List of works - Alkes Price

A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia

scientific article

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

A genomewide admixture map for Latino populations

scientific article

A second generation human haplotype map of over 3.1 million SNPs

scientific article

Abundant contribution of short tandem repeats to gene expression variation in humans

scientific article

Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population

scientific article

Analysis of case-control association studies with known risk variants

scientific article

Analysis of shared heritability in common disorders of the brain

scientific article published on 21 June 2018

Application of ancestry informative markers to association studies in European Americans

scientific article

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation

scientific article published on 7 April 2016

Author Correction: Distinguishing genetic correlation from causation across 52 diseases and complex traits

scientific article published on 01 December 2018

Author Correction: Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection

scientific article published on 01 August 2019

Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants

scientific article

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies

scientific article

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

scientific article published on 03 September 2018

Discerning the ancestry of European Americans in genetic association studies

scientific article

Dissecting the genetics of complex traits using summary association statistics ⬇️

scientific article

Effects of cis and trans genetic ancestry on gene expression in African Americans

scientific article

Efficient Bayesian mixed-model analysis increases association power in large cohorts.

scientific article

Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium

scientific article

Erratum. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes 2019;68:441-456

scientific article published on 27 April 2020

Erratum: Corrigendum: Reconstructing Native American population history

scientific article published in Nature

Estimating cross-population genetic correlations of causal effect sizes

scientific article published on 25 November 2018

Evaluating the informativeness of deep learning annotations for human complex diseases

scientific article published on 17 September 2020

Exome sequencing and the genetic basis of complex traits

scientific article published on 29 May 2012

Extremely low-coverage sequencing and imputation increases power for genome-wide association studies

scientific article published on 20 May 2012

Fast and accurate imputation of summary statistics enhances evidence of functional enrichment

scientific article

Finding subtle motifs by branching from sample strings

scientific article

Functional disease architectures reveal unique biological role of transposable elements

scientific article published on 06 September 2019

Functionally informed fine-mapping and polygenic localization of complex trait heritability

scientific article published on 16 November 2020

Genetic variation in RNASEL associated with prostate cancer risk and progression

scientific article published on 24 June 2010

Genome-wide association study of ancestry-specific TB risk in the South African Coloured population

scientific journal article

Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection

scientific article

Genome-wide detection and characterization of positive selection in human populations

scientific article

Genome-wide enhancer maps link risk variants to disease genes

scientific article published on 07 April 2021

Genome-wide scan of 29,141 African Americans finds no evidence of directional selection since admixture

scientific article

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

article

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

scientific article published on 23 September 2016

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

scientific article published on 24 April 2017

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

scientific article published on 8 August 2017

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types.

scientific article published on 9 April 2018

High-throughput inference of pairwise coalescence times identifies signals of selection and enriched disease heritability

scientific article published on 13 August 2018

Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics

scientific article published on 29 September 2022

Identifying repeat domains in large genomes

scientific article

Improving the informativeness of Mendelian disease-derived pathogenicity scores for common disease

scientific article published on 07 December 2020

Improving the power of GWAS and avoiding confounding from population stratification with PC-Select

scientific article

Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements

scientific article published on 30 November 2020

Informed conditioning on clinical covariates increases power in case-control association studies

scientific article published on 8 November 2012

Integrating functional data to prioritize causal variants in statistical fine-mapping studies

scientific article

Integrative approaches for large-scale transcriptome-wide association studies

scientific article published on 8 February 2016

Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia

scientific article

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis.

scientific article

Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair

scientific article published in December 2015

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

scientific article published in November 2015

Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates

scientific article

Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits

scientific article published on 25 June 2018

Leveraging population admixture to characterize the heritability of complex traits

scientific article

Liability threshold modeling of case-control status and family history of disease increases association power

scientific article published on 20 April 2020

Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection.

scientific article published on 11 September 2017

Long-range LD can confound genome scans in admixed populations

scientific article published on July 2008

Mixed-model association for biobank-scale datasets

scientific article published on 01 July 2018

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

scientific article

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

scientific article published on 28 November 2018

Multiethnic polygenic risk scores improve risk prediction in diverse populations.

scientific article published on 7 November 2017

New approaches to disease mapping in admixed populations

scientific article (publication date: 28 June 2011)

New approaches to population stratification in genome-wide association studies

scientific article published on July 2010

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

scientific article

Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

scientific article

Patterns of cis regulatory variation in diverse human populations

scientific article

Pitfalls of predicting complex traits from SNPs

scientific article

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

scientific article published in September 2022

Pooled association tests for rare variants in exon-resequencing studies

scientific article (publication date: 11 June 2010)

Population Structure of UK Biobank and Ancient Eurasians Reveals Adaptation at Genes Influencing Blood Pressure

scientific article published on 14 October 2016

Population structure and eigenanalysis

scientific article

Principal component analysis of genetic data

scientific article published in May 2008

Principal components analysis corrects for stratification in genome-wide association studies

scientific article (publication date: August 2006)

Progress and promise in understanding the genetic basis of common diseases

scientific article

Publisher Correction: Shared heritability and functional enrichment across six solid cancers

scientific article published on 23 September 2019

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

scientific article published in Nature Communications

Quantifying genetic effects on disease mediated by assayed gene expression levels

scientific article published on 18 May 2020

Quantifying missing heritability at known GWAS loci

scientific article

Reconciling S-LDSC and LDAK functional enrichment estimates

scientific article published on 01 August 2019

Reconstructing Indian population history

scientific article published on 24 September 2009

Reconstructing Native American population history

scientific article

Replication and fine mapping of asthma-associated loci in individuals of African ancestry

scientific article

Response to Sul and Eskin

scientific article published on 26 February 2013

Sensitive detection of chromosomal segments of distinct ancestry in admixed populations

scientific article

Shared heritability and functional enrichment across six solid cancers

scientific article published in Nature Communications

Shared heritability and functional enrichment across six solid cancers

Single-tissue and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals

scientific article

The history of African gene flow into Southern Europeans, Levantines, and Jews

scientific article

The impact of divergence time on the nature of population structure: an example from Iceland

scientific article published in June 2009

The landscape of recombination in African Americans

scientific article

The role of the CD58 locus in multiple sclerosis

scientific article

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

article

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis

scientific article

Whole-genome analysis of Alu repeat elements reveals complex evolutionary history

scientific article (publication date: November 2004)

List of works by Alkes Price

A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

A genomewide admixture map for Latino populations

A second generation human haplotype map of over 3.1 million SNPs

Abundant contribution of short tandem repeats to gene expression variation in humans

Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population

Analysis of case-control association studies with known risk variants

Analysis of shared heritability in common disorders of the brain

Application of ancestry informative markers to association studies in European Americans

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation

Author Correction: Distinguishing genetic correlation from causation across 52 diseases and complex traits

Author Correction: Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection

Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Defining the role of common variation in the genomic and biological architecture of adult human height

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

Discerning the ancestry of European Americans in genetic association studies

Dissecting the genetics of complex traits using summary association statistics ⬇️

Effects of cis and trans genetic ancestry on gene expression in African Americans

Efficient Bayesian mixed-model analysis increases association power in large cohorts.

Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium

Erratum. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes 2019;68:441-456

Erratum: Corrigendum: Reconstructing Native American population history

Estimating cross-population genetic correlations of causal effect sizes

Evaluating the informativeness of deep learning annotations for human complex diseases

Exome sequencing and the genetic basis of complex traits

Extremely low-coverage sequencing and imputation increases power for genome-wide association studies

Fast and accurate imputation of summary statistics enhances evidence of functional enrichment

Finding subtle motifs by branching from sample strings

Functional disease architectures reveal unique biological role of transposable elements

Functionally informed fine-mapping and polygenic localization of complex trait heritability

Genetic variation in RNASEL associated with prostate cancer risk and progression

Genome-wide association study of ancestry-specific TB risk in the South African Coloured population

Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection

Genome-wide detection and characterization of positive selection in human populations

Genome-wide enhancer maps link risk variants to disease genes

Genome-wide scan of 29,141 African Americans finds no evidence of directional selection since admixture

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types.

High-throughput inference of pairwise coalescence times identifies signals of selection and enriched disease heritability

Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics

Identifying repeat domains in large genomes

Improving the informativeness of Mendelian disease-derived pathogenicity scores for common disease

Improving the power of GWAS and avoiding confounding from population stratification with PC-Select

Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements

Informed conditioning on clinical covariates increases power in case-control association studies

Integrating functional data to prioritize causal variants in statistical fine-mapping studies

Integrative approaches for large-scale transcriptome-wide association studies

Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis.

Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates

Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits

Leveraging population admixture to characterize the heritability of complex traits

Liability threshold modeling of case-control status and family history of disease increases association power

Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection.

Long-range LD can confound genome scans in admixed populations

Mixed-model association for biobank-scale datasets

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

Multiethnic polygenic risk scores improve risk prediction in diverse populations.

New approaches to disease mapping in admixed populations

New approaches to population stratification in genome-wide association studies

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

Patterns of cis regulatory variation in diverse human populations

Pitfalls of predicting complex traits from SNPs

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

Pooled association tests for rare variants in exon-resequencing studies

Population Structure of UK Biobank and Ancient Eurasians Reveals Adaptation at Genes Influencing Blood Pressure

Population structure and eigenanalysis

Principal component analysis of genetic data

Principal components analysis corrects for stratification in genome-wide association studies