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List of works by Patrick S. Ward

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

scientific article

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

scientific article published on June 2010

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition

scientific article published on September 2013

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

scientific article published on 21 November 2011

IDH mutation impairs histone demethylation and results in a block to cell differentiation

scientific article (publication date: 15 February 2012)

Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production ⬇️

scientific article published on September 26, 2011

Induction of sarcomas by mutant IDH2

scientific article published on September 2013

Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate

scientific article published in Journal of Biological Chemistry

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

scientific article (publication date: 14 December 2010)

Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

scientific article (publication date: 20 March 2012)

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

scientific article

Signaling in control of cell growth and metabolism

scientific article published on July 2012

SnapShot: cancer metabolism pathways

scientific article published on 01 March 2013

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

scientific article

The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization.

scientific article published on 21 December 2012

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