List of works - Dolors Serra Cucurull

(-)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects.

scientific article

Altered circadian rhythm and metabolic gene profile in rats subjected to advanced light phase shifts

scientific article published on 2 April 2015

An overview of nanomedicines for neuron targeting

scientific article published on 03 July 2020

Brown Adipose Tissue Bioenergetics: A New Methodological Approach

scientific article

C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight

scientific article

CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance

scientific article published on 24 October 2006

CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity.

scientific article

CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity

scientific journal article

Carnitine Palmitoyltransferase 1 Increases Lipolysis, UCP1 Protein Expression and Mitochondrial Activity in Brown Adipocytes

scientific article

Carnitine palmitoyltransferase 1C: From cognition to cancer.

scientific article published on 17 December 2015

Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance

scientific article published on 02 October 2014

Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition

scientific article

Ceramides and mitochondrial fatty acid oxidation in obesity.

scientific article

Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A

scientific article

Developmental changes in carnitine octanoyltransferase gene expression in intestine and liver of suckling rats

scientific article

Developmental changes in the phospho(enol)pyruvate carboxykinase gene expression in small intestine and liver of suckling rats.

scientific article published in May 1996

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation.

scientific article published on 24 February 2015

Enhancing hepatic fatty acid oxidation as a strategy for reversing metabolic disorders programmed by maternal undernutrition during gestation

scientific article published on 14 May 2014

Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes

scientific article

Fatty acid metabolism and the basis of brown adipose tissue function

scientific article

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.

scientific article published on 3 November 2014

Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex.

scientific article

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

scientific article published on 24 November 2017

Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin.

scientific article published on 14 March 2013

Hypothalamic regulation of liver and muscle nutrient partitioning by brain-specific carnitine palmitoyltransferase 1C (CPT1C) in male mice.

scientific article published on 3 May 2017

Identification of the two histidine residues responsible for the inhibition by malonyl-CoA in peroxisomal carnitine octanoyltransferase from rat liver

scientific article published on 18 January 2000

Impaired ketogenesis is a major mechanism for disturbed hepatic fatty acid metabolism in rats with long-term cholestasis and after relief of biliary obstruction

scientific journal article

Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake.

scientific article published on 4 June 2013

Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice

scientific article published on 22 November 2017

Influence of etomoxir on the expression of several genes in liver, testis and heart.

scientific article published on September 1995

Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues

scientific journal article

Ketogenic mitochondrial 3-hydroxy 3-methylglutaryl-CoA synthase gene expression in intestine and liver of suckling rats

scientific article published in March 1993

Localization of an exonic splicing enhancer responsible for mammalian natural trans-splicing.

scientific article

Long-term increased carnitine palmitoyltransferase 1A expression in ventromedial hypotalamus causes hyperphagia and alters the hypothalamic lipidomic profile

scientific article

Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a

scientific article published on 20 April 2011

Mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase and carnitine palmitoyltransferase II as potential control sites for ketogenesis during mitochondrion and peroxisome proliferation

scientific journal article

Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase promoter contains a CREB binding site that regulates cAMP action in Caco-2 cells

scientific article published on January 2000

Mitochondrial fatty acid oxidation in obesity

scientific article

Modulation in vitro of H-ras oncogene expression by trans-splicing

scientific article published in June 2001

Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation

scientific article published on 11 February 2011

Mutagenesis of Specific Amino Acids Converts Carnitine Acetyltransferase into Carnitine Palmitoyltransferase†

scientific article published in May 2006

Natural trans-splicing in carnitine octanoyltransferase pre-mRNAs in rat liver

scientific article

Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation

scientific article

Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells

scientific journal article

Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes

scientific article

Redesign of carnitine acetyltransferase specificity by protein engineering

scientific journal article

Regulation of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase protein by starvation, fat feeding, and diabetes

scientific journal article

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

scientific article published in March 2021

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

scientific article published on 23 December 2019

Short-term vitamin E treatment impairs reactive oxygen species signaling required for adipose tissue expansion, resulting in fatty liver and insulin resistance in obese mice

scientific article published on 13 October 2017

Structural (betaalpha)8 TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase

scientific article published on 13 May 2003

Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain

scientific journal article

Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal

scientific article

Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity

scientific article

Ten novel HMGCL mutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduria

scientific article

The effect of etomoxir on the mRNA levels of enzymes involved in ketogenesis and cholesterogenesis in rat liver

scientific article published in April 1994

The effect of fasting/refeeding and insulin treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats

scientific journal article

List of works by Dolors Serra Cucurull

(-)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects.

Altered circadian rhythm and metabolic gene profile in rats subjected to advanced light phase shifts

An overview of nanomedicines for neuron targeting

Brown Adipose Tissue Bioenergetics: A New Methodological Approach

C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight

CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance

CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity.

CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity

Carnitine Palmitoyltransferase 1 Increases Lipolysis, UCP1 Protein Expression and Mitochondrial Activity in Brown Adipocytes

Carnitine palmitoyltransferase 1C: From cognition to cancer.

Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance

Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition

Ceramides and mitochondrial fatty acid oxidation in obesity.

Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A

Developmental changes in carnitine octanoyltransferase gene expression in intestine and liver of suckling rats

Developmental changes in the phospho(enol)pyruvate carboxykinase gene expression in small intestine and liver of suckling rats.

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation.

Enhancing hepatic fatty acid oxidation as a strategy for reversing metabolic disorders programmed by maternal undernutrition during gestation

Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes

Fatty acid metabolism and the basis of brown adipose tissue function

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.

Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex.

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin.

Hypothalamic regulation of liver and muscle nutrient partitioning by brain-specific carnitine palmitoyltransferase 1C (CPT1C) in male mice.

Identification of the two histidine residues responsible for the inhibition by malonyl-CoA in peroxisomal carnitine octanoyltransferase from rat liver

Impaired ketogenesis is a major mechanism for disturbed hepatic fatty acid metabolism in rats with long-term cholestasis and after relief of biliary obstruction

Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake.

Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice

Influence of etomoxir on the expression of several genes in liver, testis and heart.

Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues

Ketogenic mitochondrial 3-hydroxy 3-methylglutaryl-CoA synthase gene expression in intestine and liver of suckling rats

Localization of an exonic splicing enhancer responsible for mammalian natural trans-splicing.

Long-term increased carnitine palmitoyltransferase 1A expression in ventromedial hypotalamus causes hyperphagia and alters the hypothalamic lipidomic profile

Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a

Mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase and carnitine palmitoyltransferase II as potential control sites for ketogenesis during mitochondrion and peroxisome proliferation

Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase promoter contains a CREB binding site that regulates cAMP action in Caco-2 cells

Mitochondrial fatty acid oxidation in obesity

Modulation in vitro of H-ras oncogene expression by trans-splicing

Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation

Mutagenesis of Specific Amino Acids Converts Carnitine Acetyltransferase into Carnitine Palmitoyltransferase†

Natural trans-splicing in carnitine octanoyltransferase pre-mRNAs in rat liver

Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation

Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells

Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes

Redesign of carnitine acetyltransferase specificity by protein engineering

Regulation of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase protein by starvation, fat feeding, and diabetes

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

Short-term vitamin E treatment impairs reactive oxygen species signaling required for adipose tissue expansion, resulting in fatty liver and insulin resistance in obese mice

Structural (betaalpha)8 TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase

Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain

Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal

Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity

Ten novel HMGCL mutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduria

The effect of etomoxir on the mRNA levels of enzymes involved in ketogenesis and cholesterogenesis in rat liver

The effect of fasting/refeeding and insulin treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats