List of works - Martin J. Humphries

Integrin ligands at a glance

scientific article

Integrin structure, activation, and interactions

scientific article published on March 2011

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments

scientific article

Demonstration of catch bonds between an integrin and its ligand.

scientific article published on June 2009

Synergistic control of cell adhesion by integrins and syndecans.

scientific article published on December 2007

PKCalpha regulates beta1 integrin-dependent cell motility through association and control of integrin traffic

scientific article published on July 1999

Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.

scientific article published on November 1995

SHARPIN is an endogenous inhibitor of β1-integrin activation

scientific article

Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.

scientific article

Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6

scientific article

Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1.

scientific article published on 27 January 2005

Crystal structure of a heparin- and integrin-binding segment of human fibronectin.

scientific article

Integrin activation: the link between ligand binding and signal transduction

scientific article published on October 1996

The cell-binding domain of intimin from enteropathogenic Escherichia coli binds to beta1 integrins

scientific article published on August 1996

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance

scientific article

Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

scientific article published in Journal of Biological Chemistry

The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine.

scientific article

Anti-integrin monoclonal antibodies

scientific article

Integrin-specific signaling pathways controlling focal adhesion formation and cell migration.

scientific article

Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit

scientific article published on 01 April 1995

Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

scientific article published in Journal of Biological Chemistry

Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis.

scientific article

Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration

scientific article

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain

scientific article published on 13 March 2002

Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling

scientific article

Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1.

scientific article published on March 1990

Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1.

scientific article published on May 1998

The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy

scientific article published in Journal of Biological Chemistry

The Integrin α1 A-domain Is a Ligand Binding Site for Collagens and Laminin

scientific article published in Journal of Biological Chemistry

Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.

scientific article

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

scientific article published on 19 July 2003

Cyclic mechanical reinforcement of integrin-ligand interactions

scientific article published on 14 February 2013

Focal adhesions are sites of integrin extension

scientific article

Syndecan-4 phosphorylation is a control point for integrin recycling.

scientific article published on 28 February 2013

Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling

scientific article

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex

scientific article

Global analysis reveals the complexity of the human glomerular extracellular matrix

scientific article published on 16 January 2014

A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.

scientific article published on 22 December 2004

Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?

scientific article published in October 2004

A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain

scientific article published in January 1997

Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins.

scientific article

Recent advances in research on fibronectin and other cell attachment proteins

scientific article

Homology modelling of integrin EF-hands. Evidence for widespread use of a conserved cation-binding site

scientific article

Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segment

scientific article published on April 1, 1988

A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis

scientific article published on 6 October 2011

Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviour

scientific article published on July 2009

Requirement for Rho in integrin signalling.

scientific article published on March 1997

Molecular interplay between endostatin, integrins, and heparan sulfate.

scientific article published on 05 June 2009

α4 Integrin Binding Interfaces on VCAM-1 and MAdCAM-1

scientific article published in Journal of Biological Chemistry

Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.

scientific article published on 7 October 2003

List of works by Martin J. Humphries

Integrin ligands at a glance

Integrin structure, activation, and interactions

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments

Demonstration of catch bonds between an integrin and its ligand.

Synergistic control of cell adhesion by integrins and syndecans.

PKCalpha regulates beta1 integrin-dependent cell motility through association and control of integrin traffic

Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.

SHARPIN is an endogenous inhibitor of β1-integrin activation

Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.

Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6

Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1.

Crystal structure of a heparin- and integrin-binding segment of human fibronectin.

Integrin activation: the link between ligand binding and signal transduction

The cell-binding domain of intimin from enteropathogenic Escherichia coli binds to beta1 integrins

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance

Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine.

Anti-integrin monoclonal antibodies

Integrin-specific signaling pathways controlling focal adhesion formation and cell migration.

Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit

Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis.

Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain

Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling

Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1.

Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1.

The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy

The Integrin α1 A-domain Is a Ligand Binding Site for Collagens and Laminin

Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

Cyclic mechanical reinforcement of integrin-ligand interactions

Focal adhesions are sites of integrin extension

Syndecan-4 phosphorylation is a control point for integrin recycling.

Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex

Global analysis reveals the complexity of the human glomerular extracellular matrix

A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.

Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?

A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain

Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins.

Recent advances in research on fibronectin and other cell attachment proteins

Homology modelling of integrin EF-hands. Evidence for widespread use of a conserved cation-binding site

Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segment

A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis

Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviour

Requirement for Rho in integrin signalling.

Molecular interplay between endostatin, integrins, and heparan sulfate.

α4 Integrin Binding Interfaces on VCAM-1 and MAdCAM-1

Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.