List of works by Florence Nguyen-Khac

14q deletions are associated with trisomy 12,NOTCH1mutations and unmutatedIGHVgenes in chronic lymphocytic leukemia and small lymphocytic lymphoma

scientific article published on 12 April 2014

A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation

scientific article published on 24 April 2019

A Scoring System for the Classification of CD5- B CLL versus CD5+ B CLL and B PLL

A common alternative splicing signature is associated with SF3B1 mutations in malignancies from different cell lineages.

scientific article

A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection

scientific article published on 27 March 2014

A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia.

scientific article

A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia.

scientific article published on 20 May 2010

AML1-MTG16 fusion gene in therapy-related acute leukemia with t(16;21)(q24;q22); two new cases

article

Aberrant telomere structure is characteristic of resistant chronic lymphocytic leukaemia cells

scientific article published on 22 October 2009

Abnormalities of the short arm of chromosome 12 in T cell prolymphocytic leukemia

scientific article published in June 1998

Absence of microsatellite instability in human chronic lymphocytic leukaemia B cells

Acquired initiating mutations in early hematopoietic cells of CLL patients

scientific article

Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia

scientific article published on 12 November 2009

Acute myeloid leukaemia with 8p11 (MYST3) rearrangement: an integrated cytologic, cytogenetic and molecular study by the groupe francophone de cytogénétique hématologique.

scientific article published on 5 June 2008

Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference

scientific article published on 21 April 2016

Analyses of TET2 mutations in post-myeloproliferative neoplasm acute myeloid leukemias

scientific article published on 27 August 2009

Anomalies chromosomiques et macroglobulinémie de Waldenström

scientific article published on 05 May 2008

Antibody-dependent cellular cytotoxicity of the optimized anti-CD20 monoclonal antibody ublituximab on chronic lymphocytic leukemia cells with the 17p deletion

Antiviral therapy is associated with a better survival in patients with hepatitis C virus and B-cell non-Hodgkin lymphomas, ANRS HC-13 lympho-C study

scientific article

Autologous stem cell transplantation as a first-line treatment strategy for chronic lymphocytic leukemia: a multicenter, randomized, controlled trial from the SFGM-TC and GFLLC

scientific article published on 15 March 2011

Automated differential white blood cell count and cytological analysis can detect near-tetraploid cells in chronic lymphoproliferative disorders

scientific article published on 04 March 2019

B-cell regulator of immunoglobulin heavy-chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells.

scientific article published on 3 April 2012

Burkitt-type acute leukemia in a patient with B-prolymphocytic leukemia: evidence for a common origin

CALM-AF10 fusion gene in leukemias: simple and inversion-associated translocation (10;11).

scientific article published in October 2000

CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans

scientific article

Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia

scientific article published on 12 October 2012

Chromosomal abnormalities in transformed Ph-negative myeloproliferative neoplasms are associated to the transformation subtype and independent of JAK2 and the TET2 mutations.

scientific article published in October 2010

Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: a systematic reappraisal of classic cytogenetic data

scientific article

Chromosomal translocations involving the IGH@ locus in B-cell precursor acute lymphoblastic leukemia: 29 new cases and a review of the literature

scientific article published on May 2013

Chromosome 21 abnormalities with AML1 amplification in acute lymphoblastic leukemia

scientific article

Chronic lymphocytic leukaemia genomics and the precision medicine era.

scientific article

Chronic lymphocytic leukemia and prolymphocytic leukemia with MYC translocations: a subgroup with an aggressive disease course

scientific article published on 30 December 2011

Chronic lymphocytic leukemia: Time to go past genomics?

scientific article

Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study

scientific article

Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in males

scientific article

Concomitant telomere shortening, acquisition of multiple chromosomal aberrations and in vitro resistance to apoptosis in a single case of progressive CLL

article published in 2011

Conséquences moléculaires et fonctionnelles des anomalies chromosomiques des hémopathies malignes humaines

scientific article published on 01 August 2003

Correction: Refinement of 1p36 Alterations Not Involving PRDM16 in Myeloid and Lymphoid Malignancies.

scientific article published on 13 December 2011

Correlation of cytoplasmic Ig mu (C mu) and E2A-PBX1 fusion transcripts in t(1;19) B lineage ALL: discrepancy in C mu detection by slide immunofluorescence and flow cytometry

scientific article published on 01 March 1995

Cryptic translocations involving chromosome 20 in polycythemia vera

scientific article published on 01 October 2004

Cyclin D3 deregulation by juxtaposition with IGH locus in a t(6;14)(p21;q32)-positive T-cell acute lymphoblastic leukemia

scientific article published on 08 August 2009

Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact

scientific article published on 02 January 2019

Cytogenetic study of 75 erythroleukemias.

scientific article

Cytogenetics in the management of chronic lymphocytic leukemia: an update by the Groupe francophone de cytogénétique hématologique (GFCH).

scientific article published on 14 September 2016

Cytogenetics in the management of hematologic malignancies: an update by the Groupe francophone de cytogénétique hématologique (GFCH).

scientific article

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia.

scientific article published on 29 July 2009

Deregulation of AhR function by the human acute leukemia TEL-ARNT fusion protein

scientific article published on 28 February 2014

Deregulation of cyclin D2 by juxtaposition with T-cell receptor alpha/delta locus in t(12;14)(p13;q11)-positive childhood T-cell acute lymphoblastic leukemia.

scientific article

Description of a novel FR1 IgH PCR strategy and its comparison with three other strategies for the detection of clonality in B cell malignancies

scientific article published on 01 March 1995

Diagnosis and Treatment of Chronic Lymphocytic Leukemia: Recommendations of the French CLL Study Group (FILO)

scientific article published on 23 September 2020

Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors

scientific article published on 19 May 2016

Drug-perturbation-based stratification of blood cancer

scientific article published on 11 December 2017

EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia.

scientific article published on 28 November 2016

Early-onset invasive aspergillosis and other fungal infections in patients treated with ibrutinib

scientific article published in February 2018

Establishment and characterization of a new human erythroleukemic cell line, ERY-1.

scientific article

Evaluating abbreviated induction with fludarabine, cyclophosphamide, and dose-dense rituximab in elderly patients with chronic lymphocytic leukemia

scientific article published on 3 July 2015

Evidence of chromosomal inversion using fluorescence in situ hybridization to stretched DNA.

scientific article

FISH detection of chromosome 14q32/IgH translocations: evaluation in follicular lymphoma

scientific article published on 01 November 1998

Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).

scientific article

Fluorescence in situ hybridization analysis of chromosome 1 abnormalities in hematopoietic disorders: rearrangements of DNA satellite II and new recurrent translocations

scientific article

Functional analyses of the TEL-ARNT fusion protein underscores a role for oxygen tension in hematopoietic cellular differentiation

scientific article published on 20 March 2006

Functional assessment of p53 in chronic lymphocytic leukemia

scientific article published on 25 February 2011

Gain in the short arm of chromosome 2 (2p+) induces gene overexpression and drug resistance in chronic lymphocytic leukemia: analysis of the central role of XPO1.

scientific article

Gain of the short arm of chromosome 2 (2p gain) has a significant role in drug-resistant chronic lymphocytic leukemia

scientific article published on 07 May 2019

Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages

article

Gene expression profiling of chronic lymphocytic leukemia can discriminate cases with stable disease and mutated Ig genes from those with progressive disease and unmutated Ig genes.

scientific article published in November 2005

Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53

scientific article published on 01 November 2019

Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases

scientific article published on 25 September 2008

Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multi-center study

scientific article published on 23 January 2020

Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms

scientific article published on 08 April 2016

High frequency of clonal hematopoiesis in Erdheim-Chester disease

scientific article published on 16 October 2020

High frequency of somatic mutations in the VH genes expressed in prolymphocytic leukemia.

scientific article published in November 1996

Hypoxia enhances human B19 erythrovirus gene expression in primary erythroid cells.

scientific article

IGHV gene mutational status and LPL/ADAM29 gene expression as clinical outcome predictors in CLL patients in remission following treatment with oral fludarabine plus cyclophosphamide

scientific article

Identical abnormality of the short arm of chromosome 18 in two Philadelphia-positive chronic myelocytic leukemia patients with erythroblastic transformation, resulting in duplication of BCR-ABL1 fusion.

scientific article published in October 2002

Intracranial Cell Lymphomas That Mimic Meningiomas: Case Report To Understand Complex Genetic, Radiologic, and Histopathologic Entities

scientific article published on 22 February 2019

Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia

scientific article

Isolated isochromosomes i(X)(p10) and idic(X)(q13) are associated with myeloid malignancies and dysplastic features

scientific article published on 26 August 2019

LHX2 deregulation by juxtaposition with the IGH locus in a pediatric case of chronic myeloid leukemia in B-cell lymphoid blast crisis.

scientific article published on 22 June 2012

Long-term follow up of the CLL2007FMP trial evaluating fludarabine and cyclophosphamide in combination with either rituximab or alemtuzumab in previously untreated patients with chronic lymphocytic leukemia.

scientific article published on 15 March 2018

MLL-AF1q fusion resulting from t(1;11) in acute leukemia

scientific article published on 01 February 1999

MYC-containing double minutes in hematologic malignancies: evidence in favor of the episome model and exclusion of MYC as the target gene

article

Minimally differentiated erythroleukaemia (AML M6 Variant'): a rare subset of AML distinct from AML M6

scientific article published on 01 August 1995

Mutational and cytogenetic analyses of 188 CLL patients with trisomy 12: A retrospective study from the French Innovative Leukemia Organization (FILO) working group

article

Mutations des gènes impliqués dans l’épissage dans les hémopathies malignes humaines

article

NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique.

scientific article

No chromosome arm unturned: in memory of Roland Berger 1934-2012.

scientific article published in February 2014

No improvement in long-term survival over time for chronic lymphocytic leukemia patients in stereotyped subsets #1 and #2 treated with chemo(immuno)therapy

scientific article published on 21 December 2017

Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations

scientific article

Obinutuzumab and ibrutinib induction therapy followed by a minimal residual disease-driven strategy in patients with chronic lymphocytic leukaemia (ICLL07 FILO): a single-arm, multicentre, phase 2 trial

scientific article published on 16 July 2019

Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia.

scientific article

Poor prognosis of chromosome 7 clonal aberrations in Philadelphia-negative metaphases and relevance of potential underlying myelodysplastic features in chronic myeloid leukemia

scientific article published on 20 December 2018

Presence of multiple recurrent mutations confers poor trial outcome of relapsed/refractory CLL.

scientific article published on 27 August 2015

Prognosis of Binet stage A chronic lymphocytic leukemia patients: the strength of routine parameters

scientific article published on 25 August 2010

Recommendations for cytogenomic analysis of hematologic malignancies: comments from the Francophone Group of Hematological Cytogenetics (GFCH)

scientific article published on 20 December 2019

Recurrence of OTT-MAL fusion in t(1;22) of infant AML-M7.

scientific article published on January 2002

Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies

scientific article

Report of 34 patients with clonal chromosomal abnormalities in Philadelphia-negative cells during imatinib treatment of Philadelphia-positive chronic myeloid leukemia.

scientific article published on August 2004

Results of a randomized trial of chlorambucil versus fludarabine for patients with untreated Waldenström macroglobulinemia, marginal zone lymphoma, or lymphoplasmacytic lymphoma

scientific article

Rituximab maintenance versus observation following abbreviated induction with chemoimmunotherapy in elderly patients with previously untreated chronic lymphocytic leukaemia (CLL 2007 SA): an open-label, randomised phase 3 study

scientific article published on 20 December 2017

STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model.

scientific article published on 19 July 2013

Sex chromosome loss may represent a disease-associated clonal population in chronic lymphocytic leukemia

Specific chromosomal IG translocations have different prognoses in chronic lymphocytic leukemia

scientific article published on 15 April 2011

Spliceosome and other novel mutations in chronic lymphocytic leukemia and myeloid malignancies.

scientific article published on 09 April 2012

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

scientific journal article

Targeting chronic lymphocytic leukemia with N-methylated thrombospondin-1-derived peptides overcomes drug resistance

scientific article published on 01 October 2019

Telomere dysfunction-induced foci arise with the onset of telomeric deletions and complex chromosomal aberrations in resistant chronic lymphocytic leukemia cells

article published in 2010

The complex karyotype and chronic lymphocytic leukemia. A review of the literature

scientific article published on 10 August 2020

The most frequent t(14;19)(q32;q13)-positive B-cell malignancy corresponds to an aggressive subgroup of atypical chronic lymphocytic leukemia

article

The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion.

scientific article published on June 2000

The value of the monoclonal antibody, DBA44, in the diagnosis of B-lymphoid disorders

scientific article published on 01 November 1996

Therapy-related myelodysplastic syndrome after allogeneic BMT: successful treatment by donor lymphocyte infusions

scientific article published on 25 January 2010

Transcriptional activation of the cardiac homeobox gene CSX1/NKX2-5 in a B-cell chronic lymphoproliferative disorder

article

Trisomy 4 associated with double minute chromosomes and MYC amplification in acute myeloblastic leukemia

scientific article

Trisomy 4, a new chromosomal abnormality in Waldenström's macroglobulinemia: a study of 39 cases

scientific article published on 13 July 2006

When the eye gives it all: Diagnosis of relapsing acute myeloblastic leukemia with anterior chamber tap of a chronic hypopyon

scientific article published on 01 August 2014

[Chronic myeloid leukemia with variant e19a2 BCR-ABL1 fusion transcript: interest of the molecular identification at diagnosis for minimal residual disease follow-up].

scientific article

[Cytogenetic markers in chronic lymphocytic leukemia]

scientific article published on 01 May 2010

t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH).

scientific article published in September 2003

“Double-hit” chronic lymphocytic leukemia: An aggressive subgroup with 17p deletion and 8q24 gain

scientific article published on 18 December 2017

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