List of works - João Laranjinha

3,4-Dihydroxyphenylacetic acid (DOPAC) modulates the toxicity induced by nitric oxide in PC-12 cells via mitochondrial dysfunctioning.

scientific article published on 29 July 2008

A comparative study of carbon fiber-based microelectrodes for the measurement of nitric oxide in brain tissue

scientific article published in July 2008

A shortcut to wide-ranging biological actions of dietary polyphenols: modulation of the nitrate-nitrite-nitric oxide pathway in the gut.

scientific article

Age-associated changes of nitric oxide concentration dynamics in the central nervous system of Fisher 344 rats

scientific article published on 2 October 2014

Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation

scientific article

Antioxidant protection of low density lipoprotein by procyanidins: structure/activity relationships

scientific article published in September 2003

Biomimetic sensor based on hemin/carbon nanotubes/chitosan modified microelectrode for nitric oxide measurement in the brain.

scientific article published on 18 January 2013

Brain nitric oxide inactivation is governed by the vasculature.

scientific article published on 28 December 2010

Cholesteryl ester hydroperoxide formation in myoglobin-catalyzed low density lipoprotein oxidation: concerted antioxidant activity of caffeic and p-coumaric acids with ascorbate.

scientific article

Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor

scientific article

Coupling of ascorbate and nitric oxide dynamics in vivo in the rat hippocampus upon glutamatergic neuronal stimulation: a novel functional interplay

scientific article published on 14 March 2015

Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress.

scientific article published on 14 January 2012

Dietary Nitrite in Nitric Oxide Biology: A Redox Interplay with Implications for Pathophysiology and Therapeutics ⬇️

scientific article published on August 1, 2011

Dietary flavonoids with a catechol structure increase alpha-tocopherol in rats and protect the vitamin from oxidation in vitro

scientific article

Dietary nitrite induces nitrosation of the gastric mucosa: the protective action of the mucus and the modulatory effect of red wine.

scientific article published on 29 January 2015

Dietary nitrite induces occludin nitration in the stomach

scientific article published on 8 September 2016

Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation.

scientific article published on 22 September 2009

Diffusion of nitric oxide through the gastric wall upon reduction of nitrite by red wine: physiological impact

scientific article published on 18 January 2010

Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LDL oxidation in vitro.

scientific article published on 13 March 2008

Dynamic and interacting profiles of *NO and O2 in rat hippocampal slices.

scientific article published on 25 January 2010

Effect of dietary phenolic compounds on apoptosis of human cultured endothelial cells induced by oxidized LDL

scientific article

Electrochemical measurement of endogenously produced nitric oxide in brain slices using Nafion/o-phenylenediamine modified carbon fiber microelectrodes

Ethyl nitrite is produced in the human stomach from dietary nitrate and ethanol, releasing nitric oxide at physiological pH: potential impact on gastric motility

scientific article published on 30 January 2015

Evidence for a pathway that facilitates nitric oxide diffusion in the brain

article

Glutamate induces release of glutathione from cultured rat astrocytes--a possible neuroprotective mechanism?

scientific article published on 7 January 2008

In vivo modulation of nitric oxide concentration dynamics upon glutamatergic neuronal activation in the hippocampus

scientific article

In vivo real-time measurement of nitric oxide in anesthetized rat brain.

scientific article published on January 2008

Inhibition of human LDL lipid peroxidation by phenol-rich beverages and their impact on plasma total antioxidant capacity in humans

scientific article (publication date: November 2000)

Inhibition of metmyoglobin/H2o2-dependent low density lipoprotein lipid peroxidation by naturally occurring phenolic acids

scientific article published on 01 February 1996

Intestinal anti-inflammatory activity of red wine extract: unveiling the mechanisms in colonic epithelial cells

scientific article published on 11 December 2012

Intragastric nitration by dietary nitrite: Implications for modulation of protein and lipid signaling

scientific article published on 20 November 2011

Kinetics and thermodynamics of lipid amphiphile exchange between lipoproteins and albumin in serum.

scientific article published on October 2004

LDL isolated from plasma-loaded red wine procyanidins resist lipid oxidation and tocopherol depletion

scientific article published on 3 May 2008

Lipid peroxidation and its inhibition in low density lipoproteins: Quenching of cis-parinaric acid fluorescence

scientific article published on 01 August 1992

Luteolin suppresses the JAK/STAT pathway in a cellular model of intestinal inflammation

scientific article published on 9 January 2017

Modulation of cellular respiration by endogenously produced nitric oxide in rat hippocampal slices

scientific article published in January 2012

NO-mediated apoptosis in yeast.

scientific article

Neurovascular and neurometabolic derailment in aging and Alzheimer's disease

scientific article published on 27 May 2015

Neurovascular coupling in hippocampus is mediated via diffusion by neuronal-derived nitric oxide

scientific article published on 2 June 2014

Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling

scientific article published in February 2017

Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration.

scientific article

Nitric oxide and DOPAC-induced cell death: from GSH depletion to mitochondrial energy crisis

article by Carla Nunes et al published September 2011 in Molecular and Cellular Neuroscience

Nitric oxide inactivation mechanisms in the brain: role in bioenergetics and neurodegeneration.

scientific article published on 10 June 2012

Nitric oxide monitoring in hippocampal brain slices using electrochemical methods.

scientific article published in January 2002

Nitric oxide signaling is disrupted in the yeast model for Batten disease

scientific article published on 2 May 2007

Nutrition and ageing: from phenomenological observations to molecular mechanisms

scientific article

Oxidation of DOPAC by nitric oxide: effect of superoxide dismutase

scientific article

Pepsin is nitrated in the rat stomach, acquiring antiulcerogenic activity: A novel interaction between dietary nitrate and gut proteins

scientific article published on 28 December 2012

Photoactivation of phthalocyanine-loaded low density lipoproteins induces a local oxidative stress that propagates to human erythrocytes: protection by caffeic acid

scientific article

Reactivity of dietary phenolic acids with peroxyl radicals: Antioxidant activity upon low density lipoprotein peroxidation

scientific article published on 01 August 1994

Real Time In Vivo Measurement of Ascorbate in the Brain Using Carbon Nanotube-Modified Microelectrodes

Red wine extract preserves tight junctions in intestinal epithelial cells under inflammatory conditions: implications for intestinal inflammation

scientific article published on 01 March 2019

Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation opposite modulation of JAK/STAT and Nrf2 pathways

scientific article published on 05 October 2015

Red wine-dependent reduction of nitrite to nitric oxide in the stomach

scientific article published on 13 June 2007

Redox cycles of caffeic acid with alpha-tocopherol and ascorbate

scientific article published in January 2001

Reduction of ferrylmyoglobin by dietary phenolic acid derivatives of cinnamic acid

scientific article published in September 1995

Role of nitrite, urate and pepsin in the gastroprotective effects of saliva

scientific article published on 8 April 2016

Scavenging of nitric oxide by an antagonist of adenosine receptors.

scientific article

Self-mixing microprobe for monitoring microvascular perfusion in rat brain

scientific article

Simultaneous measurement of cholinergic tone and neuronal network dynamics in vivo in the rat brain using a novel choline oxidase based electrochemical biosensor

scientific article published on 7 February 2015

Simultaneous measurements of ascorbate and glutamate in vivo in the rat brain using carbon fiber nanocomposite sensors and microbiosensor arrays.

scientific article published on 31 January 2018

Simultaneous production of superoxide radical and singlet oxygen by sulphonated chloroaluminum phthalocyanine incorporated in human low-density lipoproteins: implications for photodynamic therapy

scientific article published in September 2004

Stimulation of NMDA and AMPA glutamate receptors elicits distinct concentration dynamics of nitric oxide in rat hippocampal slices

scientific article

Synergistic inhibition of respiration in brain mitochondria by nitric oxide and dihydroxyphenylacetic acid (DOPAC). Implications for Parkinson's disease

scientific article published in August 2005

The Peculiar Facets of Nitric Oxide as a Cellular Messenger: From Disease-Associated Signaling to the Regulation of Brain Bioenergetics and Neurovascular Coupling

scientific article published on 19 March 2020

The pattern of glutamate-induced nitric oxide dynamics in vivo and its correlation with nNOS expression in rat hippocampus, cerebral cortex and striatum

article

The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions

scientific article published on 26 April 2008

The redox interplay between nitrite and nitric oxide: From the gut to the brain

scientific article

Tuning constitutive and pathological inflammation in the gut via the interaction of dietary nitrate and polyphenols with host microbiome.

scientific article published on 28 October 2016

Two Related Phenolic Antioxidants with Opposite Effects on Vitamin E Content in Low Density Lipoproteins Oxidized by Ferrylmyoglobin: Consumption vs Regeneration

scientific article published on 01 November 1995

List of works by João Laranjinha

3,4-Dihydroxyphenylacetic acid (DOPAC) modulates the toxicity induced by nitric oxide in PC-12 cells via mitochondrial dysfunctioning.

A comparative study of carbon fiber-based microelectrodes for the measurement of nitric oxide in brain tissue

A shortcut to wide-ranging biological actions of dietary polyphenols: modulation of the nitrate-nitrite-nitric oxide pathway in the gut.

Age-associated changes of nitric oxide concentration dynamics in the central nervous system of Fisher 344 rats

Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation

Antioxidant protection of low density lipoprotein by procyanidins: structure/activity relationships

Biomimetic sensor based on hemin/carbon nanotubes/chitosan modified microelectrode for nitric oxide measurement in the brain.

Brain nitric oxide inactivation is governed by the vasculature.

Cholesteryl ester hydroperoxide formation in myoglobin-catalyzed low density lipoprotein oxidation: concerted antioxidant activity of caffeic and p-coumaric acids with ascorbate.

Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor

Coupling of ascorbate and nitric oxide dynamics in vivo in the rat hippocampus upon glutamatergic neuronal stimulation: a novel functional interplay

Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress.

Dietary Nitrite in Nitric Oxide Biology: A Redox Interplay with Implications for Pathophysiology and Therapeutics ⬇️

Dietary flavonoids with a catechol structure increase alpha-tocopherol in rats and protect the vitamin from oxidation in vitro

Dietary nitrite induces nitrosation of the gastric mucosa: the protective action of the mucus and the modulatory effect of red wine.

Dietary nitrite induces occludin nitration in the stomach

Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation.

Diffusion of nitric oxide through the gastric wall upon reduction of nitrite by red wine: physiological impact

Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LDL oxidation in vitro.

Dynamic and interacting profiles of *NO and O2 in rat hippocampal slices.

Effect of dietary phenolic compounds on apoptosis of human cultured endothelial cells induced by oxidized LDL

Electrochemical measurement of endogenously produced nitric oxide in brain slices using Nafion/o-phenylenediamine modified carbon fiber microelectrodes

Ethyl nitrite is produced in the human stomach from dietary nitrate and ethanol, releasing nitric oxide at physiological pH: potential impact on gastric motility

Evidence for a pathway that facilitates nitric oxide diffusion in the brain

Glutamate induces release of glutathione from cultured rat astrocytes--a possible neuroprotective mechanism?

In vivo modulation of nitric oxide concentration dynamics upon glutamatergic neuronal activation in the hippocampus

In vivo real-time measurement of nitric oxide in anesthetized rat brain.

Inhibition of human LDL lipid peroxidation by phenol-rich beverages and their impact on plasma total antioxidant capacity in humans

Inhibition of metmyoglobin/H2o2-dependent low density lipoprotein lipid peroxidation by naturally occurring phenolic acids

Intestinal anti-inflammatory activity of red wine extract: unveiling the mechanisms in colonic epithelial cells

Intragastric nitration by dietary nitrite: Implications for modulation of protein and lipid signaling

Kinetics and thermodynamics of lipid amphiphile exchange between lipoproteins and albumin in serum.

LDL isolated from plasma-loaded red wine procyanidins resist lipid oxidation and tocopherol depletion

Lipid peroxidation and its inhibition in low density lipoproteins: Quenching of cis-parinaric acid fluorescence

Luteolin suppresses the JAK/STAT pathway in a cellular model of intestinal inflammation

Modulation of cellular respiration by endogenously produced nitric oxide in rat hippocampal slices

NO-mediated apoptosis in yeast.

Neurovascular and neurometabolic derailment in aging and Alzheimer's disease

Neurovascular coupling in hippocampus is mediated via diffusion by neuronal-derived nitric oxide

Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling

Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration.

Nitric oxide and DOPAC-induced cell death: from GSH depletion to mitochondrial energy crisis

Nitric oxide inactivation mechanisms in the brain: role in bioenergetics and neurodegeneration.

Nitric oxide monitoring in hippocampal brain slices using electrochemical methods.

Nitric oxide signaling is disrupted in the yeast model for Batten disease

Nutrition and ageing: from phenomenological observations to molecular mechanisms

Oxidation of DOPAC by nitric oxide: effect of superoxide dismutase

Pepsin is nitrated in the rat stomach, acquiring antiulcerogenic activity: A novel interaction between dietary nitrate and gut proteins

Photoactivation of phthalocyanine-loaded low density lipoproteins induces a local oxidative stress that propagates to human erythrocytes: protection by caffeic acid

Reactivity of dietary phenolic acids with peroxyl radicals: Antioxidant activity upon low density lipoprotein peroxidation

Real Time In Vivo Measurement of Ascorbate in the Brain Using Carbon Nanotube-Modified Microelectrodes

Red wine extract preserves tight junctions in intestinal epithelial cells under inflammatory conditions: implications for intestinal inflammation

Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation opposite modulation of JAK/STAT and Nrf2 pathways

Red wine-dependent reduction of nitrite to nitric oxide in the stomach

Redox cycles of caffeic acid with alpha-tocopherol and ascorbate

Reduction of ferrylmyoglobin by dietary phenolic acid derivatives of cinnamic acid

Role of nitrite, urate and pepsin in the gastroprotective effects of saliva

Scavenging of nitric oxide by an antagonist of adenosine receptors.

Self-mixing microprobe for monitoring microvascular perfusion in rat brain

Simultaneous measurement of cholinergic tone and neuronal network dynamics in vivo in the rat brain using a novel choline oxidase based electrochemical biosensor

Simultaneous measurements of ascorbate and glutamate in vivo in the rat brain using carbon fiber nanocomposite sensors and microbiosensor arrays.

Simultaneous production of superoxide radical and singlet oxygen by sulphonated chloroaluminum phthalocyanine incorporated in human low-density lipoproteins: implications for photodynamic therapy

Stimulation of NMDA and AMPA glutamate receptors elicits distinct concentration dynamics of nitric oxide in rat hippocampal slices

Synergistic inhibition of respiration in brain mitochondria by nitric oxide and dihydroxyphenylacetic acid (DOPAC). Implications for Parkinson's disease

The Peculiar Facets of Nitric Oxide as a Cellular Messenger: From Disease-Associated Signaling to the Regulation of Brain Bioenergetics and Neurovascular Coupling

The pattern of glutamate-induced nitric oxide dynamics in vivo and its correlation with nNOS expression in rat hippocampus, cerebral cortex and striatum

The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions

The redox interplay between nitrite and nitric oxide: From the gut to the brain

Tuning constitutive and pathological inflammation in the gut via the interaction of dietary nitrate and polyphenols with host microbiome.

Two Related Phenolic Antioxidants with Opposite Effects on Vitamin E Content in Low Density Lipoproteins Oxidized by Ferrylmyoglobin: Consumption vs Regeneration