List of works - Martin J. Humphries

The alpha 4 integrin chain is a ligand for alpha 4 beta 7 and alpha 4 beta 1

scientific article published on August 1, 1995

Mechanisms of integration of cells and extracellular matrices by integrins.

scientific article published in November 2004

Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling

scientific article

Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin alpha5beta1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding.

scientific article

Elucidation of the structural features of heparan sulfate important for interaction with the Hep-2 domain of fibronectin.

scientific article published on February 2000

Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin

scientific article published on December 1, 1991

Relating conformation to function in integrin α5β1.

scientific article published on 17 June 2016

Molecular basis for the dynamic strength of the integrin alpha4beta1/VCAM-1 interaction.

scientific article

The structure of cell-adhesion molecules

scientific article published in February 1998

Conformational equilibria and intrinsic affinities define integrin activation.

scientific article published on 25 January 2017

Generation of a minimal alpha5beta1 integrin-Fc fragment

scientific article

Identification of a novel heparin-binding site in the alternatively spliced IIICS region of fibronectin: roles of integrins and proteoglycans in cell adhesion to fibronectin splice variants

scientific article published in February 2001

Integrin alpha 4 beta 1-mediated melanoma cell adhesion and migration on vascular cell adhesion molecule-1 (VCAM-1) and the alternatively spliced IIICS region of fibronectin

scientific article published in Journal of Biological Chemistry

Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver

scientific article (publication date: 3 August 2012)

The integrin adhesome network at a glance

scientific article

Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal α5 integrin

scientific article published on 06 March 2007

Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation.

scientific article published on 20 March 2007

Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.

scientific article published on 22 November 2004

Monoclonal antibodies as probes of integrin priming and activation.

scientific article published on June 2004

Fibronectin is a survival factor for differentiated osteoblasts.

scientific article published in May 1998

Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.

scientific article published in December 1999

Mapping functional residues onto integrin crystal structures.

scientific article

Integrin adhesion receptors: structure, function and implications for biomedicine

scientific article published on July 1996

Identification of Amino Acid Residues That Form Part of the Ligand-binding Pocket of Integrin α5β1

scientific article published in Journal of Biological Chemistry

Glomerular cell cross-talk influences composition and assembly of extracellular matrix

scientific article published on 16 January 2014

Role of adhesion receptor trafficking in 3D cell migration

scientific article

Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment

scientific article (publication date: July 2012)

β1-Integrin Cytoplasmic Subdomains Involved in Dominant Negative Function

scientific article published on April 1, 1998

E-cadherin is a ligand for integrin α2β1

article

Cell Adhesion Assays

scientific article published on 01 January 2009

An RGD to LDV Motif Conversion within the Disintegrin Kistrin Generates an Integrin Antagonist That Retains Potency but Exhibits Altered Receptor Specificity

scientific article published in Journal of Biological Chemistry

Dynamic aspects of adhesion receptor function--integrins both twist and shout

scientific article

Identification of heparin as a ligand for the A-domain of Plasmodium falciparum thrombospondin-related adhesion protein

scientific article published on 01 May 1999

Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1.

scientific article published on February 1994

A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting

scientific article

Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway

scientific article

Proteomic definitions of basement membrane composition in health and disease

scientific article

The importance of podocyte adhesion for a healthy glomerulus

scientific article

Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking

scientific article published on 21 April 2011

Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1.

scientific article published on 26 September 2008

Cell Adhesion Assays

scientific article published on 01 May 2001

Cell-Substrate Adhesion Assays

scientific article published on 01 May 2001

Conformation-dependent platelet adhesion to collagen involving integrin alpha 2 beta 1-mediated and other mechanisms: multiple alpha 2 beta 1-recognition sites in collagen type I.

scientific article published on May 1994

The A-Domain of Integrin alpha2 Binds Specifically to a Range of Collagens but is not a General Receptor for the Collagenous Motif

scientific article published on 01 November 1996

Conformation dependence of integrin-type II collagen binding. Inability of collagen peptides to support alpha 2 beta 1 binding, and mediation of adhesion to denatured collagen by a novel alpha 5 beta 1-fibronectin bridge

scientific article published on 01 April 1994

The integrin beta subunit

scientific article published in February 1998

Association between receptor density, cellular activation, and transformation of adhesive behavior of flowing lymphocytes binding to VCAM-1

article

Regulation of integrin activity by MIA.

scientific article published on 3 March 2006

Fibronectin supports neurite outgrowth and axonal regeneration of adult brain neurons in vitro

scientific article published on 17 March 2012

Human natural killer cells express VLA-4 and VLA-5, which mediate their adhesion to fibronectin

scientific article published on January 1, 1991

List of works by Martin J. Humphries

The alpha 4 integrin chain is a ligand for alpha 4 beta 7 and alpha 4 beta 1

Mechanisms of integration of cells and extracellular matrices by integrins.

Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling

Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin alpha5beta1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding.

Elucidation of the structural features of heparan sulfate important for interaction with the Hep-2 domain of fibronectin.

Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin

Relating conformation to function in integrin α5β1.

Molecular basis for the dynamic strength of the integrin alpha4beta1/VCAM-1 interaction.

The structure of cell-adhesion molecules

Conformational equilibria and intrinsic affinities define integrin activation.

Generation of a minimal alpha5beta1 integrin-Fc fragment

Identification of a novel heparin-binding site in the alternatively spliced IIICS region of fibronectin: roles of integrins and proteoglycans in cell adhesion to fibronectin splice variants

Integrin alpha 4 beta 1-mediated melanoma cell adhesion and migration on vascular cell adhesion molecule-1 (VCAM-1) and the alternatively spliced IIICS region of fibronectin

Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver

The integrin adhesome network at a glance

Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal α5 integrin

Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation.

Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.

Monoclonal antibodies as probes of integrin priming and activation.

Fibronectin is a survival factor for differentiated osteoblasts.

Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.

Mapping functional residues onto integrin crystal structures.

Integrin adhesion receptors: structure, function and implications for biomedicine

Identification of Amino Acid Residues That Form Part of the Ligand-binding Pocket of Integrin α5β1

Glomerular cell cross-talk influences composition and assembly of extracellular matrix

Role of adhesion receptor trafficking in 3D cell migration

Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment

β1-Integrin Cytoplasmic Subdomains Involved in Dominant Negative Function

E-cadherin is a ligand for integrin α2β1

Cell Adhesion Assays

An RGD to LDV Motif Conversion within the Disintegrin Kistrin Generates an Integrin Antagonist That Retains Potency but Exhibits Altered Receptor Specificity

Dynamic aspects of adhesion receptor function--integrins both twist and shout

Identification of heparin as a ligand for the A-domain of Plasmodium falciparum thrombospondin-related adhesion protein

Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1.

A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting

Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway

Proteomic definitions of basement membrane composition in health and disease

The importance of podocyte adhesion for a healthy glomerulus

Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking

Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1.

Cell Adhesion Assays

Cell-Substrate Adhesion Assays

Conformation-dependent platelet adhesion to collagen involving integrin alpha 2 beta 1-mediated and other mechanisms: multiple alpha 2 beta 1-recognition sites in collagen type I.

The A-Domain of Integrin alpha2 Binds Specifically to a Range of Collagens but is not a General Receptor for the Collagenous Motif

Conformation dependence of integrin-type II collagen binding. Inability of collagen peptides to support alpha 2 beta 1 binding, and mediation of adhesion to denatured collagen by a novel alpha 5 beta 1-fibronectin bridge

The integrin beta subunit

Association between receptor density, cellular activation, and transformation of adhesive behavior of flowing lymphocytes binding to VCAM-1

Regulation of integrin activity by MIA.

Fibronectin supports neurite outgrowth and axonal regeneration of adult brain neurons in vitro

Human natural killer cells express VLA-4 and VLA-5, which mediate their adhesion to fibronectin