Search filters

List of works by Patrício Soares-da-Silva

814 ANTIHYPERTENSIVE EFFECT OF BIA 5–1058 A NEW SELECTIVE PERIPHERAL DOPAMINE β-HYDROXYLASE INHIBITOR

scientific article (publication date: September 2012)

A chiral HPLC‐UV method for the quantification of dibenz[b,f]azepine‐5‐carboxamide derivatives in mouse plasma and brain tissue: Eslicarbazepine acetate, carbamazepine and main metabolites ⬇️

scientific article published on 09 May 2011

A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain

scientific article

A comparative study on the synthesis of dopamine in the human, dog and rat kidney

scientific article published on 01 July 1993

A comparative study on the synthesis of the natriuretic hormone dopamine in OK and LLC-PK1 cells.

scientific article published on August 1996

A comparison of the action of the endothelium-derived relaxant factor and the inhibitory factor from the bovine retractor penis on rabbit aortic smooth muscle

scientific article published on January 1986

A double-blind, randomized, placebo and active-controlled study of nebicapone for the treatment of motor fluctuations in Parkinson's disease.

scientific article published on December 2010

A kinetic study of the rate of formation of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the brain of the rat: implications for the origin of DOPAC.

scientific article published in October 1990

A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates

scientific article published on 30 January 2016

A new approach on the purification of recombinant human soluble catechol-O-methyltransferase from an Escherichia coli extract using hydrophobic interaction chromatography

scientific article published on 7 June 2007

A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.

scientific article published on 19 July 2017

A study of the neuronal and non-neuronal stores of dopamine in rat and rabbit kidney.

scientific article published in September 1992

Abstracts from the ASENT 2008 Annual Meeting March 6–8, 2008.

scientific article

Actin cytoskeleton, tubular sodium and the renal synthesis of dopamine

scientific article published on 01 November 1992

Activity and regulation of Na+-HCO3- cotransporter in immortalized spontaneously hypertensive rat and Wistar-Kyoto rat proximal tubular epithelial cells.

scientific article published on 26 February 2007

Acute salt loading induces sympathetic nervous system overdrive in mice lacking salt-inducible kinase 1 (SIK1)

scientific article published on 20 March 2019

Age-dependent effect of ouabain on renal Na+,K+-ATPase

scientific article published on 19 February 2011

Age-related changes in renal expression of oxidant and antioxidant enzymes and oxidative stress markers in male SHR and WKY rats

scientific article published on 18 February 2011

Age-related changes in the renal dopaminergic system and expression of renal amino acid transporters in WKY and SHR rats

scientific article published on 15 June 2011

Aging increases oxidative stress and renal expression of oxidant and antioxidant enzymes that are associated with an increased trend in systolic blood pressure.

scientific article published on July 2009

Aging, high salt intake, and renal dopaminergic activity in Fischer 344 rats

scientific article published on 01 October 1999

Altered dopaminergic transmission in the anorexic anx/anx mouse striatum

scientific article published in August 2001

Amine neurotransmitters, inflammation and epithelial sodium transport

scientific article

Amino acid and metal content of<i>Crassostrea gigas</i>shell infested by<i>Polydora</i>sp. in the prismatic layer insoluble matrix and blister membrane

scientific article published in 1996

An HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite in human plasma

scientific article

Analysis of cutaneous allergic reactions in clinical trials of eslicarbazepine acetate

scientific article published on 23 January 2020

Angiotensin-II type 1 receptor-mediated hypertension in D4 dopamine receptor-deficient mice

scientific article published on 27 December 2005

Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives

scientific article

Antihypertensive effect of etamicastat in dopamine D2 receptor-deficient mice.

scientific article published on 13 April 2018

Apical and basolateral 4F2hc and the amino acid exchange of L-DOPA in renal LLC-PK1 cells

scientific article published on 5 September 2005

Assessment of renal dopaminergic system activity during the recovery of renal function in human kidney transplant recipients

scientific article published on 01 December 1997

Assessment of the efficacy and safety of eslicarbazepine acetate in acute mania and prevention of recurrence: experience from multicentre, double-blind, randomised phase II clinical studies in patients with bipolar disorder I.

scientific article

BIA 3-202, a novel catechol-O-methyltransferase inhibitor, enhances the availability of L-DOPA to the brain and reduces its O-methylation

scientific article published in May 2001

BIA 3-202, a novel catechol-O-methyltransferase inhibitor, reduces the peripheral O-methylation of L-DOPA and enhances its availability to the brain

scientific article published in May 2003

Binding of licarbazepine enantiomers to mouse and human plasma proteins

scientific article published in July 2010

Bioanalytical chromatographic methods for the determination of catechol-O-methyltransferase inhibitors in rodents and human samples: a review

scientific article published on 20 October 2011

Bioavailability and bioequivalence of two enteric-coated formulations of omeprazole in fasting and fed conditions.

scientific article

Bioelectrical impedance analysis of body composition for the anesthetic induction dose of propofol in older patients

scientific article published on 11 October 2019

Bioequivalence of eslicarbazepine acetate from two different sources of its active product ingredient in healthy subjects.

scientific article published on June 2013

Blood pressure decrease in spontaneously hypertensive rats folowing renal denervation or dopamine β-hydroxylase inhibition with etamicastat.

scientific article published on 9 April 2015

Blood pressure-decreasing effect of etamicastat alone and in combination with antihypertensive drugs in the spontaneously hypertensive rat

scientific article published on 09 October 2014

Brain and peripheral pharmacokinetics of levodopa in the cynomolgus monkey following administration of opicapone, a third generation nitrocatechol COMT inhibitor

scientific article published on 19 October 2013

Ca2+/calmodulin mediated pathways regulate the uptake of L-DOPA in mouse neuroblastoma neuro 2A cells

scientific article published on 01 November 2000

Carbamazepine aggravates absence seizures in two dedicated mouse models

scientific article published on 23 March 2015

Carbamazepine and oxcarbazepine, but not eslicarbazepine, enhance excitatory synaptic transmission onto hippocampal CA1 pyramidal cells through an antagonist action at adenosine A1 receptors

scientific article published on 3 February 2015

Carbamazepine inhibits L-type Ca2+ channels in cultured rat hippocampal neurons stimulated with glutamate receptor agonists.

scientific article published in September 1999

Cardiometabolic and Inflammatory Benefits of Sympathetic Down-Regulation with Zamicastat in Aged Spontaneously Hypertensive Rats

scientific article published on 04 September 2019

Cardiovascular safety pharmacology profile of etamicastat, a novel peripheral selective dopamine-β-hydroxylase inhibitor

scientific article published on 30 January 2015

Catechol-O-methyltransferase and its inhibitors in Parkinson's disease

scientific article

Catechol-O-methyltransferase inhibition in erythrocytes and liver by BIA 3-202 (1-[3,4-dibydroxy-5-nitrophenyl]-2-phenyl-ethanone).

scientific article published in June 2003

Characterization of the interaction of the novel antihypertensive etamicastat with human dopamine-β-hydroxylase: comparison with nepicastat.

scientific article

Chronopharmacology of nebicapone, a new catechol-O-methyltransferase inhibitor

scientific article published in May 2010

Cloning and gene silencing of LAT2, the L-3,4-dihydroxyphenylalanine (L-DOPA) transporter, in pig renal LLC-PK1 epithelial cells.

scientific article published in October 2004

Comments on the Eslicarbazepine Acetate Section of the Article ‘Therapeutic Drug Monitoring of the Newer Anti-Epilepsy Medications’.

scientific article published on 17 December 2010

Comparative analysis of the safety and tolerability of eslicarbazepine acetate in older (≥60 years) and younger (18-59 years) adults

scientific article published on 10 October 2020

Comparative study of ortho- and meta-nitrated inhibitors of catechol-O-methyltransferase: interactions with the active site and regioselectivity of O-methylation

scientific article published on 17 April 2006

Comparative study on sodium transport and Na+,K+-ATPase activity in Caco-2 and rat jejunal epithelial cells: effects of dopamine

scientific article

Competitive and non-competitive inhibition of l-3,4-dihydroxyphenylalanine uptake in Opossum kidney cells ⬇️

scientific article published on 01 August 1997

Computation of the binding affinities of catechol-O-methyltransferase inhibitors: multisubstate relative free energy calculations.

scientific article published on 25 January 2012

Concerns Regarding Opicapone as Adjunct to Levodopa Therapy-Reply

scientific article published on 01 July 2017

Contemporary Options for the Management of Motor Complications in Parkinson's Disease: Updated Clinical Review

scientific article published on 01 April 2019

Correction to: Effectiveness and safety of opicapone in Parkinson's disease patients with motor fluctuations: the OPTIPARK open-label study

scientific article published on 28 April 2020

Crystallization and preliminary X-ray diffraction studies of a catechol-O-methyltransferase/inhibitor complex

scientific article published on 24 December 2004

Crystallization and preliminary crystallographic characterization of catechol-O-methyltransferase in complex with its cosubstrate and an inhibitor

scientific article published on 25 May 2001

D1-like dopamine receptor activation and natriuresis by nitrocatechol COMT inhibitors.

scientific article published on May 2001

Deamination of newly-formed dopamine in rat renal tissues

scientific article published on March 1991

Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats

scientific article published in August 2003

Decreased availability of intestinal dopamine in transmural colitis may relate to inhibitory effects of interferon-gamma upon L-DOPA uptake.

scientific article published on April 2004

Defective D1-like receptor-mediated inhibition of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells

scientific article published on 17 February 2004

Deficiency of renal dopaminergic-dependent natriuretic response to acute sodium load in black salt-sensitive subjects in contrast to salt-resistant subjects

scholarly article by Albertino Damasceno et al published December 1999 in Journal of Hypertension

Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma

scientific article published on 18 April 2010

Development and validation of an enantioselective liquid-chromatography/tandem mass spectrometry method for the separation and quantification of eslicarbazepine acetate, eslicarbazepine, R-licarbazepine and oxcarbazepine in human plasma

scientific article published on 20 July 2011

Development of Blood-Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity

scientific article published on 27 July 2016

Development of a liquid chromatography assay for the determination of opicapone and BIA 9-1079 in rat matrices

scientific article published on 6 July 2015

Differential substrate specificity of monoamine oxidase in the rat heart and renal cortex

scientific article

Discovery of a Potent, Long-Acting, and CNS-Active Inhibitor (BIA 10-2474) of Fatty Acid Amide Hydrolase

scientific article published on 11 September 2018

Discovery of a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase.

scientific article published in April 2010

Disposition of eslicarbazepine acetate in the mouse after oral administration

scientific article published on 15 August 2008

Distinct signalling cascades downstream to Gsalpha coupled dopamine D1-like NHE3 inhibition in rat and opossum renal epithelial cells

scientific article published in January 2004

Does brain 3,4-dihydroxyphenylacetic acid reflect dopamine release?

scientific article published on 01 February 1987

Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells

Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells.

scientific article

Dopamine D1-like receptor-mediated inhibition of Cl/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6)

scientific journal article

Dopamine D2 receptor polymorphisms in inflammatory bowel disease and the refractory response to treatment.

scientific article

Dopamine D2-like receptor-mediated opening of K+ channels in opossum kidney cells

scientific article

Dopamine D2-like receptors in the rat kidney: effect of denervation.

scientific article published on September 1997

Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells

scientific journal article

Dopamine acutely decreases type 3 Na(+)/H(+) exchanger activity in renal OK cells through the activation of protein kinases A and C signalling cascades

scientific article published in March 2004

Dopamine and G protein-coupled receptor kinase 4 in the kidney: role in blood pressure regulation

scientific article

Dopamine released from nerve terminals activates prejunctional dopamine receptors in dog mesenteric arterial vessels

scientific article published on July 1987

Dopamine-induced inhibition of Na+-K+-ATPase activity requires integrity of actin cytoskeleton in opossum kidney cells

scientific article

Dosage form proportionality and food effect of the final tablet formulation of eslicarbazepine acetate: randomized, open-label, crossover, single-centre study in healthy volunteers

scientific article published on January 2008

Effect of 3 Single-Dose Regimens of Opicapone on Levodopa Pharmacokinetics, Catechol-O-Methyltransferase Activity and Motor Response in Patients With Parkinson Disease

article

Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers

scientific article published on 18 June 2010

Effect of eslicarbazepine acetate in the corneal kindling progression and the amygdala kindling model of temporal lobe epilepsy

scientific article published on December 2013

Effect of eslicarbazepine acetate on the pharmacokinetics of a combined ethinylestradiol/levonorgestrel oral contraceptive in healthy women

scientific article published on 6 April 2013

Effect of eslicarbazepine acetate on the pharmacokinetics of digoxin in healthy subjects.

scientific article published on 4 June 2009

Effect of eslicarbazepine acetate on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy subjects during a three-stage, open-label, multiple-dose, single-period study.

scientific article published on January 2010

Effect of food on the pharmacokinetic profile of eslicarbazepine acetate (BIA 2-093).

scientific article published in January 2005

Effect of food on the pharmacokinetic profile of etamicastat (BIA 5-453).

scientific article published on January 2011

Effect of gender on the pharmacokinetics of eslicarbazepine acetate (BIA 2-093), a new voltage-gated sodium channel blocker

scientific article published in July 2007

Effect of moderate liver impairment on the pharmacokinetics of opicapone

scientific article published on 24 November 2013

Effect of nebicapone on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects.

scientific article

Effect of opicapone and entacapone upon levodopa pharmacokinetics during three daily levodopa administrations

scientific article published on 14 June 2014

Effect of opicapone multiple-dose regimens on levodopa pharmacokinetics.

scientific article

Effect of repeated administration of eslicarbazepine acetate on the pharmacokinetics of simvastatin in healthy subjects

scientific article published on 30 May 2013

Effect of saline load and metoclopramide on the renal dopaminergic system in patients with heart failure and healthy controls.

scientific article

Effect of salt intake on jejunal dopamine, Na+,K+-ATPase activity and electrolyte transport.

scientific article

Effectiveness and safety of opicapone in Parkinson's disease patients with motor fluctuations: the OPTIPARK open-label study

scientific article published on 04 March 2020

Effectiveness of opicapone and switching from entacapone in fluctuating Parkinson disease

scientific article

Effects of adjunctive eslicarbazepine acetate on serum lipids in patients with partial-onset seizures: Impact of concomitant statins and enzyme-inducing antiepileptic drugs.

scientific article

Effects of chemical sympathectomy on dopamine and noradrenaline content of the dog gastrointestinal tract.

scientific article published in September 1985

Effects of cyclic hydrostatic pressure on the brain biogenic amines concentrations in the flounder, Platichthys flesus

scientific article published on 18 May 2007

Effects of enalapril and imidapril in the capsaicin cough challenge test and spirometry parameters in healthy volunteers

Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus

scientific article published on 20 December 2014

Effects of eslicarbazepine on slow inactivation processes of sodium channels in dentate gyrus granule cells

scientific article published on 28 June 2018

Effects of nebicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity, and motor fluctuations in patients with Parkinson disease

scientific article

Effects of nepicastat upon dopamine-β-hydroxylase activity and dopamine and norepinephrine levels in the rat left ventricle, kidney, and adrenal gland

scientific article published on 01 March 2019

Effects of sympathetic denervation on liver fibroblasts: prevention by adenosine.

scientific article published on June 1990

Effects of tolcapone upon soluble and membrane-bound brain and liver catechol-O-methyltransferase

scientific article

Effects of zamicastat treatment in a genetic model of salt-sensitive hypertension and heart failure

scientific article published on 26 October 2018

Efficacy and safety of 800 and 1200 mg eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures

scientific article published in November 2009

Efficacy and safety of eslicarbazepine acetate as adjunctive therapy for refractory focal-onset seizures in children: A double-blind, randomized, placebo-controlled, parallel-group, multicenter, phase-III clinical trial

scientific article published on 06 March 2020

Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: a randomized, double-blind, placebo-controlled, parallel-group phase III study

scientific article published on 21 February 2009

Efficacy and safety of eslicarbazepine acetate versus controlled-release carbamazepine monotherapy in newly diagnosed epilepsy: A phase III double-blind, randomized, parallel-group, multicenter study

scientific article published on 25 January 2018

Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors

scientific article

Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: no interference with carbamazepine and its metabolites

scientific article published in August 2010

Endogenous dopamine modulates jejunal sodium absorption during high-salt diet in young but not in adult rats

scientific article published on 01 September 1994

Enhanced protein kinase C mediated inhibition of renal dopamine synthesis during high sodium intake

scientific article published on 01 May 1993

Erratum to: Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells

scholarly article published in Molecular and Cellular Biochemistry

Eslicarbazepine Acetate: A Double-blind, Add-on, Placebo-controlled Exploratory Trial in Adult Patients with Partial-onset Seizures

scientific article published on 21 February 2007

Eslicarbazepine acetate (BIA 2-093) : relative bioavailability and bioequivalence of 50 mg/mL oral suspension and 200mg and 800mg tablet formulations

scientific article published in January 2005

Eslicarbazepine acetate (BIA 2-093).

scientific article

Eslicarbazepine acetate as adjunctive therapy in adult patients with partial epilepsy

scientific article published on 17 March 2010

Eslicarbazepine acetate as adjunctive therapy in patients with uncontrolled partial-onset seizures: Results of a phase III, double-blind, randomized, placebo-controlled trial

scientific article

Eslicarbazepine acetate exposure in pregnant women with epilepsy

scientific article published on 10 April 2018

Eslicarbazepine acetate for the treatment of focal epilepsy: an update on its proposed mechanisms of action

scientific article published on 30 March 2015

Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: a comparison with carbamazepine, oxcarbazepine and lacosamide.

scientific article published on 19 September 2014

Etamicastat, a new dopamine-ß-hydroxylase inhibitor, pharmacodynamics and metabolism in rat.

scientific article

Etamicastat, a novel dopamine β-hydroxylase inhibitor: tolerability, pharmacokinetics, and pharmacodynamics in patients with hypertension.

scientific article

Evaluation of Eslicarbazepine Acetate on Cardiac Repolarization in a Thorough QT/QTc Study

scientific article published on 01 February 2012

Evaluation of neurotoxic and neuroprotective pathways affected by antiepileptic drugs in cultured hippocampal neurons.

scientific article published on 19 September 2013

Evaluation of opicapone on cardiac repolarization in a thorough QT/QTc study

scientific article published on 7 May 2015

Evaluation of the permeability and P‐glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique ⬇️

scientific article published on 01 March 2012

Evidence for a non-precursor dopamine pool in noradrenergic neurones of the dog mesenteric artery

scientific article published on 01 July 1986

Evidence for dopaminergic co-transmission in dog mesenteric arterial vessels

scientific article published on September 1988

Evidence for the involvement of P-glycoprotein on the extrusion of taken up L-DOPA in cyclosporine A treated LLC-PK1 cells.

scientific article

Expression and characterization of rat soluble catechol-O-methyltransferase fusion protein

scientific article published in October 2001

Expression and function of LAT1, a neutral amino acid exchanger, in renal porcine epithelial cell line LLC-PK.

scientific article published on September 2005

Expression and function of sodium transporters in two opossum kidney cell clonal sublines

scientific article published in July 2002

Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells

scientific article published on 20 July 2005

Further evidence for a noradrenaline-independent storage of dopamine in the dog kidney.

scientific article

Genomic regulation of intestinal amino acid transporters by aldosterone

scientific article

Gialpha3 protein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated event.

scientific article published on 20 July 2004

H2 O2 stimulates Cl- /HCO 3- exchanger activity through oxidation of thiol groups in immortalized SHR renal proximal tubular epithelial cells.

scientific article

H2O2 stimulation of the Cl-/HCO3- exchanger by angiotensin II and angiotensin II type 1 receptor distribution in membrane microdomains

scientific article published on 07 April 2008

Heart failure, aging, and renal synthesis of dopamine

scientific article

Hepatic UDP-glucuronosyltransferase is responsible for eslicarbazepine glucuronidation.

scientific article

High sodium intake increases the urinary excretion of L-3,4-dihydroxyphenylalanine but fails to alter the urinary excretion of dopamine and amine metabolites in Wistar rats

scientific article published on 01 December 1996

High- and low-affinity transport of L-leucine and L-DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK1 renal cells.

scientific article

High-salt intake and the renal expression of amino acid transporters in spontaneously hypertensive rats

scientific journal article

Human Metabolism of Nebicapone (BIA 3-202), a Novel Catechol-O-Methyltransferase Inhibitor: Characterization of in Vitro Glucuronidation

scientific article published on 21 June 2006

Human disposition, metabolism and excretion of etamicastat, a reversible, peripherally selective dopamine β-hydroxylase inhibitor.

scientific article published on June 2014

Identification of SLC26A transporters involved in the Cl⁻/HCO₃⁻ exchange in proximal tubular cells from WKY and SHR.

scientific article

Impaired synthesis or cellular storage of norepinephrine, dopamine, and 5-hydroxytryptamine in human inflammatory bowel disease.

scientific article published on January 2002

In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein.

scientific article published on 8 February 2018

In-vivo evaluation of prolonged release bilayer tablets of anti-Parkinson drugs in Göttingen minipigs

scientific article published on 28 April 2011

Increased arterial blood pressure and vascular remodeling in mice lacking salt-inducible kinase 1 (SIK1).

scientific article published on 2 January 2015

Increased responsiveness to JNK1/2 mediates the enhanced H2O2-induced stimulation of Cl-/HCO3- exchanger activity in immortalized renal proximal tubular epithelial cells from the SHR.

scientific article

Increases in intracellular sodium activate transcription and gene expression via the salt-inducible kinase 1 network in an atrial myocyte cell line

scientific article

Increases in transepithelial vectorial Na+ transport facilitates Na+-dependent L-DOPA transport in renal OK cells.

scientific article published on 6 March 2006

Influence of titration schedule and maintenance dose on the tolerability of adjunctive eslicarbazepine acetate: An integrated analysis of three randomized placebo-controlled trials

scientific article

Inhibition of calcium-independent luminal uptake of L-dopa by calmodulin antagonists in immortalized rat capillary cerebral endothelial cells

scientific article published on January 2001

Inhibition of catechol-O-methyltransferase in the cynomolgus monkey by opicapone after acute and repeated administration

scientific article published on 02 October 2018

Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels.

scientific article published in May 2001

Inhibitory effect of phenolic compounds from grape seeds (Vitis vinifera L.) on the activity of angiotensin I converting enzyme

Interaction between L-DOPA and 3-O-methyl-L-DOPA for transport in immortalised rat capillary cerebral endothelial cells

scientific article published on September 1999

Interaction of the novel anticonvulsant, BIA 2-093, with voltage-gated sodium channels: comparison with carbamazepine

scientific article

Interferon-gamma-induced STAT1-mediated membrane retention of NHE1 and associated proteins ezrin, radixin and moesin in HT-29 cells

scientific article published in November 2005

Intestinal 5-Hydroxytryptamine and Mast Cell Infiltration in Rat Experimental Colitis

scientific article published on 01 March 2006

Intestinal Na+-K+-ATPase activity and molecular events downstream of interferon-gamma receptor stimulation

scientific article published on 26 July 2004

Intestinal dopaminergic activity in obese and lean Zucker rats: response to high salt intake

scientific article

Involvement of G protein-coupled receptor kinase 4 and 6 in rapid desensitization of dopamine D1 receptor in rat IEC-6 intestinal epithelial cells

scientific journal article

Isosorbide 5-mononitrate reverses high blood pressure in NG-nitro-L-arginine methyl ester treated rats

scientific article published on 01 November 1994

Kinetic inhibitory profile of BIA 3-202, a novel fast tight-binding, reversible and competitive catechol-O-methyltransferase inhibitor.

scientific article

Kinetic study of the tubular dopamine outward transporter in the rat and dog kidney

scientific article published on June 1993

Kinetics and crystal structure of catechol-o-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application

scientific article

Kinetics of rat brain and liver solubilized membrane-bound catechol-O-methyltransferase

scientific article

L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan share the same transporter in Opossum kidney cells

scientific article published in February 1998

L-type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acids

scientific article published on 01 April 2002

LAT1 overexpression and function compensates downregulation of ASCT2 in an in vitro model of renal proximal tubule cell ageing

scientific article published on 2 December 2010

Lack of salt-inducible kinase 2 (SIK2) prevents the development of cardiac hypertrophy in response to chronic high-salt intake.

scientific article

Liver says no: the ongoing search for safe catechol O-methyltransferase inhibitors to replace tolcapone

scientific article published on 17 July 2020

Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex

scientific article published in January 2005

Long-term efficacy and safety of eslicarbazepine acetate monotherapy for adults with newly diagnosed focal epilepsy: An open-label extension study

scientific article published on 17 September 2020

Long-term efficacy and safety of eslicarbazepine acetate: results of a 1-year open-label extension study in partial-onset seizures in adults with epilepsy

scientific article published on October 2010

Long-term food restriction attenuates age-related changes in the expression of renal aldosterone-sensitive sodium transporters in Wistar-Kyoto rats: a comparison with SHR.

scientific article published on 9 June 2012

Long-term regulation of Na+,K+-ATPase in opossum kidney cells by ouabain.

scientific article published on September 2011

Long-term safety and efficacy of eslicarbazepine acetate as adjunctive therapy in the treatment of partial-onset seizures in adults with epilepsy: results of a 1-year open-label extension study

scientific article published on 4 August 2012

Loss of oxidative stress tolerance in hypertension is linked to reduced catalase activity and increased c-Jun NH2-terminal kinase activation.

scientific article

Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024.

scientific article

Medicinal chemistry of catechol O-methyltransferase (COMT) inhibitors and their therapeutic utility

scientific article published on 2 September 2014

Metabolism of 10,11-dihydro-10-hydroxyimino-5H-dibenz/b, f/azepine-5-carboxamide, a potent anti-epileptic drug

scientific article published in February 2002

Metabolism of two new antiepileptic drugs and their principal metabolites S(+)- and R(-)-10,11-dihydro-10-hydroxy carbamazepine

scientific article published in May 2001

Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive

scientific article (publication date: 15 December 2002)

Modulation of insulin transport in rat brain microvessel endothelial cells by an ecto-phosphatase activity

scientific article published on January 2002

Molecular modeling and metabolic studies of the interaction of catechol-O-methyltransferase and a new nitrocatechol inhibitor

scientific journal article

N-acetylation of etamicastat, a reversible dopamine-β-hydroxylase inhibitor

scientific article published on 6 September 2013

Na(+)/H(+) exchanger activity and dopamine D(1)-like receptor function in two opossum kidney cell clonal sublines

scientific article published in January 2002

Na+-independent transporters, LAT-2 and b0,+, exchange L-DOPA with neutral and basic amino acids in two clonal renal cell lines

scientific article published on March 2002

Nature and kinetic characteristics of L-DOPA uptake in rat renal proximal tubules

scientific article published in September 1995

Neurohormonal activation, the renal dopaminergic system and sodium handling in patients with severe heart failure under vasodilator therapy

scientific article published in May 2001

Neurotoxic/neuroprotective profile of carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2-024

scientific article published on 01 October 2000

Neurotoxicity induced by antiepileptic drugs in cultured hippocampal neurons: a comparative study between carbamazepine, oxcarbazepine, and two new putative antiepileptic drugs, BIA 2-024 and BIA 2-093.

scientific article published in December 2004

New insights into the regulation of Na+,K+-ATPase by ouabain.

scientific article published on January 2012

Ontogenic aspects of D1 receptor coupling to G proteins and regulation of rat jejunal Na+, K+ ATPase activity and electrolyte transport.

scientific article

Ontogeny of the cell outward dopamine transporter in canine renal tissues

scientific article published in January 1995

Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor Fluctuations: A Randomized Clinical Trial

scientific article published on 27 December 2016

Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial

scientific article published on 22 December 2015

Opicapone enhances the reversal of MPTP-induced Parkinson-like syndrome by levodopa in cynomolgus monkeys

scientific article published on 18 November 2020

Opicapone pharmacokinetics and pharmacodynamics comparison between healthy Japanese and matched white subjects

scientific article published on 16 October 2015

Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following multiple dose administration in healthy subjects

scientific article (publication date: 21 October 2013)

Opossum kidney (OK) cells in culture synthesize and degrade the natriuretic hormone dopamine: a comparison with rat renal tubular cells.

scientific article published on April 1997

Opossum kidney cells take up L-DOPA through an organic cation potential-dependent and proton-independent transporter.

scientific article published on April 1997

Optimization of a Parallel Artificial Membrane Permeability Assay for the Fast and Simultaneous Prediction of Human Intestinal Absorption and Plasma Protein Binding of Drug Candidates: Application to Dibenz[b,f]azepine-5-Carboxamide Derivatives

scientific article published on 03 November 2011

Organ specific underexpression renal of Na+-dependent B0AT1 in the SHR correlates positively with overexpression of NHE3 and salt intake

scientific article published on 24 July 2007

Organ-specific overexpression of renal LAT2 and enhanced tubular L-DOPA uptake precede the onset of hypertension

scientific article published on 15 September 2003

Outflow of dopamine and noradrenaline originating from L-dopa and L-threo-DOPS in rat renal tissues

scientific article published on 01 September 1994

Over-expression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR immortalized renal proximal tubular cells.

scientific article published on July 2004

Overexpression of Na(+)/K (+)-ATPase parallels the increase in sodium transport and potassium recycling in an in vitro model of proximal tubule cellular ageing.

scientific article

Overexpression of Non-Functional LAT1/4F2hc in Renal Proximal Tubular Epithelial Cells from the Spontaneous Hypertensive Rat

scientific article published on 01 January 2007

Overflow of endogenous dopamine and 3,4-dihydroxyphenylacetic acid from tissues of the rat brain, elicited by electrical stimulation, depolarization by potassium and activation of carrier-mediated release

scientific article published in December 1990

Oxidative and non-oxidative mechanisms of neuronal cell death and apoptosis by L-3,4-dihydroxyphenylalanine (L-DOPA) and dopamine.

scientific article published in December 2002

Oxidative stress and alpha1-adrenoceptor-mediated stimulation of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells

scientific article

Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells

scientific article published on 20 December 2007

Oxidative stress plays a permissive role in alpha2-adrenoceptor-mediated events in immortalized SHR proximal tubular epithelial cells.

scientific article

P-glycoprotein phosphorylation/dephosphorylation and cellular accumulation of L-DOPA in LLC-GA5 Col300 cells.

scientific article published on June 1999

Pharmacodynamic evaluation of novel Catechol-O-methyltransferase inhibitors

scientific article published on 24 January 2019

Pharmacokinetic and pharmacodynamic profiles of BIA 3-202, a novel catechol-O-methyltransferase (COMT) inhibitor, during multiple-dose administration to healthy subjects.

scientific article published in December 2003

Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers

scientific article published in May 2009

Pharmacokinetic interaction study between eslicarbazepine acetate and lamotrigine in healthy subjects

scientific article published on 28 December 2009

Pharmacokinetic interaction study between eslicarbazepine acetate and topiramate in healthy subjects

scientific article published in June 2010

Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/benserazide

scientific article published on 27 September 2003

Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/carbidopa

scientific article published in January 2004

Pharmacokinetic-pharmacodynamic interaction between nebicapone and controlled-release levodopa/benserazide: a single-center, Phase I, double-blind, randomized, placebo-controlled, four-way crossover study in healthy subjects

scientific article published in October 2009

Pharmacokinetic-pharmacodynamic interaction between nebicapone, a novel catechol-o-methyltransferase inhibitor, and controlled-release levodopa/carbidopa 200 mg/50 mg : randomized, double-blind, placebo-controlled, crossover study in healthy subject

scientific article

Pharmacokinetics and drug interactions of eslicarbazepine acetate.

scientific article

Pharmacokinetics and pharmacodynamics of BIA 3-202, a novel COMT inhibitor, during first administration to humans

scientific article published in January 2003

Pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine at steady state in healthy volunteers

scientific article

Pharmacokinetics and tolerability of etamicastat following single and repeated administration in elderly versus young healthy male subjects: an open-label, single-center, parallel-group study

scientific article published in June 2011

Pharmacokinetics of eslicarbazepine acetate at steady-state in adults with partial-onset seizures

article

Pharmacokinetics of eslicarbazepine acetate in patients with moderate hepatic impairment

scientific article published on 21 December 2007

Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration: A comparative study in the rat.

scientific article published on 16 March 2017

Pharmacokinetics of trans-resveratrol following repeated administration in healthy elderly and young subjects

scientific article published in October 2009

Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new set of data for predictive in silico ADME models

scientific article

Pharmacokinetics, disposition, and metabolism of [14C]-nebicapone in humans

scientific article published on August 2010

Pharmacokinetics, drug interactions and exposure-response relationship of eslicarbazepine acetate in adult patients with partial-onset seizures: population pharmacokinetic and pharmacokinetic/pharmacodynamic analyses.

scientific article published on January 2012

Pharmacokinetics, efficacy, and tolerability of eslicarbazepine acetate in children and adolescents with epilepsy

scientific article published on 28 May 2008

Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel catechol-O-methyltransferase inhibitor, in healthy subjects: prediction of slow enzyme-inhibitor complex dissociation of a short-living and very long-acting inhibitor.

scientific article published in February 2013

Polyamine Modulation of Anticonvulsant Drug Response: A Potential Mechanism Contributing to Pharmacoresistance in Chronic Epilepsy

scientific article published on 22 May 2018

Pooled efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures: Data from four double-blind placebo-controlled pivotal phase III clinical studies

scientific article

Population Pharmacokinetic-Pharmacodynamic Modeling for Propofol Anesthesia Guided by the Bispectral Index (BIS)

scientific article published on 03 December 2019

Preclinical pharmacological evaluation of the fatty acid amide hydrolase inhibitor BIA 10-2474

scientific article published on 12 February 2020

Preferential decarboxylation of L-threo-3,4-dihydroxyphenylserine in rat renal tissues

scientific article published on 01 January 1993

Preliminary studies on the development of a high cell-density fed-batch bioprocess for the heterologous production of hSCOMT in Escherichia coli

scientific article published in 2007

Protein cytoskeleton and overexpression of Na(+),K(+)-ATPase in opossum kidney cells

scientific article

Purification of membrane-bound catechol-O-methyltransferase

scientific article published on 01 January 2003

Rat liver catechol-O-methyltransferase kinetics and assay methodology

scientific article published on 01 September 1998

Reactive oxygen species and the regulation of renal Na+-K+-ATPase in opossum kidney cells.

scientific article published on August 2007

Reduced urinary excretion of dopamine and metabolites in chronic renal parenchymal disease

scientific article published on 01 January 1998

Regional intestinal adaptations in Na+,K+-ATPase in experimental colitis and the contrasting effects of interferon-gamma

scientific article

Regulation of Renal LAT2 and 4F2hc Expression by Aldosterone

Regulation of [(3)H]MPP(+) transport by phosphorylation/dephosphorylation pathways in RBE4 cells: role of ecto-alkaline phosphatase

scientific article

Regulation of amino acid transporters in the rat remnant kidney

scientific article published on 20 January 2009

Regulation of apical transporter of L-DOPA in human intestinal Caco-2 cells.

scientific article

Regulatory safety pharmacology evaluation of BIA 10-2474

scientific article published on 22 January 2020

Relative Bioavailability of Two Enteric-Coated Formulations of Omeprazole following Repeated Doses in Healthy Volunteers

scientific article published in March 2001

Relaxant effects of alpha-human atrial natriuretic peptide on venous smooth muscle

scientific article published on 01 June 1991

Renal aging in WKY rats: changes in Na+,K+ -ATPase function and oxidative stress.

scientific article published on 29 September 2010

Renal amino acid transport systems and essential hypertension ⬇️

scientific article published on April 24, 2013

Renal and intestinal autocrine monoaminergic systems: dopamine versus 5-hydroxytryptamine

scientific article published on January 1997

Renal dopamine and salt sensitivity of blood pressure in IgA nephropathy

scientific article

Renal dopaminergic system in nephrotic syndrome and after remission.

scientific article published on October 1998

Renal synthesis of dopamine in asymptomatic post-infarction left ventricular systolic dysfunction

scientific article published on 01 September 2000

Renal tubular dopamine outward transfer during Na(+)-H+ exchange activation by alpha 1- and alpha 2-adrenoceptor agonists

scientific article published on June 1993

Repurposing nitrocatechols: 5-Nitro-α-cyanocarboxamide derivatives of caffeic acid and caffeic acid phenethyl ester effectively inhibit aggregation of tau-derived hexapeptide AcPHF6

scientific article published on 04 February 2019

Response of jejunal Na+, K+-ATPase to 5-hydroxytryptamine in young and adult rats: effect of fasting and refeeding

scientific article published on June 2000

Response: Comparing the dosages of lacosamide, eslicarbazepine acetate, and controlled-release carbamazepine in noninferiority epilepsy monotherapy trials: How much "fair" is "fair".

scientific article published in April 2018

Role of H(2)O(2) on the kinetics of low-affinity high-capacity Na(+)-dependent alanine transport in SHR proximal tubular epithelial cells.

scientific article published on July 2010

Role of P-glycoprotein and permeability upon the brain distribution and pharmacodynamics of etamicastat: a comparison with nepicastat.

scientific article published on 27 April 2015

Role of cAMP-PKA-PLC signaling cascade on dopamine-induced PKC-mediated inhibition of renal Na(+)-K(+)-ATPase activity.

scientific article published in June 2002

Role of epithelial ion transports in inflammatory bowel disease

scientific article

Role of type A and B monoamine oxidase on the formation of 3,4-dihydroxyphenylacetic acid (DOPAC) in tissues from the brain of the rat.

scientific article published in October 1990

Safety Profile of Eslicarbazepine Acetate as Add-On Therapy in Adults with Refractory Focal-Onset Seizures: From Clinical Studies to 6 Years of Post-Marketing Experience

scientific article

Safety Profile of Opicapone in the Management of Parkinson's Disease

scientific article published on 01 January 2019

Safety, Tolerability and Efficacy of Eslicarbazepine Acetate as Adjunctive Therapy in Patients Aged ≥ 65 Years with Focal Seizures

Safety, Tolerability, and Pharmacokinetics of Etamicastat, a Novel Dopamine-β-Hydroxylase Inhibitor, in a Rising Multiple-Dose Study in Young Healthy Subjects

scientific article (publication date: November 2010)

Safety, tolerability and pharmacokinetic profile of BIA 2-093, a novel putative antiepileptic agent, during first administration to humans

scientific article published in January 2003

Safety, tolerability, and pharmacokinetic profile of BIA 2-093, a novel putative antiepileptic, in a rising multiple-dose study in young healthy humans

scientific article

Salt intake and intestinal dopaminergic activity in adult and old Fischer 344 rats

scientific article

Salt intake and sensitivity of intestinal and renal Na+-K+ atpase to inhibition by dopamine in spontaneous hypertensive and Wistar-Kyoto rats

scientific article published on 01 July 2000

Salt sensitivity of blood pressure in patients with psoriasis on ciclosporin therapy.

scientific article

Salt-inducible kinase 1 regulates E-cadherin expression and intercellular junction stability

scientific article

Short- and long-term regulation of intestinal Na+/H+ exchange activity associated with TLR2 receptor activation is independent of nuclear factor-κB signaling

scientific article published on 11 July 2013

Short- and long-term regulation of intestinal Na+/H+ exchange by Toll-like receptors TLR4 and TLR5.

scientific article published on 20 August 2015

Short-term effect on intestinal epithelial Na+/H+ exchanger by Giα1,2-coupled 5-HT1A and Gq/11-coupled 5-HT2 receptors

scientific article published on 10 July 2007

Short-term regulation of the Cl-/HCO3(-) exchanger in immortalized SHR proximal tubular epithelial cells.

scientific article

Short-term vs. sustained inhibition of proximal tubule Na,K-ATPase activity by dopamine: cellular mechanisms

scientific article published on 01 January 1997

Signaling of short- and long-term regulation of intestinal epithelial type 1 Na+/H+ exchanger by interferon-gamma

scientific article published in May 2005

Single-Dose Tolerability, Pharmacokinetics, and Pharmacodynamics of Etamicastat (BIA 5-453), a New Dopamine β-Hydroxylase Inhibitor, in Healthy Subjects

scientific article published on 01 February 2012

Single-dose and steady-state pharmacokinetics of eslicarbazepine acetate (BIA 2-093) in healthy elderly and young subjects

scientific article published in September 2005

Species differences in pharmacokinetic and pharmacodynamic properties of nebicapone.

scientific article

Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers

scientific article

Stereoselective disposition of S- and R-licarbazepine in mice

scientific article

Sustained high blood pressure reduction with etamicastat, a peripheral selective dopamine β-hydroxylase inhibitor

scientific article

Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase

scientific article published on December 2005

Synthesis and biological evaluation of novel, peripherally selective chromanyl imidazolethione-based inhibitors of dopamine beta-hydroxylase.

scientific article published in February 2006

Synthesis, anticonvulsant properties and pharmacokinetic profile of novel 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide derivatives

scientific article

Synthesis, biological evaluation, and molecular modeling studies of a novel, peripherally selective inhibitor of catechol-O-methyltransferase.

scientific article

Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug

scientific article published on 2 December 2014

The L-3,4-dihydroxyphenylalanine transporter in human and rat epithelial intestinal cells is a type 2 hetero amino acid exchanger.

scientific article

The O-methylated derivative of L-DOPA, 3-O-methyl-L-DOPA, fails to inhibit neuronal and non-neuronal aromatic L-amino acid decarboxylase

scientific article published on 01 April 2000

The activity of MAO A and B in rat renal cells and tubules ⬇️

scientific article published on 01 January 1998

The chemistry of catechol-O-methyltransferase inhibitors

scientific article published on January 2010

The dopamine antagonist sch 23390 reverses dizocilpine-induced blockade of cocaine sensitization

scientific article published in July 2000

The effect of PRR ligands on the membrane potential of intestinal epithelial cells

scientific article published on 23 April 2017

The effect of dietary sodium restriction on neurohumoral activity and renal dopaminergic response in patients with heart failure.

scientific article

The effects of eslicarbazepine on persistent Na⁺ current and the role of the Na⁺ channel β subunits

scientific article

The novel anticonvulsant BIA 2-093 inhibits transmitter release during opening of voltage-gated sodium channels: a comparison with carbamazepine and oxcarbazepine

scientific article published in April 2002

The renal dopaminergic system, neurohumoral activation, and sodium handling in heart failure

scientific article published in March 2002

Transport of the organic cations gonyautoxin 2/3 epimers, a paralytic shellfish poison toxin, through the human and rat intestinal epitheliums.

scientific article published in October 2002

Underexpression of the Na+-dependent neutral amino acid transporter ASCT2 in the spontaneously hypertensive rat kidney.

scientific article published on 2 May 2007

Upregulation of apical NHE3 in renal OK cells overexpressing the rodent alpha(1)-subunit of the Na(+) pump.

scientific article published on 17 November 2005

Uptake of l-3,4-dihydroxyphenylalanine and dopamine formation in cultured renal epithelial cells ⬇️

scientific article published on 01 November 1997

Who volunteers for phase I clinical trials? Influences of anxiety, social anxiety and depressive symptoms on self-selection and the reporting of adverse events

scientific article published in June 2008

Why healthy subjects volunteer for phase I studies and how they perceive their participation?

scientific article published on 20 September 2007

α2-Adrenoceptors mediate the effect of dopamine on adult rat jejunal electrolyte transport ⬇️

scientific article published on August 28, 1998

Paulina is supported by:

About Paulina

Help