List of works by Fernando Albericio

"Head-to-side-chain" cyclodepsipeptides of marine origin.

scientific article published on 21 May 2013

"High-load" polyethylene glycol-polystyrene (PEG-PS) graft supports for solid-phase synthesis

scientific article published on 01 January 1998

-2-(2,4-dinitrophenyl)ethyloxycarbonyl-amino acids, new base labile protected derivatives suitable for solid-phase peptide synthesis

1,2-Dimethylindole-3-sulfonyl (MIS) as protecting group for the side chain of arginine.

scientific article

1,3,5-Triazino-Peptide Derivatives: Synthesis, Characterization and Preliminary Antileishmanial Activity

scientific article published in February 2018

1-Hydroxy-6,7-dimethoxy-8-nitro-1,2,3,4-tetrahydroisoquinoline

2-(Dibenzylamino)butane-1,4-dithiol (DABDT), a Friendly Disulfide-Reducing Reagent Compatible with a Broad Range of Solvents

scientific article published on 27 November 2019

2-Mercaptopyridine-1-oxide-based peptide coupling reagents

2-Methoxy-4-methylsulfinylbenzyl: a backbone amide safety-catch protecting group for the synthesis and purification of difficult peptide sequences

scientific article published on 3 October 2014

2017 FDA Peptide Harvest

scientific article published on 07 May 2018

2018 FDA Tides Harvest

scientific article published on 05 April 2019

2019 FDA TIDES (Peptides and Oligonucleotides) Harvest

scientific article published on 05 March 2020

4-(4,6-Di[2,2,2-trifluoroethoxy]-1,3,5-triazin-2-yl)-4-methylomorpholinium Tetrafluoroborate. Triazine-Based Coupling Reagents Designed for Coupling Sterically Hindered Substrates

6-(Bromomaleimido)hexanoic acid as a connector for the construction of multiple branched peptide platforms.

scientific article

A COMPARATIVE STUDY OF SUPPORTS FOR THE SYNTHESIS OF OLIGONUCLEOTIDES WITHOUT USING AMMONIA

A New 6H-Pyran-3-one Scaffold Derived from a C-Glycoside (SUPPORTING INFORMATION)

A New Class of Foldamers Based oncis-γ-Amino-l-proline [J. Am. Chem. Soc.2004,126, 6048−6057]

scientific article published in 2005

A Nonacid Degradable Linker for Solid-Phase Synthesis

scientific article published on 15 September 2007

A Straightforward Synthesis of 5‘-Peptide Oligonucleotide Conjugates UsingNα-Fmoc-Protected Amino Acids

scientific article published on 01 September 2005

A comparative evaluation of biological activities and bioactive compounds of the seagrasses Zostera marina and Zostera noltei from southern Portugal

scientific article published on 20 July 2015

A comparative study of different presentation strategies for an HIV peptide immunogen.

scientific article

A convenient microwave-enhanced solid-phase synthesis of short chainN-methyl-rich peptides

scientific article published on 01 March 2010

A hybrid indoloquinolizidine peptide as allosteric modulator of dopamine D1 receptors

scientific article

A modified backbone amide linker (BAL) solid-phase peptide synthesis strategy accommodating prolyl, N-alkylamino acyl, or histidyl derivatives at the C-terminus

article

A natural peptide and its variants derived from the processing of infectious pancreatic necrosis virus (IPNV) displaying enhanced antimicrobial activity: a novel alternative for the control of bacterial diseases.

scientific article published on 2 February 2011

A new approach to Hmb-backbone protection of peptides: Synthesis and reactivity of Nα-Fmoc-Nα-(Hmb)amino acids

A new approach to the solid-phase peptide synthesis of peptide alkyl-amides and esters

A new class of foldamers based on cis-gamma-amino-L-proline

scientific article

A new flourene-derived anchor for solid-phase synthesis of protected peptides

A new quinoxaline-containing peptide induces apoptosis in cancer cells by autophagy modulation

scientific article published on 20 May 2015

A new strategy for solid-phase depsipeptide synthesis using recoverable building blocks.

scientific article

A novel dipeptidomimetic containing a cyclic threonine

scientific article published on 13 January 2010

A novel phospholipase A2 (D49) from the venom of the Crotalus oreganus abyssus (North American Grand canyon rattlesnake).

scientific article

A novel protecting/activating strategy for beta-hydroxy acids and its use in convergent peptide synthesis

scientific article

A novel, convenient, three-dimensional orthogonal strategy for solid-phase synthesis of cyclic peptides

A simple protocol for combinatorial cyclic depsipeptide libraries sequencing by matrix-assisted laser desorption/ionisation mass spectrometry.

scientific article

A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D(1) and D(2) dopamine receptors.

scientific article published on 28 April 2015

A synthetic procedure for the preparation of oligonucleotides without using ammonia and its application for the synthesis of oligonucleotides containing 0-4-alkyl thymidines

A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins

scientific article (publication date: 15 September 2014)

A universal strategy for preparing protected C-terminal peptides on the solid phase through an intramolecular click chemistry-based handle.

scientific article

A useful and sensitive color test to monitor aldehydes on solid-phase

article by Jesús Vázquez & Fernando Albericio published September 2001 in Tetrahedron Letters

AN IMPROVED SYNTHESIS OF N-[(9-HYDROXYMETHYL)-2-FLUORENYL]SUCCINAMIC ACID (HMFS), A VERSATILE HANDLE FOR THE SOLID-PHASE SYNTHESIS OF BIOMOLECULES

article by Fernando Albericio et al published January 2001 in Synthetic Communications

Abbreviated nomenclature for cyclic and branched homo- and hetero-detic peptides.

scientific article published in June 2005

Acetic Acid Mediated for One-Pot Synthesis of Novel Pyrazolyl -Triazine Derivatives for the Targeted Therapy of Triple-Negative Breast Tumor Cells (MDA-MB-231) EGFR/PI3K/AKT/mTOR Signaling Cascades

Acid-Labile Cys-Protecting Groups for the Fmoc/tBu Strategy: Filling the Gap

scientific article published on 17 October 2012

Acid-base properties of 4-nitro-l-histidine and related compounds

Acridine and quindoline oligomers linked through a 4-aminoproline backbone prefer G-quadruplex structures

scientific article published on 05 May 2011

Active carbonate resins for solid-phase synthesis through the anchoring of a hydroxyl function. Synthesis of cyclic and alcohol peptides

Active carbonate resins: Application to the solid-phase synthesis of alcohol, carbamate and cyclic peptides

Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers

scientific article published in September 2009

Advances in solid-phase cycloadditions for heterocyclic synthesis.

scientific article published on 12 May 2007

Advances in solid-phase peptide synthesis in aqueous media (ASPPS)

scientific article published in 2022

Advantageous applications of azabenzotriazole (triazolopyridine)-based coupling reagents to solid-phase peptide synthesis

article published in 1994

Affinity chromatography based on a combinatorial strategy for rerythropoietin purification.

scientific article

Alkylation of histidine residues of Bothrops jararacussu venom proteins and isolated phospholipases A2: a biotechnological tool to improve the production of antibodies

scientific article

Amide-to-ester substitution allows fine-tuning of the cyclopeptide conformational ensemble.

scientific article published on April 2010

Amide-to-ester substitution in coiled coils: the effect of removing hydrogen bonds on protein structure.

scientific article

Amphiphilic cationic carbosilane-PEG dendrimers: synthesis and applications in gene therapy.

scientific article

An Androsterone-H<sub>2</sub> @C<sub>60</sub> hybrid: Synthesis, Properties and Molecular Docking Simulations with SARS-Cov-2

scientific article published on 04 February 2021

An Easy Entry to a New High-Symmetry, Large Molecular Framework for Molecular Recognition Studies and de Novo Protein Design. Solvent Modulation of the Spontaneous Formation of a Cyclic Monomer, Dimer, or Trimer from a Bis-cysteine Peptide

article by Miriam Royo et al published July 1998 in Journal of the American Chemical Society

An HPLC-ESMS study on the solid-phase assembly ofC-terminal proline peptides

scientific article published on 01 March 1999

An efficient solid-phase strategy for the construction of chemokines

scientific article published on 01 October 2000

An efficient solid-phase strategy for total synthesis of naturally occurring amphiphilic marine siderophores: amphibactin-T and moanachelin ala-B.

scientific article

An immunochemical strategy based on peptidoglycan synthetic peptide epitopes to diagnose Staphylococcus aureus infections.

scientific article published on 8 August 2015

Animal toxins and their advantages in biotechnology and pharmacology.

scientific article published on 22 May 2014

Antibiotic Resistance: From the Bench to Patients

scientific article published on 27 August 2019

Antibodies cross-reactive with the scorpion-toxin ii fromAndroctonus australis Hector elicited in mice by a synthetic peptide

scientific article published on 01 January 1993

Antimicrobial peptides from skin secretions of Hypsiboas pulchellus (Anura: Hylidae).

scientific article published on 9 April 2014

Antioxidant activity andin vitroinhibition of tumor cell growth by leaf extracts from the carob tree (Ceratonia siliqua)

Antioxidant and cytotoxic activities of carob tree fruit pulps are strongly influenced by gender and cultivar.

scientific article published on 3 June 2011

Application of Decafluorobiphenyl (DFBP) Moiety as a Linker in Bioconjugation.

scientific article published on 17 January 2018

Arenesulphonyltriazolides as condensing reagents in solid phasepeptide synthesis

Asymmetric Synthesis of α-Unsubstituted β-Hydroxy Acids

BAL resin for the preparation of secondary amines

BOP-OXy, BOP-OBt, and BOP-OAt: novel organophosphinic coupling reagents useful for solution and solid-phase peptide synthesis

scientific article published on 22 November 2013

Backbone Amide Linker (BAL) Strategy forNα-9-Fluorenylmethoxycarbonyl (Fmoc) Solid-Phase Synthesis of Unprotected Peptidep-Nitroanilides and Thioesters1

scientific article published on 01 November 1999

Bacteria hunt bacteria through an intriguing cyclic peptides

scientific article published on 10 December 2018

Bicyclic homodetic peptide libraries: comparison of synthetic strategies for their solid-phase synthesis

scientific article published in November 2003

Binding and toxicity of apamin. Characterization of the active site

article

Biocompatible, multifunctional, and well-defined OEG-based dendritic platforms for biomedical applications

scientific article published on 01 June 2013

Bioconjugation through Mesitylene Thiol Alkylation.

scientific article published on 13 February 2018

Botryococcus braunii and Nannochloropsis oculata extracts inhibit cholinesterases and protect human dopaminergic SH-SY5Y cells from H2O2-induced cytotoxicity

scholarly article by Luísa Custódio et al published 3 September 2014 in Journal of Applied Phycology

Bypassing Osmotic Shock Dilemma in a Polystyrene Resin Using the Green Solvent Cyclopentyl methyl Ether (CPME): A Morphological Perspective.

scientific article

COMU: a safer and more effective replacement for benzotriazole-based uronium coupling reagents

scientific article published in September 2009

COMU: a third generation of uronium-type coupling reagents

scientific article

COMU: scope and limitations of the latest innovation in peptide acyl transfer reagents.

scientific article published on 24 May 2013

Calculating Resin Functionalization in Solid-Phase Peptide Synthesis Using a Standardized Method based on Fmoc Determination

scientific article published on 28 October 2019

Cancer prognostics by direct detection of p53-antibodies on gold surfaces by impedance measurements.

scientific article published on 17 April 2012

Cell adhesion and focal contact formation on linear RGD molecular gradients: study of non-linear concentration dependence effects.

scientific article published on 19 August 2011

Cell-penetrating cis-gamma-amino-l-proline-derived peptides.

scientific article published in July 2005

Chapter 1 Lamellarins: Isolation, activity and synthesis

ChemMatrix(®) for complex peptides and combinatorial chemistry

scientific article published in December 2010

ChemMatrix, a poly(ethylene glycol)-based support for the solid-phase synthesis of complex peptides

scientific article

Chemical Modification of Microcin J25 Reveals New Insights on the Stereospecific Requirements for Antimicrobial Activity

scientific article published on 17 October 2019

Chemical Platforms for Peptide Vaccine Constructs

scientific article published on 27 April 2015

Chemical Protein Synthesis Using a Second-Generation N-Acylurea Linker for the Preparation of Peptide-Thioester Precursors.

scientific article published on 2 June 2015

Chemical Synthesis and Functional Analysis of VarvA Cyclotide.

scientific article

Chemical Synthesis of 19F-labeled HIV-1 Protease using Fmoc-Chemistry and ChemMatrix Resin

article

Chemical synthesis of a fully active transcriptional repressor protein.

scientific article

Chiral thiazoline and thiazole building blocks for the synthesis of peptide-derived natural products.

scientific article published on January 2014

Chloromethoxymethyl Polystyrene (CMM Resin), an Acid Labile Resin for Anchoring/Cleavage of N-Heterocycles and Oxygen Aromatic Compounds

Chlorotrityl Chloride (CTC) Resin as a Convenient Reusable Protecting Group

Combined solid phase and solution synthesis of a library of α,α-disubstituted-α-acylaminoketones

Conformationally restricted hydantoin-based peptidomimetics as inhibitors of caspase-3 with basic groups allowed at the S3 enzyme subsite.

scientific article

Conjugation of Kahalalide F with Gold Nanoparticles to Enhance inVitro Antitumoral Activity

Constella™(EU)-Linzess™(USA): the last milestone in the long journey of the peptide linaclotide and its implications for the future of peptide drugs.

scientific article published on March 2013

Continuous-flow solid-phase peptide synthesis using polystyrene resins

scientific article published on 01 June 1999

Controlling multivalency and multimodality: up to pentamodal dendritic platforms based on diethylenetriaminepentaacetic acid cores.

scientific article published on 14 February 2014

Convenient synthesis of a cyclic peptide disulfide: A type II β-turn structural model

article

Convergent Solid Phase Peptide Synthesis: An Efficient Approach to the Synthesis of Highly Repetitive Protein Domains

Convergent approaches for the synthesis of the antitumoral peptide, Kahalalide F. Study of orthogonal protecting groups

scientific article published in September 2006

Convergent solid phase peptide synthesis vi : synthesis by the fmoc procedure with a modified protocol of two protected segments, sequence 5-17 and 18-31 of the neurotoxin ii of the scorpion androctonus australis hector

Convergent solid phase peptide synthesis. II. Synthesis of the 1–6 apamin protected segment on a NBB-resin. Synthesis of apamin

Convergent solid phase peptide synthesis. VII. Good yields in the coupling of protected segments on a solid support

Convergent solid phase peptide synthesis. v. synthesis of the 1-4, 32-34, and 53-59 protected segments of the toxin ii of androctonus australis hector

Convergent solid-phase peptide synthesis

scientific article published on January 1997

Convergent solid-phase peptide synthesis

article

Convergent solid-phase peptide synthesis. X. Synthesis and purification of protected peptide fragments using the photolabile Nbb-resin

Convergent solid-phase peptide synthesis. XI. Synthesis and purification of protected peptide segments spanning the entire sequence of the uteroglobin monomer using the photolabile nbb-resin

Converting Teixobactin into a Cationic Antimicrobial Peptide (AMP).

scientific article published on 10 August 2017

Corrigendum to “Combined solid phase and solution synthesis of a library of α,α-disubstituted-α-acylaminoketones”

scholarly article published in Tetrahedron Letters

Coupling reagents and activation

scientific article published on January 1997

Covalent immobilization of hLf1-11 peptide on a titanium surface reduces bacterial adhesion and biofilm formation

scientific article published on 2 April 2014

Cu(OBt)2 and Cu(OAt)2, copper(II)-based racemization suppressors ready for use in fully automated solid-phase peptide synthesis

scientific article published on 01 March 2001

Cysteine pseudoprolines for thiol protection and peptide macrocyclization enhancement in Fmoc-based solid-phase peptide synthesis.

scientific article published on 11 March 2014

Cysteine-S-trityl a key derivative to prepare N-methyl cysteines

scientific article published on 20 November 2007

Deprotection Reagents in Fmoc Solid Phase Peptide Synthesis: Moving Away from Piperidine?

scientific article published on 15 November 2016

Design and facile solid-phase synthesis of peptide-based LPS-inhibitors containing PEG-like functionalities.

scientific article

Design and synthesis of FAJANU: a de novo C(2) symmetric cyclopeptide family.

scientific article

Design and synthesis of indole-based peptoids as potent noncompetitive antagonists of transient receptor potential vanilloid 1.

scientific article published on 7 November 2007

Design of a minimized cyclic tetrapeptide that neutralizes bacterial endotoxins.

scientific article

Design, synthesis, and complexing properties of (1Cys-1'Cys,4Cys-4'Cys)-dithiobis(Ac-L-1Cys-L-Pro-D-Val-L-4Cys-NH2). The first example of a new family of ion-binding peptides

scientific article published in 1993

Design, synthesis, and conformational analysis of azacycloalkane amino acids as conformationally constrained probes for mimicry of peptide secondary structures

scientific article

Development of a Genetic Algorithm to Design and Identify Peptides that can Cross the Blood-Brain Barrier

article

Development of surface modified biodegradable polymeric nanoparticles to deliver GSE24.2 peptide to cells: a promising approach for the treatment of defective telomerase disorders.

scientific article

Developments in peptide and amide synthesis.

scientific article published on June 2004

Dissecting the structure of thiopeptides: assessment of thiazoline and tail moieties of baringolin and antibacterial activity optimization.

scientific article

Disulfide-Based Protecting Groups for the Cysteine Side Chain

scientific article published on 24 November 2020

Does the Solid-Phase Synthesis of a Tetrapeptide Represent a Challenge at the Onset of the XXI Century? The Case of Cyclo [(3R)-3-hydroxydecanoyl-l-seryl-(3R)-3-hydroxydecanoyl-l-seryl]

Domino Reactions with Fluorinated Five-membered Heterocycles – Syntheses of Trifluoromethyl Substituted Butenolides and γ-Ketoacids

Domino reactions with fluorinated five-membered heterocycles. α-Trifluoromethyl α-amino acids with unsaturated side-chains

scientific article published on 22 May 2006

Drug discovery: a multifactorial ecosystem

scientific article published on 11 July 2022

EDOTn and MIM, new peptide backbone protecting groups.

scientific article published in January 2008

Eco-friendly combination of the immobilized PGA enzyme and the S-Phacm protecting group for the synthesis of Cys-containing peptides

scientific article published on 18 October 2012

Eco-friendly methodology to prepare N-heterocycles related to dihydropyridines: microwave-assisted synthesis of alkyl 4-arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate and 4-arylsubstituted-4,7-dihydrofuro[3,4-b]pyridine

scientific article published on 21 November 2011

Editorial

Editorial: Current perspectives in peptide chemistry. II. Supports

scientific article published on 01 January 2000

Effects of L- and D-REKR amino acid-containing peptides on HIV and SIV envelope glycoprotein precursor maturation and HIV and SIV replication

scientific article published on September 2002

Efficient γ-amino-proline-derived cell penetrating peptide–superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents

scientific article published on 20 April 2012

Electrostatic binding and hydrophobic collapse of peptide-nucleic acid aggregates quantified using force spectroscopy ⬇️

scientific article

Engineering Advanced Capsosomes: Maximizing the Number of Subcompartments, Cargo Retention, and Temperature-Triggered Reaction

Enhanced microwave-assisted method for on-bead disulfide bond formation: Synthesis of α-conotoxin MII

scientific article published in 2009

Enhancing Atom Economy of SPS: Recoverable and Reusable Building Blocks for Depsipeptide Synthesis

Enhancing immunogenicity and cross-reactivity of HIV-1 antigens by in vivo targeting to dendritic cells

scientific article published on October 2012

Enzymatic peptide fragment condensation. Choice of reaction media for the synthesis of an insect neuropeptide derivative

article by N. Xaus et al published January 1992 in Biotechnology Letters

Enzyme-labile protecting groups for the synthesis of natural products: solid-phase synthesis of thiocoraline.

scientific article published on 25 April 2013

Evaluation of solution and solid-phase approaches to the synthesis of libraries of alpha,alpha-disubstituted-alpha-acylaminoketones

scientific article

Evolutionary combinatorial chemistry, a novel tool for SAR studies on peptide transport across the blood-brain barrier. Part 2. Design, synthesis and evaluation of a first generation of peptides

scientific article

Exploiting the Thiobarbituric Acid Scaffold for Antibacterial Activity

scholarly article by Anamika Sharma et al published 13 August 2018 in ChemMedChem

Exploring solid-phase approaches for the preparation of new beta-lactams from amino acids.

scientific article published in January 2003

Extracts from Quercus sp. acorns exhibit in vitro neuroprotective features through inhibition of cholinesterase and protection of the human dopaminergic cell line SH-SY5Y from hydrogen peroxide-induced cytotoxicity

scholarly article by Luísa Custódio et al published February 2013 in Industrial Crops and Products

Facile and Mild Synthesis of Linear and Cyclic Peptides via Thioesters

scientific article published on 17 July 2014

Fatty acid composition and biological activities of Isochrysis galbana T-ISO, Tetraselmis sp. and Scenedesmus sp.: possible application in the pharmaceutical and functional food industries

article

Fatty acid profile of different species of algae of the Cystoseira genus: a nutraceutical perspective

scientific article published on 2 January 2015

Fmoc Solid-Phase Synthesis of Peptide Thioesters by Masking as Trithioortho Esters

scientific article published on 01 August 2003

Fmoc-2-mercaptobenzothiazole, for the introduction of the Fmoc moiety free of side-reactions.

scientific article published in January 2007

Formation of Nα-terminal 2-dialkyl amino oxazoles from guanidinated derivatives under mild conditions

scientific article published on 01 August 2018

Formylation of electron-rich aromatic rings mediated by dichloromethyl methyl ether and TiCl4: scope and limitations.

scientific article published on 26 March 2015

Four-dimensional orthogonal solid-phase synthesis of new scaffolds based on cyclic tetra-β-peptides

Friendly strategy to prepare encoded one bead-one compound cyclic peptide library.

scientific article

From Production of Peptides in Milligram Amounts for Research to Multi-Tons Quantities for Drugs of the Future

scientific article

From Ugi Multicomponent Reaction to Linkers for Bioconjugation

scientific article published on 23 March 2020

From the one-bead-one-compound concept to one-bead-one-reactor.

scientific article published on 31 March 2007

Gated Mesoporous Silica Nanoparticles Using a Double-Role Circular Peptide for the Controlled and Target-Preferential Release of Doxorubicin in CXCR4-Expresing Lymphoma Cells

Gold nanoparticles for photothermally controlled drug release

scientific article

Handles for Fmoc solid-phase synthesis of protected peptides.

scientific article published on 26 April 2013

Hantzsch dihydropyridines: Privileged structures for the formation of well-defined gold nanostars

scientific article published on May 2015

Hexafluoroacetone as protecting and activating reagent: new routes to amino, hydroxy, and mercapto acids and their application for peptide and glyco- and depsipeptide modification.

scientific article published on November 2006

Hydroxylamine Derivatives as a New Paradigm in the Search of Antibacterial Agents

scientific article published on 11 December 2018

Hypersensitive acid-labile (HAL) tris(alkoxy)benzyl ester anchoring for solid-phase synthesis of protected peptide segments

IB-01212, a new cytotoxic cyclodepsipeptide isolated from the marine fungus Clonostachys sp. ESNA-A009.

scientific article

Identification of New Ocellatin Antimicrobial Peptides by cDNA Precursor Cloning in the Frame of This Family of Intriguing Peptides

scientific article published on 29 October 2020

Identification of Peptides in Flowers of Sambucus nigra with Antimicrobial Activity against Aquaculture Pathogens.

scientific article published on 27 April 2018

Identification of protein-binding peptides by direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry analysis of peptide beads selected from the screening of one bead-one peptide combinatorial libraries.

scientific article

Imidazole-1-sulfonyl Azide-Based Diazo-Transfer Reaction for the Preparation of Azido Solid Supports for Solid-Phase Synthesis

scientific article published on 06 June 2013

Immobilized N-chlorosuccinimide as a friendly peptide disulfide-forming reagent

scientific article

Immobilized coupling reagents: synthesis of amides/peptides.

scientific article

Improved antimicrobial activity of h-lysozyme (107-115) by rational Ala substitution

scientific article published in August 2010

Improved pharmacokinetic profile of lipophilic anti-cancer drugs using ανβ3-targeted polyurethane-polyurea nanoparticles

scientific article published on 7 November 2017

Improving the brain delivery of gold nanoparticles by conjugation with an amphipathic peptide

In vitro antioxidant and inhibitory activity of water decoctions of carob tree (Ceratonia siliqua L.) on cholinesterases, α-amylase and α-glucosidase

scientific article published on 13 January 2015

Indoloquinolizidine-peptide hybrids as multiple agonists for D1 and D2 dopamine receptors.

scientific article published in September 2009

Inhibition of HIV-2(ROD) replication in a lymphoblastoid cell line by the alpha1-antitrypsin Portland variant (alpha1-PDX) and the decRVKRcmk peptide: comparison with HIV-1(LAI).

scientific article

Inhibition of VAP1: Quickly Gaining Ground as an Anti-Inflammatory Therapy

scientific article published on 01 February 2007

Inhibition of beta-amyloid toxicity by short peptides containing N-methyl amino acids.

scientific article published in March 2004

Inhibitory effect of short cationic homopeptides against gram-positive bacteria

scientific article published on 31 October 2013

Injectable Hyaluronan Hydrogels with Peptide-Binding Dendrimers Modulate the Controlled Release of BMP-2 and TGF-β1

scientific article published on 05 May 2015

Installing multifunctionality on titanium with RGD-decorated polyurethane-polyurea roxithromycin loaded nanoparticles: toward new osseointegrative therapies

scientific article published on 14 August 2015

Introducing an Asp-Pro linker in the synthesis of random one-bead-one-compound hexapeptide libraries compatible with ESI-MS analysis

scientific article

Investigating Triorthogonal Chemoselectivity. Effect of Azide Substitution on the Triazine Core

scientific article published on 18 September 2019

Investigating green ethers for the precipitation of peptides after global deprotection in solid-phase peptide synthesis

scholarly article published June 2018

Investigation of the N-Terminus Amino Function of Arg10-Teixobactin

scientific article

Isolation and biochemical characterization of a new thrombin-like serine protease from Bothrops pirajai snake venom

scientific article published on 26 February 2014

Isolation, structural assignment, and total synthesis of barmumycin. ⬇️

scientific article published on 23 November 2010

Kahalalide B. Synthesis of a natural cyclodepsipeptide

Kahalalide F, an antitumor depsipeptide in clinical trials, and its analogues as effective antileishmanial agents

scientific article published in May 2009

Lamellarin D bioconjugates I: Synthesis and cellular internalization of PEG-derivatives.

scientific article

Large-Area Biomolecule Nanopatterns on Diblock Copolymer Surfaces for Cell Adhesion Studies.

scientific article

Leishmania mexicana: LACK (Leishmania homolog of receptors for activated C-kinase) is a plasminogen binding protein.

scientific article

Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides

scientific article published on 11 November 2018

Linear versus branched poly-lysine/arginine as polarity enhancer tags

scientific article published on 01 October 2014

Liposomes containing NY‑ESO‑1/tetanus toxoid and adjuvant peptides targeted to human dendritic cells via the Fc receptor for cancer vaccines

scientific article published in April 2014

Lysine Scanning of Arg-Teixobactin: Deciphering the Role of Hydrophobic and Hydrophilic Residues

scientific article published on 19 December 2016

Manufacturing peptides as active pharmaceutical ingredients.

scientific article published on May 2009

Methods, setup and safe handling for anhydrous hydrogen fluoride cleavage in Boc solid-phase peptide synthesis

scientific article

Microalgae of different phyla display antioxidant, metal chelating and acetylcholinesterase inhibitory activities

Microreactors for peptide synthesis: looking through the eyes of twenty first century !!!

scientific article published on 25 June 2014

Microwave assisted SPPS of amylin and its toxicity of the pure product to RIN-5F cells

scientific article

Modular total synthesis of lamellarin D.

scientific article published in September 2005

Molecular cloning of cDNAs encoding a putative cell wall protein from Zea mays and immunological identification of related polypeptides

scientific article

Monoclonal antibody purification by affinity chromatography with ligands derived from the screening of peptide combinatory libraries

scientific article published in September 2003

Morpholine-based immonium and halogenoamidinium salts as coupling reagents in Peptide synthesis1.

scientific article

Morphological characterization of fullerene-androsterone conjugates.

scientific article

Multicomponent reactions with dihydroazines: efficient synthesis of a diverse set of pyrido-fused tetrahydroquinolines.

scientific article

Multifaceted roles of disulfide bonds. Peptides as therapeutics.

scientific article published on 29 October 2013

Multifunctionalized gold nanoparticles with peptides targeted to gastrin-releasing peptide receptor of a tumor cell line

scientific article

Multivalent dendrimers presenting spatially controlled clusters of binding epitopes in thermoresponsive hyaluronan hydrogels

scientific article published on 30 June 2014

N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate (TCFH), a powerful coupling reagent for bioconjugation

scientific article published on 20 September 2008

N-Chlorosuccinimide, an efficient reagent for on-resin disulfide formation in solid-phase peptide synthesis.

scientific article published on 15 January 2013

N-Triethylene glycol (N-TEG) as a surrogate for the N-methyl group: application to Sansalvamide A peptide analogs

scientific article published on July 2013

N-methylation in amino acids and peptides: Scope and limitations.

scientific article published on 12 March 2018

NPE-resin, a new approach to the solid-phase synthesis of protected peptides and oligonucleotides I : Synthesis of the supports and their application to oligonucleotide synthesis

NPE-resin, a new approach to the solid-phase synthesis of protected peptides and oligonucleotides II. Synthesis of protected peptides

Naturally Occurring Oxazole-Containing Peptides

scientific article published on 10 April 2020

Neurotoxicity of prion peptides mimicking the central domain of the cellular prion protein

scientific article (publication date: 2013)

New Nomenclature for Complex Cyclopeptides

New carbamate supports for the preparation of 3′-amino-modified oligonucleotides

scientific article published on 01 October 1996

New developments in the synthesis of oligonucleotide-peptide conjugates.

scientific article published in January 2007

New efficient substrates for semicarbazide-sensitive amine oxidase/VAP-1 enzyme: analysis by SARs and computational docking

scientific article

New peptide architectures through C-H activation stapling between tryptophan-phenylalanine/tyrosine residues

scientific article published on 21 May 2015

Novel 4,6-Disubstituted s-Triazin-2-yl Amino Acid Derivatives as Promising Antifungal Agents

scientific article published on 21 October 2020

Novel ergopeptides as dual ligands for adenosine and dopamine receptors

scientific article

Novel peptide-based platform for the dual presentation of biologically active peptide motifs on biomaterials.

scientific article published on 15 April 2014

Novel proton acceptor immonium-type coupling reagents: application in solution and solid-phase peptide synthesis.

scientific article published on 28 September 2007

Nsc and Fmoc Nalpha-amino protection for solid-phase peptide synthesis: a parallel study.

scientific article

Occurrence and Minimization of Cysteine Racemization during Stepwise Solid-Phase Peptide Synthesis1,2

scientific article published on 01 June 1997

On the use of PyAOP, a phosphonium salt derived from HOAt, in solid-phase peptide synthesis

On the use of novel coupling reagents for solid-phase peptide synthesis

On the use of s-t-butylsulphenyl group for protection of cysteine in solid-phase peptide synthesis using fmoc-amino acids

One-Pot Peptide Ligation–Oxidative Cyclization Protocol for the Preparation of Short-/Medium-Size Disulfide Cyclopeptides

scientific article published on 28 June 2018

Optimized Fmoc solid-phase synthesis of Thymosin alpha1 by side-chain anchoring onto a PEG resin

scientific article published in January 2009

Optimized Microwave Assisted Synthesis of LL37, a Cathelicidin Human Antimicrobial Peptide

Optimized Stepwise Synthesis of the API Liraglutide Using BAL Resin and Pseudoprolines

scientific article published on 17 May 2019

Oral Insulin-Mimetic Compounds That Act Independently of Insulin

scientific article published on 01 February 2007

Orthogonal chemistry for the synthesis of thiocoraline-triostin hybrids. Exploring their structure-activity relationship.

scientific article published on 19 June 2013

Oxidative couplings on tryptophan-based diketopiperazines leading to fused and bridged chemotypes.

scientific article published on 16 February 2017

Oxime-based carbonates as useful reagents for both N-protection and peptide coupling.

scientific article published on 5 December 2012

Oxyma-B, an excellent racemization suppressor for peptide synthesis

scientific article published in November 2014

Oxyma: an efficient additive for peptide synthesis to replace the benzotriazole-based HOBt and HOAt with a lower risk of explosion.

scientific article published in September 2009

OxymaPure/DIC: An Efficient Reagent for the Synthesis of a Novel Series of 4-[2-(2-Acetylaminophenyl)-2-oxo-acetylamino] Benzoyl Amino Acid Ester Derivatives

scientific article

Partially Fluorinated Heterocycles from 4,4-Bis(trifluoromethyl)-hetero-1,3-dienes via C–F Bond Activation – Synthesis of 2-Fluoro-3-(trifluoromethyl)furans

Peptide Therapeutics 2.0.

scientific article published on 13 May 2020

Peptide affinity chromatography based on combinatorial strategies for protein purification.

scientific article

Peptide and amide bond-containing dendrimers

scientific article

Peptide dendrimers based on polyproline helices

scientific article

Peptide ligations using aryloxycarbonyl-o-methylaminoanilides: chemical synthesis of palmitoylated-Sonic Hedgehog

scientific article published on 08 November 2018

Peptide synthesis beyond DMF: THF and ACN as excellent and friendlier alternatives

scientific article published in February 2015

Peptides and metallic nanoparticles for biomedical applications

scientific article published on June 2007

Peptides conjugated to silver nanoparticles in biomedicine - a "value-added" phenomenon.

scientific article

Phakellistatins: An Underwater Unsolved Puzzle

scientific article

Phenolic composition, antioxidant potential and in vitro inhibitory activity of leaves and acorns of Quercus suber on key enzymes relevant for hyperglycemia and Alzheimer's disease

article

Phormidolides B and C, cytotoxic agents from the sea: enantioselective synthesis of the macrocyclic core.

scientific article

Phytochemical profile, antioxidant and cytotoxic activities of the carob tree (Ceratonia siliqua L.) germ flour extracts.

scientific article published in March 2011

Postsynthetic modification of peptides: chemoselective C-arylation of tryptophan residues

scientific article published in January 2010

Practical protocols for stepwise solid-phase synthesis of cysteine-containing peptides

scientific article published in November 2002

Preparation and Applications of Xanthenylamide (XAL) Handles for Solid-Phase Synthesis ofC-Terminal Peptide Amides under Particularly Mild Conditions1-3

scientific article published on 01 September 1996

Preparation and applications of polyethylene glycol-polystyrene graft resin supports for solid-phase peptide synthesis

Preparation of de novo globular proteins based on proline dendrimers

scientific article published in August 2005

Proline N-oxides: modulators of the 3D conformation of linear peptides through "NO-turns".

scientific article

Protection by conformationally restricted mobility: first solid-phase synthesis of triostin A.

scientific article

Pseudo-Wang Handle for the Preparation of Fully Protected Peptides. Synthesis of Liraglutide by Fragment Condensation

scientific article published on 14 March 2019

PyOxP and PyOxB: the Oxyma-based novel family of phosphonium salts

scientific article published on 17 June 2010

Péptidos que atraviesan la membrana celular como potenciales transportadores de fármacos

Qualitative colorimetric tests for solid phase synthesis.

scientific article

Quantitative monitoring of carboxyl groups in polymers

Racemization studies during solid-phase peptide synthesis using azabenzotriazole-based coupling reagents

Radical Dendrimers Based on Biocompatible Oligoethylene Glycol Dendrimers as Contrast Agents for MRI

scientific article published on 14 August 2020

Rapid and high-yielding cysteine labelling of peptides with N-succinimidyl 4-[18F]fluorobenzoate

Re-Evaluation of a Solid-Phase Hydantoin Synthesis

Re-evaluating the stability of COMU in different solvents

scientific article published on 6 July 2017

Re-evaluation of the N-terminal substitution and the D-residues of teixobactin

scholarly article in RSC Advances, vol. 6 no. 77, 2016

Rearrangement of Glu(OtBu)- and Asp(OtBu)-containing peptides upon fluoride treatment in solid-phase synthesis

Rescuing biological activity from synthetic phakellistatin 19.

scientific article published on 2 December 2013

Reversible protection of lysine to facilitate the purification of protected peptide segments

Revisiting NO2 as Protecting Group of Arginine in Solid-Phase Peptide Synthesis

scientific article published on 23 June 2020

Role of the Nozaki-Hiyama-Takai-Kishi Reaction in the Synthesis of Natural Products.

scientific article published on 19 June 2017

S-2-(2,4-dinitrophenyl)ethyl--cysteine: a new derivative for solid-phase peptide synthesis

S-Phenylacetamidomethyl (Phacm): an orthogonal cysteine protecting group for Boc and Fmoc solid-phase peptide synthesis strategies

Sample preparation for sequencing hits from one-bead-one-peptide combinatorial libraries by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

scientific article

Saturated resins or stress of the resin

Scope and Limitations of γ-Valerolactone (GVL) as a Green Solvent to be Used with Base for Fmoc Removal in Solid Phase Peptide Synthesis

scientific article published on 05 November 2019

Screening of N-alkyl-cyanoacetamido oximes as substitutes for N-hydroxysuccinimide

scientific article

Screening of one-bead-one-peptide combinatorial library using red fluorescent dyes. Presence of positive and false positive beads

scientific article

Selective formation of a Z-trisubstituted double bond using a 1-(tert-butyl)tetrazolyl sulfone

scientific article published on 14 October 2014

Semi-synthesis of acylated triterpenes from olive-oil industry wastes for the development of anticancer and anti-HIV agents

scientific article published on 8 January 2014

Semipermanent C-Terminal Carboxylic Acid Protecting Group: Application to Solubilizing Peptides and Fragment Condensation

scientific article published on 29 December 2014

Severe side-reaction in the acidolytic cleavage of a C-terminal Met-containing peptide from the solid support. Formation of the homoserine lactone peptide

Siamese depsipeptides: constrained bicyclic architectures.

scientific article published in January 2009

Simple machine-assisted protocol for solid-phase synthesis of depsipeptides

scientific article published in January 2007

Single-molecule kinetics and footprinting of DNA bis-intercalation: the paradigmatic case of Thiocoraline.

scientific article published on 17 February 2015

Smallest peptoids with antiproliferative activity on human neoplastic cells.

scientific article

Solid phase synthesis of sulfahydantoins

Solid phase synthesis of α-acylamino-α,α-disubstituted ketones

Solid-Phase Peptide Synthesis Using ChemMatrix®, a Polyethylenglycol (PEG)-based Solid

article

Solid-Phase Peptide Synthesis in Water Using Microwave-Assisted Heating

scientific article published in 2009

Solid-Phase Peptide Synthesis in the Reverse (N→C) Direction

scientific article published on 01 June 2000

Solid-Phase Synthesis and Structural Study of Substituted 1,4,5,6-Tetrahydro-6-oxopyridine-3-carboxylic Acids

Solid-Phase Synthesis of Glycopeptide Amides under Mild Conditions: Morphiceptin Analogues

scholarly article by Eduard Bardají et al published March 1990 in Angewandte Chemie International Edition

Solid-Phase Synthesis of Pyrrole Derivatives through a Multicomponent Reaction Involving Lys-Containing Peptides.

scientific article published on 14 February 2018

Solid-Phase Total Synthesis of the Pentacyclic System Lamellarins U and L†

scientific article published on 01 August 2003

Solid-phase N-glycopeptide synthesis using allyl side-chain protected Fmoc-amino acids

Solid-phase chemistry in the total synthesis of non-peptidic natural products.

scientific article

Solid-phase combinatorial synthesis of a lysyl-tRNA synthetase (LysRS) inhibitory library

scientific article

Solid-phase combinatorial synthesis of peptide-biphenyl hybrids as calpain inhibitors

scientific article

Solid-phase library synthesis of bi-functional derivatives of oleanolic and maslinic acids and their cytotoxicity on three cancer cell lines.

scientific article

Solid-phase peptide synthesis (SPPS), C-terminal vs. side-chain anchoring: a reality or a myth.

scientific article published on 26 April 2014

Solid-phase peptide synthesis using acetonitrile as a solvent in combination with PEG-based resins.

scientific article published in October 2009

Solid-phase syntheses of N-substituted carbamates. Reaction monitoring by gel-phase 13C NMR using a 13C enriched BAL-linker

Solid-phase syntheses of constrained RGD scaffolds and their binding to the αvβ3 integrin receptor

article by Miriam Royo et al published October 2001 in Tetrahedron Letters

Solid-phase syntheses of furopyridine and furoquinoline systems.

scientific article

Solid-phase synthesis and characterization of N-methyl-rich peptides.

scientific article

Solid-phase synthesis of 4-aminopiperidine analogues using the Alloc protecting group: an investigation of Alloc removal from secondary amines

Solid-phase synthesis of C-terminal modified peptides.

scientific article published on January 2003

Solid-phase synthesis of NMe-IB-01212, a highly N-methylated cyclic peptide.

scientific article

Solid-phase synthesis of chiral bicyclic guanidinium oligomers

scientific article published in May 2009

Solid-phase synthesis of diketopiperazines, useful scaffolds for combinatorial chemistry

Solid-phase synthesis of homodetic cyclic peptides from Fmoc-MeDbz-resin

Solid-phase synthesis of new Trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers.

scientific article published on 15 July 2010

Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones

scientific article published on 05 March 2008

Solid-phase synthesis of oxathiocoraline by a key intermolecular disulfide dimer.

scientific article published on 10 April 2007

Solid-phase synthesis of peptides using allylic anchoring groups 2. Palladium-catalysed cleavage of Fmoc-protected peptides

scholarly article by Paul Lloyd-Williams et al published June 1994 in Tetrahedron Letters

Solid-phase synthesis of peptides using allylic anchoring groups. An investigation of their palladium-catalysed cleavage

scholarly article by Paul Lloyd-Williams et al published August 1991 in Tetrahedron Letters

Solid-phase synthesis of second-generation polyproline dendrimers

scientific article published in January 2004

Solid-phase synthesis of sulfamate peptidomimetics.

scientific article published on 16 March 2007

Solid-phase synthesis of the cyclic lipononadepsipeptide [N-Mst(Ser1), d-Ser4, L-Thr6, L-Asp8, L-Thr9]syringotoxin.

scientific article published in March 2003

Solid-phase synthesis of “head-to-tail” cyclic peptides via lysine side-chain anchoring

Solid-phase synthesis: a linker for side-chain anchoring of arginine

Solid-phase total synthesis of trunkamide A(1).

scientific article published in November 2001

Solid-phase-mediated peptide heterodisulfide formation

scientific article published in 1990

Solution structure of the antitumor candidate trunkamide A by 2D NMR and restrained simulated annealing methods

scientific article published in January 2003

Solution- and solid-phase synthesis and anti-HIV activity of maslinic acid derivatives containing amino acids and peptides.

scientific article

Somuncurins: Bioactive Peptides from the Skin of the Endangered Endemic Patagonian Frog Pleurodema somuncurense

scientific article published on 05 March 2020

Stable conjugates of peptides with gold nanorods for biomedical applications with reduced effects on cell viability

scientific article published on 6 May 2013

Stapled Peptides by Late-Stage C(sp3 )-H Activation.

scientific article

Stellatolides, a new cyclodepsipeptide family from the sponge Ecionemia acervus: isolation, solid-phase total synthesis, and full structural assignment of stellatolide A.

scientific article

Stepwise solid-phase synthesis of oligonucleotide-peptide hybrids

Structural glance into a novel anti-staphylococcal peptide

scientific article published in January 2014

Structural studies of reagents for peptide bond formation: Crystal and molecular structures of HBTU and HATU

Structural, kinetic and cytotoxicity aspects of 12-28 beta-amyloid protein fragment: a reappraisal

Structure, bioactivity and synthesis of natural products with hexahydropyrrolo[2,3-b]indole.

scientific article published on 12 January 2011

Structure-Acid Lability Relationship of <i>N</i>-Alkylated α,α-Dialkylglycine Obtained via a Ugi Multicomponent Reaction

scientific article published on 02 January 2021

Structure-activity relationship of 1-desamino-8-D-arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor-expressing cancer cells

scientific article published on 11 April 2014

Structure-activity relationship of kahalalide F synthetic analogues

scientific article

Study of various presentation forms for a peptide mimetic of Neisseria meningitidis serogroup B capsular polysaccharide

scientific article

Sudemycin K: A Synthetic Antitumor Splicing Inhibitor Variant with Improved Activity and Versatile Chemistry.

scientific article published in December 2016

Sulfonamide-Linked Ciprofloxacin, Sulfadiazine and Amantadine Derivatives as a Novel Class of Inhibitors of Jack Bean Urease; Synthesis, Kinetic Mechanism and Molecular Docking.

scientific article

Surface-adhered composite poly(vinyl alcohol) physical hydrogels: polymersome-aided delivery of therapeutic small molecules.

scientific article published on 29 August 2012

Synthesis and Antimicrobial Activity of a New Series of Thiazolidine-2,4-diones Carboxamide and Amino Acid Derivatives

scientific article published on 27 December 2019

Synthesis and NMR structure of p41icf, a potent inhibitor of human cathepsin L

scientific article (publication date: 12 February 2003)

Synthesis and SAR of alpha-acylaminoketone ligands for control of gene expression

scientific article

Synthesis and Thermal Properties of Novel Polyamides Containing α-Amino Acid Moieties: Structure-Property Relationship

Synthesis and antifungal activity of an acivicine-based dipeptide library

Synthesis and antitumor activity of mechercharmycin A analogues

scientific article

Synthesis and applications of a new base-labile fluorene derived linker for solid-phase peptide synthesis

Synthesis and biological evaluation of a post-synthetically modified Trp-based diketopiperazine

Synthesis and in vivo evaluation of the biodistribution of a 18F-labeled conjugate gold-nanoparticle-peptide with potential biomedical application.

scientific article published on 23 February 2012

Synthesis and ion-binding properties of an immobilized bis-cysteine peptide

scientific article published in 1992

Synthesis and screening of a small library of proline-based biodendrimers for use as delivery agents

scientific article

Synthesis and structure determination of kahalalide F (1,2).

scientific article published in November 2001

Synthesis in vitro of a seven amino acid peptide encoded in the leader RNA of Rous sarcoma virus

scientific article published in July 1986

Synthesis of 2-(4,6-dimethoxy-1,3,5-triazin-2-yloxyimino) derivatives: application in solution peptide synthesis.

scientific article published on 20 December 2010

Synthesis of C-2 arylated tryptophan amino acids and related compounds through palladium-catalyzed C-H activation

scientific article published on 2 August 2013

Synthesis of Fmoc-protected amino ketones bearing tert-butyl based side-chain protecting groups

Synthesis of IB-01211, a cyclic peptide containing 2,4-concatenated thia- and oxazoles, via Hantzsch macrocyclization.

scientific article published in February 2007

Synthesis of Oligonucleotide Derivatives Using ChemMatrix Supports

scientific article published on 01 January 2008

Synthesis of a 24-Membered Cyclic Peptide-Biphenyl Hybrid

Synthesis of aspartimide-free protected peptides on base-labile functionalized resins

Synthesis of defined peptide-oligonucleotide hybrids containing a nuclear transport signal sequence

Synthesis of derivatives of (2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoic acid, a constituent of the didemnins

Synthesis of orthogonally protected L-threo-beta-ethoxyasparagine

scientific article published on 17 November 2009

Synthesis of peptides containing α, β-didehydroamino acids. Scope and limitations

Synthesis of the pyrrolo[2,3-c]carbazole core of the dictyodendrins

scientific article published on 13 January 2009

Synthesis of variolin B

Synthesis of α-trifluoromethyl α-amino acids with aromatic, heteroaromatic and ferrocenyl subunits in the side chain

scientific article published on 22 May 2006

Synthesis, in vitro evaluation, and 68 Ga-radiolabeling of CDP1 toward PET/CT imaging of bacterial infection.

scientific article published on 22 March 2017

THAL, a sterically unhindered linker for the solid-phase synthesis of acid-sensitive protected peptide acids

scientific article published on 22 August 2008

TOMBU and COMBU as Novel Uronium-type peptide coupling reagents derived from Oxyma-B.

scientific article published on 18 November 2014

TRPV1 modulators: structure-activity relationships using a rational combinatorial approach.

scientific article

Tackling lipophilicity of peptide drugs: replacement of the backbone N-methyl group of cilengitide by N-oligoethylene glycol (N-OEG) chains

scientific article published on 17 December 2013

Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro

scientific article published on 13 February 2010

Targeting nanoparticles to dendritic cells for immunotherapy

scientific article published on January 2012

Targeting nanosystems to human DCs via Fc receptor as an effective strategy to deliver antigen for immunotherapy

scientific article published on 20 December 2010

Tea Bags for Fmoc Solid-Phase Peptide Synthesis: An Example of Circular Economy

scientific article published in 2021

Tentoxin as a scaffold for drug discovery. Total solid-phase synthesis of tentoxin and a library of analogues

scientific article

Tetrahydrofuran-containing macrolides: a fascinating gift from the deep sea.

scientific article published on 18 March 2013

Tetrahydropyranyl, a nonaromatic acid-labile Cys protecting group for Fmoc peptide chemistry.

scientific article published on 12 March 2015

Tetrahydropyranyl: A Non-aromatic, Mild-Acid-Labile Group for Hydroxyl Protection in Solid-Phase Peptide Synthesis

scientific article

The 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl group (Pbf) as arginine side chain protectant

The Pharmaceutical Industry in 2016. An Analysis of FDA Drug Approvals from a Perspective of the Molecule Type.

scientific article

The Pharmaceutical Industry in 2017. An Analysis of FDA Drug Approvals from the Perspective of Molecules.

scientific article published on 27 February 2018

The Pharmaceutical Industry in 2018. An Analysis of FDA Drug Approvals from the Perspective of Molecules

scientific article published on 23 February 2019

The Pharmaceutical Industry in 2019. An Analysis of FDA Drug Approvals from the Perspective of Molecules

scientific article published on 09 February 2020

The Power of Functional Resins in Organic Synthesis

article

The Sea as a Source of New Drugs

The antitumoral depsipeptide IB-01212 kills Leishmania through an apoptosis-like process involving intracellular targets

scientific article published on 17 August 2010

The backbone N-(4-azidobutyl) linker for the preparation of peptide chimera.

scientific article published on 22 August 2013

The marine halophytes Carpobrotus edulis L. and Arthrocnemum macrostachyum L. are potential sources of nutritionally important PUFAs and metabolites with antioxidant, metal chelating and anticholinesterase inhibitory activities

The synergy of ChemMatrix resin® and pseudoproline building blocks renders Rantes, a complex aggregated chemokine

scientific article published on 01 January 2006

The synthesis of an EDTA-like chelating peptidomimetic building block suitable for solid-phase peptide synthesis

scientific article published on 15 February 2017

The tea-bag protocol for comparison of Fmoc removal reagents in solid-phase peptide synthesis

scientific article published on 26 August 2020

The use of the Nbb-resin for the solid-phase synthesis of peptide alkylesters and alkylamides. Synthesis of leuprolide

Therapeutic peptides.

scientific article published in August 2012

Thiadiazines, N,N-heterocycles of biological relevance

scientific article published on 25 June 2012

Thioester Bonds of Thiocoraline Can Be Replaced with NMe-Amide Bridges without Affecting Its DNA-Binding Properties

scientific article published on 4 November 2013

Thiopeptide antibiotics: retrospective and recent advances

scientific article

Thiopeptide engineering: a multidisciplinary effort towards future drugs.

scientific article published on 23 May 2014

Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the cell.

scientific article published on October 2008

Total Solid-Phase Synthesis of Marine Cyclodepsipeptide IB-01212

article by Luis J. Cruz et al published April 2006 in Journal of Organic Chemistry

Total Synthesis of Dehydrodidemnin B. Use of Uronium and Phosphonium Salt Coupling Reagents in Peptide Synthesis in Solution†

scientific article published on 01 January 1997

Total regioselective control of tartaric acid

scientific article published on August 2010

Total solid-phase synthesis of the azathiocoraline class of symmetric bicyclic peptides

scientific article

Total syntheses of variolin B and deoxyvariolin B.

scientific article published in December 2003

Total synthesis and antiproliferative activity screening of (+/-)-aplicyanins A, B and E and related analogues.

scientific article published on October 2009

Total synthesis and stereochemical assignment of baringolin.

scientific article published on 18 June 2013

Total synthesis of a depsidomycin analogue by convergent solid-phase peptide synthesis and macrolactonization strategy for antitubercular activity.

scientific article published on 18 July 2011

Total synthesis of aeruginazole A.

scientific article published on 3 August 2011

Triazene as a powerful tool for solid-phase derivatization of phenylalanine containing peptides: zygosporamide analogues as a proof of concept.

scientific article published on 18 November 2014

Trimethoxyphenylthio as a Highly Labile Replacement for tert-Butylthio Cysteine Protection in Fmoc Solid Phase Synthesis

scientific article published on 17 October 2012

Trishomocubane Amino Acid as a β-turn scaffold

Understanding Tetrahydropyranyl as a Protecting Group in Peptide Chemistry.

scientific article

Understanding acid lability of cysteine protecting groups

scientific article published on 6 May 2013

Understanding the mechanism of action of the novel SSAO substrate (C7NH10)6(V10O28).2H2O, a prodrug of peroxovanadate insulin mimetics.

scientific article published in June 2007

Understanding the structure/reactivity of aminium/uronium salts as coupling reagents in peptide synthesis

Undesired removal of the Fmoc group by the free ε-amino function of a lysine residue

Unequivocal synthesis and characterization of a parallel and an antiparallel bis-cystine peptide

Use of Alloc-amino acids in solid-phase peptide synthesis. Tandem deprotection-coupling reactions using neutral conditions

Use of BOP reagent for the suppression of diketopiperazine formation in boc/bzl solid-phase peptide synthesis

Use of N-methylpiperazine for the preparation of piperazine-based unsymmetrical bis-ureas as anti-HIV agents.

scientific article

Use of N-tritylamino acids and PyAOP1 for the suppression of diketopiperazine formation in Fmoc/tBu solid-phase peptide synthesis using alkoxybenzyl ester anchoring linkages

article published in 1996

Use of Onium Salt-Based Coupling Reagents in Peptide Synthesis1

article

Use of Oxyma as pH modulatory agent to be used in the prevention of base-driven side reactions and its effect on 2-chlorotrityl chloride resin.

scientific article

Use of a Base-Labile Protected Derivative of 6-Mercaptohexanol for the Preparation of Oligonucleotides Containing a Thiol Group at the 5′-End

Use of an internal reference for the quantitative HPLC-UV analysis of solid-phase reactions: a case study of 2-chlorotrityl chloride resin.

scientific article published on 15 April 2013

Use of polystyrene-1% divinylbenzene and Kel-F-g-styrene for the simultaneous synthesis of peptides

Useful scaffolds and handles for creating diversity in the preparation of chemical libraries

article by Miriam Royo et al published July 1999 in Reactive & Functional Polymers

Uteroglobin-like peptide cavities I. Synthesis of antiparallel and parallel dimers of bis-cysteine peptides

Wang Linker Free of Side Reactions

scientific article published on 27 December 2012

Welcome to the New Journal Methods and Protocols.

scientific article published on 27 June 2017

ds-Oligonucleotide–Peptide Conjugates Featuring Peptides from the Leucine-Zipper Region of Fos as Switchable Receptors for the Oncoprotein Jun

scientific article published on 01 July 2007

o-Formylation of electron-rich phenols with dichloromethyl methyl ether and TiCl4

article published in 2003

p-Nitrobenzyloxycarbonyl (pNZ) as an Alternative to Fmoc for the Protection of Amines in Solid-Phase Peptide Synthesis

p-Nitromandelic Acid as a Highly Acid-Stable Safety-Catch Linker for Solid-Phase Synthesis of Peptide and Depsipeptide Acids

scientific article published on 17 March 2007

r1andr2Relaxivities of Dendrons Based on a OEG-DTPA Architecture: Effect of Gd3+Placement and Dendron Functionalization

α-Ketoamino acid ester derivatives as promising MAO inhibitors

scientific article published on 07 November 2014

“Clicking” Porphyrins to Magnetic Nanoparticles for Photodynamic Therapy

scientific article published on 23 October 2013

“High-load” polyethylene glycol-polystyrene (PEG-PS) graft supports for solid-phase synthesis

article

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