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List of works by Patricia Bozza

A PPARγ AGONIST ENHANCES BACTERIAL CLEARANCE THROUGH NEUTROPHIL EXTRACELLULAR TRAP FORMATION AND IMPROVES SURVIVAL IN SEPSIS.

scientific article published on 25 November 2015

A role for adrenoceptors in the regulation of pleural neutrophilia induced by LPS

article

Adipose-derived Mesenchymal Stromal Cells Modulate Lipid Metabolism and Lipid Droplet Biogenesis via AKT/mTOR -PPARγ Signalling in Macrophages

scientific article published on 30 December 2019

Adrenal response in severe community-acquired pneumonia: impact on outcomes and disease severity

scientific article published on 27 August 2008

Adrenergic modulation of the blood neutrophilia induced by platelet activating factor in rats

scientific article published on 01 April 1994

Allergic challenge-elicited lipid bodies compartmentalize in vivo leukotriene C4 synthesis within eosinophils

scientific article published on 09 June 2005

An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels.

scientific article published on 17 May 2018

Analgesic and anti-inflammatory activity of the aqueous extract of Rheedia longifolia Planch & Triana

scientific article published on 01 February 2007

Anti-allergic properties of Cissampelos sympodialis and its isolated alkaloid warifteine

scientific article published on 06 March 2006

Anti-allergic properties of curine, a bisbenzylisoquinoline alkaloid.

scientific article published on 13 March 2015

Anti-allergic properties of the bromeliaceae Nidularium procerum: inhibition of eosinophil activation and influx

scientific article published on 20 June 2005

Anti-inflammatory activity in the aqueous crude extract of the leaves of Nidularium procerum: A bromeliaceae from the Brazilian coastal rain forest

scientific article

Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance

scientific article

Antinociceptive effect of Nidularium procerum: a Bromeliaceae from the Brazilian coastal rain forest

scientific article published in January 2005

Apoptotic mimicry by an obligate intracellular parasite downregulates macrophage microbicidal activity

scientific article published in November 2001

Arginase I, Polyamine, and Prostaglandin E2Pathways Suppress the Inflammatory Response and Contribute to Diffuse Cutaneous Leishmaniasis

article

Arrest of oogenesis in the bug Rhodnius prolixus challenged with the fungus Aspergillus niger is mediated by immune response-derived PGE2.

scientific article published on 25 December 2008

Bacterial clearance in septic mice is modulated by MCP-1/CCL2 and nitric oxide

scientific article published on January 2013

Bacterial clearance is improved in septic mice by platelet-activating factor-acetylhydrolase (PAF-AH) administration

scientific article

Biomarkers of sepsis: Lost in translation?*

scientific article published on 01 July 2008

Breast-cancer extracellular vesicles induce platelet activation and aggregation by tissue factor-independent and -dependent mechanisms

scientific article published on 21 September 2017

Cell Cycle Progression Regulates Biogenesis and Cellular Localization of Lipid Droplets

scientific article published on 16 April 2019

Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis

scientific article published on 06 September 2016

Circulating levels of macrophage migration inhibitory factor are associated with mild pulmonary dysfunction after cardiopulmonary bypass

scientific article published in December 2004

Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs

scientific article published on 21 November 2017

Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils.

scientific article published on April 2011

Cognitive dysfunction is sustained after rescue therapy in experimental cerebral malaria, and is reduced by additive antioxidant therapy

scientific article

Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture

scientific article published on 22 February 2022

Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection

scientific article published on 23 September 2009

Corrigendum: The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication

scientific article published on 24 April 2017

Cortisol levels and adrenal response in severe community-acquired pneumonia: a systematic review of the literature

scientific article published on September 2010

Culture of mouse peritoneal macrophages with mouse serum induces lipid bodies that associate with the parasitophorous vacuole and decrease their microbicidal capacity against Toxoplasma gondii

scientific article

Curine inhibits eosinophil activation and airway hyper-responsiveness in a mouse model of allergic asthma

scientific article published on 28 August 2013

Curine inhibits mast cell-dependent responses in mice

scientific article

Curine, an alkaloid isolated from Chondrodendron platyphyllum inhibits prostaglandin E2 in experimental models of inflammation and pain

scientific article published in August 2014

Current perspectives for the use of corticosteroids in sepsis: patient selection is the key

Cutting Edge: Lipoxin (LX) A4 and Aspirin-Triggered 15-Epi-LXA4 Block Allergen-Induced Eosinophil Trafficking

scientific article published on 01 March 2000

Cutting edge: prostaglandin D2 enhances leukotriene C4 synthesis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin

scientific article published in February 2006

Cyclosporin A inhibits colon cancer cell growth independently of the calcineurin pathway.

scientific article

Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis

scientific article published in 2007

Cytoplasmic lipid bodies in eosinophils: Central roles in eicosanoid generation

Cytosolic phospholipase A2-driven PGE2 synthesis within unsaturated fatty acids-induced lipid bodies of epithelial cells

scientific article published on March 2009

Deciphering the contribution of lipid droplets in leprosy: multifunctional organelles with roles in Mycobacterium leprae pathogenesis

scientific article published on December 2012

Dengue Virus Capsid Protein Usurps Lipid Droplets for Viral Particle Formation

scientific article

Dengue virus capsid protein binding to hepatic lipid droplets (LD) is potassium ion dependent and is mediated by LD surface proteins

scientific article published on 30 November 2011

Dengue virus-activated platelets modulate monocyte immunometabolic response through lipid droplet biogenesis and cytokine signaling

scientific article published on 14 July 2020

Differential Expression of the Eicosanoid Pathway in Patients With Localized or Mucosal Cutaneous Leishmaniasis

scientific article

Differential Shedding and Antibody Kinetics of Zika and Chikungunya Viruses, Brazil

article

Differential TLR2 downstream signaling regulates lipid metabolism and cytokine production triggered by Mycobacterium bovis BCG infection

scientific article published on 10 October 2013

Early short-term versus prolonged low-dose methylprednisolone therapy in acute lung injury

scientific article

Effectiveness of Cissampelos sympodialis and its isolated alkaloid warifteine in airway hyperreactivity and lung remodeling in a mouse model of asthma

scientific article published on 3 April 2012

EicosaCell: An Imaging-Based Assay to Identify Spatiotemporal Eicosanoid Synthesis

scientific article published in January 2017

Eicosanoid-mediated proinflammatory activity of Pseudomonas aeruginosa ExoU.

scientific article published on December 2005

Emergence of the East-Central-South-African genotype of Chikungunya virus in Brazil and the city of Rio de Janeiro may have occurred years before surveillance detection

article

Eosinophil Lipid Bodies: Specific, Inducible Intracellular Sites for Enhanced Eicosanoid Formation ⬇️

scientific article published on September 15, 1997

Eosinophil recruitment and activation: the role of lipid mediators

scientific article published on 22 March 2013

Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation.

scientific article published on 18 November 2011

Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis

scientific article published in July 2006

Fat, fight, and beyond: The multiple roles of lipid droplets in infections and inflammation

scientific article published on 23 May 2019

Genome sequencing reveals Zika virus diversity and spread in the Americas

scientific article (publication date: 18 February 2017)

Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells

scientific article

Hepatic myofibroblasts derived from Schistosoma mansoni-infected mice are a source of IL-5 and eotaxin: controls of eosinophil populations in vitro

scientific article

High Vascular Endothelial Growth Factor Levels in NZW Mice Do Not Correlate with Collagen Deposition in Allergic Asthma

scientific article published on 29 September 2006

Histopathological analysis of initial cellular response in TLR-2 deficient mice experimentally infected by Leishmania (L.) amazonensis.

scientific article published in October 2010

Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection

scientific article published in April 2009

Homologous tachyphylaxis to bradykinin and its interference with allergic pleurisy in actively sensitized rats

article

Host cell lipid bodies triggered by Trypanosoma cruzi infection and enhanced by the uptake of apoptotic cells are associated with prostaglandin E₂ generation and increased parasite growth

scientific article published in September 2011

IL-5 accounts for the mouse pleural eosinophil accumulation triggered by antigen but not by LPS.

scientific article

Identifying intracellular sites of eicosanoid lipid mediator synthesis with EicosaCell assays

scientific article published on January 2011

Immunization of Experimental Dogs With Salivary Proteins From , Using DNA and Recombinant Canarypox Virus Induces Immune Responses Consistent With Protection Against

article

In vitro and in vivo responses of murine granulocytes to human complement-derived, haemolytically inactive C5b67 (iC5b67)

article

In vivo and in vitro antimalarial effect and toxicological evaluation of the chloroquine analogue PQUI08001/06

IncreasedLeishmaniaReplication in HIV‐1–Infected Macrophages Is Mediated by Tat Protein through Cyclooxygenase‐2 Expression and Prostaglandin E2Synthesis

article

Induction of autophagy correlates with increased parasite load of Leishmania amazonensis in BALB/c but not C57BL/6 macrophages

scientific article

Infection by HTLV-1 Is Associated With High Levels of Proinflammatory Cytokines in HIV-HCV-Coinfected Patients

scientific article published on 27 October 2017

Inflammatory response and bacterial dissemination after laparotomy and abdominal CO2 insufflation in a murine model of peritonitis

scientific article published on 15 May 2006

Influence of murine Toxocara canis infection on plasma and bronchoalveolar lavage fluid eosinophil numbers and its correlation with cytokine levels

scientific article

Integrin αDβ2 (CD11d/CD18) Modulates Leukocyte Accumulation, Pathogen Clearance, and Pyroptosis in Experimental Salmonella Typhimurium Infection.

scientific article

Integrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS).

scientific article published on 30 July 2016

Interaction of Macrophages with Apoptotic Cells Enhances HIV Type 1 Replication Through PGE2, PAF, and Vitronectin Receptor

article

Intererence of the PAF receptor antagonist, PCA 4248, with the rat pleurisy evoked by inflammatory mediators or allergen

scientific article published on 01 June 1993

Interplay of cysteinyl leukotrienes and TGF-β in the activation of hepatic stellate cells from Schistosoma mansoni granulomas

scientific article published on 15 September 2010

Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis

scientific article published on 19 May 2009

Involvement of TLR6 in the induction of COX-2, PGE 2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains

scientific article published on 22 April 2016

Leishmania infantum lipophosphoglycan induced-Prostaglandin E2 production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2.

scientific article published on 30 October 2017

Leprosy and its reactional episodes: Serum levels and possible roles of omega-3 and omega-6-derived lipid mediators

scientific article published on 14 July 2018

Leptin Elicits LTC Synthesis by Eosinophils Mediated by Sequential Two-Step Autocrine Activation of CCR3 and PGD Receptors

article by Natália R T Amorim et al published 2018 in Frontiers in Immunology

Leptin Mediates In Vivo Neutrophil Migration: Involvement of Tumor Necrosis Factor-Alpha and CXCL1.

scientific article

Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation.

scientific article

Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism

scientific article published on 25 November 2007

Leukocyte lipid bodies - Biogenesis and functions in inflammation

scientific article published on 21 January 2009

Leukocyte lipid bodies regulation and function: contribution to allergy and host defense

scientific article published on September 2006

Lipid Body Organelles within the Parasite Trypanosoma cruzi: A Role for Intracellular Arachidonic Acid Metabolism

scientific article (publication date: 2016)

Lipid Droplet, a Key Player in Host-Parasite Interactions.

scientific article

Lipid bodies accumulation in Leishmania infantum-infected C57BL/6 macrophages

scientific article published on 18 May 2017

Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells

scientific article

Lipid bodies in inflammatory cells: structure, function, and current imaging techniques.

scientific article

Lipid bodies in innate immune response to bacterial and parasite infections

scientific article published on 07 March 2008

Lipid bodies in oxidized LDL-induced foam cells are leukotriene-synthesizing organelles: a MCP-1/CCL2 regulated phenomenon.

scientific article published on 30 June 2009

Lipid body function in eicosanoid synthesis: an update

scientific article published on 12 May 2011

Lipid body mobilization in the ExoU-induced release of inflammatory mediators by airway epithelial cells

scientific article

Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis

scientific article published in December 2009

Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

scientific article published on 16 December 2020

Lipid droplets in host–pathogen interactions

Lipid droplets in inflammation and cancer.

scientific article

Lipid droplets: platforms with multiple functions in cancer hallmarks

scientific article published on 06 February 2020

Lipids From Trypanosoma cruzi Amastigotes of RA and K98 Strains Generate a Pro-inflammatory Response via TLR2/6.

scientific article published on 8 May 2018

Lipids from attenuated and virulent Babesia bovis strains induce differential TLR2-mediated macrophage activation.

scientific article published on 12 November 2009

Lipopolysaccharide-induced pleural neutrophil accumulation depends on marrow neutrophils and platelet-activating factor.

scientific article

Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils

scientific article published on 17 June 2011

Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E₂ production in murine macrophages

scientific article

Lysophosphatidylcholine triggers TLR2- and TLR4-mediated signaling pathways but counteracts LPS-induced NO synthesis in peritoneal macrophages by inhibiting NF-κB translocation and MAPK/ERK phosphorylation

scientific article

Macrophage lipid body induction by Chagas disease in vivo: putative intracellular domains for eicosanoid formation during infection.

scientific article published in February 2003

Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense

scientific article published on 01 October 2020

Mechanisms of increased survival after lipopolysaccharide-induced endotoxic shock in mice consuming olive oil-enriched diet

scientific article

Metabonomics reveals drastic changes in anti-inflammatory/pro-resolving polyunsaturated fatty acids-derived lipid mediators in leprosy disease

scientific article (publication date: 2013)

Methylprednisolone improves lung mechanics and reduces the inflammatory response in pulmonary but not in extrapulmonary mild acute lung injury in mice

scientific article published in September 2008

Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes.

scientific article

Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity

scientific article (publication date: 25 June 2008)

Murine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor.

scientific article published on 14 August 2014

Mycobacterium bovis bacillus Calmette-Guérin infection induces TLR2-dependent peroxisome proliferator-activated receptor gamma expression and activation: functions in inflammation, lipid metabolism, and pathogenesis.

scientific article

Mycobacterium leprae intracellular survival relies on cholesterol accumulation in infected macrophages: a potential target for new drugs for leprosy treatment

scientific article

NS-398: cyclooxygenase-2 independent inhibition of leukocyte priming for lipid body formation and enhanced leukotriene generation

scientific article published in October 2002

Neutrophils increase or reduce parasite burden in Trypanosoma cruzi-infected macrophages, depending on host strain: role of neutrophil elastase

scientific article

Neutrophils recruited to the site of Mycobacterium bovis BCG infection undergo apoptosis and modulate lipid body biogenesis and prostaglandin E production by macrophages.

scientific article

Oleic acid induces lung injury in mice through activation of the ERK pathway

scientific article published on 13 November 2012

Oleic acid inhibits lung Na/K-ATPase in mice and induces injury with lipid body formation in leukocytes and eicosanoid production

scientific article

Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis

scientific article

Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis

scientific article published on 13 November 2018

Outer membrane vesicles (OMVs) and detoxified lipooligosaccharide (dLOS) obtained from Brazilian prevalent N. meningitidis serogroup B strains protect mice against homologous and heterologous meningococcal infection and septic shock

scientific article

PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves

scientific article published on 06 July 2018

PPAR gamma activation protects the brain against microvascular dysfunction in sepsis

scientific article published on 31 May 2012

PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing

scientific article published on 17 July 2012

Paradise revealed: first-class science rocked by the sound of the waves

scientific article published on 28 May 2010

Patterns of c-reactive protein RATIO response in severe community-acquired pneumonia: a cohort study

scientific article published on 12 December 2012

Peripheral leptin signaling persists in innate immune cells during diet-induced obesity

scientific article published on 18 October 2020

Persistent platelet activation and apoptosis in virologically suppressed HIV-infected individuals

scientific article published in Scientific Reports

Pharmacological modulation of Paf-induced rat pleurisy and its role in inflammation by zymosan

scientific article

Pharmacological modulation of lipopolysaccharide-induced pleural eosinophilia in the rat; a role for a newly generated protein

scientific article

Phenolic constituents from Wissadula periplocifolia (L.) C. Presl. and anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein

scientific article published on 11 September 2015

Platelet activation and apoptosis modulate monocyte inflammatory responses in dengue

scientific article

Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue

scientific article (publication date: May 2017)

Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19

scientific article published on 14 April 2022

Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation

scientific article

Pro-inflammatory activity of enterolobin: A haemolytic protein purified from seeds of the Brazilian tree Enterolobium contortisiliquum

article

Prostaglandin E2/leukotriene B4 balance induced by Lutzomyia longipalpis saliva favors Leishmania infantum infection

scientific article

Pulmonary and extrapulmonary acute lung injury: inflammatory and ultrastructural analyses

scientific article published on 13 January 2005

Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum.

scientific article published on September 2017

Reduced plasma nonesterified fatty acid levels and the advent of an acute lung injury in mice after intravenous or enteral oleic acid administration

scientific article published on 27 February 2012

Resolvin D1 drives establishment of Leishmania amazonensis infection

scientific article published on 10 April 2017

Role of prostaglandin F2α production in lipid bodies from Leishmania infantum chagasi: insights on virulence.

scientific article published on 21 May 2014

Schistosomal Lipids Activate Human Eosinophils via Toll-Like Receptor 2 and PGD Receptors: 15-LO Role in Cytokine Secretion

scientific article published on 01 January 2018

Schistosomal-derived lysophosphatidylcholine triggers M2 polarization of macrophages through PPARγ dependent mechanisms.

scientific article published on 15 November 2016

Schistosome infection-derived Hepatic Stellate Cells are cellular source of prostaglandin D₂: role in TGF-β-stimulated VEGF production

scientific article published on 3 February 2015

Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae

scientific article published on 25 August 2017

Statins decrease neuroinflammation and prevent cognitive impairment after cerebral malaria

scientific article

TLR6-driven lipid droplets in Mycobacterium leprae-infected Schwann cells: immunoinflammatory platforms associated with bacterial persistence

scientific article

The cellular biology of eosinophil eicosanoid formation and function

scientific article

The clinically approved antiviral drug sofosbuvir impairs Brazilian zika virus replication

scientific article

The disordered N-terminal region of dengue virus capsid protein contains a lipid-droplet-binding motif

scientific article

The effect of thiamine deficiency on inflammation, oxidative stress and cellular migration in an experimental model of sepsis

scientific article

The impact of coagulation parameters on the outcomes of patients with severe community-acquired pneumonia requiring intensive care unit admission ⬇️

scientific article published on March 30, 2011

The innate immune response in HIV/AIDS septic shock patients: a comparative study

scientific article

The role of corticosteroids in severe community-acquired pneumonia: a systematic review

scientific article published on 7 November 2008

The role of corticosteroids in severe community-acquired pneumonia: a systematic review

scientific article published on 11 June 2008

The role of forced swim test on neutrophil leukocytosis observed during inflammation induced by LPS in rodents

scientific article published on 01 June 2002

Time course of pulmonary burden in mice exposed to residual oil fly ash

scientific article

Toll-like receptor-2-mediated C-C chemokine receptor 3 and eotaxin-driven eosinophil influx induced by Mycobacterium bovis BCG pleurisy

scientific article

Toxoplasma gondii-skeletal muscle cells interaction increases lipid droplet biogenesis and positively modulates the production of IL-12, IFN-g and PGE2.

scientific article published on 23 January 2014

Turnover of Neutrophils Mediated by Fas Ligand Drives Leishmania major Infection

scientific article published on 10 August 2005

Two-dimensional difference gel electrophoresis (DiGE) analysis of plasmas from dengue fever patients

scientific article published on December 2009

Understanding the mechanisms controlling Leishmania amazonensis infection in vitro: the role of LTB4 derived from human neutrophils

scientific article

WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo

scientific article

Yangambin: A New Naturally-Occurring Platelet-Activating Factor Receptor Antagonist: Binding andIn VitroFunctional Studies

Yangambin: a new naturally-occurring platelet-activating factor receptor antagonist: in vivo pharmacological studies.

scientific article

Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo

scientific article published on 30 January 2019

Zika virus evolution and spread in the Americas

scientific article

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