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List of works by Colin W. Pouton

'Stealth' lipid-based formulations: poly(ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug

scientific article published on 22 July 2014

50years of oral lipid-based formulations: Provenance, progress and future perspectives

scientific article published on 15 April 2016

8-(omega-aminoalkyl)theophyllines and their use in preparing fluorescently labeled derivatives for applications in immunoassay

scientific article published on 01 July 1997

A Nonionic Polyethylene Oxide (PEO) Surfactant Model: Experimental and Molecular Dynamics Studies of Kolliphor EL

scientific article published on 28 November 2018

A PITX3-EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells

scientific article

A comparison of the lung clearance kinetics of Solid lipid nanoparticles and Liposomes by following the 3H-labelled structural lipids after pulmonary delivery in rats.

scientific article published on 5 January 2018

A microtubule-facilitated nuclear import pathway for cancer regulatory proteins.

scientific article published on June 2007

A new in vitro lipid digestion - in vivo absorption model to evaluate the mechanisms of drug absorption from lipid-based formulations

scientific article published on 24 December 2015

A novel highly selective adenosine A1 receptor agonist VCP28 reduces ischemia injury in a cardiac cell line and ischemia-reperfusion injury in isolated rat hearts at concentrations that do not affect heart rate

scientific article published on September 2010

A stably engineered, suicidal strain of listeria monocytogenes delivers protein and/or DNA to fully differentiated intestinal epithelial monolayers.

scientific article

A suicidal strain of Listeria monocytogenes is effective as a DNA vaccine delivery system for oral administration.

scientific article

A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives.

scientific article published on March 2011

Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke.

scientific article published on 30 January 2018

An in vitro digestion test that reflects rat intestinal conditions to probe the importance of formulation digestion vs first pass metabolism in Danazol bioavailability from lipid based formulations

scientific article published on 29 September 2014

Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine.

scientific article published on May 2009

Characterising the developmental profile of human embryonic stem cell-derived medium spiny neuron progenitors and assessing mature neuron function using a CRISPR-generated human DARPP-32WT/eGFP-AMP reporter line

scientific article published on 5 January 2017

Choice of nonionic surfactant used to formulate type IIIA self-emulsifying drug delivery systems and the physicochemical properties of the drug have a pronounced influence on the degree of drug supersaturation that develops during in vitro digestion

scientific article published on 27 January 2014

Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination

scientific article

Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs

scientific article published on 21 January 2019

Colloidal characteristics and formulation of pure protein particulate vaccines

scientific article published on 29 May 2012

Commercially Supplied Amine-Modified siRNAs May Require Ultrafiltration prior to Conjugation with Amine-Reactive Compounds

scientific article published on 29 May 2011

Comparing mouse and human pluripotent stem cell derived cardiac cells: Both systems have advantages for pharmacological and toxicological screening

scientific article published on 06 May 2015

Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon

scientific article published on 12 January 2007

Computational Models of the Gastrointestinal Environment. 1. The Effect of Digestion on the Phase Behavior of Intestinal Fluids.

scientific article

Computational Models of the Gastrointestinal Environment. 2. Phase Behavior and Drug Solubilization Capacity of a Type I Lipid-Based Drug Formulation after Digestion.

scientific article

Computational Models of the Intestinal Environment. 3. The Impact of Cholesterol Content and pH on Mixed Micelle Colloids.

scientific article

Cooperative cardioprotection through adenosine A1 and A2A receptor agonism in ischemia-reperfused isolated mouse heart

scientific article published on October 2010

DNA-dependent protein kinase is a context dependent regulator of Lmx1a and midbrain specification

scientific article

Design of lipid-based formulations for oral administration of poorly water-soluble drugs: precipitation of drug after dispersion of formulations in aqueous solution.

scientific article published in October 2009

Digestion of phospholipids after secretion of bile into the duodenum changes the phase behavior of bile components.

scientific article published on 16 July 2014

Directed expression of Gata2, Mash1, and Foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells

scientific article published in June 2011

Disposition and safety of inhaled biodegradable nanomedicines: Opportunities and challenges

scientific article published on 23 March 2016

Dual acting antioxidant A1 adenosine receptor agonists.

scientific article published on 25 July 2007

Dynein light chain association sequences can facilitate nuclear protein import

scientific article

Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers.

scientific article published on 13 July 2017

Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents.

scientific article

Electrical and neurotransmitter activity of mature neurons derived from mouse embryonic stem cells by Sox-1 lineage selection and directed differentiation.

scientific article

Embryonic stem cells as a source of models for drug discovery

scientific article published in August 2007

Endothelin-1 and angiotensin II modulate rate and contraction amplitude in a subpopulation of mouse embryonic stem cell-derived cardiomyocyte-containing bodies

scientific article published on 18 September 2010

Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNA-albumin conjugation

scientific article published on 19 December 2011

Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid Based Formulations

scientific article published on 13 November 2018

Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs.

scientific article published in February 2008

Evaluation of the structural determinants of polymeric precipitation inhibitors using solvent shift methods and principle component analysis.

scientific article published on 2 July 2013

Extended periods of neural induction and propagation of embryonic stem cell-derived neural progenitors with EGF and FGF2 enhances Lmx1a expression and neurogenic potential

scientific article

Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies.

scientific article

Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system.

scientific article published on 16 May 2006

Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants

article

Glyceride lipid formulations: molecular dynamics modeling of phase behavior during dispersion and molecular interactions between drugs and excipients

scientific article published on 3 October 2013

Haplotyping the human leukocyte antigen system from single chromosomes.

scientific article published on 27 July 2016

Heterogeneous population of dopaminergic neurons derived from mouse embryonic stem cells: preliminary phenotyping based on receptor expression and function

scientific article published in April 2007

High Molecular Weight DNA Enrichment with Peptide Nucleic Acid Probes.

scientific article published in January 2017

Human leukocyte antigen haplotype phasing by allele-specific enrichment with peptide nucleic acid probes

scientific article

Human pluripotent stem cell derived midbrain PITX3(eGFP/w) neurons: a versatile tool for pharmacological screening and neurodegenerative modeling

scientific article published on 31 March 2015

Identification of a melanocortin receptor expressed by murine brain microvascular endothelial cells in culture

scientific article published on 01 July 1995

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

scientific article published on 13 April 2020

Improvement in the Predicted Partitioning of Alcohol and Polyethylene Oxide Groups Between Water and Octanol (logP) in Molecular Dynamics Simulations

scientific article published on 20 November 2018

In vitro assessment of drug-free and fenofibrate-containing lipid formulations using dispersion and digestion testing gives detailed insights into the likely fate of formulations in the intestine

scientific article published on 16 May 2013

In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion products.

scientific article published on 23 November 2012

In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation

scientific article

Inclusion of Digestible Surfactants in Solid SMEDDS Formulation Removes Lag Time and Influences the Formation of Structured Particles During Digestion.

scientific article published on 23 January 2017

Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs

scientific article published on 15 February 2007

Interaction of viruses with host cell molecular motors.

scientific article published on 16 July 2010

Investigations into the binding affinities of different human 5-HT4 receptor splice variants.

scientific article published on 17 March 2010

Isolation of LMX1a Ventral Midbrain Progenitors Improves the Safety and Predictability of Human Pluripotent Stem Cell-Derived Neural Transplants in Parkinsonian Disease

scientific article published on 22 October 2019

Key issues in non-viral gene delivery.

scientific article

Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug delivery systems.

scientific article published on 15 June 2012

Lipid-based formulations and drug supersaturation: harnessing the unique benefits of the lipid digestion/absorption pathway.

scientific article published on 04 July 2013

Local inflammation alters the lung disposition of a drug loaded pegylated liposome after pulmonary dosing to rats

scientific article published on 29 May 2019

Location of Solvated Probe Molecules within Non-Ionic Surfactant Micelles using Molecular Dynamics

scientific article published on 03 November 2018

Midbrain and forebrain patterning delivers immunocytochemically and functionally similar populations of neuropeptide Y containing GABAergic neurons.

scientific article

Modulation of nucleocytoplasmic trafficking by retention in cytoplasm or nucleus

scientific article

NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes.

scientific article published on 23 October 2011

Non-linear increases in danazol exposure with dose in older vs. younger beagle dogs: the potential role of differences in bile salt concentration, thermodynamic activity, and formulation digestion

scientific article published on 30 January 2014

Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides.

scientific article published on 23 March 2009

PI3K Activation in Neural Stem Cells Drives Tumorigenesis which can be Ameliorated by Targeting the cAMP Response Element Binding (CREB) Protein.

scientific article

Pharmaceutical and biological properties of poly(amino acid)/DNA polyplexes

scientific article published on 01 January 1999

Polymeric Nanotubes as Drug Delivery Vectors─Comparison of Covalently and Supramolecularly Assembled Constructs

scientific article published on 18 May 2022

Polymeric Precipitation Inhibitors Promote Fenofibrate Supersaturation and Enhance Drug Absorption from a Type IV Lipid-Based Formulation.

scientific article published on 16 April 2018

Polymeric materials for advanced drug delivery.

scientific article

Preparation and in vitro evaluation of novel lipopeptide transfection agents for efficient gene delivery

scientific article published on 12 March 2008

SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development.

scientific article published on 4 May 2014

Self-Crosslinking Lipopeptide/DNA/PEGylated Particles: A New Platform for DNA Vaccination Designed for Assembly in Aqueous Solution.

scientific article published on 18 July 2018

Solubilisation behaviour of poorly water-soluble drugs during digestion of solid SMEDDS

scientific article published on 04 July 2018

Specification of murine ground state pluripotent stem cells to regional neuronal populations.

scientific article published on 22 November 2017

Strategies to address low drug solubility in discovery and development.

scientific article published on January 2013

Suggested Procedures for the Reproducible Synthesis of Poly(d,l-lactide-co-glycolide) Nanoparticles Using the Emulsification Solvent Diffusion Platform

scientific article published on 01 October 2018

Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents

scientific article published on 14 September 2018

Synthesis and biological evaluation of N-substituted noscapine analogues

scientific article

Synthesis and biological evaluation of adenosines with heterobicyclic and polycyclic N(6)-substituents as adenosine A(1) receptor agonists.

scientific article

Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists.

scientific article published on 27 March 2010

Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists

scientific article

Targeted delivery to the nucleus.

scientific article published on 4 July 2007

Tetraspanins in viral infections: a fundamental role in viral biology?

scientific article

The mRNA Vaccine Technology Era and the Future Control of Parasitic Infections

scientific article published in 2023

The synthesis and biological evaluation of multifunctionalised derivatives of noscapine as cytotoxic agents

scientific article published on 11 December 2013

Tissue-specific Calibration of Real-time PCR Facilitates Absolute Quantification of Plasmid DNA in Biodistribution Studies

scientific article

Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations, Part 1: Method Parameterization and Comparison of In Vitro Digestion Profiles Across a Range of Representative Formulations

scientific article published on 29 May 2012

Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations during in Vitro Digestion

scientific article published on 22 October 2012

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of type I, II, IIIA, IIIB and IV lipid-based formulations.

scientific article published on 10 May 2013

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system

scientific article published on 01 July 2014

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 6: effects of varying pancreatin and calcium levels

scientific article

Toward the establishment of standardized in vitro tests for lipid-based formulations. 5. Lipolysis of representative formulations by gastric lipase.

scientific article published on 7 October 2014

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

scientific article published on 21 May 2021

Transformation of Biopharmaceutical Classification System Class I and III Drugs Into Ionic Liquids and Lipophilic Salts for Enhanced Developability Using Lipid Formulations.

scientific article

Transient Supersaturation Supports Drug Absorption from Lipid-Based Formulations for Short Periods of Time, but Ongoing Solubilization Is Required for Longer Absorption Periods.

scientific article published on 21 December 2016

Ultrafast star-shaped acoustic micromixer for high throughput nanoparticle synthesis

scientific article published on 03 January 2020

Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms

scientific article published on 01 March 2019

Unravelling cytosolic delivery of cell penetrating peptides with a quantitative endosomal escape assay

scientific article published on 17 June 2021

Using molecular dynamics to study liquid phase behavior: simulations of the ternary sodium laurate/sodium oleate/water system

scientific article published on 26 August 2011

Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility.

scientific article published on 26 October 2010

Zinc-finger nuclease enhanced gene targeting in human embryonic stem cells

scientific article published on 23 August 2014

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