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List of works by Patrício Soares-da-Silva

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Eslicarbazepine acetate for the treatment of focal epilepsy: an update on its proposed mechanisms of action

scientific article published on 30 March 2015
Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following multiple dose administration in healthy subjects

scientific article (publication date: 21 October 2013)
Effect of food on the pharmacokinetic profile of eslicarbazepine acetate (BIA 2-093).

scientific article published in January 2005
Age-related changes in renal expression of oxidant and antioxidant enzymes and oxidative stress markers in male SHR and WKY rats

scientific article published on 18 February 2011
Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels.

scientific article published in May 2001
New insights into the regulation of Na+,K+-ATPase by ouabain.

scientific article published on January 2012
Gialpha3 protein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated event.

scientific article published on 20 July 2004
Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers

scientific article published on 18 June 2010
Decreased availability of intestinal dopamine in transmural colitis may relate to inhibitory effects of interferon-gamma upon L-DOPA uptake.

scientific article published on April 2004
Synthesis and biological evaluation of novel, peripherally selective chromanyl imidazolethione-based inhibitors of dopamine beta-hydroxylase.

scientific article published in February 2006
Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells

scientific article published on 20 December 2007
High-salt intake and the renal expression of amino acid transporters in spontaneously hypertensive rats

scientific journal article
Medicinal Chemistry of CatecholO-Methyltransferase (COMT) Inhibitors and Their Therapeutic Utility

scientific article published on September 2, 2014
Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells

scientific article published on 20 July 2005
Pharmacokinetic interaction study between eslicarbazepine acetate and lamotrigine in healthy subjects

scientific article published on 28 December 2009
Interaction between L-DOPA and 3-O-methyl-L-DOPA for transport in immortalised rat capillary cerebral endothelial cells

scientific article published on September 1999
Distinct signalling cascades downstream to Gsalpha coupled dopamine D1-like NHE3 inhibition in rat and opossum renal epithelial cells

scientific article published in January 2004
The effect of dietary sodium restriction on neurohumoral activity and renal dopaminergic response in patients with heart failure.

scientific article
Dopamine D2 receptor polymorphisms in inflammatory bowel disease and the refractory response to treatment

scientific article
Dopamine acutely decreases type 3 Na(+)/H(+) exchanger activity in renal OK cells through the activation of protein kinases A and C signalling cascades

scientific article published in March 2004
Comparative study of ortho- and meta-nitrated inhibitors of catechol-O-methyltransferase: interactions with the active site and regioselectivity of O-methylation

scientific article published on 17 April 2006
Role of type A and B monoamine oxidase on the formation of 3,4-dihydroxyphenylacetic acid (DOPAC) in tissues from the brain of the rat.

scientific article published in October 1990
Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells

scientific journal article
Effect of eslicarbazepine acetate on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy subjects during a three-stage, open-label, multiple-dose, single-period study.

scientific article published on January 2010
Who volunteers for phase I clinical trials? Influences of anxiety, social anxiety and depressive symptoms on self-selection and the reporting of adverse events

scientific article published in June 2008
Pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine at steady state in healthy volunteers

scientific article
Deficiency of renal dopaminergic-dependent natriuretic response to acute sodium load in black salt-sensitive subjects in contrast to salt-resistant subjects

scholarly article by Albertino Damasceno et al published December 1999 in Journal of Hypertension
Deamination of newly-formed dopamine in rat renal tissues

scientific article published on March 1991
Pharmacokinetics, drug interactions and exposure-response relationship of eslicarbazepine acetate in adult patients with partial-onset seizures: population pharmacokinetic and pharmacokinetic/pharmacodynamic analyses.

scientific article published on January 2012
Pharmacokinetic interaction study between eslicarbazepine acetate and topiramate in healthy subjects

scientific article published in June 2010
Endogenous dopamine modulates jejunal sodium absorption during high-salt diet in young but not in adult rats

scientific article published on 01 September 1994
Modulation of insulin transport in rat brain microvessel endothelial cells by an ecto-phosphatase activity

scientific article published on January 2002
Renal and intestinal autocrine monoaminergic systems: dopamine versus 5-hydroxytryptamine

scientific article published on January 1997
Over-expression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR immortalized renal proximal tubular cells.

scientific article published on July 2004
Salt-inducible kinase 1 regulates E-cadherin expression and intercellular junction stability

scientific article
Reactive oxygen species and the regulation of renal Na+-K+-ATPase in opossum kidney cells.

scientific article published on August 2007
Brain and peripheral pharmacokinetics of levodopa in the cynomolgus monkey following administration of opicapone, a third generation nitrocatechol COMT inhibitor

scientific article published on 19 October 2013
H2O2 stimulation of the Cl-/HCO3- exchanger by angiotensin II and angiotensin II type 1 receptor distribution in membrane microdomains

scientific article published on 07 April 2008
D1-like dopamine receptor activation and natriuresis by nitrocatechol COMT inhibitors.

scientific article published on May 2001
Increases in intracellular sodium activate transcription and gene expression via the salt-inducible kinase 1 network in an atrial myocyte cell line

scientific article
Effects of nebicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity, and motor fluctuations in patients with Parkinson disease

scientific article
Eslicarbazepine acetate (BIA 2-093) : relative bioavailability and bioequivalence of 50 mg/mL oral suspension and 200mg and 800mg tablet formulations

scientific article published in January 2005
Overexpression of Na(+)/K (+)-ATPase parallels the increase in sodium transport and potassium recycling in an in vitro model of proximal tubule cellular ageing.

scientific article
Evidence for a non-precursor dopamine pool in noradrenergic neurones of the dog mesenteric artery

scientific article published on 01 July 1986
Effect of eslicarbazepine acetate on the pharmacokinetics of digoxin in healthy subjects

scientific article published on 4 June 2009
Effects of chemical sympathectomy on dopamine and noradrenaline content of the dog gastrointestinal tract

scientific article published in September 1985
Effect of eslicarbazepine acetate on the pharmacokinetics of a combined ethinylestradiol/levonorgestrel oral contraceptive in healthy women

scientific article published on 6 April 2013
High- and low-affinity transport of L-leucine and L-DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK1 renal cells.

scientific article
Regulation of [(3)H]MPP(+) transport by phosphorylation/dephosphorylation pathways in RBE4 cells: role of ecto-alkaline phosphatase

scientific article
Intestinal Na+-K+-ATPase activity and molecular events downstream of interferon-gamma receptor stimulation

scientific article published on 26 July 2004

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