List of works by Paola Secchiero

Aberrant expression of TRAIL in B chronic lymphocytic leukemia (B-CLL) cells

scientific article published on 01 November 2005

Accumulation of catalytically active PKC-zeta into the nucleus of HL-60 cell line plays a key role in the induction of granulocytic differentiation mediated by all-trans retinoic acid.

scientific article

Activated human NK and CD8+ T cells express both TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors but are resistant to TRAIL-mediated cytotoxicity

scientific article

Activation of the nitric oxide synthase pathway represents a key component of tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity on hematologic malignancies

scientific article

Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells

scientific article published on 13 November 2007

Activation of the p53 pathway induces α-smooth muscle actin expression in both myeloid leukemic cells and normal macrophages

scientific article published on 01 May 2012

An imbalanced OPG/TRAIL ratio is associated to severe acute myocardial infarction

An increased osteoprotegerin serum release characterizes the early onset of diabetes mellitus and may contribute to endothelial cell dysfunction

scientific article published on December 2006

Anti-leukemic activity of dasatinib in both p53(wild-type) and p53(mutated) B malignant cells

scientific article published on 16 October 2010

Antiangiogenic Activity of the MDM2 Antagonist Nutlin-3

scientific article published on 30 November 2006

Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA.

scientific article published in December 1997

Association of serum tumor necrosis factor-related apoptosis inducing ligand with body fat distribution as assessed by dual X-rays absorptiometry

scientific article

Association of soluble Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL) with central adiposity and low-density lipoprotein cholesterol.

scientific article

Association of tumor necrosis factor-related apoptosis-inducing ligand with total and cardiovascular mortality in older adults ⬇️

scientific article

Baseline serum concentrations of TRAIL in early rheumatoid arthritis: relationship with response to disease-modifying antirheumatic drugs

scientific article published on 15 May 2010

C-Reactive protein downregulates TRAIL expression in human peripheral monocytes via an Egr-1-dependent pathway

scientific article published on 6 March 2013

Cell-based therapies for diabetic complications

scientific article

Circulating TRAIL shows a significant post-partum decline associated to stressful conditions

scientific article

Circulating levels of frizzled-related protein (FRZB) are increased in patients with early rheumatoid arthritis and decrease in response to disease-modifying antirheumatic drugs

scientific article published on 06 May 2010

Cloning, restriction endonuclease mapping and partial sequence analysis of the genome of human herpesvirus 7 strain JI.

scientific article published on August 1996

Combined treatment of CpG-oligodeoxynucleotide with Nutlin-3 induces strong immune stimulation coupled to cytotoxicity in B-chronic lymphocytic leukemic (B-CLL) cells

scientific article published on 12 November 2007

Conjunctival sac fluid contains elevated levels of soluble TRAIL: implications for the anti-tumoral surveillance of the anterior surface of the eye.

scientific article published on January 2009

Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets

scientific article

Dasatinib plus Nutlin-3 shows synergistic antileukemic activity in both p53 wild-type and p53 mutated B chronic lymphocytic leukemias by inhibiting the Akt pathway

scientific article published on 24 November 2010

Decreased levels of soluble TNF-related apoptosis-inducing ligand (TRAIL) in the conjunctival sac fluid of patients with diabetes affected by proliferative retinopathy

scientific article published on 01 October 2011

Design, Synthesis, and Biological Characterization of Novel Mitochondria Targeted Dichloroacetate-Loaded Compounds with Antileukemic Activity

scientific article published on 11 December 2015

Detection of TP53 dysfunction in chronic lymphocytic leukemia by an in vitro functional assay based on TP53 activation by the non-genotoxic drug Nutlin-3: a proposal for clinical application.

scientific article

Dexamethasone counteracts the anti-osteoclastic, but not the anti-leukemic, activity of TNF-related apoptosis inducing ligand (TRAIL)

scientific article published on 01 February 2010

Differential effects of stromal derived factor-1 alpha (SDF-1 alpha) on early and late stages of human megakaryocytic development

article

Differential gene expression induction by TRAIL in B chronic lymphocytic leukemia (B-CLL) cells showing high versus low levels of Zap-70

article

Elevated levels of TRAIL in systemic lupus erythematosus are associated to the presence of anti-SSA/SSB antibodies

scientific article published on 01 January 2007

Endothelial PDGF-BB produced ex vivo correlates with relevant hemodynamic parameters in patients affected by chronic venous disease

scientific article published on 7 May 2013

Endothelial cells obtained from patients affected by chronic venous disease exhibit a pro-inflammatory phenotype

scientific article

Enforced expression of human bcl-2 in CD4+ T cells enhances human herpesvirus 7 replication and induction of cytopathic effects

scientific article published on May 1998

Evidence for a proangiogenic activity of TNF-related apoptosis-inducing ligand

scientific article

Evidence for a role of TNF-related apoptosis-inducing ligand (TRAIL) in the anemia of myelodysplastic syndromes

scientific article

Exposure of B cell chronic lymphocytic leukemia (B-CLL) cells to nutlin-3 induces a characteristic gene expression profile, which correlates with nutlin-3-mediated cytotoxicity.

scientific article published in June 2009

Functional expression of TRAIL and TRAIL-R2 during human megakaryocytic development

article

Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL).

scientific article published on 26 January 2006

GM-CSF exhibits anti-inflammatory activity on endothelial cells derived from chronic venous disease patients

scientific article

HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway

scientific article (publication date: February 2001)

HIV-1 Tat-mediated inhibition of the tyrosine hydroxylase gene expression in dopaminergic neuronal cells

scientific article (publication date: 11 February 2000)

Human bone marrow mesenchymal stem cells display anti-cancer activity in SCID mice bearing disseminated non-Hodgkin's lymphoma xenografts

scientific article

Human colostrum and breast milk contain high levels of TNF-related apoptosis-inducing ligand (TRAIL).

scientific article published on 23 April 2012

Human herpesvirus 6 (variant A) in Kaposi's sarcoma

scientific article published in The Lancet

Human herpesvirus 7 induces the functional up-regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) coupled to TRAIL-R1 down-modulation in CD4(+) T cells

scientific article

Human herpesvirus type 7 in Hodgkin's disease

scientific article published on 01 June 1998

Hydrogen sulfide down-regulates the expression and release of osteoprotegerin (OPG) by vascular endothelial cells

scientific article published on 04 May 2011

IFN-alpha2b increases interleukin-10 expression in primary activated human CD8+ T cells.

scientific article

Identification and analysis of a novel heparin-binding glycoprotein encoded by human herpesvirus 7.

scientific article published on May 2000

In Vitro Susceptibility of Macaca nemestrina to Human Herpesvirus 6: A Potential Animal Model of Coinfection with Primate Immunodeficiency Viruses

scientific article published on 01 February 1994

In vitro characterization of circulating endothelial progenitor cells isolated from patients with acute coronary syndrome

scientific article

In vitro endothelial cell proliferation assay reveals distinct levels of proangiogenic cytokines characterizing sera of healthy subjects and of patients with heart failure

scientific article published on 23 March 2014

In vivo anti-lymphoma activity of an agonistic human recombinant anti-TRAIL-R2 minibody

scientific article published on 17 August 2010

Inhibitory effect of natural anti-inflammatory compounds on cytokines released by chronic venous disease patient-derived endothelial cells

scientific article published on 31 December 2013

Intranasal administration of recombinant TRAIL down-regulates CXCL-1/KC in an ovalbumin-induced airway inflammation murine model

scientific article

Inverse correlation between circulating levels of TNF-related apoptosis-inducing ligand and 17β-estradiol

scientific article

Involvement of TRAIL/TRAIL-receptors in human intestinal cell differentiation

scientific article published on March 2006

Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by selective up-regulation of TRAIL-R1

scientific article published on 01 May 2001

Is there any role for tumour necrosis factor related apoptosis inducing ligand-osteoprotegerin (TRAIL-OPG) interaction in rheumatoid arthritis?

scientific article published on 01 August 2008

Is vestibular papillomatosis associated with human papillomavirus?

scientific article published on 01 September 1991

JCV+ Patients with Inflammatory Bowel Disease show elevated plasma levels of MIG and SCF

Latent BK virus infection and Kaposi's sarcoma pathogenesis

scientific article published in June 1996

Letter by Secchiero and Zauli regarding article, "Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice".

scientific article

Levels of TNF-related apoptosis-inducing ligand (TRAIL) show a long-term stability in the breast milk of mothers of preterm infants

scientific article published on 14 March 2013

Levels of circulating TNF-related apoptosis-inducing ligand in celiac disease

scientific article

MCL1 down-regulation plays a critical role in mediating the higher anti-leukaemic activity of the multi-kinase inhibitor Sorafenib with respect to Dasatinib.

scientific article published on 8 February 2012

MDM2 antagonist Nutlin-3 suppresses the proliferation and differentiation of human pre-osteoclasts through a p53-dependent pathway.

scientific article published in October 2007

MDM2 non-genotoxic inhibitors as innovative therapeutic approaches for the treatment of pediatric malignancies

scientific article

MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53wild-type CLL with a poor cytotoxic response to Nutlin-3.

scientific article published on 28 April 2010

Mechanisms of remodelling: a question of life (stem cell production) and death (myocyte apoptosis).

scientific article published on 10 October 2009

Merkel-cell polyomavirus (MCPyV) is rarely associated to B-chronic lymphocytic leukemia (1 out of 50) samples and occurs late in the natural history of the disease.

scientific article published on 7 September 2012

Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts

scientific article published on 9 September 2010

Metalloproteinase 2 cleaves in vitro recombinant TRAIL: potential implications for the decreased serum levels of TRAIL after acute myocardial infarction

scientific article published on 24 February 2010

MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer

scientific article

MicroRNAs as new players in the genomic galaxy and disease puzzles

scientific article

Modulation of circulating cytokine-chemokine profile in patients affected by chronic venous insufficiency undergoing surgical hemodynamic correction

scientific article published on 25 March 2014

Modulation of the expression and activity of cyclooxygenases in normal and accelerated erythropoiesis

scientific article published in October 2004

Molecular targets for selective killing of TRAIL-resistant leukemic cells

scientific article

Multiple dye-doped NIR-emitting silica nanoparticles for both flow cytometry and in vivo imaging

scholarly article in RSC Advances, vol. 4 no. 35, 2014

NK-active cytokines IL-2, IL-12, and IL-15 selectively modulate specific protein kinase C (PKC) isoforms in primary human NK cells

scientific article published in February 2002

NK-active cytokines IL-2, IL-12, and IL-15 selectively modulate specific protein kinase C (PKC) isoforms in primary human NK cells

Nanoparticles engineered with rituximab and loaded with Nutlin-3 show promising therapeutic activity in B-leukemic xenografts

scientific article published on 29 May 2013

Nanoparticles loaded with Nutlin-3 display cytotoxicity towards p53(wild-type) JVM-2 but not towards p53(mutated) BJAB leukemic cells

scientific article published on January 2013

Nutlin-3 downregulates the expression of the oncogene TCL1 in primary B chronic lymphocytic leukemic cells

scientific article published on 13 July 2011

Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism

scientific article

Osteoprotegerin increases in metabolic syndrome and promotes adipose tissue proinflammatory changes.

scientific article published on 3 July 2014

Osteoprotegerin increases leukocyte adhesion to endothelial cells both in vitro and in vivo

scientific article published on 15 March 2007

Osteoprotegerin induces morphological and functional alterations in mouse pancreatic islets

Osteoprotegerin promotes vascular fibrosis via a TGF-β1 autocrine loop

scientific article published on 27 May 2011

Patients affected by metabolic syndrome show decreased levels of circulating platelet derived growth factor (PDGF)-BB.

scientific article

Pegylated TRAIL retains anti-leukemic cytotoxicity and exhibits improved signal transduction activity with respect to TRAIL.

scientific article published on 2 December 2010

Perifosine plus nutlin-3 combination shows a synergistic anti-leukaemic activity

scientific article published in December 2009

Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication

scientific article

Potential involvement of TRAIL in Treg cell–mediated osteoclast suppression: Comment on the article by Zaiss et al

scientific article published on 01 June 2008

Potential pathogenetic implications of cyclooxygenase-2 overexpression in B chronic lymphoid leukemia cells

scientific article

Potential prognostic significance of decreased serum levels of TRAIL after acute myocardial infarction

scientific article

Potential role of TRAIL in the management of autoimmune diabetes mellitus

scientific article published on January 2012

Presence and physical state of HPV DNA in prostate and urinary-tract tissues

scientific article

Proper design of silica nanoparticles combines high brightness, lack of cytotoxicity and efficient cell endocytosis

scientific article published on September 2013

Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL) Modulates the Expression of Genes Involved in Apoptosis and Cell Cycle in Human Osteoclasts

article

Reduced expression of cell cycle-associated genes in B lymphocytes purified from the peripheral blood of early-stage B chronic lymphocytic leukaemia patients.

scientific article published on 4 February 2009

Rehabilitation Improves Mitochondrial Energetics in Progressive Multiple Sclerosis: The Significant Role of Robot-Assisted Gait Training and of the Personalized Intensity

scientific article published on 17 October 2020

Release of a specific set of proinflammatory adipokines by differentiating 3T3-L1 cells

scientific article published on January 2013

Role of TRAIL in osteoclastogenesis

Role of full-length osteoprotegerin in tumor cell biology

scientific article published on March 2009

Role of the RANKL/RANK system in the induction of interleukin-8 (IL-8) in B chronic lymphocytic leukemia (B-CLL) cells

scientific article published in April 2006

Selective induction of TP53I3/p53-inducible gene 3 (PIG3) in myeloid leukemic cells, but not in normal cells, by Nutlin-3.

scientific article published on 28 November 2012

Serum TRAIL levels increase shortly after insulin therapy and metabolic stabilization in children with type 1 diabetes mellitus

scientific article

Simultaneous determination of multiple cytokines reveals a pro-inflammatory and pro-angiogenic signature after major cardiothoracic surgery: Potential role of C-reactive protein

Soluble TRAIL does not impair the anti-osteoclastic activity of osteoprotegerin

scientific article published on 4 February 2008

Soluble TRAIL is elevated in recurrent miscarriage and inhibits the in vitro adhesion and migration of HTR8 trophoblastic cells

scientific article published on 21 August 2012

Soluble TRAIL is present at high concentrations in seminal plasma and promotes spermatozoa survival

scholarly article by Giorgio Zauli et al published August 2014 in Reproduction

Sorafenib inhibits in vitro osteoclastogenesis by down-modulating Mcl-1.

scientific article

State of art and recent developments of anti-cancer strategies based on TRAIL.

scientific article published on May 2012

State of the art of the therapeutic perspective of sorafenib against hematological malignancies

scientific article published on January 2012

Stromal derived factor-1α induces apoptosis in activated primary CD4+ T cells

scientific article published on 01 April 2000

Synergistic cytotoxic activity of recombinant TRAIL plus the non-genotoxic activator of the p53 pathway nutlin-3 in acute myeloid leukemia cells

scientific article published on May 2007

Systemic Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Delivery Shows Antiatherosclerotic Activity in Apolipoprotein E–Null Diabetic Mice

scientific article published on 25 September 2006

TNF-alpha modulates the migratory response of mesenchymal stem cells to TRAIL.

scientific article

TNF-related apoptosis inducing ligand in ocular cancers and ocular diabetic complications

scientific article published on 5 March 2015

TNF-related apoptosis-inducing ligand (TRAIL) blocks osteoclastic differentiation induced by RANKL plus M-CSF.

scientific article published on 22 June 2004

TNF-related apoptosis-inducing ligand (TRAIL): a potential candidate for combined treatment of hematological malignancies

scientific article

TNF-related apoptosis-inducing ligand significantly attenuates metabolic abnormalities in high-fat-fed mice reducing adiposity and systemic inflammation.

scientific article published in November 2012

TRAIL Promotes the Survival and Proliferation of Primary Human Vascular Endothelial Cells by Activating the Akt and ERK Pathways

scientific article published on 31 March 2003

TRAIL administration down-modulated the acute systemic inflammatory response induced in a mouse model by muramyldipeptide or lipopolysaccharide

scientific article published on 21 June 2012

TRAIL and osteoprotegerin: a role in endothelial physiopathology?

scientific article published on January 2008

TRAIL as biomarker and potential therapeutic tool for cardiovascular diseases

scientific article published on August 2012

TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release

scientific article published on 11 January 2005

TRAIL inhibits osteoclastic differentiation by counteracting RANKL-dependent p27Kip1 accumulation in pre-osteoclast precursors

scientific article published on 01 January 2008

TRAIL modulates the immune system and protects against the development of diabetes

scientific article

TRAIL pathway components and their putative role in granulosa cell apoptosis in the human ovary.

scientific article published on 20 January 2009

TRAIL promotes the survival, migration and proliferation of vascular smooth muscle cells

scientific article published on 01 August 2004

TRAIL regulates normal erythroid maturation through an ERK-dependent pathway

scientific article published on 11 September 2003

TRAIL shows potential cardioprotective activity

TRAIL, a New Weapon against Neointimal Hyperplasia

scientific article published on 27 September 2012

TRAIL, caspases and maturation of normal and leukemic myeloid precursors

scientific article published on August 2006

The MDM-2 antagonist nutlin-3 promotes the maturation of acute myeloid leukemic blasts

scientific article published on October 2007

The MDM2 inhibitor Nutlin-3 attenuates streptozotocin-induced diabetes mellitus and increases serum level of IL-12p40.

scientific article published on 25 April 2013

The MDM2 inhibitor Nutlins as an innovative therapeutic tool for the treatment of haematological malignancies

scientific article published on January 2008

The Puzzling Role of TRAIL in Endothelial Cell Biology

scientific article published on 01 February 2008

The circulating levels of TRAIL are extremely low after delivery but rapidly recover in both mothers and newborns

scientific article

The early determination of circulating TRAIL levels does not predict the development of pre-eclampsia

article

The energy balance positively regulates the levels of circulating TNF-related apoptosis inducing ligand in humans.

scientific article

The engagement of CD4 surface antigen in the HEL haemopoietic cell line up-regulates the transforming growth factor-beta1 (TGF-beta1) promoter activity.

scientific article published on June 1997

The expression levels of the pro-apoptotic XAF-1 gene modulate the cytotoxic response to Nutlin-3 in B chronic lymphocytic leukemia

scientific article published on 22 October 2009

The levels of circulating TRAIL at the onset of type 1 diabetes are markedly decreased in patients with ketoacidosis and with the highest insulin requirement

scientific article published on 8 August 2013

The negative prognostic value of TRAIL overexpression in oral squamous cell carcinomas does not preclude the potential therapeutic use of recombinant TRAIL

The oncogene DEK promotes leukemic cell survival and is downregulated by both Nutlin-3 and chlorambucil in B-chronic lymphocytic leukemic cells

scientific article published on 9 March 2010

The role of the TRAIL/TRAIL receptors system in hematopoiesis and endothelial cell biology

scientific article

The soluble terminal complement complex (SC5b-9) up-regulates osteoprotegerin expression and release by endothelial cells: implications in rheumatoid arthritis

scientific article published on 23 January 2009

The sorafenib plus nutlin-3 combination promotes synergistic cytotoxicity in acute myeloid leukemic cells irrespectively of FLT3 and p53 status

scientific article

The tumour necrosis factor-related apoptosis-inducing ligand-osteoprotegerin system in limited systemic sclerosis: a new disease marker?

scientific article published on 18 March 2010

Trail down-regulates the release of osteoprotegerin (OPG) by primary stromal cells

scientific article published on September 2011

Treatment with recombinant tumor necrosis factor-related apoptosis-inducing ligand alleviates the severity of streptozotocin-induced diabetes

scientific article

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and TNF-alpha promote the NF-kappaB-dependent maturation of normal and leukemic myeloid cells

scientific article published in August 2003

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sequentially upregulates nitric oxide and prostanoid production in primary human endothelial cells

scientific article published on 20 March 2003

Tumor necrosis factor-related apoptosis-inducing ligand induces monocytic maturation of leukemic and normal myeloid precursors through a caspase-dependent pathway

scientific article published on October 2002

Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells.

scientific article published on 4 September 2008

Tumor-necrosis-factor-related apoptosis-inducing ligand and the regulation of hematopoiesis

scientific article published on January 2008

Tumour necrosis factor-related apoptosis-inducing ligand sequentially activates pro-survival and pro-apoptotic pathways in SK-N-MC neuronal cells

scientific article published on 01 July 2003

Unsung Hero Robert C. Gallo

scientific article

Upregulation of SOCS-1 by Nutlin-3 in acute myeloid leukemia cells but not in primary normal cells

scientific article published on January 2014

miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation

scientific article

miR-34a induces the downregulation of both E2F1 and B-Myb oncogenes in leukemic cells

scientific article

microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival

scientific article published on 14 April 2010

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