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List of works by Doris Marko

11-Substituted Benzo[c]phenanthridines: New Structures and Insight into Their Mode of Antiproliferative Action

scientific article

7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine, a potent inhibitor of cAMP-specific phosphodiesterase, enhancing nuclear protein binding to the CRE consensus sequence in human tumour cells

scientific article

A 4-week consumption of medium roast and dark roast coffees affects parameters of energy status in healthy subjects

article by Annett Riedel et al published September 2014 in Food Research International

A Dual Topoisomerase Inhibitor of Intense Pro-Apoptotic and Antileukemic Nature for Cancer Treatment

scientific article published on 18 January 2017

A Generic Liquid Chromatography-Tandem Mass Spectrometry Exposome Method for the Determination of Xenoestrogens in Biological Matrices

scientific article published on 22 August 2019

A possible link between nutritional uptake of ubiquitous topoisomerase inhibitors and autism?

scientific article published on 10 June 2016

Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II.

scientific article

Alternaria alternata Toxins Synergistically Activate the Aryl Hydrocarbon Receptor Pathway In Vitro

scientific article published on 09 July 2020

Alternaria toxins as casein kinase 2 inhibitors and possible consequences for estrogenicity: a hybrid in silico/in vitro study

scientific article published on 23 April 2020

Alternariol acts as a topoisomerase poison

Alternariol acts as a topoisomerase poison, preferentially affecting the IIalpha isoform

scientific article

Amorphous Silica Particles Relevant in Food Industry Influence Cellular Growth and Associated Signaling Pathways in Human Gastric Carcinoma Cells

scientific article (publication date: 13 January 2017)

An Efficient Synthesis of a Lycobetaine-Tortuosine Analogue: A Potent Topoisomerase Inhibitor

An integrated in silico/in vitro approach to assess the xenoestrogenic potential of Alternaria mycotoxins and metabolites

scientific article published on 7 December 2017

Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity

scientific article published in September 2005

Anthocyanin-Rich Blackberry Extract Suppresses the DNA-Damaging Properties of Topoisomerase I and II Poisons in Colon Carcinoma Cells

scientific article published on 10 June 2011

Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human colon cancer cells

scientific article published on 31 January 2011

Anthocyanin-rich red grape extract impedes adenoma development in the Apc(Min) mouse: pharmacodynamic changes and anthocyanin levels in the murine biophase

scientific article published on 7 January 2010

Anthocyanins suppress the cleavable complex formation by irinotecan and diminish its DNA-strand-breaking activity in the colon of Wistar rats

scientific article published on 28 December 2012

Antioxidative activity and health benefits of anthocyanin-rich fruit juice in healthy volunteers

scientific article published on 04 June 2019

Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells

scientific article published on 2 June 2007

Apple polyphenols diminish the phosphorylation of the epidermal growth factor receptor in HT29 colon carcinoma cells

scientific article published on 01 May 2007

Apple procyanidins affect several members of the ErbB receptor tyrosine kinase family in vitro

scientific article published on April 2013

Application of low-energy scanning transmission electron microscopy for the study of Pt-nanoparticle uptake in human colon carcinoma cells

scientific article

Backscattered electron SEM imaging of cells and determination of the information depth

scientific article

Bilberry extract, its major polyphenolic compounds, and the soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells

scientific article published on 3 August 2016

Bioavailability, metabolism, and excretion of a complex Alternaria culture extract versus altertoxin II: a comparative study in rats

scientific article published on 22 October 2019

Biological activities of malvidin, a red wine anthocyanidin

scientific article published in April 2006

Biomonitoring of Mycotoxins in Human Breast Milk: Current State and Future Perspectives.

scientific article published on 14 June 2016

Cellular uptake and DNA damaging properties of platinum nanoparticles

scholarly article by H. Gehrke et al published August 2011 in Toxicology Letters

Cellular uptake of platinum nanoparticles in human colon carcinoma cells and their impact on cellular redox systems and DNA integrity

scientific article

Characterization of a genotoxic impact compound in Alternaria alternata infested rice as Altertoxin II.

scientific article published on 18 October 2012

Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression

scientific article published in May 2011

Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo

scientific article

Combinatory effects of cereulide and deoxynivalenol on in vitro cell viability and inflammation of human Caco-2 cells

scientific article published on 17 February 2020

Combinatory estrogenic effects between the isoflavone genistein and the mycotoxins zearalenone and alternariol in vitro

scientific article published on 14 October 2016

Combinatory estrogenic effects of bisphenol A in mixtures with alternariol and zearalenone in human endometrial cells

scientific article published on 13 November 2019

Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation

scientific article

Consumption of anthocyanin-rich beverages affects Nrf2 and Nrf2-dependent gene transcription in peripheral lymphocytes and DNA integrity of healthy volunteers

scientific article published on 29 May 2020

Contaminants: a dark side of food supplements?

scientific article published on 10 September 2019

DNA damaging properties of single walled carbon nanotubes in human colon carcinoma cells.

scientific article

DNA strand breaking capacity of acrylamide and glycidamide in mammalian cells.

scientific article published on February 2005

Daily consumption of a dark-roast coffee for eight weeks improved plasma oxidized LDL and alpha-tocopherol status: A randomized, controlled human intervention study

scientific article published in 2019

Dark roast coffee is more effective than light roast coffee in reducing body weight, and in restoring red blood cell vitamin E and glutathione concentrations in healthy volunteers

scientific article published on 2 August 2011

Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family

scientific article

Delphinidin interferes with the DNA-damaging properties of the topoisomerase II poisons doxorubicin and etoposide in human colon carcinoma cells

Delphinidin is a novel inhibitor of lymphangiogenesis but promotes mammary tumor growth and metastasis formation in syngeneic experimental rats.

scientific article published on 23 August 2013

Delphinidin modulates the DNA-damaging properties of topoisomerase II poisons

scientific article

Delphinidin protects colon carcinoma cells against the genotoxic effects of the mycotoxin altertoxin II.

scientific article published on 4 December 2017

Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs?

scientific article published on 18 March 2009

Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase

scientific article published on 28 September 2016

Effect of coffee combining green coffee bean constituents with typical roasting products on the Nrf2/ARE pathway in vitro and in vivo

scientific article published on 14 September 2012

Effect of microformulation on the bioactivity of an anthocyanin-rich bilberry pomace extract ( Vaccinium myrtillus L.) in vitro

scientific article published on 13 May 2013

Endoplasmic Reticulum Adaptation and Autophagic Competence Shape Response to Fluid Shear Stress in T24 Bladder Cancer Cells

scientific article published on 03 May 2021

Exploring the TTC approach as a basis for risk management: The example of emerging Alternaria mycotoxins

scientific article published on 27 November 2019

Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier functio

scientific article published on 23 April 2021

Food-borne Mycotoxins

scientific article published on 01 April 2009

Four-week coffee consumption affects energy intake, satiety regulation, body fat, and protects DNA integrity

article by Tamara Bakuradze et al published September 2014 in Food Research International

Genistein acts as topoisomerase II poison in vivo

scholarly article by S. Baechler et al published August 2011 in Toxicology Letters

Genistein and delphinidin antagonize the genotoxic effects of the mycotoxin alternariol in human colon carcinoma cells

scientific article

Genotoxicity of crude alternaria extract and ATX-II on human colon carcinoma cells

scholarly article by C. Schwarz & Doris Marko published August 2011 in Toxicology Letters

Genotoxicity of dietary, environmental and therapeutic topoisomerase II poisons is uniformly correlated to prolongation of enzyme DNA residence

scientific article published on 24 March 2011

Gut microbiota and undigested food constituents modify toxin composition and suppress the genotoxicity of a naturally occurring mixture of Alternaria toxins in vitro

scientific article published on 04 July 2020

Hybrid in silico/in vitro target fishing to assign function to “orphan” compounds of food origin – The case of the fungal metabolite atromentin

scientific article published on 04 July 2018

Identification of a novel human deoxynivalenol metabolite enhancing proliferation of intestinal and urinary bladder cells.

scientific article published on 23 September 2016

Impact of Alternaria toxins on CYP1A1 expression in different human tumor cells and relevance for genotoxicity

scientific article published on 13 October 2015

Impact of delphinidin on the maintenance of DNA integrity in human colon carcinoma cells

scientific article

Impact of glutathione modulation on the toxicity of the Fusarium mycotoxins deoxynivalenol (DON), NX-3 and butenolide in human liver cells

article

Impact of phase I metabolism on uptake, oxidative stress and genotoxicity of the emerging mycotoxin alternariol and its monomethyl ether in esophageal cells

scientific article published on 15 July 2016

Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells

scientific article

In vitro combinatory effects of the Alternaria mycotoxins alternariol and altertoxin II and potentially involved miRNAs

scientific article

In vitro toxicity of amorphous silica nanoparticles in human colon carcinoma cells

scientific article published on 20 January 2012

In vivo bioassay to detect irinotecan-stabilized DNA/topoisomerase I complexes in rats

scientific article published in March 2010

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

scientific article published in January 2001

Induction of antioxidative Nrf2 gene transcription by coffee in humans: depending on genotype?

scientific article published in June 2012

Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells

scientific article

Inhibition of topoisomerase II by phase II metabolites of resveratrol in human colon cancer cells

scientific article published in December 2015

Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate

scientific article published in May 2001

Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity

scientific article

Inhibitors of the epidermal growth factor receptor in apple juice extract.

scientific article

Intracellular localization of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine in membrane structures impeding the inhibition of cytosolic cyclic AMP-specific phosphodiesterase

scientific article

Less-toxic rearrangement products of NX-toxins are formed during storage and food processing

scientific article published on 22 December 2017

Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid

scientific article published in September 2007

Long-Term Consumption of Anthocyanin-Rich Fruit Juice: Impact on Gut Microbiota and Antioxidant Markers in Lymphocytes of Healthy Males

scientific article published on 29 December 2020

Lycobetaine acts as a selective topoisomerase II beta poison and inhibits the growth of human tumour cells

scientific article

Maillard reaction products modulating the growth of human tumor cells in vitro

scientific article published in January 2003

Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization

scientific article published in December 1998

Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases

scientific article

Microfiltration results in the loss of analytes and affects the in vitro genotoxicity of a complex mixture of Alternaria toxins

scientific article published on 14 August 2020

Minor contribution of alternariol, alternariol monomethyl ether and tenuazonic acid to the genotoxic properties of extracts from Alternaria alternata infested rice

scientific article published on 13 August 2012

Modulation of Nrf2-dependent gene transcription by bilberry anthocyanins in vivo

scientific article

Modulation of inflammatory gene transcription after long-term coffee consumption

article

Modulation of key elements of the Wnt pathway by apple polyphenols

scientific article published in September 2006

Modulation of the cellular redox status by the Alternaria toxins alternariol and alternariol monomethyl ether

scientific article

Monitoring Early Life Mycotoxin Exposures via LC-MS/MS Breast Milk Analysis

scientific article published on 30 November 2018

Mycotoxin Altertoxin II Induces Lipid Peroxidation Connecting Mitochondrial Stress Response to NF-κB Inhibition in THP-1 Macrophages

scientific article published on 05 February 2020

Naturally occurring mixtures of Alternaria toxins: anti-estrogenic and genotoxic effects in vitro

scientific article published on 26 September 2019

Nitrate and nitrite in the diet: how to assess their benefit and risk for human health

scientific article

Non-synergistic cytotoxic effects of Fusarium and Alternaria toxin combinations in Caco-2 cells

scientific article published on 31 October 2015

Nonivamide enhances miRNA let-7d expression and decreases adipogenesis PPARγ expression in 3T3-L1 cells

scientific article published on June 2015

Oak ellagitannins suppress the phosphorylation of the epidermal growth factor receptor in human colon carcinoma cells

scientific article

Oxidative metabolism enhances the cytotoxic and genotoxic properties of the soy isoflavone daidzein

scientific article published on 3 March 2014

Oxidative stress and DNA interactions are not involved in Enniatin- and Beauvericin-mediated apoptosis induction

scientific article

Platinum nanoparticles and their cellular uptake and DNA platination at non-cytotoxic concentrations

scientific article published on 13 January 2011

Potential antioxidant response to coffee - A matter of genotype?

scientific article

Proposal of a comprehensive definition of modified and other forms of mycotoxins including "masked" mycotoxins

scientific article published on 26 June 2014

Quantitation of free and modified Alternaria mycotoxins in European food products by LC-MS/MS

Repair of DNA damage induced by the mycotoxin alternariol involves tyrosyl-DNA phosphodiesterase 1

scientific article published on 27 July 2010

Resveratrol modulates the topoisomerase inhibitory potential of doxorubicin in human colon carcinoma cells

Role of topoisomerase inhibition and DNA repair mechanisms in the genotoxicity of alternariol and altertoxin-II

Selected methyleugenol metabolites suppress topoisomerase I activity and diminish the DNA-damaging properties of the DNA-topoisomerase poison camptothecin in human colon carcinoma cells

Silica particles with a quercetin-R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus

scientific article published on 24 July 2019

Smart Protein-Based Formulation of Dendritic Mesoporous Silica Nanoparticles: Toward Oral Delivery of Insulin

scientific article published on 14 February 2020

Spatiotemporal Dynamics of Oligofructan Metabolism and Suggested Functions in Developing Cereal Grains

scientific article

Stable Isotope-Assisted Metabolomics for Deciphering Xenobiotic Metabolism in Mammalian Cell Culture

scientific article published on 25 March 2020

Structure-activity relationships of targeted RuII(η6-p-cymene) anticancer complexes with flavonol-derived ligands

scientific article

Studies on the inhibition of tumor cell growth and microtubule assembly by 3-hydroxy-4-[(E)-(2-furyl)methylidene]methyl-3-cyclopentene-1,2-dione, an intensely colored Maillard product formed from carbohydrates and l-proline

Studies on the inhibition of tumor cell growth and microtubule assembly by 3-hydroxy-4-[(E)-(2-furyl)methylidene]methyl-3-cyclopentene-1,2-dione, an intensively coloured Maillard reaction product ⬇️

scientific article published on January 1, 2002

Super-resolution Microscopical Localization of Dopamine Receptors 1 and 2 in Rat Hippocampal Synaptosomes.

scientific article

Suppression of the kinase activity of receptor tyrosine kinases by anthocyanin-rich mixtures extracted from bilberries and grapes

scientific article published on April 2009

Synergistic estrogenic effects of Fusarium and Alternaria mycotoxins in vitro

scientific article published on 11 July 2016

Synthesis of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and novel derivatives free of positional isomers. Potent inhibitors of cAMP-specific phosphodiesterase and of malignant tumor cell growth.

scientific article published on November 1998

Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs

scientific article

TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II

scientific article

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder.

scientific article published on 12 April 2012

The Alternaria Mycotoxin Alternariol Triggers the Immune Response of IL-1β-stimulated, Differentiated Caco-2 Cells

scientific article published on 04 October 2019

The Alternaria mycotoxins alternariol and alternariol methyl ether induce cytochrome P450 1A1 and apoptosis in murine hepatoma cells dependent on the aryl hydrocarbon receptor

scientific article

The Fusarium metabolite culmorin suppresses the in vitro glucuronidation of deoxynivalenol

scientific article published on 02 May 2019

The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor

scientific article published on February 2001

The cell-stretcher: A novel device for the mechanical stimulation of cell populations

scientific article published on August 2016

The epidermal growth factor receptor and human topoisomerases represent potential cellular targets of oligomeric procyanidins

scientific article published on February 2007

The mycotoxin alternariol suppresses lipopolysaccharide-induced inflammation in THP-1 derived macrophages targeting the NF-κB signalling pathway

scholarly article by Jessica Kollarova et al published November 2018 in Archives of Toxicology

The secondary Fusarium metabolite aurofusarin induces oxidative stress, cytotoxicity and genotoxicity in human colon cells

scientific article published on 14 December 2017

The substitution pattern of anthocyanidins affects different cellular signaling cascades regulating cell proliferation

scientific article published in September 2004

Topoisomerase II-targeting properties of a grapevine-shoot extract and resveratrol oligomers

scientific article published on 10 January 2014

Topoisomerase poisoning by genistein in the intestine of rats

scientific article published on 23 December 2015

Uncommon toxic microbial metabolite patterns in traditionally home-processed maize dish (fufu) consumed in rural Cameroon.

scientific article published on 06 June 2017

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