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List of works by Martin J. Humphries

A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids

scientific article published on 13 September 2021

A novel gain-of-function mutation of the integrin alpha2 VWFA domain

scientific article published in February 2002

A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting

scientific article

A secondary structure model of the integrin alpha subunit N-terminal domain based on analysis of multiple alignments

article

A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.

scientific article published on 22 December 2004

A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain

scientific article published in January 1997

A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis

scientific article published on 6 October 2011

Activation of integrin alpha5beta1 delays apoptosis of Ntera2 neuronal cells.

scientific article published on March 2005

Adhesion articulated

scientific article published in Nature

Adhesion signalling complexes ⬇️

scientific article published on December 21, 2010

Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1.

scientific article published on March 1990

Allosteric Regulation of Fibronectin/α5β1 Interaction by Fibronectin-Binding MSCRAMMs

scientific article

Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration

scientific article

Alternative cellular roles for proteins identified using proteomics

scientific article published on 9 May 2012

Alternative splicing of the IIICS domain in fibronectin governs the role of the heparin II domain in fibrillogenesis and cell spreading.

scientific article

Amino acid motifs required for isolated beta cytoplasmic domains to regulate 'in trans' beta1 integrin conformation and function in cell attachment.

scientific article

An RGD to LDV Motif Conversion within the Disintegrin Kistrin Generates an Integrin Antagonist That Retains Potency but Exhibits Altered Receptor Specificity

scientific article published in Journal of Biological Chemistry

An assessment of the effects of swainsonine on survival of mice injected with B16-F10 melanoma cells

scientific article published on 01 January 1990

Analysis of ligand-induced and ligand-attenuated epitopes on the leukocyte integrin alpha4beta1: VCAM-1, mucosal addressin cell adhesion molecule-1, and fibronectin induce distinct conformational changes

scientific article published on May 1998

Anti-integrin monoclonal antibodies

scientific article

Association between receptor density, cellular activation, and transformation of adhesive behavior of flowing lymphocytes binding to VCAM-1

article

Calpha-H...O = C hydrogen bonds contribute to the specificity of RGD cell-adhesion interactions

scientific article

Cell Adhesion Assays

scientific article published on 01 January 2009

Cell Adhesion Assays

scientific article published on 01 May 2001

Cell adhesion is regulated by CDK1 during the cell cycle

Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation.

scientific article published on 20 March 2007

Cell-Substrate Adhesion Assays

scientific article published on 01 May 2001

Cell-to-cell contact and extracellular matrix

scientific article published on 19 September 2009

Characterization of the Phospho-Adhesome by Mass Spectrometry-Based Proteomics

scientific article published on January 2017

Clathrin-containing adhesion complexes

scientific article published on 17 June 2019

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance

scientific article

Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1.

scientific article published on February 1994

Conformation dependence of integrin-type II collagen binding. Inability of collagen peptides to support alpha 2 beta 1 binding, and mediation of adhesion to denatured collagen by a novel alpha 5 beta 1-fibronectin bridge

scientific article published on 01 April 1994

Conformation-dependent platelet adhesion to collagen involving integrin alpha 2 beta 1-mediated and other mechanisms: multiple alpha 2 beta 1-recognition sites in collagen type I.

scientific article published on May 1994

Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

scientific article published in Journal of Biological Chemistry

Conformational equilibria and intrinsic affinities define integrin activation.

scientific article published on 25 January 2017

Connections between the cell cycle, cell adhesion and the cytoskeleton

scientific article published on 01 July 2019

Crystal structure of a heparin- and integrin-binding segment of human fibronectin.

scientific article

Cyclic mechanical reinforcement of integrin-ligand interactions

scientific article published on 14 February 2013

Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling

scientific article

Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

scientific article published in Journal of Biological Chemistry

Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling

scientific article

Demonstration of catch bonds between an integrin and its ligand.

scientific article published on June 2009

Direct Role of the Carboxy-Terminal Cell-Binding Domain of Fibronectin in Neural Crest Cell Motility

scientific article published on 01 May 1997

Disruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors.

scientific article published on December 2014

Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins.

scientific article

Distinct mechanism of human neuroblastoma cell adhesion to fibronectin

scientific article published on July 1991

Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1.

scientific article published on 26 September 2008

Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking

scientific article published on 21 April 2011

DrhoGEF3 encodes a new Drosophila DH domain protein that exhibits a highly dynamic embryonic expression pattern

scientific article published in May 2001

Dynamic aspects of adhesion receptor function--integrins both twist and shout

scientific article

E-cadherin is a ligand for integrin α2β1

article

ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells

scientific article published on 19 October 2020

Effect of beta-mercaptoethanol on the detection of biotinylated proteins

scientific article published on February 1995

Effects of collagenase-cleavage of type I collagen on α2β1 integrin-mediated cell adhesion ⬇️

scientific article published on April 1, 1998

Elucidation of the structural features of heparan sulfate important for interaction with the Hep-2 domain of fibronectin.

scientific article published on February 2000

Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells.

scientific article

Evidence for the presence of a low-mass beta1 integrin on the cell surface.

scientific article published on 16 August 2005

Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.

scientific article published on 22 November 2004

Expression and characterisation of a very-late antigen-4 (alpha 4 beta 1) integrin-binding fragment of vascular cell-adhesion molecule-1.

scientific article published on December 1994

Fibronectin and cancer: rationales for the use of antiadhesives in cancer treatment.

scientific article

Fibronectin is a survival factor for differentiated osteoblasts.

scientific article published in May 1998

Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1.

scientific article published on 27 January 2005

Fibronectin supports neurite outgrowth and axonal regeneration of adult brain neurons in vitro

scientific article published on 17 March 2012

Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling

scientific article

Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.

scientific article published in December 1999

Focal adhesions are sites of integrin extension

scientific article

Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin alpha5beta1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding.

scientific article

Functional role of β1 integrin-mediated signalling in the human hair follicle

scientific article published on 12 November 2007

Generation of a minimal alpha5beta1 integrin-Fc fragment

scientific article

Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization

scientific article

Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviour

scientific article published on July 2009

Global analysis reveals the complexity of the human glomerular extracellular matrix

scientific article published on 16 January 2014

Glomerular cell cross-talk influences composition and assembly of extracellular matrix

scientific article published on 16 January 2014

Homology modelling of integrin EF-hands. Evidence for widespread use of a conserved cation-binding site

scientific article

Human natural killer cells express VLA-4 and VLA-5, which mediate their adhesion to fibronectin ⬇️

scientific article published on January 1, 1991

IQGAP1 is a key node within the small GTPase network

scientific article published on October 2013

Identification of Amino Acid Residues That Form Part of the Ligand-binding Pocket of Integrin α5β1

scientific article published in Journal of Biological Chemistry

Identification of a key integrin-binding sequence in VCAM-1 homologous to the LDV active site in fibronectin

scientific article published in August 1994

Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit

scientific article published on 01 April 1995

Identification of a novel heparin-binding site in the alternatively spliced IIICS region of fibronectin: roles of integrins and proteoglycans in cell adhesion to fibronectin splice variants

scientific article published in February 2001

Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin ⬇️

scientific article published on December 1, 1991

Identification of fibronectin IIICS variants in human bone marrow stroma

scientific article published on 01 January 1999

Identification of heparin as a ligand for the A-domain of Plasmodium falciparum thrombospondin-related adhesion protein

scientific article published on 01 May 1999

Identification of integrin alpha 2 beta 1 as cell surface receptor for the carboxyl-terminal propeptide of type I procollagen

scientific article published in Journal of Biological Chemistry

Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio)

scientific article published on 20 June 2006

Improved LC-MS chromatographic alignment increases the accuracy of label-free quantitative proteomics: Comparison of spectral counting versus ion intensity-based proteomic quantification strategies

Influence of interleukin-3 and other growth factors on alpha4beta1 integrin-mediated adhesion and migration of human hematopoietic progenitor cells

scientific article published on 01 September 1997

Insights into integrin-ligand binding and activation from the first crystal structure.

scientific article

Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates

scientific article published on 15 July 2020

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain

scientific article published on 13 March 2002

Integrin activation: the link between ligand binding and signal transduction

scientific article published on October 1996

Integrin adhesion receptors: structure, function and implications for biomedicine

scientific article published on July 1996

Integrin alpha 4 beta 1-mediated melanoma cell adhesion and migration on vascular cell adhesion molecule-1 (VCAM-1) and the alternatively spliced IIICS region of fibronectin

scientific article published in Journal of Biological Chemistry

Integrin cell adhesion receptors and the concept of agonism.

scientific article

Integrin ligands at a glance

scientific article

Integrin signalling defects in T-lymphocytes in systemic lupus erythematosus

scientific article published on 01 January 1999

Integrin structure, activation, and interactions

scientific article published on March 2011

Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons

scientific journal article

Integrin-specific signaling pathways controlling focal adhesion formation and cell migration.

scientific article

Integrin-syndecan cooperation governs the assembly of signalling complexes during cell spreading.

scientific article published on January 2005

Integrins and syndecan-4 make distinct, but critical, contributions to adhesion contact formation.

scientific article published on January 2007

Integrins: a review of their structure and mechanisms of ligand binding.

scientific article published on January 1993

Interaction of filamin A with the integrin beta 7 cytoplasmic domain: role of alternative splicing and phosphorylation

scientific article

Interaction of the α2A domain of integrin with small collagen fragments

scientific article published on April 2010

Investigation of the antimetastatic effects of agents that inhibit cell adhesion or protein glycosylation

scientific article published on April 1987

Isolation of integrin-based adhesion complexes

scientific article

Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION.

scientific article

Lymphocyte adhesion to high endothelium is mediated by two beta 1 integrin receptors for fibronectin, alpha 4 beta 1 and alpha 5 beta 1

scientific article published on April 1, 1992

Mapping functional residues onto integrin crystal structures.

scientific article

Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach.

scientific article published on 11 November 2009

Mechanisms of VCAM-1 and fibronectin binding to integrin alpha 4 beta 1: implications for integrin function and rational drug design

scientific article

Mechanisms of integration of cells and extracellular matrices by integrins.

scientific article published in November 2004

Mechanisms of ligand binding by integrins

scientific article published on 01 May 1994

Microtubule-dependent modulation of adhesion complex composition

scientific article

Modulation of cartilage differentiation by melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP).

scientific article published on March 2010

Molecular Characterisation of Integrin-Procollagen C-Propeptide Interactions

scientific article published on 01 June 1997

Molecular and cellular biology of integrins

scientific article published on October 1993

Molecular basis for the dynamic strength of the integrin alpha4beta1/VCAM-1 interaction.

scientific article

Molecular interplay between endostatin, integrins, and heparan sulfate.

scientific article published on 05 June 2009

Monoclonal antibodies as probes of integrin priming and activation.

scientific article published on June 2004

Monoclonal antibodies identify residues 199-216 of the integrin alpha2 vWFA domain as a functionally important region within alpha2beta1.

scientific article published in September 2000

Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segment ⬇️

scientific article published on April 1, 1988

Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.

scientific article

Novel activating and inactivating mutations in the integrin beta1 subunit A domain.

scientific article published on June 2004

PKCalpha regulates beta1 integrin-dependent cell motility through association and control of integrin traffic

scientific article published on July 1999

PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis.

scientific article

Peptide recognition motifs involved in the binding of integrins to their ligands

scientific article published on March 1, 1992

Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal α5 integrin

scientific article published on 06 March 2007

Production of recombinant soluble human integrin alpha4beta1.

scientific article

Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver

scientific article (publication date: 3 August 2012)

Proteomic analysis of integrin adhesion complexes

scientific article

Proteomic analysis of integrin-associated complexes from mesenchymal stem cells

scientific article published on 6 July 2015

Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6

scientific article

Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment

scientific article (publication date: July 2012)

Proteomic definitions of basement membrane composition in health and disease

scientific article

Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking

scientific article published on 28 June 2019

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex

scientific article

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments

scientific article

Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway

scientific article

Recent advances in research on fibronectin and other cell attachment proteins

scientific article

Recent insights into ligand binding, activation and signalling by integrin adhesion receptors

scientific article published on January 1995

Recruitment of a Heparan Sulfate Subunit to the Interleukin-1 Receptor Complex

scientific article published in Journal of Biological Chemistry

Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.

scientific article

Regulation of integrin activity by MIA.

scientific article published on 3 March 2006

Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.

scientific article published on November 1995

Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?

scientific article published in October 2004

Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1.

scientific article published on May 1998

Regulation of macrophage phagocytosis of apoptotic neutrophils by adhesion to fibronectin

scientific article published on 01 November 1998

Regulation of the extracellular ligand binding activity of integrins.

scientific article published on 2 July 1998

Relating conformation to function in integrin α5β1.

scientific article published on 17 June 2016

Requirement for Rho in integrin signalling.

scientific article published on March 1997

Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis

Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.

scientific article published on 7 October 2003

Role of adhesion receptor trafficking in 3D cell migration

scientific article

SHARPIN is an endogenous inhibitor of β1-integrin activation

scientific article

Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis.

scientific article

Stimulation of DNA synthesis by cathepsin D digests of fibronectin

scientific article published in Nature

Stimulation of DNA synthesis in murine lymphocytes by the drug swainsonine: Immunomodulatory properties

scientific article published on 01 January 1988

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

scientific article published on 19 July 2003

Structure. An anthropomorphic integrin

scientific article

Swainsonine Inhibition of Spontaneous Metastasis

scientific article published on 01 July 1989

Syndecan-4 phosphorylation is a control point for integrin recycling.

scientific article published on 28 February 2013

Synergistic control of cell adhesion by integrins and syndecans.

scientific article published on December 2007

T lymphocyte adhesion to fibronectin (FN): a possible mechanism for T cell accumulation in the rheumatoid joint

scientific article

The "linker" region (amino acids 38-47) of the disintegrin elegantin is a novel inhibitory domain of integrin alpha5beta1-dependent cell adhesion on fibronectin: evidence for the negative regulation of fibronectin synergy site biological activity.

scientific article published on 18 September 2006

The A-Domain of Integrin alpha2 Binds Specifically to a Range of Collagens but is not a General Receptor for the Collagenous Motif

scientific article published on 01 November 1996

The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy

scientific article published in Journal of Biological Chemistry

The Integrin α1 A-domain Is a Ligand Binding Site for Collagens and Laminin

scientific article published in Journal of Biological Chemistry

The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.

scientific article published on 03 August 2017

The alpha 4 integrin chain is a ligand for alpha 4 beta 7 and alpha 4 beta 1 ⬇️

scientific article published on August 1, 1995

The cell interaction sites of fibronectin in tumour metastasis

scientific article

The cell-binding domain of intimin from enteropathogenic Escherichia coli binds to beta1 integrins

scientific article published on August 1996

The effect of alpha4 beta1-integrin binding sequences of fibronectin on growth of cells from human hematopoietic progenitors

scientific article published on 01 May 1998

The effect of peptide adsorption on signal linearity and a simple approach to improve reliability of quantification

scientific article published on 9 May 2013

The importance of podocyte adhesion for a healthy glomerulus

scientific article

The integrin adhesome network at a glance

scientific article

The integrin beta subunit

scientific article published in February 1998

The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family.

scientific article

The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine.

scientific article

The structure of cell-adhesion molecules

scientific article published in February 1998

Therapeutic ultrasound bypasses canonical syndecan-4 signaling to activate rac1

scientific article

Unique expression of integrin fibronectin receptors in human neuroblastoma cell lines

scientific article

Use of antiadhesive peptide and swainsonine to inhibit metastasis

scientific article published on January 1988

Use of synthetic peptides to probe lymphocyte--high endothelial cell interactions. Lymphocytes recognize a ligand on the endothelial surface which contains the CS1 adhesion motif

scientific article published on January 1990

VCAM-1 is a CS1 peptide-inhibitable adhesion molecule expressed by lymph node high endothelium

scientific article published on September 1993

α4 Integrin Binding Interfaces on VCAM-1 and MAdCAM-1

scientific article published in Journal of Biological Chemistry

β1 integrin signaling maintains human epithelial progenitor cell survival in situ and controls proliferation, apoptosis and migration of their progeny

scientific article

β1-Integrin Cytoplasmic Subdomains Involved in Dominant Negative Function ⬇️

scientific article published on April 1, 1998

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