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List of works by Padraic G. Fallon

A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming.

scientific article

A mineral extract from red algae ameliorates chronic spontaneous colitis in IL-10 deficient mice in a mouse strain dependent manner.

scientific article published on 4 April 2013

A novel role for the macrophage galactose-type lectin (MGL) receptor in mediating von Willebrand factor clearance.

scientific article published on 27 December 2017

A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria

scientific article

A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.

scientific article published on 09 December 2013

A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins

scientific article

ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism

article

AGA/AGG codon usage in parasites: implications for gene expression in Escherichia coli.

scientific article

Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells

scientific article

Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide.

scientific article published on 13 April 2011

Active immunization of mice with Schistosoma mansoni worm membrane antigens enhances efficacy of praziquantel ⬇️

scientific article published on May 1, 1995

Addition of a Viral Immunomodulatory Domain to Etanercept Generates a Bifunctional Chemokine and TNF Inhibitor

scientific article published on 20 December 2019

Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis

scientific article published on 12 May 2014

Alterations in cytochrome-c oxidase expression between praziquantel-resistant and susceptible strains of Schistosoma mansoni.

scientific article

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.

scientific article

An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia

scientific article published on 13 December 2010

Bcl11b is essential for group 2 innate lymphoid cell development

scientific article published on 11 May 2015

Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells.

scientific article

Btk regulates macrophage polarization in response to lipopolysaccharide.

scientific article published on 21 January 2014

C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide

scientific article published on 03 February 2010

Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction.

scientific article

Clumping Factor B Promotes Adherence of Staphylococcus aureus to Corneocytes in Atopic Dermatitis.

scientific article published on 3 April 2017

Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A.

scientific article published on 26 October 2017

Construction of an sIgE:FLAG-mIgE:GFP Reporter Mouse Strain

scientific article published on 01 April 2003

Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice.

scientific article published on 28 October 2013

Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27

scientific article

Decoy receptors in the regulation of T helper cell type 2 responses

scientific article published on March 2003

Defective in vivo induction of functional type 2 cytokine responses in aged mice

article

Design, synthesis, and pharmacological effects of a cyclization-activated steroid prodrug for colon targeting in inflammatory bowel disease.

scientific article published in May 2009

Determining Coreceptor Expression and Function in Murine ILC2 Through Flow Cytometry Characterization and Coculture Techniques

scientific article published on 01 January 2020

Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific.

scientific article

Dysregulated skin barrier function in Tmem79 mutant mice promotes IL-17A-dependent spontaneous skin and lung inflammation

scientific article published on 09 July 2020

Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus

scientific article published on 30 October 2010

Effect of praziquantel and oxamniquine treatment on human isotype responses to Schistosoma mansoni: elevated IgE to adult worm

article

Effects of Lactobacillus salivarius 433118 on intestinal inflammation, immunity status and in vitro colon function in two mouse models of inflammatory bowel disease

scientific article published on 20 December 2007

Efficacy of treatment of murine Schistosoma mansoni infections with praziquantel and oxamniquine correlates with infection intensity: role of host antibody ⬇️

scientific article published on July 1, 1995

Elevated type 1, diminished type 2 cytokines and impaired antibody response are associated with hepatotoxicity and mortalities during Schistosoma mansoni infection of CD4-depleted mice

scientific article published on 01 February 2000

Enhancement of Schistosoma mansoni infectivity by intradermal injections of larval extracts: a putative role for larval proteases

scientific article published on 01 June 1996

Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses

scientific article

Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion

scientific article published on October 2017

Evaluation of immune dependence of anthelmintic treatment of Heligmosomoides polygyrus in CBA/Ca mice

scientific article published in May 1996

Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo

scientific article

Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice

scientific article published on 31 August 2019

Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase

scientific article published on February 2016

Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency.

scientific article published on 8 February 2012

Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment

scientific article

Functional conservation of an ancestral Pellino protein in helminth species

scientific article published on 29 June 2015

Generation of parasite antigens for use in Toll-like receptor research

scientific article published in January 2009

Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses

scientific article

Helminth Modulation of Lung Inflammation.

scientific article published on 12 January 2018

Helminth infection protects mice from anaphylaxis via IL-10-producing B cells

scientific article published in November 2004

Helminth therapies: translating the unknown unknowns to known knowns

scientific article published on 03 January 2013

Helminth-derived immunomodulatory molecules

scientific article published on January 2009

Helminth-modified pulmonary immune response protects mice from allergen-induced airway hyperresponsiveness

scientific article published in January 2006

Highly efficient CRISPR-targeting of the murine Hipp11 intergenic region supports inducible human transgene expression

scientific article published on 06 December 2019

Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea

scientific article published on 13 October 2010

Hypoxia-dependent regulation of inflammatory pathways in immune cells

scientific article

IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation.

scientific article published on 14 June 2017

IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration

scientific article (publication date: 2 April 2014)

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.

scientific article published on 16 December 2013

IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss

scientific article published on 22 April 2011

IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation.

scientific article published on 27 January 2016

IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13.

scientific article published in July 2002

ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.

scientific article

Identification of a functioning mitochondrial uncoupling protein 1 in thymus

scientific article published on 28 January 2005

Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion

scientific article

Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 activation and IFN-beta expression: relevance to therapeutic effects in models of multiple sclerosis

scientific article

IgG4 and IgE responses to Schistosoma mansoni adult worms after treatment

article

Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy

scientific article published on 18 October 2007

Immune-dependent chemotherapy of schistosomiasis

scientific article published on January 1, 1992

Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice

scientific article published on 11 March 2011

Impaired development of Th2 cells in IL-13-deficient mice.

scientific article published on September 1998

Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism

scientific article published on 01 April 2007

Inhibition of type 1 cytokine-mediated inflammation by a soluble CD30 homologue encoded by ectromelia (mousepox) virus

scientific article

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells

scientific article published on 12 December 2017

Innate lymphoid cells and parasites: ancient foes with shared history

scientific article published on 26 December 2017

Innate type 2 cells and asthma

scientific article published on 29 June 2012

Interleukin 33: an innate alarm for adaptive responses beyond Th2 immunity-emerging roles in obesity, intestinal inflammation, and cancer

scientific article published on 22 March 2016

Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction

scientific article published on 05 September 2019

Intestinal expression of Fas and Fas ligand is upregulated by bacterial signaling through TLR4 and TLR5, with activation of Fas modulating intestinal TLR-mediated inflammation

scientific article

Intraperitoneal influx of neutrophils in response to IL-33 is mast cell-dependent

scientific article published on 23 October 2012

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

scientific article published on 28 March 2018

Juvenile Rhesus Monkeys Have Lower Type 2 Cytokine Responses than Adults after Primary Infection with Schistosoma mansoni

scientific article published on 15 March 2003

Juvenile rhesus monkeys have more colonic granulomas than adults after primary infection with Schistosoma mansoni

scientific article published on 30 July 2004

Keratinocyte interleukin-36 receptor expression orchestrates psoriasiform inflammation in mice

scientific article published on 21 February 2020

Lethal, neonatal ichthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome

scientific article published on 8 December 2004

Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling

scientific article

Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.

scientific article published on 14 April 2015

Lipid rafts are disrupted in mildly inflamed intestinal microenvironments without overt disruption of the epithelial barrier

scientific article published on 12 January 2012

Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function

scientific article published on 30 June 2010

Lymphomagenesis, hydronephrosis, and autoantibodies result from dysregulation of IL-9 and are differentially dependent on Th2 cytokines

scientific article published in July 2004

MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion

scientific article

Macrophage and Innate Lymphoid Cell Interplay in the Genesis of Fibrosis

scientific article

Mast Cells as Sensors of Cell Injury through IL-33 Recognition

scientific article published on 14 January 2011

Mitochondrial uncoupling protein 1 expression in thymocytes.

scientific article published on 18 April 2008

MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C ⬇️

scientific article published on April 24, 2013

MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice

scientific article published on 06 March 2014

N-linked glycan truncation causes enhanced clearance of plasma-derived von Willebrand factor.

scientific article

N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance.

scientific article published on 23 August 2016

Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice

scientific article

Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis

scientific article published on 21 February 2018

New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression.

scientific article published on 23 March 2016

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

scientific article

Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia

scientific article

PD-L1hi B cells are critical regulators of humoral immunity.

scientific article published on 22 January 2015

Partial redundancy of the pattern recognition receptors, scavenger receptors, and C-type lectins for the long-term control of Mycobacterium tuberculosis infection

scientific article published on 19 May 2010

Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis

scientific article published on 12 February 2013

Pathogen-derived immunomodulatory molecules. Preface.

scientific article

Pathogen-derived immunomodulatory molecules: future immunotherapeutics?

scientific article published on 21 August 2006

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

scientific journal article

Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung.

scientific article published on 5 December 2016

Periodate-sensitive immunological cross-reactivity between keyhole limpet haemocyanin (KLH) and serodiagnostic Schistosoma mansoni egg antigens

scientific article published on 01 January 1999

Previous infection with the nematode Nippostrongylus brasiliensis alters the immune specific response against Chlamydophila abortus infection.

scientific article published on July 2002

Primitive Toll signalling: bugs, flies, worms and man.

scientific article published in February 2001

Promutagenic methylation damage in liver DNA of mice infected with Schistosoma mansoni.

scientific article published in April 1993

Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation

scientific article published on 16 June 2009

Protection of mice against Schistosoma mansoni infection by passive transfer of sera from infected rabbits

scientific article published on 01 January 1996

Quantification of praziquantel-induced damage on the surface of adult Schistosoma mansoni worms: estimation of esterase and alkaline phosphatase activity

scientific article published on 01 January 1994

Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies

scientific article

Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2

scientific article published on March 2013

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.

scientific article published on 21 October 2013

Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model

scientific article published on 20 March 2010

Retinoic Acid–Related Orphan Receptor α Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation

scientific article published in 2023

Role for CTLA-4 but not CD25+ T cells during Schistosoma mansoni infection of mice

scientific article published on 01 June 2007

SIGN-R1 contributes to protection against lethal pneumococcal infection in mice.

scientific article

SIPPET: insights into factor VIII immunogenicity.

scientific article published on 28 October 2017

SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.

scientific article

SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation

scientific article published on 16 September 2021

Schistosoma "Eggs-Iting" the Host: Granuloma Formation and Egg Excretion

scientific article published on 29 October 2018

Schistosoma mansoni Worm Infection Regulates the Intestinal Microbiota and Susceptibility to Colitis

scientific article published on 23 July 2019

Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity

scientific article

Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages

scientific article published in July 2004

Schistosoma mansoni: maturation rate and drug susceptibility of different geographic isolates

scientific article published in May 1997

Schistosome resistance to praziquantel

scientific article published on 01 January 1998

Schistosome resistance to praziquantel: Fact or artifact?

scientific article published in August 1996

Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year

scientific article published on 05 September 2016

Sm480: a high molecular weight Schistosoma mansoni antigen associated with protective immunity ⬇️

scientific article published on March 1, 1996

Soluble IL-2Rα (sCD25) exacerbates autoimmunity and enhances the development of Th17 responses in mice

scientific article

Specific intracellular adhesion molecule-grabbing nonintegrin R1 is not involved in the murine antibody response to pneumococcal polysaccharides.

scientific article published on 17 September 2007

Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β

scientific article published on 29 April 2019

Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity

scientific article published on 20 August 2015

Suppression of TH2-type allergic reactions by helminth infection.

scientific article published on March 2007

Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization.

scientific article published on 21 November 2012

Synergistic action of cyclosporin A and polyspecific rabbit anti-sera against murine Schistosoma mansoni

scientific article published on 01 February 1996

T helper type-2 cytokine responses: potential therapeutic targets.

scientific article

T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammation

scientific article published on 01 May 2007

Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation.

scientific article published on September 2015

Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells.

scientific article published in September 2002

The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection

scientific article published on 3 November 2008

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

scientific article published on 6 May 2016

The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis

scientific article

The alarmin IL-33 promotes regulatory T-cell function in the intestine

scientific article

The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses

scientific article

The emergence of the IL-36 cytokine family as novel targets for inflammatory diseases

scientific article published on 26 October 2016

The generation of regulatory B cells by helminth parasites

scientific article published in January 2014

The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism.

scientific article published on 21 October 2015

The high and lows of type 2 asthma and mouse models

scientific article published on 05 December 2019

The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells

scientific article

The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis.

scientific article published on 10 October 2007

The schistosoma granuloma: friend or foe?

scientific article published on 15 April 2013

The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.

scientific article

The vaccine adjuvant alum promotes IL-10 production that suppresses Th1 responses.

scientific article published on 19 January 2018

Tim-1 is induced on germinal centre B cells through B-cell receptor signalling but is not essential for the germinal centre response.

scientific article published on 26 May 2010

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.

scientific article published on 12 June 2018

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

scientific journal article

Toll IL-1R8/single Ig IL-1-related receptor regulates psoriasiform inflammation through direct inhibition of innate IL-17A expression by γδ T cells

scientific article published on 14 August 2013

Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis.

scientific article published on 11 December 2017

Transcription factor RORα is critical for nuocyte development

scientific article

Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells

scientific article published on 11 July 2016

Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice

scientific article

Ursodeoxycholic acid attenuates colonic epithelial secretory function

scientific article published on 18 March 2013

Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer

scientific article

Why does work on same mouse models give different results?

scientific article published on 01 August 2008

von Willebrand factor arginine 1205 substitution results in accelerated macrophage-dependent clearancein vivo

scientific article published on 13 April 2015

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