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PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of trastuzumab in rats but increases plasma clearance after subcutaneous administration.

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Description scientific article
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author: Lisa M. Kaminskas  Christopher J.H. Porter  Charlotte C. Williams  Juergen Bulitta  David B Ascher 

Publication date February 18, 2015
Language English
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