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List of works by Loic Yengo

A unified framework for association and prediction from vertex-wise grey-matter structure

scientific article published on 20 July 2020

ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers

Alzheimer's disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness

scientific article published on 16 July 2020

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

scientific article published on 31 May 2017

Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children.

scientific article

Association Between Population Density and Genetic Risk for Schizophrenia

Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications

scientific article published on 14 July 2013

Associations Between Type 2 Diabetes-Related Genetic Scores and Metabolic Traits, in Obese and Normal-Weight Youths.

scientific article

Assortative Mating in Autism Spectrum Disorder: Toward an Evidence Base From DNA Data, but Not There Yet

scientific article published on 01 August 2019

Assortative mating on complex traits revisited: Double first cousins and the X-chromosome

Author Correction: Misestimation of heritability and prediction accuracy of male-pattern baldness

scientific article published in Nature Communications

Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children.

scientific article published on 14 November 2014

CO-68: L'étude génomique et fonctionnelle des gènes du diabète de type 2 confirme leur rôle dans les cellules beta-pancréatiques

scientific article published in March 2016

Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study.

scientific article

Combined Global Sensitivity Analysis and Population PBPK Modeling for Assessing Consistency of TCDD Toxicokinetics Data in Mice

Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations

scientific article published on 3 May 2013

Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population

scientific article published on 23 October 2012

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 23 August 2017

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Detection of human adaptation during the past 2000 years

scientific article

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Discovery and implications of polygenicity of common diseases

scholarly article

Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.

scientific article

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

scientific journal article

Early metabolic markers identify potential targets for the prevention of type 2 diabetes

scientific article published on 08 June 2017

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study

scientific article

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 23 January 2018

Erratum: The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

scholarly article published in Obesity

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

scientific article

European genetic variants associated with type 2 diabetes in North African Arabs

scientific article

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

scientific article published on 19 November 2012

Expectation of the intercept from bivariate LD score regression in the presence of population stratification

Extreme inbreeding in a European ancestry sample from the contemporary UK population

scientific article published on 03 September 2019

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

scientific article published on 08 October 2018

GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm

scientific article

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

article

Genetic analyses of medication-use and implications for precision medicine

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

scientific article

Genetic correlates of social stratification in Great Britain

scientific article published on 21 October 2019

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

scientific article

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

scientific article published in November 2018

Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

scientific article published on 01 July 2019

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

scientific article

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

scientific article published in Nature Communications

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

scientific article published in February 2013

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

scientific article published on 24 November 2015

Genome-wide association study of medication-use and associated disease in the UK Biobank

scientific article published on 23 April 2019

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

scientific article

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 27 April 2017

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

scientific article

Genomic insights into the origin of farming in the ancient Near East

scientific article (publication date: 25 August 2016)

Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity

scientific article published on 30 December 2011

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

scientific article published on 14 April 2013

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood.

scientific article published on 11 June 2018

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

scientific article published on 12 September 2017

Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling

scientific article published on 23 August 2016

Imprint of Assortative Mating on the Human Genome

Imprint of assortative mating on the human genome

scientific article published on 26 November 2018

Improved polygenic prediction by Bayesian multiple regression on summary statistics

scientific article published on 08 November 2019

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes.

scientific article

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response

scientific article published on 20 April 2016

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

scientific article

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

scientific article

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

scientific article

Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles

scientific article

Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk

scientific article published on 30 December 2011

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

article by Sara Pulit et al published 1 January 2019 in Human Molecular Genetics

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

scholarly article published 2 March 2018

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

article

Misestimation of heritability and prediction accuracy of male-pattern baldness.

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

scientific article published on February 2016

No Evidence for Social Genetic Effects or Genetic Similarity Among Friends Beyond that Due to Population Stratification: A Reappraisal of Domingue et al (2018)

scientific article published on 11 November 2019

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

scientific article published on 12 October 2020

O06 Le mutant perte de fonction p.R46L de PCSK9 n’est pas associé à un risque accru de diabète chez l’homme

scientific article published in March 2015

O31 Deux scores de risque génétique sont fortement associés aux variations de glycémie à jeun et à l’incidence d’hyperglycémie et de diabète de type 2 dans l’étude prospective D.E.S.I.R

scientific article published in March 2014

O52 L’activité enzymatique plasmatique de l’amylase pancréatique est associée à une diminution de l’indice de masse corporelle et protège du risque de diabète dans la cohorte D.E.S.I.R

scientific article published in March 2015

O53 L’altération du récepteur des acides gras insaturés de type omega-3 GPR120 entraîne une obésité chez l’Homme et la Souris

scientific article published in March 2012

O61 Le diabète de type 2 est responsable d’anomalies chromosomiques somatiques en mosaïques qui sont pré-cancéreuses

scientific article published in March 2013

PO11 Deux nouveaux loci associés au diabète de type 2 dans la population mexicaine identifiés par les puces Metabochip

scientific article published in March 2015

Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts

scientific article

Pathogenic variants in actionable MODY genes are associated with type 2 diabetes

scientific article published on 12 October 2020

Phenotypic and genetic factors associated with differential consent to record linkage for prescription history in the Australian Genetics of Depression Study

scientific article

Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals

scientific article

Polygenic burden could explain high rates of affective disorders in a community with restricted founder population

scientific article

Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis

scientific article

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

scientific article published on 29 January 2012

Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes.

scientific article published on 6 December 2012

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

article

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

scientific article published on 9 April 2018

Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach

scientific article

Reply to Kardos et al.: Estimation of inbreeding depression from SNP data

article published in the Proceedings of the National Academy of Sciences of the United States of America

Risk in Relatives, Heritability, SNP-Based Heritability, and Genetic Correlations in Psychiatric Disorders: A Review

scientific article published on 10 June 2020

Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture

scientific article published on 23 September 2020

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 19 December 2017

Signatures of negative selection in the genetic architecture of human complex traits

scientific article published on 16 April 2018

Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases

scientific article

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

The genetic structure of the world's first farmers

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

article

The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis

scientific article published on 7 June 2015

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

scientific article published on 31 July 2020

Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms

scientific article published on 23 February 2016

Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family

scientific article

Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study

scientific article published on 4 June 2014

Using prior information from humans to prioritize genes and gene-associated variants for complex traits in livestock

scientific article published on 14 September 2020

Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients

scientific article

Widespread signatures of natural selection across human complex traits and functional genomic categories

scientific article published in 2021

Widespread signatures of negative selection in the genetic architecture of human complex traits

scholarly article published 3 June 2017

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