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List of works by Paola Secchiero

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Activation of the nitric oxide synthase pathway represents a key component of tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity on hematologic malignancies

scientific article
HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway

scientific article (publication date: February 2001)
State of art and recent developments of anti-cancer strategies based on TRAIL.

scientific article published on May 2012
Proper design of silica nanoparticles combines high brightness, lack of cytotoxicity and efficient cell endocytosis

scientific article published on September 2013
Osteoprotegerin increases in metabolic syndrome and promotes adipose tissue proinflammatory changes

scientific article published on 3 July 2014
Osteoprotegerin induces morphological and functional alterations in mouse pancreatic islets

TRAIL and osteoprotegerin: a role in endothelial physiopathology?

scientific article published on January 2008
Differential effects of stromal derived factor-1 alpha (SDF-1 alpha) on early and late stages of human megakaryocytic development

article
TNF-related apoptosis-inducing ligand (TRAIL): a potential candidate for combined treatment of hematological malignancies

scientific article
MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53wild-type CLL with a poor cytotoxic response to Nutlin-3.

scientific article published on 28 April 2010
The oncogene DEK promotes leukemic cell survival and is downregulated by both Nutlin-3 and chlorambucil in B-chronic lymphocytic leukemic cells

scientific article published on 9 March 2010
Mechanisms of remodelling: a question of life (stem cell production) and death (myocyte apoptosis).

scientific article published on 10 October 2009
In vitro characterization of circulating endothelial progenitor cells isolated from patients with acute coronary syndrome

scientific article
Role of the RANKL/RANK system in the induction of interleukin-8 (IL-8) in B chronic lymphocytic leukemia (B-CLL) cells

scientific article published in April 2006
Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication

scientific article
Nanoparticles engineered with rituximab and loaded with Nutlin-3 show promising therapeutic activity in B-leukemic xenografts

scientific article published on 29 May 2013
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and TNF-alpha promote the NF-kappaB-dependent maturation of normal and leukemic myeloid cells

scientific article published in August 2003
The soluble terminal complement complex (SC5b-9) up-regulates osteoprotegerin expression and release by endothelial cells: implications in rheumatoid arthritis

scientific article published on 23 January 2009
In Vitro Susceptibility of Macaca nemestrina to Human Herpesvirus 6: A Potential Animal Model of Coinfection with Primate Immunodeficiency Viruses

scientific article published on 01 February 1994
Metalloproteinase 2 cleaves in vitro recombinant TRAIL: potential implications for the decreased serum levels of TRAIL after acute myocardial infarction

scientific article published on 24 February 2010
TRAIL shows potential cardioprotective activity

Association of soluble Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL) with central adiposity and low-density lipoprotein cholesterol.

scientific article
Endothelial PDGF-BB produced ex vivo correlates with relevant hemodynamic parameters in patients affected by chronic venous disease

scientific article published on 7 May 2013
MDM2 antagonist Nutlin-3 suppresses the proliferation and differentiation of human pre-osteoclasts through a p53-dependent pathway

scientific article published in October 2007
Human herpesvirus type 7 in Hodgkin's disease

scientific article published on 01 June 1998
NK-active cytokines IL-2, IL-12, and IL-15 selectively modulate specific protein kinase C (PKC) isoforms in primary human NK cells

scientific article published in February 2002
Inhibitory effect of natural anti-inflammatory compounds on cytokines released by chronic venous disease patient-derived endothelial cells

scientific article published on 31 December 2013
TRAIL modulates the immune system and protects against the development of diabetes

scientific article
Accumulation of catalytically active PKC-zeta into the nucleus of HL-60 cell line plays a key role in the induction of granulocytic differentiation mediated by all-trans retinoic acid.

scientific article published on 01 March 1998
Identification and analysis of a novel heparin-binding glycoprotein encoded by human herpesvirus 7.

scientific article published on May 2000
Nutlin-3 downregulates the expression of the oncogene TCL1 in primary B chronic lymphocytic leukemic cells

scientific article published on 13 July 2011
Aberrant expression of TRAIL in B chronic lymphocytic leukemia (B-CLL) cells

scientific article published on 01 November 2005
Human herpesvirus 7 induces the functional up-regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) coupled to TRAIL-R1 down-modulation in CD4(+) T cells

scientific article
Intranasal administration of recombinant TRAIL down-regulates CXCL-1/KC in an ovalbumin-induced airway inflammation murine model

scientific article
Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells

scientific article published on 13 November 2007
The levels of circulating TRAIL at the onset of type 1 diabetes are markedly decreased in patients with ketoacidosis and with the highest insulin requirement

scientific article published on 8 August 2013
The Puzzling Role of TRAIL in Endothelial Cell Biology

scientific article published on 01 February 2008
Patients affected by metabolic syndrome show decreased levels of circulating platelet derived growth factor (PDGF)-BB.

scientific article
Cloning, restriction endonuclease mapping and partial sequence analysis of the genome of human herpesvirus 7 strain JI.

scientific article published on August 1996
The MDM2 inhibitor Nutlin-3 attenuates streptozotocin-induced diabetes mellitus and increases serum level of IL-12p40.

scientific article published on 25 April 2013
Detection of TP53 dysfunction in chronic lymphocytic leukemia by an in vitro functional assay based on TP53 activation by the non-genotoxic drug Nutlin-3: a proposal for clinical application.

scientific article
Soluble TRAIL is elevated in recurrent miscarriage and inhibits the in vitro adhesion and migration of HTR8 trophoblastic cells

scientific article published on 21 August 2012
TNF-alpha modulates the migratory response of mesenchymal stem cells to TRAIL.

scientific article
Functional expression of TRAIL and TRAIL-R2 during human megakaryocytic development

article
State of the art of the therapeutic perspective of sorafenib against hematological malignancies

scientific article published on January 2012
TRAIL as Biomarker and Potential Therapeutic Tool for Cardiovascular Diseases

scientific article published on August 1, 2012
The energy balance positively regulates the levels of circulating TNF-related apoptosis inducing ligand in humans

scientific article
MCL1 down-regulation plays a critical role in mediating the higher anti-leukaemic activity of the multi-kinase inhibitor Sorafenib with respect to Dasatinib

scientific article published on 8 February 2012
TRAIL pathway components and their putative role in granulosa cell apoptosis in the human ovary.

scientific article published on 20 January 2009
Modulation of circulating cytokine-chemokine profile in patients affected by chronic venous insufficiency undergoing surgical hemodynamic correction

scientific article published on 25 March 2014

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