List of works by David W. Threadgill

A New Polygenic Model for Nonfamilial Colorectal Cancer Inheritance Based on the Genetic Architecture of the Azoxymethane-Induced Mouse Model

scientific article published on 26 December 2019

A Whole Genome Assembly of the Horn Fly, Haematobia irritans, and Prediction of Genes with Roles in Metabolism and Sex Determination.

scientific article published on 30 March 2018

A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner

scientific article

A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2

scientific article

Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta

scientific article

Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance.

scientific article

Animal models of autism spectrum disorders: information for neurotoxicologists

scientific article

Antecedent presentation of neurological phenotypes in the Collaborative Cross reveals four classes with complex sex-dependencies

scientific article published on 13 May 2020

Architecture of energy balance traits in emerging lines of the Collaborative Cross

scientific article

Azoxymethane Is a Genetic Background-Dependent Colorectal Tumor Initiator and Promoter in Mice: Effects of Dose, Route, and Diet

scientific article published on 08 September 2005

Bayesian Diallel Analysis Reveals Mx1-Dependent and Mx1-Independent Effects on Response to Influenza A Virus in Mice

scientific article published on 29 November 2017

Bayesian hierarchical modeling for time course microarray experiments.

scientific article published in June 2007

Bayesian multiple quantitative trait loci mapping for complex traits using markers of the entire genome

scientific article

Borrelia and Other Zoonotic Pathogens in Ixodes ricinus and Dermacentor reticulatus Ticks Collected from the Chernobyl Exclusion Zone on the 30th Anniversary of the Nuclear Disaster

scientific article published on 21 May 2019

Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts

scientific article

Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal- and background-dependent development of concentric left ventricular hypertrophy

scientific article published on 15 December 2006

Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population.

scientific article published on 30 May 2017

Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15

article

Characterizing Serpinb2 as a Modulator of TCDD-Induced Suppression of the B Cell

scientific article published on 30 October 2018

Chronic exposure to e-cig aerosols during early development causes vascular dysfunction and offspring growth deficits

scientific article published on 07 January 2019

Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice

scientific article published on 07 March 2008

Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms.

scientific article

Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function

scientific article

Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones

scientific article

Cross-talk between epidermal growth factor receptor and protein kinase C during calcium-induced differentiation of keratinocytes

scientific article published on June 2000

Deficient NRG1-ERBB signaling alters social approach: relevance to genetic mouse models of schizophrenia

scientific article

Derivation of stable embryonic stem cell-like, but transcriptionally heterogenous, induced pluripotent stem cells from non-permissive mouse strains

scientific article published on 04 October 2020

Diallel analysis reveals Mx1-dependent and Mx1-independent effects on response to influenza A virus in mice

Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer

scientific article published in February 2012

Dietary fat alters body composition, mammary development, and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptors

scientific article published on 18 May 2009

Dietary fat alters pulmonary metastasis of mammary cancers through cancer autonomous and non-autonomous changes in gene expression

article

Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis

scientific article

Differential expression of the full-length and truncated forms of the epidermal growth factor receptor in the preimplantation mouse uterus and blastocyst

scientific article published on 01 April 1996

Disruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling ⬇️

scientific article published on 8 December 2017

Diverse tumour susceptibility in Collaborative Cross mice: identification of a new mouse model for human gastric tumourigenesis

scientific article published on 06 March 2019

EGF receptor is required for KRAS-induced pancreatic tumorigenesis

scientific journal article

EGFR regulates the expression of keratinocyte-derived granulocyte/macrophage colony-stimulating factor in vitro and in vivo

scientific article published on 5 November 2009

EGFR signaling promotes TGFβ-dependent renal fibrosis

scientific article published on 17 November 2011

ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas

scientific article

ERBBs in the gastrointestinal tract: recent progress and new perspectives

scientific article

Editor's Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism.

scientific article published on 27 March 2017

Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: implications for preclinical cancer prevention and therapy trials

scientific article

Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal

scientific article

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation

scientific article

Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: roles of transforming growth factor-{alpha} and PTGS2.

scientific article

Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice

scientific article published on 09 January 2014

Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo

scientific article

Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis

scientific article

Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage

scientific article published on October 2004

Epiregulin-dependent amphiregulin expression and ERBB2 signaling are involved in luteinizing hormone-induced paracrine signaling pathways in mouse ovary

scientific article published on 13 January 2011

Erratum to: Status and access to the Collaborative Cross population

scholarly article published in Mammalian Genome

Erratum: Corrigendum: Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance

article

Erratum: Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis

scholarly article published in Nature Medicine

Expression quantitative trait Loci for extreme host response to influenza a in pre-collaborative cross mice

scientific article published on February 2012

Flat Colorectal Cancers Are Genetically Determined and Progress to Invasion without Going through a Polypoid Stage

scientific article published on 01 December 2007

Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain

scientific article published on 01 June 1997

Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor

scientific article

Genetic analysis of complex traits in the emerging Collaborative Cross

scientific article

Genetic analysis of hematological parameters in incipient lines of the collaborative cross

scientific article published on February 2012

Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross

scientific article published on 13 April 2022

Genetic characterization of invasive house mouse populations on small islands

scholarly article published 28 May 2018

Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort

scientific article

Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross

scientific article

Genetic mapping of a Ptch1-associated rhabdomyosarcoma susceptibility locus on mouse chromosome 2

scientific article published on 01 November 2004

Genetics of dark skin in mice

scientific article

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross

scientific article published on 9 October 2015

Genome-level analysis of genetic regulation of liver gene expression networks

scientific article

Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice

scientific article

Genomic mapping within the albino-deletion complex using individual early postimplantation mouse embryos

scientific article published on 01 January 1992

Genotype Sequence Segmentation: Handling Constraints and Noise

article published in Lecture Notes in Computer Science

Genotype X diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasis

scientific article published on 21 February 2008

Gestational binge alcohol-induced alterations in maternal uterine artery transcriptome

scientific article published on 09 May 2019

Hepatocyte ERBB3 and EGFR are required for maximal CCl4-induced liver fibrosis

scientific article published on September 2016

High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor

scientific article published in December 2005

Hippocampal transcriptome reveals novel targets of FASD pathogenesis

scientific article published on 29 May 2019

Host genetic background influences diverse neurological responses to viral infection in mice.

scientific article published on 22 September 2017

Human epithelial-specific response to pathogenic Campylobacter jejuni

scientific article published on September 2006

Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein

scientific article

Identification of a novel polymorphism in X-linked sterol-4-alpha-carboxylate 3-dehydrogenase (Nsdhl) associated with reduced high-density lipoprotein cholesterol levels in I/LnJ mice

scientific article published on 03 October 2013

Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice.

scientific article published in February 2017

Improving Metabolic Health Through Precision Dietetics in Mice

scientific article published on 20 November 2017

Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows

scientific article published on July 2007

Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition

scientific article

Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice

scientific article

Investigating gene function using mouse models

scientific article published on June 2004

Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype

scientific article

Leveraging a natural murine meiotic drive to suppress invasive populations

scientific article published in 2022

Locally Fixed Alleles: A method to localize gene drive to island populations

scientific article published on 01 November 2019

Long-Term Combinatorial Exposure to Trichloroethylene and Inorganic Arsenic in Genetically Heterogeneous Mice Results in Renal Tubular Damage and Cancer-Associated Molecular Changes.

scientific article published on 7 May 2019

Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice

scientific article

Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis

scientific article

Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation

scientific article published on 28 December 2006

Mapping six new susceptibility to colon cancer (Scc) loci using a mouse interspecific backcross

scientific article

Masking inWaved‐2Mice: EGF Receptor Control of Locomotion Questioned

scientific article published on 01 January 2005

Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice.

scientific article

Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors

scientific article

Meeting report for the 4th annual Complex Trait Consortium meeting: from QTLs to systems genetics

scientific article published on 13 January 2006

Metastatic potential as a heritable trait

scientific article published on 01 October 2005

MicroRNA expression in the livers of inbred mice

scientific article

Microarray foray

scientific article

Modeling cancer patient populations in mice: complex genetic and environmental factors

scientific article published on January 2008

Modeling host genetic regulation of influenza pathogenesis in the collaborative cross

scientific article (publication date: February 2013)

Modeling the cancer patient with genetically engineered mice: prediction of toxicity from molecule-targeted therapies

scientific article published on February 2004

Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice

scientific article published on 01 January 2019

Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains

scientific article

Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat.

scientific article published on 07 October 2008

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

scientific article published on 05 May 2009

Murine models of colorectal cancer

scientific article

New Zealand White Rabbits Effectively Clear Borrelia burgdorferi B31 despite the Bacterium's Functional vlsE Antigenic Variation System

scientific article published on 20 June 2019

Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice

scientific article published on 01 October 2017

Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice.

scientific article published in September 2017

PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1

scientific article published on 14 February 2009

Paradox of a tumour repressor

scientific article published on 01 January 2008

Parent-of-origin effects on cardiac response to pressure overload in mice

scientific article published on 26 June 2009

Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus musculus

scientific article published in Scientific Reports

Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and molecularly partitioned

scientific article

Phosphatidylinositol 3-kinase signaling determines kidney size

scientific article published on 18 May 2015

Phosphorylation of Forkhead Protein FoxO1 at S253 Regulates Glucose Homeostasis in Mice

scientific article published on 01 May 2019

Physical mapping of the lysozyme gene family in cattle

scientific article published in 1993

Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles

scientific article published on 29 June 2009

Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptor.

scientific article published on 23 May 2009

Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response

scientific article published on 29 August 2013

Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse

scientific article published on 25 April 2019

Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel

scientific article published on 06 May 2009

Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse.

scientific article published on 20 January 2018

Prevention of tumorigenesis in mice by exercise is dependent on strain background and timing relative to carcinogen exposure.

scientific article published on 22 February 2017

Prophylactic vaccination targeting ERBB3 decreases polyp burden in a mouse model of human colorectal cancer.

scientific article published on 07 December 2016

Quantitative Association Analysis Using Tree Hierarchies

Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironment

article

Quantitative trait locus analysis using recombinant inbred intercrosses: theoretical and empirical considerations

scientific article

Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice

scientific article published on 15 May 2009

Replication and narrowing of gene expression quantitative trait loci using inbred mice

scientific article published on 17 July 2009

Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high-risk human papillomavirus oncogene

scientific article published on August 2005

Role of the Angiotensin Type 2 Receptor Gene in Congenital Anomalies of the Kidney and Urinary Tract, CAKUT, of Mice and Men

article

SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy

scientific article

SSLPs to map genetic differences between the 129 inbred strains and closed-colony, random-bred CD-I mice

scientific article published on 01 June 1997

Sample Selection for Maximal Diversity

Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice

scientific article

Status and access to the Collaborative Cross population.

scientific article

Targeted inactivation of EGF receptor inhibits renal collecting duct development and function.

scientific article

Ten years of the Collaborative Cross

scientific article published on February 2012

Ten years of the collaborative cross

scientific article

The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics

scientific article published on June 2008

The Collaborative Cross, a community resource for the genetic analysis of complex traits

article

The EGFR is required for proper innervation to the skin

scientific article published on 02 October 2008

The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice

scientific article

The collaborative cross: a recombinant inbred mouse population for the systems genetic era.

scientific article published on January 2011

The epidermal growth factor receptor critically regulates endometrial function during early pregnancy

scientific article

The gastrointestinal microbiome: a malleable, third genome of mammals

scientific article

The nature and identification of quantitative trait loci: a community's view

scientific article published in November 2003

The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics

scientific article

The untapped potential of genetically engineered mouse models in chemoprevention research: opportunities and challenges

scientific article published on August 2008

Tissue Level Diet and Sex-by-Diet Interactions Reveal Unique Metabolite and Clustering Profiles Using Untargeted Liquid Chromatography-Mass Spectrometry on Adipose, Skeletal Muscle, and Liver Tissue in C57BL6/J Mice.

scientific article published on 26 January 2018

Toxicogenetics: population-based testing of drug and chemical safety in mouse models

scientific article

Transcriptional landscape of mouse-aged ovaries reveals a unique set of non-coding RNAs associated with physiological and environmental ovarian dysfunctions

scientific article published on 05 December 2018

Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer

scientific article published on January 2007

TreeQA: quantitative genome wide association mapping using local perfect phylogeny trees.

scientific article published on January 2009

Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK

scientific article published on 15 March 2013

Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium

scientific article published on 17 August 2009

Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene

scientific article published on 27 June 2019

Using the emerging Collaborative Cross to probe the immune system

scientific article

Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor

scientific article published in July 2004

Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice

scientific article

gQTL: A Web Application for QTL Analysis Using the Collaborative Cross Mouse Genetic Reference Population

article published in 2018

Paulina is supported by:

About Paulina

Help