Search filters

List of works by Lisa M. Kaminskas

A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats

scientific article published on 06 March 2019

A Comparison of the Pharmacokinetics and Pulmonary Lymphatic Exposure of a Generation 4 PEGylated Dendrimer Following Intravenous and Aerosol Administration to Rats and Sheep

scientific article published on 20 October 2015

A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems.

scientific article published on 23 June 2011

A comparison of the lung clearance kinetics of Solid lipid nanoparticles and Liposomes by following the 3H-labelled structural lipids after pulmonary delivery in rats.

scientific article published on 5 January 2018

Aerosol Pirfenidone Pharmacokinetics after Inhaled Delivery in Sheep: a Viable Approach to Treating Idiopathic Pulmonary Fibrosis

scientific article published on 10 December 2019

Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products.

scientific article

An Evaluation of Optimal PEGylation Strategies for Maximizing the Lymphatic Exposure and Antiviral Activity of Interferon after Subcutaneous Administration.

scientific article

Association of chemotherapeutic drugs with dendrimer nanocarriers: an assessment of the merits of covalent conjugation compared to noncovalent encapsulation.

scientific article published on 26 January 2012

Capping Methotrexate α-Carboxyl Groups Enhances Systemic Exposure and Retains the Cytotoxicity of Drug Conjugated PEGylated Polylysine Dendrimers

scientific article published on 21 January 2011

Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury

scientific article published on April 2008

Cationic poly-L-lysine dendrimers: pharmacokinetics, biodistribution, and evidence for metabolism and bioresorption after intravenous administration to rats

scientific article published in September 2006

Cetuximab Exhibits Sex Differences in Lymphatic Exposure after Intravenous Administration in Rats in the Absence of Differences in Plasma Exposure

scientific article published on 19 October 2020

Chaperone heat shock protein 90 mobilization and hydralazine cytoprotection against acrolein-induced carbonyl stress

scientific article

Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker.

scientific article published on 21 February 2011

Conjugation of 10 kDa Linear PEG onto Trastuzumab Fab' Is Sufficient to Significantly Enhance Lymphatic Exposure while Preserving in Vitro Biological Activity

scientific article published on 12 February 2016

Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties.

scientific article published on August 2011

Designing a Multicomponent Spray-Dried Formulation Platform for Pulmonary Delivery of Biomacromolecules: The Effect of Polymers on the Formation of an Amorphous Matrix for Glassy State Stabilization of Biomacromolecules

Differences in colloidal structure of PEGylated nanomaterials dictate the likelihood of accelerated blood clearance

scientific article published on 30 June 2011

Differences in lysine adduction by acrolein and methyl vinyl ketone: implications for cytotoxicity in cultured hepatocytes

scientific article

Disposition and safety of inhaled biodegradable nanomedicines: Opportunities and challenges

scientific article published on 23 March 2016

Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery.

scientific article published on 3 January 2018

Doxorubicin Conjugation and Drug Linker Chemistry Alter the Intravenous and Pulmonary Pharmacokinetics of a PEGylated Generation 4 Polylysine Dendrimer in Rats

scientific article published on 29 May 2018

Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models

scientific article published on 27 January 2012

Drug formulation and nanomedicine approaches to targeting lymphatic cancer metastases

scientific article published on 05 June 2019

Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers.

scientific article published on 13 July 2017

From sewer to saviour - targeting the lymphatic system to promote drug exposure and activity.

scientific article published on 16 October 2015

Hyaluronic Acid Molecular Weight Determines Lung Clearance and Biodistribution after Instillation.

scientific article published on 09 May 2016

Impact of surface derivatization of poly-L-lysine dendrimers with anionic arylsulfonate or succinate groups on intravenous pharmacokinetics and disposition.

scientific article published on 23 October 2007

Influence of Size and Shape on the Biodistribution of Nanoparticles Prepared by Polymerization-Induced Self-Assembly

scientific article published on 7 September 2017

Investigating the interactions of amino acid components on a mannitol-based spray-dried powder formulation for pulmonary delivery: A design of experiment approach

scientific article published on 21 September 2011

Local inflammation alters the lung disposition of a drug loaded pegylated liposome after pulmonary dosing to rats

scientific article published on 29 May 2019

Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site

scientific article published on 15 August 2017

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats

scientific article

Michael addition of acrolein to lysinyl and N-terminal residues of a model peptide: targets for cytoprotective hydrazino drugs

article

Microfluidic preparation of drug-loaded PEGylated liposomes, and the impact of liposome size on tumour retention and penetration

scientific article published on 11 October 2017

Molecular weight (hydrodynamic volume) dictates the systemic pharmacokinetics and tumour disposition of PolyPEG star polymers.

scientific article published on 4 September 2015

Nano-chemotherapeutics: maximising lymphatic drug exposure to improve the treatment of lymph-metastatic cancers.

scientific article published on 05 May 2014

New developments in dry powder pulmonary vaccine delivery.

scientific article published on 20 January 2011

Optimal PEGylation can improve the exposure of interferon in the lungs following pulmonary administration

scientific article

PEGylated interferon displays differences in plasma clearance and bioavailability between male and female mice and between female immunocompetent C57Bl/6J and athymic nude mice

scientific article published on 5 March 2015

PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin

scientific article published on 13 August 2013

PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of trastuzumab in rats but increases plasma clearance after subcutaneous administration.

scientific article

PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases.

scientific article

PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats

scientific article published on 15 August 2009

Partly-PEGylated Poly-L-lysine dendrimers have reduced plasma stability and circulation times compared with fully PEGylated dendrimers

scientific article published in October 2009

Pharmacokinetics and Tumor Disposition of PEGylated, Methotrexate Conjugated Poly-l-lysine Dendrimers

scientific article published on 01 July 2009

Practical lessons in murine thoracic lymph duct cannulations: observations in female and male mice across four different strains that impact on "cannulatability".

scientific article published on 23 December 2014

Prediction and Optimization of Pharmacokinetic and Toxicity Properties of the Ligand

scientific article published on 01 January 2018

Protein adduct-trapping by hydrazinophthalazine drugs: mechanisms of cytoprotection against acrolein-mediated toxicity.

scientific article published in March 2004

Pulmonary administration of PEGylated polylysine dendrimers: absorption from the lung versus retention within the lung is highly size-dependent

scientific article published on 26 June 2013

Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy

scientific article published on 14 March 2014

Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde

scientific article published on 20 August 2004

Reducing Dendrimer Generation and PEG Chain Length Increases Drug Release and Promotes Anticancer Activity of PEGylated Polylysine Dendrimers Conjugated with Doxorubicin via a Cathepsin-Cleavable Peptide Linker

scientific article published on 13 September 2018

Spray-Dried Influenza Antigen with Trehalose and Leucine Produces an Aerosolizable Powder Vaccine Formulation that Induces Strong Systemic and Mucosal Immunity after Pulmonary Administration

scientific article published on 25 February 2015

Strong protein adduct trapping accompanies abolition of acrolein-mediated hepatotoxicity by hydralazine in mice

scientific article

Subunit-based mucosal vaccine delivery systems for pulmonary delivery - Are they feasible?

scientific article published on 01 March 2019

Suggested Procedures for the Reproducible Synthesis of Poly(d,l-lactide-co-glycolide) Nanoparticles Using the Emulsification Solvent Diffusion Platform

scientific article published on 01 October 2018

Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae.

scientific article

Targeting the lymphatics using dendritic polymers (dendrimers).

scientific article published on 12 June 2011

The Applications of 3D Printing in Pulmonary Drug Delivery and Treatment of Respiratory Disorders

scientific article published on 01 January 2018

The Lymphatic System Plays a Major Role in the Intravenous and Subcutaneous Pharmacokinetics of Trastuzumab in Rats

scientific article published on 09 January 2014

The Pharmacokinetics and Biodistribution of a 64 kDa PolyPEG Star Polymer After Subcutaneous and Pulmonary Administration to Rats

scientific article published on 13 January 2016

The contribution of the metabolite p-hydroxyamphetamine to the central actions of p-methoxyamphetamine

scientific article published on 25 January 2002

The effect of amino acid excipients on morphology and solid-state properties of multi-component spray-dried formulations for pulmonary delivery of biomacromolecules

scientific article

The impact of molecular weight and PEG chain length on the systemic pharmacokinetics of PEGylated poly l-lysine dendrimers

scientific article published on 5 April 2008

Trisulfide-Bearing PEG Brush Polymers Donate Hydrogen Sulfide and Ameliorate Cellular Oxidative Stress

scientific article published on 19 November 2020

dendPoint: a web resource for dendrimer pharmacokinetics investigation and prediction

scientific article published on 29 October 2019

Paulina is supported by:

About Paulina

Help