List of works - Loic Yengo

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

scientific article

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

scientific article published in February 2013

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

scientific journal article

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

article

Genomic insights into the origin of farming in the ancient Near East

scientific article (publication date: 25 August 2016)

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

scientific article published on 29 January 2012

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

scientific article

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

scientific article

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

scientific article published on 31 May 2017

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

scientific article published on 08 October 2018

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study

scientific article

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

scientific article published on 14 April 2013

Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases

scientific article

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

article

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

scientific article published on 24 November 2015

Detection of human adaptation during the past 2000 years

scientific article

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

scientific article published on February 2016

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

scientific article published on 19 November 2012

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

scientific article published on 12 September 2017

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

scientific article

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

scientific article published on 9 April 2018

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

scientific article

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

scientific article

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 27 April 2017

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

scientific article published in Nature Communications

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

article

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood.

scientific article published on 11 June 2018

Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity

scientific article published on 30 December 2011

Signatures of negative selection in the genetic architecture of human complex traits

scientific article published on 16 April 2018

Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children.

scientific article published on 14 November 2014

European genetic variants associated with type 2 diabetes in North African Arabs

scientific article

Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications

scientific article published on 14 July 2013

Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population

scientific article published on 23 October 2012

Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.

scientific article

Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children.

scientific article

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

article by Sara Pulit et al published 1 January 2019 in Human Molecular Genetics

GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm

scientific article

Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family

scientific article

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

scientific article published in November 2018

Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study

scientific article published on 4 June 2014

The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis

scientific article published on 7 June 2015

List of works by Loic Yengo

Genetic studies of body mass index yield new insights for obesity biology

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Defining the role of common variation in the genomic and biological architecture of adult human height

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

New genetic loci link adipose and insulin biology to body fat distribution

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

The genetic architecture of type 2 diabetes

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

Genomic insights into the origin of farming in the ancient Near East

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

Detection of human adaptation during the past 2000 years

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

Directional dominance on stature and cognition in diverse human populations

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood.

Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity

Signatures of negative selection in the genetic architecture of human complex traits

Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children.

European genetic variants associated with type 2 diabetes in North African Arabs

Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications

Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population

Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.

Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children.

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm

Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study

The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis