetics-pharmacodynamics platform

scientific article published on 8 December 2010

Wild type and K897T polymorphisms of the hERG gene: modeling the APD in Caucasians.

scientific article

[Usefulness of some databases in medical practice]

scientific article published on 01 January 2002

hERG in vitro interchange factors--development and verification

scientific article published on 01 May 2009

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