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List of works by Paola Secchiero

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miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation

scientific article
Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA.

scientific article published in December 1997
TRAIL Promotes the Survival and Proliferation of Primary Human Vascular Endothelial Cells by Activating the Akt and ERK Pathways

scientific article published on 31 March 2003
microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival

scientific article published on 14 April 2010
Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets

scientific article
Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL).

scientific article published on 26 January 2006
Human bone marrow mesenchymal stem cells display anti-cancer activity in SCID mice bearing disseminated non-Hodgkin's lymphoma xenografts

scientific article
Activated human NK and CD8+ T cells express both TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors but are resistant to TRAIL-mediated cytotoxicity

scientific article
Systemic Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Delivery Shows Antiatherosclerotic Activity in Apolipoprotein E–Null Diabetic Mice

scientific article published on 25 September 2006
TRAIL promotes the survival, migration and proliferation of vascular smooth muscle cells

scientific article published on 01 August 2004
MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer

scientific article
Antiangiogenic Activity of the MDM2 Antagonist Nutlin-3

scientific article published on 30 November 2006
The role of the TRAIL/TRAIL receptors system in hematopoiesis and endothelial cell biology

scientific article
Evidence for a role of TNF-related apoptosis-inducing ligand (TRAIL) in the anemia of myelodysplastic syndromes

scientific article
HIV-1 Tat-mediated inhibition of the tyrosine hydroxylase gene expression in dopaminergic neuronal cells

scientific article (publication date: 11 February 2000)
TRAIL regulates normal erythroid maturation through an ERK-dependent pathway

scientific article published on 11 September 2003
Role of full-length osteoprotegerin in tumor cell biology

scientific article published on March 2009
An increased osteoprotegerin serum release characterizes the early onset of diabetes mellitus and may contribute to endothelial cell dysfunction

scientific article published on December 2006
Osteoprotegerin increases leukocyte adhesion to endothelial cells both in vitro and in vivo

scientific article published on 15 March 2007
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sequentially upregulates nitric oxide and prostanoid production in primary human endothelial cells

scientific article published on 20 March 2003
Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism

scientific article
Latent BK virus infection and Kaposi's sarcoma pathogenesis

scientific article published in June 1996
TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release

scientific article published on 11 January 2005
Potential prognostic significance of decreased serum levels of TRAIL after acute myocardial infarction

scientific article
The MDM2 inhibitor Nutlins as an innovative therapeutic tool for the treatment of haematological malignancies

scientific article published on January 2008
TNF-related apoptosis-inducing ligand (TRAIL) blocks osteoclastic differentiation induced by RANKL plus M-CSF.

scientific article published on 22 June 2004
miR-34a induces the downregulation of both E2F1 and B-Myb oncogenes in leukemic cells

scientific article
Tumor-necrosis-factor-related apoptosis-inducing ligand and the regulation of hematopoiesis

scientific article published on January 2008
Association of tumor necrosis factor-related apoptosis-inducing ligand with total and cardiovascular mortality in older adults

scientific article
Tumor necrosis factor-related apoptosis-inducing ligand induces monocytic maturation of leukemic and normal myeloid precursors through a caspase-dependent pathway

scientific article published on October 2002
Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by selective up-regulation of TRAIL-R1

scientific article published on 01 May 2001
Treatment with recombinant tumor necrosis factor-related apoptosis-inducing ligand alleviates the severity of streptozotocin-induced diabetes

scientific article
Tumour necrosis factor-related apoptosis-inducing ligand sequentially activates pro-survival and pro-apoptotic pathways in SK-N-MC neuronal cells

scientific article published on 01 July 2003
Synergistic cytotoxic activity of recombinant TRAIL plus the non-genotoxic activator of the p53 pathway nutlin-3 in acute myeloid leukemia cells

scientific article published on May 2007
Evidence for a proangiogenic activity of TNF-related apoptosis-inducing ligand

scientific article
Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells.

scientific article published on 4 September 2008
Dasatinib plus Nutlin-3 shows synergistic antileukemic activity in both p53 wild-type and p53 mutated B chronic lymphocytic leukemias by inhibiting the Akt pathway

scientific article published on 24 November 2010
An imbalanced OPG/TRAIL ratio is associated to severe acute myocardial infarction

Human herpesvirus 6 (variant A) in Kaposi's sarcoma

scientific article published in The Lancet
The sorafenib plus nutlin-3 combination promotes synergistic cytotoxicity in acute myeloid leukemic cells irrespectively of FLT3 and p53 status

scientific article
TNF-related apoptosis-inducing ligand significantly attenuates metabolic abnormalities in high-fat-fed mice reducing adiposity and systemic inflammation

scientific article published in November 2012
TRAIL inhibits osteoclastic differentiation by counteracting RANKL-dependent p27Kip1 accumulation in pre-osteoclast precursors

scientific article published on 01 January 2008
Involvement of TRAIL/TRAIL-receptors in human intestinal cell differentiation

scientific article published on March 2006
Osteoprotegerin promotes vascular fibrosis via a TGF-β1 autocrine loop

scientific article published on 27 May 2011
Presence and physical state of HPV DNA in prostate and urinary-tract tissues

scientific article published on 01 September 1992
Endothelial cells obtained from patients affected by chronic venous disease exhibit a pro-inflammatory phenotype

scientific article
Cell-based therapies for diabetic complications

scientific article
C-Reactive protein downregulates TRAIL expression in human peripheral monocytes via an Egr-1-dependent pathway

scientific article published on 6 March 2013
The MDM-2 antagonist nutlin-3 promotes the maturation of acute myeloid leukemic blasts

scientific article published on October 2007
Potential pathogenetic implications of cyclooxygenase-2 overexpression in B chronic lymphoid leukemia cells

scientific article

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