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List of works by Fernanda Borges

2,2,4,4-Tetra-tert-butyl-1,3,5,2,4-benzotrioxadisilepine-7-carbaldehyde

scientific article published on 21 January 2006

3-Amidocoumarins as Potential Multifunctional Agents against Neurodegenerative Diseases

scientific article published on 23 October 2015

3D-MEDNEs: an alternative "in silico" technique for chemical research in toxicology. 2. quantitative proteome-toxicity relationships (QPTR) based on mass spectrum spiral entropy.

scientific article published on 8 February 2008

4-Oxo-N-phenyl-4H-chromene-2-carboxamide and of a new polymorph of 7-methoxy-4-oxo-N-p-tolyl-4H-chromene-2-carboxamide and its hemihydrate

6-Methyl-2-oxo-N-(quinolin-6-yl)-2H-chromene-3-carboxamide: crystal structure and Hirshfeld surface analysis

scientific article published on 12 July 2016

8-Substituted 3-arylcoumarins as potent and selective MAO-B inhibitors: synthesis, pharmacological evaluation, and docking studies.

scientific article published on 27 January 2012

A comparative synthesis of 6-benzyl-2,3-dihydroimidazo[2,1-a]phthalazine and 2H-7-benzyl-3,4-dihydropyrimido[2,1-a]phthalazine

A comparison of the structures of some 2- and 3-substituted chromone derivatives: a structural study on the importance of the secondary carboxamide backbone for the inhibitory activity of MAO-B.

scientific article

A desirability-based multi objective approach for the virtual screening discovery of broad-spectrum anti-gastric cancer agents

scientific article published on 8 February 2018

A focus on heme oxygenase-1 (HO-1) inhibitors

scientific article published on January 2013

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients

scientific article published on 08 June 2021

Accelerating lead optimization of chromone carboxamide scaffold throughout microwave-assisted organic synthesis

article

Activation of hydrocinnamic acids with pentafluorophenol versus pentafluorothiophenol: Reactivity towards hexylamine

Activity cliffs in drug discovery: Dr Jekyll or Mr Hyde?

scientific article published on 20 February 2014

Affinity prediction on A3 adenosine receptor antagonists: the chemometric approach

scientific article

Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress

scientific article published in 2012

Alzheimer's disease and antioxidant therapy: how long how far?

scientific article published on January 2013

Alzheimer's disease, cholesterol, and statins: the junctions of important metabolic pathways

scientific article published on 20 December 2012

Alzheimer's disease, enzyme targets and drug discovery struggles: from natural products to drug prototypes

scientific article published on 13 April 2014

Anticancer activity of phenolic acids of natural or synthetic origin: a structure-activity study.

scientific article published on December 2003

Antioxidant phenolic esters with potential anticancer activity: A Raman spectroscopy study

Antioxidant phenolic esters with potential anticancer activity: solution equilibria studied by Raman spectroscopy

Antioxidant profile of dihydroxy- and trihydroxyphenolic acids--a structure-activity relationship study

scientific article published in April 2006

Antioxidant properties of hydroxycinnamic acids: a review of structure- activity relationships

scientific article published in January 2013

Antioxidant therapy: still in search of the 'magic bullet'.

scientific article

Antioxidant versus cytotoxic properties of hydroxycinnamic acid derivatives - a new paradigm in phenolic research.

scientific article published on March 2008

Antioxidants and Stroke: Success and Pitfalls

article

Application of a Potentiometric System with Data-Analysis Computer Programs to the Quantification of Metal-Chelating Activity of Two Natural Antioxidants: Caffeic Acid and Ferulic Acid

article

Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents

scientific article published on 17 April 2019

Beta-nitrostyrene derivatives as potential antibacterial agents: a structure-property-activity relationship study

scientific article published on 23 February 2006

Bioactive Coumarins from Marine Sources: Origin, Structural Features and Pharmacological Properties

scientific article published on January 2015

Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives

scientific article published on 30 October 2019

Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid

scientific article published on 01 November 2019

Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity

article

Boosting Drug Discovery for Parkinson's: Enhancement of the Delivery of a Monoamine Oxidase-B Inhibitor by Brain-Targeted PEGylated Polycaprolactone-Based Nanoparticles

scientific article published on 12 July 2019

Bridging Chemical and Biological Space: QSAR Probing Using 3D Molecular Descriptors

Bridging the Gap Between Nature and Antioxidant Setbacks: Delivering Caffeic Acid to Mitochondria

Bridging the gap between nature and antioxidant setbacks: Delivering hydroxybenzoic acids to mitochondria

Caffeic Acid Alkyl Amide Derivatives Ameliorate Oxidative Stress and Modulate ERK1/2 and AKT Signaling Pathways in a Rat Model of Diabetic Retinopathy

scientific article published on 04 December 2019

Caffeic acid derivatives, analogs and applications: a patent review (2009-2013).

scientific article published on 04 October 2014

Caffeic and Ferulic Acid Derivatives

Carbon nanotube β-cyclodextrin modified electrode as enhanced sensing platform for the determination of fungicide pyrimethanil

Carbon nanotube β-cyclodextrin-modified electrode for quantification of cocaine in seized street samples

Chalcone-based derivatives as new scaffolds for hA3 adenosine receptor antagonists

scientific article

Chemistry and Pharmacology of Modulators of Oxidative Stress

scientific article published on 01 January 2020

Chemoinformatics Profiling of the Chromone Nucleus as a MAO-B/A2AAR Dual Binding Scaffold.

scientific article

Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors ⬇️

scientific article published on December 5, 2010

Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances

scientific article published on 24 May 2017

Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors

scientific article published on July 2011

Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.

scientific article published on 27 March 2010

Chromone: a valid scaffold in medicinal chemistry

scientific article

Classifier ensemble based on feature selection and diversity measures for predicting the affinity of A(2B) adenosine receptor antagonists

scientific article published on 10 December 2013

Co-cultivation of Synechocystis salina and Pseudokirchneriella subcapitata under varying phosphorus concentrations evidences an allelopathic competition scenario

article

Combining QSAR classification models for predictive modeling of human monoamine oxidase inhibitors

scientific article published on November 2012

CompScore: Boosting Structure-Based Virtual Screening Performance by Incorporating Docking Scoring Function Components into Consensus Scoring

scientific article published on 06 September 2019

Computational Drug Target Screening through Protein Interaction Profiles

scientific article

Computational chemistry approach for the early detection of drug-induced idiosyncratic liver toxicity.

scientific article

Computational chemistry development of a unified free energy Markov model for the distribution of 1300 chemicals to 38 different environmental or biological systems.

scientific article published in August 2007

Computational modeling tools for the design of potent antimalarial bisbenzamidines: overcoming the antimalarial potential of pentamidine

scientific article published on 18 May 2007

Conformational analysis of a trihydroxylated derivative of cinnamic acid—a combined Raman spectroscopy and Ab initio study

article

Conformational analysis of the potential anticancer agent ethyl trihydroxycinnamate—A combined raman spectroscopy and ab initio study

Conformational behaviour of biologically active ferulic acid derivatives

article

Consensus strategy in genes prioritization and combined bioinformatics analysis for preeclampsia pathogenesis

scientific article published on 08 August 2017

Correction to Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors

scientific article published on 29 May 2018

Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?

scientific article published on 28 July 2017

Coumarins and adenosine receptors: New perceptions in structure-affinity relationships

scientific article

Crystal structures of ethyl 6-(4-methyl-phen-yl)-4-oxo-4H-chromene-2-carboxyl-ate and ethyl 6-(4-fluoro-phen-yl)-4-oxo-4H-chromene-2-carboxyl-ate

scientific article

Crystal structures of five 6-mercaptopurine derivatives

scientific article published on 10 February 2016

Crystal structures of three 3,4,5-tri-meth-oxy-benzamide-based derivatives

scientific article published on 15 April 2016

Crystal structures of three 6-substituted coumarin-3-carboxamide derivatives

scientific article published on 10 June 2016

Crystal structures of two 6-(2-hy-droxy-benzo-yl)-5H-thia-zolo[3,2-a]pyrimidin-5-ones.

scientific article published on 13 June 2015

Cytotoxic and COX-2 Inhibition Properties of Hydroxycinnamic Derivatives

Derivatives of caffeic acid, a natural antioxidant, as the basis for the discovery of novel nonpeptidic neurotrophic agents

scientific article published on 27 April 2017

Design and discovery of tyrosinase inhibitors based on a coumarin scaffold

article by M. J. Matos et al published 2015 in RSC Advances

Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels

scientific article published on 14 March 2020

Design, synthesis and antibacterial study of new potent and selective coumarin-chalcone derivatives for the treatment of tenacibaculosis

scientific article published on 24 September 2015

Desirability-based methods of multiobjective optimization and ranking for global QSAR studies. Filtering safe and potent drug candidates from combinatorial libraries

scientific article

Desirability-based multi-criteria virtual screening of selective antimicrobial cyclic β-hairpin cationic peptidomimetics

scientific article published in January 2013

Desirability-based multi-objective QSAR in drug discovery

scientific article published on September 2012

Desirability-based multiobjective optimization for global QSAR studies: application to the design of novel NSAIDs with improved analgesic, antiinflammatory, and ulcerogenic profiles

scientific article

Desrisking the Cytotoxicity of a Mitochondriotropic Antioxidant Based on Caffeic Acid by a PEGylated Strategy

scholarly article by Carlos Fernandes et al published 2 July 2018 in Bioconjugate Chemistry

Development of Blood-Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity

scientific article published on 27 July 2016

Development of a Mitochondriotropic Antioxidant Based on Caffeic Acid: Proof of Concept on Cellular and Mitochondrial Oxidative Stress Models

scientific article

Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood-Brain Barrier.

scientific article published on 11 April 2018

Development of electrochemical methods for determination of tramadol--analytical application to pharmaceutical dosage forms

scientific article published in August 2003

Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria

scientific article

Development of neuroprotective antioxidants: In vitro and cellular activity of lipophilic cinnamic acid derivatives

article

Development of novel adenosine receptor ligands based on the 3-amidocoumarin scaffold.

scientific article published on 22 May 2015

Dietary Phenolic Acids and Derivatives. Evaluation of the Antioxidant Activity of Sinapic Acid and Its Alkyl Esters

Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease.

scientific article

Discovery of MAO-B inhibitors - present status and future directions part I: oxygen heterocycles and analogs

scientific article published on September 2012

Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors.

scientific article published on 31 May 2016

Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid.

scientific article published in December 2018

Discovery of neurotrophic agents based on hydroxycinnamic acid scaffold

scientific article published on 28 July 2016

Discovery of novel A3 adenosine receptor ligands based on chromone scaffold

scientific article

Discovery of the first A1 adenosine receptor ligand based on the chromone scaffold

article

Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry

scientific article published on 01 February 2015

Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative

scientific article

ELECTROANALYTICAL DETERMINATION OF CODEINE IN PHARMACEUTICAL PREPARATIONS

Effects of chlorophenoxy herbicides and their main transformation products on DNA damage and acetylcholinesterase activity

scientific article published on 27 March 2014

Effects of olive oil polyphenols on erythrocyte oxidative damage

scientific article

Effects of phenolic propyl esters on the oxidative stability of refined sunflower oil.

scientific article published in August 2001

Efficient and biologically relevant consensus strategy for Parkinson's disease gene prioritization.

scientific article

Electroanalytical Determination of Oxadiazon and Characterization of Its Base-Catalyzed Ring-Opening Products

scholarly article by E. M. Garrido et al published March 2001 in Electroanalysis

Electrochemical Analysis of Opiates—An Overview

Electrochemical Behavior of a Mitochondria-Targeted Antioxidant at an Interface between Two Immiscible Electrolyte Solutions: An Alternative Approach to Study Lipophilicity

scientific article published on 12 June 2018

Electrochemical Determination of Dihydrocodeine in Pharmaceuticals

Electrochemical Determination of the Herbicide Bentazone Using a Carbon Nanotube β-Cyclodextrin Modified Electrode

Electrochemical and spectroscopic characterisation of amphetamine-like drugs: application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors.

scientific article

Electrochemical and spectroscopic studies of the oxidation mechanism of the herbicide propanil

scientific article

Electrochemical oxidation of amphetamine-like drugs and application to electroanalysis of ecstasy in human serum

scientific article published on 11 December 2009

Electrochemical oxidation of propanil and related N-substituted amides

Electrochemical sensing of the thyroid hormone thyronamine (T0AM) via molecular imprinted polymers (MIPs)

scientific article published on 29 October 2018

Electrochemical sensor for simultaneous determination of herbicide MCPA and its metabolite 4-chloro-2-methylphenol. Application to photodegradation environmental monitoring

scientific article published on 15 October 2014

Electrospray tandem mass spectrometry of aminochromes

scientific article published in January 2001

Enhanced host–guest electrochemical recognition of herbicide MCPA using a β-cyclodextrin carbon nanotube sensor

article

Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

scientific article published on 01 January 2019

Evaluation of Antioxidant and Antitrypanosomal Properties of a Selected Series of Synthetic 3-Carboxamidocoumarins

Evaluation of cinnamaldehyde and cinnamic acid derivatives in microbial growth control

Evaluation of the lipophilic properties of opioids, amphetamine-like drugs, and metabolites through electrochemical studies at the interface between two immiscible solutions

scientific article published on 27 November 2006

Exploring Nitrostyrene as a Scaffold for a New Class a of Monoamine Oxidase Inhibitors

Exploring cinnamic acid scaffold: development of promising neuroprotective lipophilic antioxidants

article

Exploring coumarin potentialities: development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold

article

Exploring natural profits: Development of novel and potent galloyl-cinnamic hybrids lipophilic antioxidants

article

Exploring nature profits: development of novel and potent lipophilic antioxidants based on galloyl-cinnamic hybrids

scientific article

Exploring the Multi-Target Performance of Mitochondriotropic Antioxidants against the Pivotal Alzheimer's Disease Pathophysiological Hallmarks

scientific article published on 09 January 2020

Fine-tuning of the hydrophobicity of caffeic acid: studies on the antimicrobial activity against Staphylococcus aureus and Escherichia coli

scholarly article by Mafalda Andrade et al published 2015 in RSC Advances

Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction

scientific article published on 06 February 2019

Flow Injection Electrochemical Determination of Apomorphine

Fluoxetine and norfluoxetine revisited: new insights into the electrochemical and spectroscopic properties

scientific article published in September 2009

From flamingo dance to (desirable) drug discovery: a nature-inspired approach

scientific article

Furocoumarins in medicinal chemistry. Synthesis, natural occurrence and biological activity.

scientific article

Furvina inhibits the 3-oxo-C12-HSL-based quorum sensing system of Pseudomonas aeruginosa and QS-dependent phenotypes

scientific article

Fusing Docking Scoring Functions Improves the Virtual Screening Performance for Discovering Parkinson's Disease Dual Target Ligands

scientific article

Harmonization of QSAR Best Practices and Molecular Docking Provides an Efficient Virtual Screening Tool for Discovering New G-Quadruplex Ligands

scientific article published on 10 September 2015

Hepatotoxicity of 3,4-methylenedioxyamphetamine and alpha-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates

scientific article published on 28 October 2003

Heterocyclic Antioxidants in Nature: Coumarins

Host-guest complexes of phenoxy alkyl acid herbicides and cyclodextrins. MCPA and β-cyclodextrin

article

Host-guest interaction between herbicide oxadiargyl and hydroxypropyl-β-cyclodextrin.

scientific article published on 25 November 2013

Hydration Structure of Cocaine and its Metabolites: A Molecular Dynamics Study

Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors.

scientific article

Hydroxycinnamic acid antioxidants: an electrochemical overview

scientific article published on 16 July 2013

Hydroxycinnamic acid as a novel scaffold for the development of cyclooxygenase-2 inhibitors

article

Identification of synthetic precursors of amphetamine-like drugs using Raman spectroscopy and ab initio calculations: beta-Methyl-beta-nitrostyrene derivatives

scientific article published on 3 September 2004

Improved Synthesis of 3-(Aminoaryl)coumarins

In search for new chemical entities as adenosine receptor ligands: development of agents based on benzo-γ-pyrone skeleton

scientific article

In vitro cellular and mitochondrial toxicity of tolcapone and related nitrocatechols

article

In vitro evaluation of bisnaphthalimidopropyl derivatives loaded into pegylated nanoparticles against Leishmania infantum protozoa

scientific article

Influence of Hydroxypropyl-β-Cyclodextrin on the Photostability of Fungicide Pyrimethanil

Insight into the interactions between novel coumarin derivatives and human A3 adenosine receptors.

scientific article

Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues

scientific article published on 02 December 2019

Interest of antioxidant agents in parasitic diseases. The case study of coumarins.

scientific article

Isocratic HPLC Separation of Scopoletin andCis/TransIsomers of Ferulic Acid as Well as Isoscopoletin andCis/TransIsomers of Isoferulic Acid

Jointly handling potency and toxicity of antimicrobial peptidomimetics by simple rules from desirability theory and chemoinformatics.

scientific article published on 9 December 2011

Lessons from black pepper: piperine and derivatives thereof

scientific article

Ligand-Based Virtual Screening Using Tailored Ensembles: A Prioritization Tool for Dual A2AAdenosine Receptor Antagonists / Monoamine Oxidase B Inhibitors

scientific article published on March 2016

Ligands and therapeutic perspectives of adenosine A(2A) receptors

scientific article

Lipophilic caffeic and ferulic acid derivatives presenting cytotoxicity against human breast cancer cells

scientific article published on 28 April 2011

Lipophilic phenolic antioxidants: correlation between antioxidant profile, partition coefficients and redox properties

scientific article

Long Chain Alkyl Esters of Hydroxycinnamic Acids as Promising Anticancer Agents: Selective Induction of Apoptosis in Cancer Cells

scientific article published on 18 July 2017

Long-Term Treatment with Low Doses of Methamphetamine Promotes Neuronal Differentiation and Strengthens Long-Term Potentiation of Glutamatergic Synapses onto Dentate Granule Neurons.

scientific article published on May 2016

MAO inhibitory activity of bromo-2-phenylbenzofurans: synthesis, study, and docking calculations

scientific article published on 07 July 2017

Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro

scientific article

Methamphetamine changes NMDA and AMPA glutamate receptor subunit levels in the rat striatum and frontal cortex

scientific article

Methamphetamine decreases dentate gyrus stem cell self-renewal and shifts the differentiation towards neuronal fate.

scientific article published on 13 August 2014

Methamphetamine induces alterations on hippocampal NMDA and AMPA receptor subunit levels and impairs spatial working memory.

scientific article published on 26 September 2007

Methamphetamine transiently increases the blood-brain barrier permeability in the hippocampus: role of tight junction proteins and matrix metalloproteinase-9.

scientific article published on 14 July 2011

Methamphetamine-induced early increase of IL-6 and TNF-alpha mRNA expression in the mouse brain

scientific article

Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin.

scientific article published on 13 January 2010

Microencapsulation of caffeic acid phenethyl ester and caffeic acid phenethyl amide by inclusion in hydroxypropyl-β-cyclodextrin.

scientific article published on 16 February 2018

Microencapsulation of herbicide MCPA with native β-cyclodextrin and its methyl and hydroxypropyl derivatives: An experimental and theoretical investigation

Microwave-Assisted Synthesis of 5-Phenyl-2-hydroxyacetophenone Derivatives by a Green Suzuki Coupling Reaction

Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants

scientific article published on 14 February 2018

Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation

scientific article published on 20 September 2021

Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine

scientific article published on 25 April 2006

Modulation of ERK1/2 and Akt Pathways Involved in the Neurotrophic Action of Caffeic Acid Alkyl Esters

Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease

scientific article published in 2022

Molecular Encapsulation of Herbicide Terbuthylazine in Native and Modifiedβ-Cyclodextrin

scholarly article in Journal of Chemistry, 2017

Molecular interaction between cocaine and opioids. Implications on Speedball's toxicity

Multi-target spectral moment: QSAR for antifungal drugs vs. different fungi species

article

Multi-target spectral moment: QSAR for antiviral drugs vs. different viral species

article

Multi-target spectral moments for QSAR and Complex Networks study of antibacterial drugs

scientific article published on 24 June 2009

Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors

scholarly article by Joana Reis et al published October 2018 in European Journal of Medicinal Chemistry

Multidimensional drug design: simultaneous analysis of binding and relative efficacy profiles of N(6)-substituted-4'-thioadenosines A3 adenosine receptor agonists

scientific article

Multifunctionality and cytotoxicity of a layered coordination polymer

scientific article published on 17 January 2020

NMR studies on the antiradical mechanism of phenolic compounds towards 2,2-diphenyl-1-picrylhydrazyl radical

NO and HNO donors, nitrones, and nitroxides: Past, present, and future

scientific article

Nanotechnology and antioxidant therapy: an emerging approach for neurodegenerative diseases

scientific article published on January 2014

Natural/random protein classification models based on star network topological indices.

scientific article

Navigating in chromone chemical space: discovery of novel and distinct A3 adenosine receptor ligands

article

Neurotoxicity of heroin-cocaine combinations in rat cortical neurons

scientific article published on 30 June 2010

New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors

scientific article

New insights in the discovery of novel h-MAO-B inhibitors: structural characterization of a series of N-phenyl-4-oxo-4H-chromene-3-carboxamide derivatives

scientific article published on 25 April 2015

New insights into highly potent tyrosinase inhibitors based on 3-heteroarylcoumarins: Anti-melanogenesis and antioxidant activities, and computational molecular modeling studies

scientific article published on 31 January 2017

New insights into the antioxidant activity of hydroxycinnamic acids: Synthesis and physicochemical characterization of novel halogenated derivatives

scientific article

New insights into the antioxidant activity of hydroxycinnamic and hydroxybenzoic systems: spectroscopic, electrochemistry, and cellular studies

scientific article published on 14 October 2014

New insights into the oxidation pathways of apomorphine

New insights on the anticancer properties of dietary polyphenols.

scientific article

Optimizing the Synthetic Route of Chromone-2-carboxylic Acids: A Step forward to Speed-Up the Discovery of Chromone-Based Multitarget-Directed Ligands

scientific article published on 20 November 2019

Oxidative behaviour of apomorphine and its metabolites.

scientific article published in January 2002

Oxidative stress and neurodegenerative diseases: looking for a therapeutic solution inspired on benzopyran chemistry

scientific article published on January 2015

Oxidative stress as a pharmacological target for medicinal chemistry: synthesis and evaluation of compounds with redox activity - part 1

scientific article published on 01 January 2014

Oxidative stress as a pharmacological target for medicinal chemistry: synthesis and evaluation of compounds with redox activity - part 2

scientific article published on 01 January 2015

Oxidative stress as a pharmacological target for medicinal chemistry: synthesis and evaluation of compounds with redox activity - part 4

scientific article published on 01 January 2015

Oxidative stress as a pharmacological target for medicinal chemistry: synthesis and evaluation of compounds with redox activity--part 3.

scientific article

PEGylated PLGA nanoparticles as a smart carrier to increase the cellular uptake of a coumarin-based monoamine oxidase B inhibitor

scientific article published on 09 November 2018

Pharmacodynamic evaluation of novel Catechol-O-methyltransferase inhibitors

scientific article published on 24 January 2019

Phenolic acid derivatives with potential anticancer properties--a structure-activity relationship study. Part 1: methyl, propyl and octyl esters of caffeic and gallic acids.

scientific article

Phenolic esters with potential anticancer activity - the structural variable

scientific article published on 06 March 2007

Photostabilization of Phenoxyacetic Acid Herbicides MCPA and Mecoprop by Hydroxypropyl-β-cyclodextrin

article published in 2013

Phytochemical profiling as a solution to palliate disinfectant limitations.

scientific article published in October 2016

Plant derived and dietary phenolic antioxidants: anticancer properties.

scientific article published on 18 March 2015

Polymorphism in the structure of N-(5-methyl-thia-zol-2-yl)-4-oxo-4H-chromene-3-carboxamide.

scientific article

Potentiometric studies on the complexation of copper(II) by phenolic acids as discrete ligand models of humic substances.

scientific article published on 18 January 2005

Powerful protective role of 3,4-dihydroxyphenylethanol-elenolic acid dialdehyde against erythrocyte oxidative-induced hemolysis

scientific article published in January 2010

Prioritizing Hits with Appropriate Trade-Offs Between HIV-1 Reverse Transcriptase Inhibitory Efficacy and MT4 Blood Cells Toxicity Through Desirability-Based Multiobjective Optimization and Ranking

scientific article

Probing the Hypothesis of SAR Continuity Restoration by the Removal of Activity Cliffs Generators in QSAR.

scientific article published on 9 May 2016

Progress in the development of small molecules as new human A3 adenosine receptor ligands based on the 3-thiophenylcoumarin core

article

QSAR and Complex Network Recognition of miRNAs in Stem Cells

QSAR, Complex Networks, Principal Components and Partial Order Analysis of Drug Cardiotoxicity with Proteome Mass- Spectra Topological Indices

Quantitative Proteome-Property Relationships (QPPRs). Part 1: finding biomarkers of organic drugs with mean Markov connectivity indices of spiral networks of blood mass spectra

scientific article published on 5 October 2008

Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold

article

Recent advances on A₃ adenosine receptor antagonists by QSAR tools

scientific article published on January 2012

Recent advances on QSAR-based profiling of agonist and antagonist A3 adenosine receptor ligands

scientific article published on January 2013

Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins

scientific article

Repurposing nitrocatechols: 5-Nitro-α-cyanocarboxamide derivatives of caffeic acid and caffeic acid phenethyl ester effectively inhibit aggregation of tau-derived hexapeptide AcPHF6

scientific article published on 04 February 2019

Role of metabolites in MDMA (ecstasy)-induced nephrotoxicity: an in vitro study using rat and human renal proximal tubular cells

scientific article published in August 2002

Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat <i>Staphylococcus aureus</i> from Diabetic Foot Ulcer Infections

scientific article published on 04 May 2022

Searching for new cytotoxic agents based on chromen-4-one and chromane-2,4-dione scaffolds

scientific article published on 01 February 2019

Separation of the Diastereoisomers of Ethyl Esters of Caffeic, Ferulic, and Isoferulic Acids by Thin-Layer and High Performance Liquid Chromatography

Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity.

scientific article

Simple stochastic fingerprints towards mathematical modeling in biology and medicine. 3. Ocular irritability classification model

scientific article published on 25 July 2006

Simultaneous Isocratic HPLC Separation of the Diastereoisomers of Caffeic, Ferulic, and Isoferulic Acids and Related Coumarins

Single or multiple injections of methamphetamine increased dopamine turnover but did not decrease tyrosine hydroxylase levels or cleave caspase-3 in caudate-putamen

scientific article

Spectroscopic and electrochemical studies of cocaine-opioid interactions

scientific article

Square‐Wave Adsorptive‐Stripping Voltammetric Detection in the Quality Control of Fluoxetine

Stochastic molecular descriptors for polymers. 4. Study of complex mixtures with topological indices of mass spectra spiral and star networks: The blood proteome case

article

Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons

scientific article published on 23 January 2007

Structural characterization of some N-phenyl-4-oxo-4H-2-chromone carboxamides

scientific article published on 8 May 2013

Structural elucidation of a series of 6-methyl-3-carboxamidocoumarins.

scientific article published on 10 November 2016

Structural elucidation of a series of benzamide derivatives

scientific article published on 18 November 2017

Structure of 7-hy-droxy-3-(2-meth-oxy-phen-yl)-2-tri-fluoro-meth-yl-4H-chromen-4-one

scientific article

Structure-Based Optimization of Coumarin hA3 Adenosine Receptor Antagonists

scientific article published on 04 December 2019

Structure-property studies on the antioxidant activity of flavonoids present in diet.

scientific article

Structure-property-activity relationship of phenolic acids and derivatives. Protocatechuic acid alkyl esters

scientific article published in June 2010

Studies on the Food Additive Propyl Gallate: Synthesis, Structural Characterization, and Evaluation of the Antioxidant Activity

article

Study of coumarin-resveratrol hybrids as potent antioxidant compounds.

scientific article

Study on the volatility of halogenated fluorenes

Substituted xanthones as selective and reversible monoamine oxidase A (MAO-A) inhibitors

scientific article published in August 1993

Surface Wiping Test to Study Biocide -Cinnamaldehyde Combination to Improve Efficiency in Surface Disinfection

scientific article published on 23 October 2020

Synthesis and NMR studies of novel chromone-2-carboxamide derivatives

scientific article published on 14 February 2013

Synthesis and adenosine receptors binding affinities of a series of 3-arylcoumarins

scientific article published on 22 August 2013

Synthesis and analysis of aminochromes by HPLC-photodiode array. Adrenochrome evaluation in rat blood.

scientific article

Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates

scientific article published on 21 December 2010

Synthesis and characterisation of new 4-oxo-N-(substituted-thiazol-2-yl)-4H-chromene-2-carboxamides as potential adenosine receptor ligands

scholarly article by Fernando Cagide et al published June 2015 in Journal of Molecular Structure

Synthesis and cytotoxic profile of 3,4-methylenedioxymethamphetamine ("ecstasy") and its metabolites on undifferentiated PC12 cells: A putative structure-toxicity relationship

scientific article

Synthesis and pharmacological activities of non-flavonoid chromones: a patent review (from 2005 to 2015).

scientific article published on 18 August 2015

Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors.

scientific article published on 25 July 2017

Synthesis of 3-arylcoumarins via Suzuki-cross-coupling reactions of 3-chlorocoumarin

Synthesis of 6-aryl/heteroaryl-4-oxo-4 H -chromene-2-carboxylic ethyl ester derivatives

Synthesis of Carbocyclic Pyrimidine Nucleosides Using theMitsunobuReaction:O2-vs. N1-Alkylation

Synthesis of Coumarins and Derivatives. Part 1. Biomimetic synthesis of esculetin and halogenated derivatives

Synthesis, crystal structure and spectral properties of 6-bromo-N-(cyclohex-1-en-1-ylmethyl)-4-oxo-4H-chromene-2-carboxamide

article published in 2013

Synthesis, evaluation and pharmacological applications of antioxidants- part 1.

scientific article

Synthesis, evaluation and pharmacological applications of antioxidants- part 2.

scientific article

Synthesis, pharmacological study and docking calculations of new benzo[f]coumarin derivatives as dual inhibitors of enzymatic systems involved in neurodegenerative diseases

scientific article published on March 2014

Synthesis, spectroscopic characterization and X-ray structure of novel 7-methoxy-4-oxo-N-phenyl-4H-chromene-2-carboxamides

Systemic QSAR and phenotypic virtual screening: chasing butterflies in drug discovery

scientific article published on 5 March 2017

Tailoring Lipid and Polymeric Nanoparticles as siRNA Carriers towards the Blood-Brain Barrier - from Targeting to Safe Administration

scientific article published on 21 May 2016

Targeting adenosine receptors with coumarins: synthesis and binding activities of amide and carbamate derivatives

scientific article published in January 2013

The Mu.Ta.Lig. Chemotheca: A Community-Populated Molecular Database for Multi-Target Ligands Identification and Compound-Repurposing.

scientific article published on 19 April 2018

The anticancer properties of dietary polyphenols and its relation with apoptosis

scientific article published on January 2010

The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease

scientific article published on 01 August 2019

The crystal structures of four N-(4-halophen-yl)-4-oxo-4H-chromene-3-carboxamides.

scientific article

The toxicity of N-methyl-alpha-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine

scientific article

Theoretical study of cocaine and ecgonine methyl ester in gas phase and in aqueous solution

Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis.

scientific article published on 12 April 2018

Topological structural alerts modulations of mammalian cell mutagenicity for halogenated derivatives.

scientific article published on 28 November 2013

Topological sub-structural molecular design (TOPS-MODE): a useful tool to explore key fragments of human A3 adenosine receptor ligands.

scientific article

Total Arsenic Content in Seafood Consumed in Portugal

article

Towards the Discovery of a Novel Class of Monoamine Oxidase Inhibitors: Structure-Property-Activity and Docking Studies on Chromone Amides

article

Two new parameters based on distances in a receiver operating characteristic chart for the selection of classification models

scientific article published on 29 September 2011

Two polymorphs ofN-(2-methoxyphenyl)-4-oxo-4H-chromone-3-carboxamide

scientific article published on 20 July 2013

Unified QSAR & network-based computational chemistry approach to antimicrobials. II. Multiple distance and triadic census analysis of antiparasitic drugs complex networks.

scientific article published in January 2010

Using microfluidic platforms to develop CNS-targeted polymeric nanoparticles for HIV therapy

scientific article published on 31 January 2018

Variable delay-to-signal: a fast paradigm for assessment of aspects of impulsivity in rats

scientific article published on 23 October 2013

Voltammetric Oxidation of Drugs of Abuse I. Morphine and Metabolites

scholarly article by J. M. P. J. Garrido et al published September 2004 in Electroanalysis

Voltammetric Oxidation of Drugs of Abuse II. Codeine and Metabolites

article

Voltammetric Oxidation of Drugs of Abuse III. Heroin and Metabolites

scholarly article by J. M. P. J. Garrido et al published September 2004 in Electroanalysis

Voltammetric and DFT Studies on Viloxazine: Analytical Application to Pharmaceuticals and Biological Fluids

Voltammetric insights in the transfer of ionizable drugs across biomimetic membranes: recent achievements

scientific article published on August 2007

Wine and grape polyphenols — A chemical perspective

article by Jorge Garrido & Fernanda Borges published December 2013 in Food Research International

Wine and grape polyphenols — A chemical perspective [Food Research International 44 (2011) 3134-3148]

article by Jorge Garrido & Fernanda Borges published December 2013 in Food Research International

Wine and grape polyphenols—A chemical perspective

article by Jorge Garrido & Fernanda Borges published December 2011 in Food Research International

β-Cyclodextrin carbon nanotube-enhanced sensor for ciprofloxacin detection

scientific article published on 7 December 2016

β-Nitrostyrene derivatives—a conformational study by combined Raman spectroscopy and ab initio MO calculations

article published in 2004

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