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List of works by Petr Pávek

1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria

scientific article published on 02 June 2014

2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists.

scientific article published on 4 May 2016

AB0511 Discontinuation of Methotrexate Treatment in Patients with Rheumatoid Arthritis and Relatiomships with Candidate Single Nucleotide Polymorphisms

scientific article published in June 2015

Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor

scientific article

Adherence to osteoporosis guideline: survey among Czech general practitioners

scientific article published on 31 July 2014

Allosteric Antagonism of the Pregnane X Receptor (PXR): Current-State-of-the-Art and Prediction of Novel Allosteric Sites

scientific article published on 24 September 2022

Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures.

scientific article published on 10 June 2011

Atorvastatin Modulates Bile Acid Homeostasis in Mice with Diet-Induced Nonalcoholic Steatohepatitis

scientific article published on 16 June 2021

Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression.

scientific article published on 12 November 2007

Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines

scientific article published on 18 January 2010

Bioinformatic analysis of miRNAs targeting the key nuclear receptors regulating CYP3A4 gene expression: The challenge of the CYP3A4 "missing heritability" enigma

scientific article published in July 2015

Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis.

scientific article

Boldine enhances bile production in rats via osmotic and farnesoid X receptor dependent mechanisms

scientific article published on 12 March 2015

Breast cancer resistance protein (BCRP/ABCG2).

scientific article

Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2.

scientific article

Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR).

scientific article

Comment on "The role of redox-sensitive transcription factors NF-kB and AP-1 in the modulation of the Cyp1A1 gene by mercury, lead, and copper"

scientific article published on 11 June 2008

Construction and characterization of a reporter gene cell line for assessment of human glucocorticoid receptor activation.

scientific article

Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells

scientific article

Construction and characterization of peroxisome proliferator-activated receptor-gamma co-activator 1 alpha (PGC-1α over-expressing cell line derived from human hepatocyte carcinoma HepG2 cells).

scientific article

Construction and characterization of stable transfected hepatocyte-like cells

scientific article published in June 2012

Correction to 2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists.

scientific article published on 8 December 2016

Corticosterone transfer and metabolism in the dually perfused rat placenta: effect of 11beta-hydroxysteroid dehydrogenase type 2.

scientific article

Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction.

scientific article published on 23 January 2014

Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis

scientific article published on 05 March 2016

Development of water-soluble 3,5-dinitrophenyl tetrazole and oxadiazole antitubercular agents.

scientific article published on 8 August 2017

Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line.

scientific article published on 30 September 2013

Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes.

scientific article published on 5 November 2008

Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain

scientific article published on 24 November 2020

Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines

scientific article published on 02 June 2013

Endogenous and exogenous ligands of aryl hydrocarbon receptor: current state of art.

scientific article published on February 2011

Entecavir Interacts with Influx Transporters hOAT1, hCNT2, hCNT3, but Not with hOCT2: The Potential for Renal Transporter-Mediated Cytotoxicity and Drug-Drug Interactions

scientific article

Examination of Glucocorticoid receptor alpha-mediated transcriptional regulation of P-glycoprotein, CYP3A4, and CYP2C9 genes in placental trophoblast cell lines.

scientific article

Examination of the functional activity of P-glycoprotein in the rat placental barrier using rhodamine 123

scientific journal article

Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma BeWo and JEG-3 cell lines

scientific article

Expression and function of p-glycoprotein in normal tissues: effect on pharmacokinetics

scientific article published in January 2010

Expression and functional activity of breast cancer resistance protein (BCRP, ABCG2) transporter in the human choriocarcinoma cell line BeWo.

scientific article published on January 2006

Expression and transport activity of breast cancer resistance protein (Bcrp/Abcg2) in dually perfused rat placenta and HRP-1 cell line

scientific journal article

Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation

scientific article

Fully automatic flow-based device for monitoring of drug permeation across a cell monolayer

scientific article published on 28 November 2015

Glucocorticoid receptor functions in HeLa Cells are perturbed by 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD).

scientific article

Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes.

scientific article published on January 2013

Honey flavonoids inhibit hOATP2B1 and hOATP1A2 transporters and hOATP-mediated rosuvastatin cell uptake in vitro

scientific article

Human breast cancer resistance protein: interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine.

scientific article published on 13 September 2004

Influence of P-glycoprotein on the transplacental passage of cyclosporine.

scientific article published in October 2001

Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates.

scientific article published on 13 July 2013

Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene

scientific article

In vitro platelet antiaggregatory properties of 4-methylcoumarins.

scientific article published on 17 September 2012

Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats.

scientific article published on 6 September 2017

JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes

scientific article published on 16 September 2007

Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents.

scientific article published in March 2006

Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions.

scientific article published on May 2014

Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene

scientific article

Methotrexate impact on radiographic progression in biologic-treated rheumatoid arthritis under clinical remission: A case report on monozygotic Caucasian twins.

scientific article published on 21 October 2016

New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase.

scientific article

Novel cell line for assessment of aryl hydrocarbon receptor transcriptional activity

scientific article published in June 2012

Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity.

scientific article published on 24 October 2015

Novel stably transfected gene reporter human hepatoma cell line for assessment of aryl hydrocarbon receptor transcriptional activity: construction and characterization.

scientific article

Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier.

scientific article published on 10 September 2013

Oligonucleotide Delivery across the Caco-2 Monolayer: The Design and Evaluation of Self-Emulsifying Drug Delivery Systems (SEDDS)

scientific article published on 28 March 2021

Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone.

scientific article

P-glycoprotein expression and distribution in the rat placenta during pregnancy

scientific journal article

P-glycoprotein in the placenta: expression, localization, regulation and function.

scientific article

PLGA Based Nanospheres as a Potent Macrophage-Specific Drug Delivery System

scientific article published on 16 March 2021

Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T.

scientific article published on 16 February 2013

Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily.

scientific article published on December 2013

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions

scientific article

Pregnane X Receptor and Cancer: Context-Specificity is Key.

scientific article published on June 2016

Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids.

scientific article

Resveratrol as an inhibitor of pregnane X receptor (PXR): another lesson in PXR antagonism.

scientific article published on January 2014

Rifampicin Does not Significantly Affect the Expression of Small Heterodimer Partner in Primary Human Hepatocytes

scientific article (publication date: 2012)

Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat

scientific journal article

S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents

scientific article published on 21 November 2016

SB203580, a pharmacological inhibitor of p38 MAP kinase transduction pathway activates ERK and JNK MAP kinases in primary cultures of human hepatocytes.

scientific article

Stereoselective interactions of warfarin enantiomers with the pregnane X nuclear receptor in gene regulation of major drug-metabolizing cytochrome P450 enzymes

scientific article published on December 2010

Stereoselective pharmacokinetics and metabolism of flobufen in guinea pigs.

scientific article published in October 2003

Stereoselective pharmacokinetics of flobufen in rats

scientific article published on 01 January 1999

Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation

scientific article published on 5 September 2017

THU0144 The Influence of the Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism on Methotrexate Treatment Outcome in Patients with Rheumatoid Arthritis in the EAST Bohemian Region

scientific article published in June 2014

The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists

scientific article published on 21 April 2015

The function of cytochrome P450 1A1 enzyme (CYP1A1) and aryl hydrocarbon receptor (AhR) in the placenta.

scientific article published on May 2011

The impact of C677T and A1298C MTHFR polymorphisms on methotrexate therapeutic response in East Bohemian region rheumatoid arthritis patients

scientific article published on 25 January 2015

The influence of coffee intake and genetics on adenosine pathway in rheumatoid arthritis

scientific article published on 03 July 2020

The plausible association of MTHFR and ADORA2A polymorphisms with nodules in rheumatoid arthritis patients treated with methotrexate

scientific article published on 14 November 2016

The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator

scientific article published on 27 February 2016

The role of residues T248, Y249 and T422 in the function of human pregnane X receptor

scientific article

U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.

scientific article published on 14 May 2014

Unidirectional transfer of D-xylose across the rat placenta

scientific article published on 01 January 1998

Valproate activates ERK signaling pathway in primary human hepatocytes

scientific article

Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3: a possible cause of valproic acid-induced osteomalacia?

scientific article published on 27 November 2010

Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.

scientific article published on 28 March 2007

Variation of drug kinetics in pregnancy.

scientific article published on June 2009

Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues

scientific journal article

[Physiologic function of P-glycoprotein]

scientific article published on 01 August 2002

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