Search filters

List of works by Dimitrios H. Roukos

A critical evaluation of effectivity of extended lymphadenectomy in patients with carcinoma of the stomach. An analysis of early results and long-term survival

scientific article published on 01 January 1990

Advances in laparoscopic gastrectomy expand clinical use.

scientific article

Advances in locating lymph nodes by endoscopic ultrasound-guided fine-needle marking

scientific article published on 01 March 2010

Advantages of staging laparoscopy in gastric cancer: they are so obvious that they are not evident

scientific article published in January 2015

Application of microRNAs in diabetes mellitus

scientific article published on 29 April 2014

Assessing both genetic variation (SNPs/CNVs) and gene-environment interactions may lead to personalized gastric cancer prevention

scientific article published in January 2009

BMI and lymph node ratio may predict clinical outcomes of gastric cancer

scientific article

Bench-top sequencing and clinical implementation: diagnostics and biomarkers challenges

scientific article published on 01 January 2014

Beyond BRCA1/2: polygenic, 'polyfunctional' molecular circuitry model to predict breast cancer risk

scientific article

Beyond HER2 and trastuzumab: heterogeneity, systems biology, and cancer origin research may guide the future for personalized treatment of very early but aggressive breast cancer

scientific article published on 20 April 2010

Bionetworks-based personalized medicine versus comparative-effectiveness research or harmonization of both in cancer management?

scientific article published on 01 April 2010

Biotechnological, genomics and systems–synthetic biology revolution: redesigning genetic code for a pragmatic systems medicine ⬇️

scientific article published on 01 March 2012

Breakthrough targeted therapeutic approaches to squamous cell carcinoma of the head and neck

scientific article published in January 2015

Breakthrough therapies in melanoma

scientific article published in April 2014

Breast cancer outcomes: the crucial role of the breast surgeon in the era of personal genetics and systems biology

scientific article published on 01 June 2009

CDH1 testing: can it predict the prophylactic or therapeutic nature of total gastrectomy in hereditary diffuse gastric cancer?

scientific article published on 28 July 2009

Can VEGF-D and VEGFR-3 be used as biomarkers for therapeutic decisions in patients with gastric cancer?

scientific article published on 01 August 2006

Cancer Genome Sequencing and Functional Genomics: From Translational to Clinical Medicine ⬇️

scientific article published on 01 October 2011

Cancer genome explosion and systems biology: impact on surgical oncology?

scientific article published on 01 January 2011

Cancer genome sequencing and potential application in oncology

scientific article published in October 2010

Cancer heterogeneity and signaling network-based drug target

scientific article published in August 2013

Caution in adding bevacizumab in the adjuvant treatment of breast cancer

scientific article published on 04 November 2009

Challenges in developing robust genetic markers and targets to predict and prevent distant and peritoneal recurrence in gastric cancer

scientific article published on 29 January 2009

Challenges in personalizing decisions on whole, partial or no breast irradiation and extent of surgery for early breast cancer

scientific article published on 12 June 2009

Chromatin: a key player in complex gene regulation and future cancer therapeutics.

scientific article published on August 2011

Circulating cancer cells: could they be used in the clinic as recurrence markers for gastric and colorectal cancer?

scientific article published on 31 December 2008

Circulating free DNA in plasma or serum as biomarkers of carcinogenesis in colon cancer

scientific article published in January 2015

Circulating tumor DNA: new horizons for improving cancer treatment

scientific article published in February 2015

Clinical cancer genome and precision medicine

scientific article published in November 2012

Clinical relevance of cancer genome sequencing

scientific article published in April 2013

Colorectal cancer: cetuximab, KRAS, BRAF, PIK3CA mutations and beyond.

scientific article

Colorectal liver metastases guidelines, tumor heterogeneity and clonal evolution: can this be translated to patient benefit?

scientific article published in August 2014

Comparative-effectiveness research to standardize retrieved nodes for quality control in colorectal cancer

scientific article published on 01 July 2010

Complete genome sequencing and network modeling to overcome trastuzumab resistance

scientific article published in August 2010

Continuous intraoperative neuromonitoring in thyroid surgery: Safety analysis of 400 consecutive electrode probe placements with standardized procedures.

scientific article published on 28 November 2015

Contralateral Prophylactic Mastectomy Overtreatment: Expectations from Personal Genomics for Tailored Breast Cancer Surgery

scientific article published on 01 March 2010

Contralateral prophylactic mastectomy: mind the genetics

scientific article published on 01 April 2008

Current concerns and challenges regarding tailored anti-angiogenic therapy in cancer

scientific article published on 01 October 2009

Current status and future perspectives in gastric cancer management.

scientific article

De novo mutations, protein-protein interactions and functional regulatory networks toward novel diagnostics in autism

scientific article published in October 2012

Decoding coronary artery disease: somatic mosaicism and genomics for personal and population risk prediction

scientific article published in April 2013

Deep sequencing and integrative genome analysis: approaching a new class of biomarkers and therapeutic targets for breast cancer

scientific article

Differential signaling transduction networks for clinical robustness ⬇️

scientific article published on 01 April 2012

Disrupting cancer cells’ biocircuits with interactome-based drugs: is ‘clinical’ innovation realistic? ⬇️

scientific article published on August 1, 2012

Does a new model improve decisions about mismatch-repair genetic testing and Lynch syndrome identification?

scientific article published on 01 December 2006

Does lymphadenectomy improve survival of patients with solid tumors?

scientific article published on 20 September 2007

Does neoadjuvant versus adjuvant systemic treatment improve outcomes in breast cancer?

scientific article published on 01 July 2005

Dynamic genome and transcriptional network-based biomarkers and drugs: precision in breast cancer therapy

scientific article published on 11 November 2018

Dynamic sequencing of circulating tumor DNA: novel noninvasive cancer biomarker

scientific article published on 01 January 2014

Dynamics of genome 'iPOP': predicting disease or 'narciss-ome'?

scientific article published on 01 July 2012

EGFR as a Prognostic Marker for Gastric Cancer.

scientific article

Early-stage gastric cancer: a highly treatable disease

scientific article published in February 2004

Emerging personalized oncology: sequencing and systems strategies

scientific article published in June 2012

Endoscopic submucosal dissection: can it safely expand indications for a minimally invasive approach to patients with early gastric cancer?

scientific article published on 01 July 2010

Epigenetics in gastric cancer: challenges for clinical implications

scientific article published on 02 May 2009

Esophagus and Gastric Cancer: How Surgeon's Experience and Personal Genomics May Improve Locoregional Control and Survival

scientific article published on 01 January 2009

Everolimus and sunitinib: from mouse models to treatment of pancreatic neuroendocrine tumors

scientific article published in September 2011

Evidence of survival benefit of extended (D2) lymphadenectomy in western patients with gastric cancer based on a new concept: a prospective long-term follow-up study

scientific article published on 01 May 1998

Exploring the role of BRCA1, BRCA2 and RAD51 as biomarkers for breast cancer

scientific article published on 17 March 2008

Extensive lymph-node dissection in gastric cancer: is it of therapeutic value?

scientific article published on 01 July 1996

Factors increasing local recurrence in breast-conserving surgery.

scientific article

Follow-up for gastric cancer: how extensive and intensive should it be?

scientific article published on 04 December 2009

From Clinical Standards to Translating Next-Generation Sequencing Research into Patient Care Improvement for Hepatobiliary and Pancreatic Cancers

scientific article published on 18 January 2017

From linear 'dogma' and trastuzumab-emtansine to future transcriptional circuitry-based drug discovery for breast cancer

scientific article published in February 2014

From next-generation sequencing to nanopore sequencing technology: paving the way to personalized genomic medicine

scientific article published in January 2013

From personalized to precision cancer medicine

scientific article published on 26 June 2020

From standard to new genome-based therapy of gastric cancer.

scientific article

From targeted monotherapy to combined BRAF-MEK inhibitors and integrated genome analysis for melanoma treatment.

scientific article published in January 2013

From traditional molecular biology to network oncology

scientific article published in February 2011

From traditional to whole-genome sequencing biomarkers for gastric cancer

scientific article published on 01 January 2015

From tumor size and HER2 status to systems oncology for very early breast cancer treatment

scientific article

Fruit and vegetable intake and the risk of gastric adenocarcinoma: A reanalysis of the european prospective investigation into cancer and nutrition (EPIC-EURGAST) study after a longer follow-up

Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).

scientific article published in May 2006

Fruits and vegetables: do they protect from gastric cancer?

scientific article published on 01 June 2003

Gastric cancer guidelines and genome differences between Japan and the west

scientific article published in August 2013

Gastroesophageal junction carcinoma multimodal treatment: standards, debate and new therapeutic options

scientific article published on 01 February 2011

Gene discovery in familial cancer syndromes by exome sequencing: prospects for the elucidation of familial colorectal cancer type X.

scientific article

Gene expression 'signature' limitations and genome architecture-based perspectives for robust cancer biomarkers

scientific article

Genetics and personal genomics for personalized breast cancer surgery: progress and challenges in research and clinical practice.

scientific article published on 26 March 2009

Genome diagnostics: next-generation sequencing, new genome-wide association studies and clinical challenges.

scientific article

Genome network medicine: innovation to overcome huge challenges in cancer therapy.

scientific article

Genome network medicine: new diagnostics and predictive tools

scientific article published in September 2013

Genome-based diagnostics and predictive tools: a new epoch for breast cancer management

scientific article published in October 2012

Genome-wide association studies and aggressive surgery toward individualized prevention, and improved local control and overall survival for gastric cancer

scientific article published on 24 January 2009

Genome-wide association studies: how predictable is a person’s cancer risk?

scientific article

Genomics and challenges toward personalized breast cancer local control

scientific article published on 01 September 2008

Genotype-phenotype map and molecular networks: a promising solution in overcoming colorectal cancer resistance to targeted treatment

scientific article published on 01 July 2010

HER-2-negative breast cancer limitations and next-generation sequencing technology promises

scientific article published on 03 March 2010

HER2 and trastuzumab: impact of a new standard agent on local control and surgery for breast cancer

scientific article published on 03 June 2008

Head and neck squamous cell carcinoma and human papillomavirus: epidemiology, treatment and future trends

scientific article published in March 2015

Hope from Japan for esophagogastric cancers: esophagectomy and endoscopic submucosal dissection for gastric tube cancer

scientific article

Human genetic and structural genomic variation: would genome-wide association studies be the solution for cancer complexity like Alexander the Great for the "Gordian Knot"?

scientific article published on 09 July 2008

Identifying and preventing high-risk gastric cancer individuals with CDH1 mutations

scientific article published on 01 April 2008

Improving women's health: advances, failures and cancer genome prospects

scientific article published on 01 November 2010

Increased risk of local recurrence after breast-conserving therapy in young patients

scientific article published on 25 October 2007

Innovation versus evidence: to trust direct-to-consumer personal genomic tests? ⬇️

scientific article published on 01 January 2011

Innovative biomarker development for personalized medicine in breast cancer care

scientific article published on 01 February 2011

Innovative genomic-based model for personalized treatment of gastric cancer: integrating current standards and new technologies.

scientific article published on January 2008

Integrated clinical genomics: new horizon for diagnostic and biomarker discoveries in cancer

scientific article published in January 2013

Integrating next-generation sequencing into the diagnostic testing of inherited cancer predisposition

scientific article published on 29 October 2012

Integrative deep-sequencing analysis of cancer samples: discoveries and clinical challenges ⬇️

scientific article published on January 8, 2013

International randomized trials' attention to locoregional breast cancer control and promise of personal genomics and whole-genome scans for personalized approaches

scientific article published on 07 November 2008

Intraoperative neuromonitoring of the external branch of the superior laryngeal nerve during thyroidectomy: the need for evidence-based data and perioperative technical/technological standardization

scientific article published on 24 November 2014

Is an aromatase inhibitor more effective than tamoxifen in neoadjuvant endocrine therapy for breast cancer?

scientific article published in February 2006

Is it time to change surgical strategy for gastric cancer in the United States?

scientific article published on 12 July 2004

Is there any long-term benefit in quality of life after laparoscopy-assisted distal gastrectomy for gastric cancer?

scientific article published on 26 March 2008

Laparoscopic and robotic rectal cancer resection: expectations for improving oncological outcomes

scientific article published in January 2010

Laparoscopic colectomy survival benefit for colon cancer: is evidence from a randomized trial true?

scientific article published on 01 April 2009

Laparoscopic gastrectomy and personal genomics: high-volume surgeons and predictive biomedicine may govern the future for resectable gastric cancer

scientific article published in October 2009

Laparoscopic gastrectomy for gastric cancer: current evidences.

scientific article

Laparoscopic gastrectomy: advances enable wide clinical application.

scientific article published on 10 April 2008

Laparoscopic surgery for gastric cancer: comparative-effectiveness research and future trends

scientific article published in April 2010

Letter to the editor: Breast cancer in young women in Africa: are there genetic and clinical differences with European ancestry patients?

scientific article published in August 2010

Level I evidence in support of perioperative chemotherapy for operable gastric cancer: sufficient for wide clinical use?

scientific article published on 26 July 2007

Limitations of isolated tumor cells in gastric cancer: heterogeneity requests systems biology approaches towards personalized medicine

scientific article published on 20 October 2009

Linking contralateral breast cancer with genetics

scientific article published on 30 January 2008

Longevity with Systems Medicine? Epigenome, Genome and Environment Interactions Network ⬇️

scientific article published on 01 April 2012

Magnetic resonance imaging and potential impact on extent of surgery in breast cancer

scientific article published on 05 August 2009

Mapping inherited and somatic variation in regulatory DNA: new roadmap for common disease clinical discoveries

scientific article published on 01 July 2013

Mea Culpa with cancer-targeted therapy: new thinking and new agents design for novel, causal networks-based, personalized biomedicine

scientific article published in April 2009

Measurable evidence of miRNAs as regulators of cancer networks and therapeutic targets ⬇️

scientific article published on 01 March 2011

Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC)

scientific article

Missing heritability, next-generation genome-wide association studies and primary cancer prevention: an Atlantean illusion?

scientific article published in April 2011

More controversy than ever - challenges and promises towards personalized treatment of gastric cancer

scientific article

Network-based drugs: promise and clinical challenges in cardiovascular disease.

scientific article published in April 2013

Networks medicine: from reductionism to evidence of complex dynamic biomolecular interactions

scientific article published on 01 May 2011

New molecular oncology-changing era: prospects and challenges of cancer genome and integrative systems biology

scientific article published in January 2011

New target therapies for patients with neuroendocrine tumors of the pancreas

scientific article published on 01 October 2011

New technology-based innovation changes surgical practice and research direction in solid cancers

scientific article published on 01 November 2010

Next-generation sequencing and epigenome technologies: potential medical applications ⬇️

scientific article published on November 1, 2010

Next-generation sequencing-based testing for cancer mutational landscape diversity: clinical implications?

scientific article published on 01 September 2012

Next-generation sequencing: from conventional applications to breakthrough genomic analyses and precision oncology.

scientific article published on 28 December 2017

Next-generation, genome sequencing-based biomarkers: concerns and challenges for medical practice

scientific article published on 01 August 2010

Nipple-sparing mastectomy: overcoming oncological outcomes challenges

scientific article published on 24 September 2009

Novel Cancer Drugs Based on Epigenetics, miRNAs and their Interactions ⬇️

scientific article published on 01 December 2011

Novel Wnt signaling and other pathway inhibitors in the colorectal cancer genomic landscape era.

scientific article published in November 2012

Novel clinico-genome network modeling for revolutionizing genotype-phenotype-based personalized cancer care.

scientific article published on January 2010

Omitting axilla lymphadenectomy even by positive sentinel lymph node: a change in breast cancer treatment practice

scientific article published on 01 July 2011

Outcomes of breast cancer patients with and without BRCA1/2 mutations

scientific article published on 01 April 2008

Ovarian cancer screening and peritoneal carcinomatosis: standards, 'omics' and miRNAs for personalized management

scientific article published on 01 June 2011

PLX4032 and melanoma: resistance, expectations and uncertainty ⬇️

scientific article published on March 1, 2011

Pathological serosa and node-based classification accurately predicts gastric cancer recurrence risk and outcome, and determines potential and limitation of a Japanese-style extensive surgery for Western patients: a prospective with quality control

scientific article published on 01 June 2001

Personal genomics and genome-wide association studies: novel discoveries but limitations for practical personalized medicine

scientific article published on 23 August 2008

Personalized cancer diagnostics and therapeutics

scientific article published in April 2009

Personalizing prophylactic surgery in cancer: current practice and future perspectives from new genome-wide association studies

scientific article published in June 2011

Perspectives and risks of breast-conservation therapy for breast cancer

scientific article published on 01 August 2003

Perspectives in the treatment of gastric cancer.

scientific article

Pharmacogenomics for tailoring cardiovascular and anticancer drugs: from genotyping to whole-genome sequencing

scientific article published on 01 August 2011

Potential of antibody-drug conjugates and novel therapeutics in breast cancer management.

scientific article published on 24 March 2014

Preventing breast, ovarian cancer in BRCA carriers: rational of prophylactic surgery and promises of surveillance

scientific article published on 15 November 2004

Preventing familial breast and ovarian cancer: major research advances with little implication

scientific article published on 01 March 2011

Primary gastric lymphomas: a clinicopathologic study with literature review

scientific article published on 01 April 1994

Primary liver cancer genome sequencing: translational implications and challenges.

scientific article published on 17 July 2017

Progress, challenges and new genome-based concepts in the multidisciplinary treatment of gastric cancer

scientific article published on 01 April 2011

Quality control in colorectal cancer care: how many lymph nodes should be harvested?

scientific article published on 01 April 2010

Randomized evidence for laparoscopic gastrectomy short-term quality of life improvement and challenges for improving long-term outcomes.

scientific article

Research and clinical applications of cancer genome sequencing

scientific article published on February 2013

Robotic surgery for rectal cancer: may it improve also survival?

scientific article published on 5 March 2008

Robotic versus laparoscopic surgery: perspectives for tailoring an optimal surgical option

scientific article published in May 2011

Spatiotemporal individual genome code–lifestyle network: revolutionizing personal diagnostics ⬇️

scientific article published on 01 April 2012

Standardizing lymphadenectomy for rectal cancer

scientific article published on 01 September 2010

Standards, advances and challenges in laparoscopic total mesorectal excision

scientific article published on 27 April 2010

Surgery in the era of gene expression profiling-based prediction and individualized, neoadjuvant breast cancer therapy: the beginning of the end?

scientific article published on 01 March 2006

Systems medicine: a real approach for future personalized oncology?

scientific article published on 01 March 2010

Targeted agents for advanced thyroid cancer: "knowledge is power" - the role of multikinase inhibitors.

scientific article

Targeted therapy for colorectal cancer resistance to EGF receptor antibodies and new trends

scientific article published in January 2013

Targeted therapy: overcoming drug resistance with clinical cancer genome

scientific article published on 01 July 2012

Targeting VEGF, EGFR, and other interacting pathways for gastric cancer-promises and reality

scientific article published on 14 March 2008

Targeting dynamics of subclones of GI, liver and pancreatic cancers.

scientific article

Targeting gastric cancer with trastuzumab: new clinical practice and innovative developments to overcome resistance

scientific article published on 20 October 2009

Targeting the optimal extent of lymph node dissection for gastric cancer

scientific article published on 01 October 2002

Ten years after human genome sequencing: is personalized breast screening and prevention reality?

scientific article published on 01 November 2010

The era of robotic surgery for colorectal cancer

scientific article published in January 2010

The predominant role of surgery in the prevention and new trends in the surgical treatment of women with BRCA1/2 mutations.

scientific article published on 17 October 2007

The role of HPV DNA testing in the follow-up period after treatment for CIN: a systematic review of the literature.

scientific article published on April 2004

The role of heat shock proteins in cancer

scientific article published on 23 February 2015

The ‘sequence everything’ approach and personalized clinical decision challenges

Thresholds and combined quality control in the multimodal treatment of colorectal cancer

scientific article published in July 2010

Totally intracorporeal laparoscopic gastrectomy for gastric cancer

scientific article published on 01 December 2010

Totally laparoscopic gastrectomy: a reality for USA and Europe?

scientific article published on 17 June 2009

Translating cancer genomes sequencing revolution into surgical oncology practice.

scientific article published on 25 November 2010

Translating epigenetics into an anticancer drug pipeline for solid tumors ⬇️

scientific article published on 01 July 2011

Trastuzumab and beyond: sequencing cancer genomes and predicting molecular networks.

scientific article published on 26 October 2010

Trastuzumab emtansine for advanced HER2-positive breast cancer and beyond: genome landscape-based targets

scientific article published in January 2013

Tumor heterogeneity-based resistance guides personalized cancer medicine

scientific article published in October 2014

Tumor heterogeneity-driven individualized therapy

scientific article published on 11 December 2020

Twenty-one-gene assay: challenges and promises in translating personal genomics and whole-genome scans into personalized treatment of breast cancer

scientific article published on 02 February 2009

‘Big’ science: genome regulatory networks and novel molecular tools to improve health ⬇️

scientific article published on 01 March 2011

Paulina is supported by:

About Paulina

Help