Search filters

List of works by Jan Balzarini

"Lock-in"-cycloSal-pronucleotides - a new generation of chemical Trojan Horses?

scientific article published on May 2004

"Second generation" of TSAO compounds directed against HIV-1 TSAO-resistant strains.

scientific article published in April 2001

(±)-7-deazaaristeromycin lacking the hydroxymethyl substituent

scientific article published in 1993

1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity

scientific article

1,2,4-Triazole Derivatives Inhibiting the Human Immunodeficiency Virus Type 1 (HIV-1) in vitro

article

1-Amino-3-(1H-1,2,3-triazol-1-yl)propylphosphonates as acyclic analogs of nucleotides

scientific article published on 6 April 2014

1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: A quest for selective cytotoxicity for malignant cells

scientific article published on 27 March 2008

1-Arylmethyl-2,3-dioxo-2,3-dihydroindole thiosemicarbazones as leads for developing cytotoxins and anticonvulsants

1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents

scientific article

1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2′,3′-dideoxyinosine on human immunodeficiency virus in peripheral blood

scientific article published in 1991

135 Safety Concerns for Cyanovirin as a Microbicidal Anti-HIV Agent

article

2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcri

scientific article (publication date: 15 May 1992)

2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside.

scientific article

2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance

scientific article published on 17 April 2009

2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition

scientific article published on 5 December 2017

2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells

scientific article published on 15 December 2017

2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization

scientific article published on September 2009

229

3',3'-Difluoro-3'-deoxythymidine: comparison of anti-HIV activity to 3'-fluoro-3'-deoxythymidine

scientific article (publication date: 4 September 1992)

3'-(N-hydroxyimino)-2',3-dideoxynucleosides and their derivatives: synthesis, broad spectrum antiviral properties and synthetical application for the preparation of other nucleoside analogues

scientific article

3'-C-branched 2'-deoxy-5-methyluridines: synthesis, enzyme inhibition, and antiviral properties

scientific article

3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2', 5'-bis-O-(tert-butyldimethylsilyl)-.beta.-D-xylo- and -ribofuranose]-3'-spiro-5''-[4''-amino-1'', 2''-oxathiole 2''

3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase

scientific article published on April 2010

3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: A Novel Class of Potent Tumor-Selective Cytotoxins

scientific article published on 4 January 2016

3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones: a novel cluster of potent tumor-selective cytotoxins

scientific article

3,5-Bis(benzylidene)-4-oxo-1-phosphonopiperidines and related diethyl esters: Potent cytotoxins with multi-drug-resistance reverting properties

scientific article

4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action

scientific article

4"-H-TSAO-T, a novel prototype in the HIV-1 specific TSAO family.

scientific article published in April 2001

4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus

scientific article

4-Benzyloxy-γ-Sultone Derivatives: Discovery of a Novel Family of Non-Nucleoside Inhibitors of Human Cytomegalovirus and Varicella Zoster Virus

4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation

scientific article published on 7 October 2010

5'-Nor carbocyclic 5'-deoxy-5'-(isobutylthio)adenosine and a 2',3'-dideoxy-2',3'-didehydro derivative

scientific article

5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity

scientific article

5-(1-Acetoxyvinyl)-cycloSaligenyl-2',3'-dideoxy-2',3'- didehydrothymidine monophosphates, a second type of new, enzymatically activated cycloSaligenyl pronucleotides

scientific article published in December 2008

5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series

scientific article published on June 2004

5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity

scientific article published on November 2003

5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells

scientific article published on 23 May 2007

6-Benzylidene-2-[4-(pyridin-3-ylcarboxy)benzylidene]cyclohexanones: A novel cluster of tumour-selective cytotoxins

scientific article published on 10 February 2017

6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity

scientific article

6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity

scientific article published in October 2004

6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains

scientific article

7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase

scientific article published on 01 October 1998

9-(2-Phosphonylmethoxyethyl) adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system

scientific article published on October 1994

9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo

scientific article published on December 1989

9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys

scientific article

9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections

scientific article (publication date: November 1989)

9-(2-Phosphonylmethoxyethyl)adenine induces tumor cell differentiation or cell death by blocking cell cycle progression through the S phase.

scientific article published on June 1999

9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo

scientific article

92 Ara-A-5′-phenyl methoxy alaninyl phosphate as a prodrug of the adenine arabinoside -monophosphate: synthesis and anti viral evaluation

scientific article published in 2000

A Multitarget Approach toward the Development of 8-Substituted Purines for Photoprotection and Prevention of UV-Related Damage

scientific article published on 18 April 2017

A highly reliable, sensitive, flow cytometric/fluorometric assay for the evaluation of the anti-HIV activity of antiviral compounds in MT-4 cells

scientific article

A mercapto analogue of 5'-noraristeromycin

scientific article published in February 2002

A multi-targeted drug candidate with dual anti-HIV and anti-HSV activity

scientific article (publication date: 2013)

A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2

scientific article

A new four-component reaction involving the Michael addition and the Gewald reaction, leading to diverse biologically active 2-aminothiophenes

scientific article published on 26 April 2017

A novel family of diarylpyrimidines (DAPYs) featuring a diatomic linker: Design, synthesis and anti-HIV activities

scientific article published on 11 September 2015

A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine

scientific article (publication date: December 1989)

A novel mannose-binding tuber lectin from Typhonium divaricatum (L.) Decne (family Araceae) with antiviral activity against HSV-II and anti-proliferative effect on human cancer cell lines

scientific article

A novel selective broad-spectrum anti-DNA virus agent

scientific article published on October 1986

A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression

scientific article published on 30 November 2007

A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions ⬇️

scientific article published on November 12, 2012

A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity

scientific article published on December 2002

Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase.

scientific article published on November 1998

Actinohivin, a broadly neutralizing prokaryotic lectin, inhibits HIV-1 infection by specifically targeting high-mannose-type glycans on the gp120 envelope

scientific article published on 24 May 2010

Activity and mechanism of action of HDVD, a novel pyrimidine nucleoside derivative with high levels of selectivity and potency against gammaherpesviruses

scientific article published on 23 January 2013

Activity of acyclic nucleoside phosphonate analogues against human immunodeficiency virus in monocyte/macrophages and peripheral blood lymphocytes

scientific article

Activity of different antiviral drug combinations against human cytomegalovirus replication in vitro.

scientific article

Activity of reverse transcriptase inhibitors in monocyte-derived dendritic cells: a possible in vitro model for postexposure prophylaxis of sexual HIV transmission

scientific article published on October 2002

Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems

scientific article published on February 1996

Acute cytotoxicity of arabinofuranosyl nucleoside analogs is not dependent on mitochondrial DNA.

scientific article

Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.

scientific article

Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: efficient synthesis and antiviral activity

scientific article published on 22 June 2011

Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication

scientific article

Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents.

scientific article

Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues

scientific article

Additions and Corrections - Resolution of Aristeromycin Enantiomers

article

Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus

scientific article published on 14 March 2009

Alkyloxyphenyl furano pyrimidines as potent and selective anti-VZV agents with enhanced water solubility

scientific article published in March 2002

All trans 1-(3-arylacryloyl)-3,5-bis(pyridin-4-ylmethylene)piperidin-4-ones as curcumin-inspired antineoplastics

scientific article published on 30 September 2014

Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro

scientific article (publication date: March 1991)

Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics

scientific article

Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster

scientific article

An emerging understanding of the Janus face of the human microbiome: enhancement versus impairment of cancer therapy

scientific article published on 12 June 2014

An epimer of 5'-noraristeromycin and its antiviral properties.

scientific article published on April 1994

An in situ pig liver esterase assay as a useful predictive tool for the likely in vitro anti viral activity of phosphoramidate pro-drugs

scientific article

An investigation into the anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U) and 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.

scientific article

Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes

scientific article

Anti-HIV I/II activity and molecular cloning of a novel mannose/sialic acid-binding lectin from rhizome of Polygonatum cyrtonema Hua.

scientific article published on February 2006

Anti-HIV-1 activity of benzothiadiazine dioxide

scientific article

Anti-Hiv-1 Activity of 2',3'-Dideoxinucleoside Analogues : Structure-Activity Relationship

article

Anti-angiogenic activity of a novel multi-substrate analogue inhibitor of thymidine phosphorylase

scientific article published in January 2002

Anti-human immunodeficiency virus effects of cationic metalloporphyrin-ellipticine complexes

scientific article (publication date: 20 October 1992)

Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered

scientific article published on August 1990

Anti-varicella-zoster virus bicyclic nucleosides: replacement of furo by pyrro base reduces antiviral potency

scientific article published in September 2000

Antiadenovirus activities of several classes of nucleoside and nucleotide analogues

scientific article published on March 2005

Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione ⬇️

scientific article published on March 14, 2013

Antiherpesvirus activities of two novel 4'-thiothymidine derivatives, KAY-2-41 and KAH-39-149, are dependent on viral and cellular thymidine kinases

scientific article published on 12 May 2014

Antinociceptive and antitumor activity of novel synthetic mononuclear Ruthenium (II) compounds

scientific article published on March 2013

Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines

scientific article

Antiproliferative and antiviral activity of three libraries of adamantane derivatives

scientific article

Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected [...]

scientific article

Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine

scientific article

Antiretroviral activity of semisynthetic derivatives of glycopeptide antibiotics

scientific article published on June 2003

Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates

scientific article published on July 2002

Antitumor Potential of Acyclic Nucleoside Phosphonates

scientific article published on 01 April 1999

Antiviral Activity of Carbohydrate Binding Agents (CBAS) and the Role of DC-SIGN in Dengue Virus and HIV Infection

article

Antiviral activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4- carboxamide and related compounds

scientific article

Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV.

scientific article published in January 2007

Antiviral activity of carbohydrate-binding agents against Nidovirales in cell culture

scientific article published on 21 May 2007

Antiviral activity of carbohydrate-binding agents and the role of DC-SIGN in dengue virus infection

scientific article

Antiviral activity of cyclosaligenyl prodrugs of acyclovir, carbovir and abacavir

scientific article published on September 2001

Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines

scientific article

Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6.

scientific article published on December 1995

Antiviral activity of the 3'-amino derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine

scientific article

Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds

scientific article published on 14 February 2007

Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines

scientific article

Antiviral and cytostatic evaluation of the novel 6-acyclic chain substituted thymine derivatives

scientific article published on January 2005

Antiviral enantiomeric preference for 5'-noraristeromycin.

scientific article published on February 1994

Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines

scientific article published on January 2005

Application of phosphoramidate ProTide technology significantly improves antiviral potency of carbocyclic adenosine derivatives

scientific article published on November 2006

Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency

scientific article

Application of the Phosphoramidate Protide Approach to the Antiviral Drug Ribavirin

scientific article published in 2008

Application of the dipeptidyl peptidase IV (DPPIV/CD26) based prodrug approach to different amine-containing drugs

scientific article published in January 2010

Aryl furano pyrimidines: the most potent and selective anti-VZV agents reported to date

scientific article

Aryl-substituted and benzo-annulated cyc/osal-derivatives of 2',3'-dideoxy-2',3'-didehydrothymidine monophosphate--correlation of structure, hydrolysis properties and anti-HIV activity

scientific article published in March 2002

Arylazolyl(azinyl)thioacetanilides. Part 10: design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors

scientific article

Arylazolyl(azinyl)thioacetanilides. Part 16: Structure-based bioisosterism design, synthesis and biological evaluation of novel pyrimidinylthioacetanilides as potent HIV-1 inhibitors

scientific article

Aryloxy phosphoramidate triesters as pro-tides

scientific article published on May 2004

Aryloxy phosphoramidate triesters: a technology for delivering monophosphorylated nucleosides and sugars into cells

scientific article

Benzylidene-bis-(4-hydroxycoumarin) and benzopyrano-coumarin derivatives: synthesis, ¹H/¹³C-NMR conformational and X-ray crystal structure studies and in vitro antiviral activity evaluations

scientific article

Benzylidene/2-chlorobenzylidene hydrazides: synthesis, antimicrobial activity, QSAR studies and antiviral evaluation

scientific article published on 7 March 2010

Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity

scientific article published in May 2004

Bicyclic furo pyrimidine nucleosides with aryloxyphenyl and halophenyl substituted side chains as potent and selective varicella-zoster virus inhibitors

scientific article published in April 2001

Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain.

scientific article

Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of terminal unsaturation in the side chain

scientific article

Bicyclic nucleoside inhibitors of Varicella-Zoster virus: the effect of branching in the p-alkylphenyl side chain

scientific article published on August 2005

Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): Pd-catalysed synthesis of 5-aryl derivatives and their biological evaluation

scientific article published on May 2001

Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): effect of terminal unsaturation in the side-chain

scientific article published in April 2001

Bicyclic nucleoside inhibitors of varicella-zoster virus: 5'-chloro and 3'-chloro derivatives

scientific article published in May 2003

Bicyclic nucleoside inhibitors of varicella-zoster virus: effect of terminal aryl substitution in the side-chain

scientific article

Bicyclic nucleoside inhibitors of varicella-zoster virus: synthesis and biological evaluation of 2',3'-dideoxy-3'-fluoro and 2'-deoxy-xylo derivatives

scientific article published in May 2003

Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication

scientific article

Bioinformatics analyses of the mannose-binding lectins from Polygonatum cyrtonema, Ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities

scientific article

Bis(benzoyloxybenzyl)-DiPPro nucleoside diphosphates of anti-HIV active nucleoside analogues

scientific article

Bis-cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides

scientific article published on March 2007

Bis[3,5-bis(benzylidene)-4-oxo-1-piperidinyl]amides: a novel class of potent cytotoxins

scientific article

Branched-chain C-cyano pyranonucleosides: Synthesis of 3′-C-cyano & 3′-C-cyano-3′-deoxy pyrimidine pyranonucleosides as novel cytotoxic agents ⬇️

scientific article published on September 1, 2011

Broad antiviral activity of carbohydrate-binding agents against the four serotypes of dengue virus in monocyte-derived dendritic cells

scientific article

Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives

scientific article (publication date: August 1989)

Broad-spectrum antiviral activity and mechanism of antiviral action of the fluoroquinolone derivative K-12.

scientific article published on September 1998

Capture and transmission of HIV-1 by the C-type lectin L-SIGN (DC-SIGNR) is inhibited by carbohydrate-binding agents and polyanions

scientific article

Carbocyclic 5'-nor "reverse" fleximers. Design, synthesis, and preliminary biological activity

scientific article published on July 2011

Carbocyclic analogues of nucleosides from bis-(Hydroxymethyl)-cyclopentane: synthesis, antiviral and cytostatic activities of adenosine, inosine and uridine analogues

scientific article published on September 2003

Carbohydrate-binding Agents Cause Deletions of Highly Conserved Glycosylation Sites in HIV GP120

scientific article published in Journal of Biological Chemistry

Carbohydrate-binding agents act as potent trypanocidals that elicit modifications in VSG glycosylation and reduced virulence in Trypanosoma brucei

scientific article published on 14 October 2013

Carbohydrate-binding agents efficiently prevent dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-directed HIV-1 transmission to T lymphocytes

scientific article published on 20 October 2006

Cell-dependent interference of a series of new 6-aminoquinolone derivatives with viral (HIV/CMV) transactivation

scientific article published on 8 September 2005

Cellular uptake of phosphonylmethoxyalkylpurine derivatives

scientific article

Characterization and carbohydrate specificity of pradimicin S.

scientific article

Characterization and structural analysis of novel mutations in human immunodeficiency virus type 1 reverse transcriptase involved in the regulation of resistance to nonnucleoside inhibitors

scientific article

Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin

scientific article published on May 2005

Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues

scientific article published on July 2012

Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine

scientific article

Characterization of the catalytic subunit of the human herpesvirus 6 (HHV-6) DNA polymerase expressed in an in vitro transcription/translation assay

scientific article published in May 2003

ChemInform Abstract: Design, Synthesis and Enzymatic Activity of Highly Selective Human Mitochondrial Thymidine Kinase Inhibitors

Chemo-enzymatic synthesis of 3-deoxy-beta-D-ribofuranosyl purines and study of their biological properties

scientific article published in May 2003

Chemotherapy of varicella-zoster virus by a novel class of highly specific anti-VZV bicyclic pyrimidine nucleosides

scientific article

Chimeric human immunodeficiency virus type 1 and feline immunodeficiency virus reverse transcriptases: role of the subunits in resistance/sensitivity to non-nucleoside reverse transcriptase inhibitors

scientific article published in February 2002

Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors

scientific article published on 21 April 2012

Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies

scientific article published on January 2006

Combination of Antiretroviral Drugs as Microbicides ⬇️

scientific article published on January 1, 2012

Combinations of griffithsin with other carbohydrate-binding agents demonstrate superior activity against HIV Type 1, HIV Type 2, and selected carbohydrate-binding agent-resistant HIV Type 1 strains

scientific article

Comparative inhibitory effects of suramin and other selected compounds on the infectivity and replication of human T-cell lymphotropic virus (HTLV-III)/lymphadenopathy-associated virus (LAV)

scientific article (publication date: 15 March 1986)

Comparative study of bis(benzyl)phosphate triesters of 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) and cyclosal-d4TMP--hydrolysis, mechanistic insights and anti-HIV activity

scientific article published in March 2002

Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.

scientific article published in May 2005

Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents

scientific article

Conservation of antiviral activity and improved selectivity in PMEO-DAPym upon pyrimidine to triazine scaffold hopping

scientific article published on 11 August 2015

Conversion of acyclic nucleoside phosphonates to their diphosphate derivatives by 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase.

scientific article

Correction: Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products

scientific article published on 19 January 2017

Correlations between cytotoxicity and topography of some 2-arylidenebenzocycloalkanones determined by X-ray crystallography.

scientific article published on July 2002

Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection

scientific article

Crystal Structure and Thermal Stability of Silver Selenite

Crystal Structure of tert -Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket

scientific article

Crystal structure of poxvirus thymidylate kinase: An unexpected dimerization has implications for antiviral therapy

scientific article

Crystal structure of varicella zoster virus thymidine kinase

scientific article (publication date: 4 July 2003)

Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives

scientific article

Crystal structures of the mitochondrial deoxyribonucleotidase in complex with two specific inhibitors

scientific article published in April 2004

Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors

scientific article published on 20 August 2015

CycloSal-2'-ara(ribo)-fluoro-2',3'-dideoxyadenosine monophosphates--an effort to solve the structure-activity relationship of 2'-fluoro-ddA

scientific article

Cyclopentene carbocyclic nucleosides related to the antitumor nucleoside clitocine and their conversion to 8-Aza-neplanocin analogues. Synthesis and antiviral activity

scientific article published in October 1993

Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy

scientific article published on August 2003

Cytostatic activity of novel 4′-aminochalcone-based imides

scientific article published in 2007

Cytostatic and antiviral activity evaluations of hydroxamic derivatives of some non-steroidal anti-inflammatory drugs

scientific article

Cytotoxic 1,3-diarylidene-2-tetralones and related compounds

scientific article published on 01 October 2002

Cytotoxic 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds

scientific article published in January 2002

Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds

scientific article published on 3 April 2006

Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones and related compounds

scientific article published on December 2002

Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones

scientific article published on February 2003

Cytotoxic and anticonvulsant aryloxyaryl Mannich bases and related compounds

scientific article published on January 2004

DC-SIGN increases the affinity of HIV-1 envelope glycoprotein interaction with CD4.

scientific article

Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods

scientific article published on June 2002

Deletion of the highly conserved N-glycan at Asn260 of HIV-1 gp120 affects folding and lysosomal degradation of gp120, and results in loss of viral infectivity

scientific article

Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore

scientific article published on 25 January 2010

Design and Discovery of a Novel Dipeptidyl-peptidase IV (CD26)-Based Prodrug Approach

article by Carlos García-Aparicio et al published August 2006 in Journal of Medicinal Chemistry

Design and development of curcumin bioconjugates as antiviral agents

scientific article

Design and synthesis of N₁-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article published on 30 December 2013

Design and synthesis of a new series of cyclopropylamino-linking diarylpyrimidines as HIV non-nucleoside reverse transcriptase inhibitors

scientific article

Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors

scientific article published on 5 June 2014

Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR

scientific article

Design and synthesis of phosphonoacetic acid (PPA) ester and amide bioisosters of ribofuranosylnucleoside diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory, cytostatic and antiviral activity

scientific article published on July 2003

Design, Synthesis and Biological Evaluation of Novel Acyclovir ProTides

scientific article published in 2008

Design, Synthesis and Evaluation of Novel Anti-VZV BCNAs

scientific article published in 2008

Design, Synthesis, Antiviral, and Cytotoxic Evaluation of Novel Phosphonylated 1,2,3-Triazoles as Acyclic Nucleotide Analogues ⬇️

scientific article published on April 1, 2012

Design, Synthesis, and Biological Evaluation of Novel Fluoro Derivatives of BCNA

scientific article published in 2009

Design, synthesis and antiproliferative activity of novel heterobivalent hybrids based on imidazo[2,1-b][1,3,4]thiadiazole and imidazo[2,1-b][1,3]thiazole scaffolds

scientific article published on 25 June 2015

Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells

scientific article published on 10 July 2007

Design, synthesis and bioevaluation of novel candidate selective estrogen receptor modulators ⬇️

scientific article published on May 30, 2011

Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents

scientific article published on 22 September 2009

Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides

scientific article published on 27 May 2011

Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents

scientific article

Design, synthesis and biological evaluation of 3-benzyloxy-linked pyrimidinylphenylamine derivatives as potent HIV-1 NNRTIs

scientific article published on October 2013

Design, synthesis and biological evaluation of N2,N4-disubstituted-1,1,3-trioxo-2H,4H-pyrrolo[1,2-b][1,2,4,6]thiatriazine derivatives as HIV-1 NNRTIs

scientific article published on 14 September 2013

Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs

scientific article published on 7 October 2011

Design, synthesis and biological evaluation of substituted guanidine indole derivatives as potential inhibitors of HIV-1 Tat-TAR interaction

scientific article published on January 2014

Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds

scientific article published on 22 September 2006

Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs

scientific article published on 6 November 2013

Design, synthesis and preliminary antiviral screening of new N-phenylpyrazole and dihydroisoxazole derivatives

article

Design, synthesis of new β-carboline derivatives and their selective anti-HIV-2 activity

scientific article published on 30 January 2015

Design, synthesis, and SAR of naphthyl-substituted Diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase

scientific article

Design, synthesis, and anti-HIV activity of 2′,3′-didehydro-2′,3′-dideoxyuridine (d4U), 2′,3′-dideoxyuridine (ddU) phosphoramidate ‘ProTide’ derivatives

article

Design, synthesis, and biological evaluation of C1–phosphonamidate analogues of 2-deoxy-d-ribose-1-phosphate

Design, synthesis, and biological evaluation of hybrid molecules containing alpha-methylene-gamma-butyrolactones and polypyrrole minor groove binders

scientific article published on May 2004

Design, synthesis, and biological evaluation of novel 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives as HIV-1 NNRTIs

scientific article published on 10 September 2013

Design, synthesis, and biological evaluation of thiophene analogues of chalcones

scientific article

Design, synthesis, and biological evaluation of unconventional aminopyrimidine, aminopurine, and amino-1,3,5-triazine methyloxynucleosides

scientific article

Design, synthesis, and cytostatic activity of novel cyclic curcumin analogues

scientific article published on 22 August 2007

Design, synthesis, and enzymatic evaluation of multisubstrate analogue inhibitors of Escherichia coli thymidine phosphorylase

scientific article

Design, synthesis, antiviral and cytostatic activity of ω-(1H-1,2,3-triazol-1-yl)(polyhydroxy)alkylphosphonates as acyclic nucleotide analogues

scientific article

Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker ⬇️

scientific article published on November 20, 2011

Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a carbamoyl linker ⬇️

scientific article published on January 16, 2013

Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach

scholarly article by Delia Preti et al published December 2018 in Journal of Enzyme Inhibition and Medicinal Chemistry

Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents

scientific article published on November 2002

Diastereoselective Synthesis of Aryloxy Phosphoramidate Prodrugs of 3′-Deoxy-2′,3′-didehydrothymidine Monophosphate ⬇️

scientific article published on November 11, 2010

Differences in the mannose oligomer specificities of the closely related lectins from Galanthus nivalis and Zea mays strongly determine their eventual anti-HIV activity

scientific article published on 11 February 2011

Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir-containing regimens

scientific article published on November 2010

Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages

scientific article published on April 1, 1992

Differential activities of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives against different human immunodeficiency virus type 1 mutant strains

scientific article

Differential activity of candidate microbicides against early steps of HIV-1 infection upon complement virus opsonization

scientific article

Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine

scientific article

Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3)- and alpha-(1-6)-D-mannose specific plant lectins: implication for microbicide development

scientific article published on 12 June 2007

Differential inhibition of retroviral reverse transcriptase by poly(2-fluoroadenylic acid), a template analogue

scientific article

Differential inhibition of various deoxyribonucleic acid polymerases by Evans blue and aurintricarboxylic acid

scientific article published in October 1988

Differential inhibitory effects of several pyrimidine 2',3'-dideoxynucleoside 5'-triphosphates on the activities of reverse transcriptase and various cellular DNA polymerases

scientific article (publication date: May 1989)

Differential inhibitory effects of sulfated polysaccharides and polymers on the replication of various myxoviruses and retroviruses, depending on the composition of the target amino acid sequences of the viral envelope glycoproteins

scientific article

Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds

scientific article (publication date: 15 April 1989)

Dinucleoside monophosphates containing AZT and 1-methyladenosine or 7-methylguanosine

scientific article published on May 2003

Dipeptidyl peptidase IV dependent water-soluble prodrugs of highly lipophilic bicyclic nucleoside analogues

scientific article published on 18 February 2011

Dipeptidyl peptidase IV-activated prodrugs of anti-varicella zoster virus bicyclic nucleoside analogues containing different self-cleavage spacer systems

scientific article published on 6 August 2012

Dipeptidyl-peptidase IV (DPP IV/CD26)-activated prodrugs: a successful strategy for improving water solubility and oral bioavailability

scientific article

Discovery and SAR studies of a novel class of cytotoxic 1,4-disubstituted piperidines via Ugi reaction

scientific article

Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays

scientific article published on 6 February 2014

Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study

scientific article published on June 2009

Discovery of TSAO derivatives with an unusual HIV-1 activity/resistance profile

scientific article published on 29 March 2006

Discovery of a nanomolar inhibitor of lung adenocarcinoma in vitro

scientific article published on 3 September 2014

Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains

scientific article published on 19 January 2007

Discovery of novel diarylpyrimidines as potent HIV NNRTIs via a structure-guided core-refining approach

scientific article published on 13 April 2014

Discovery of piperidine-linked pyridine analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article published on 3 May 2013

Doubly loaded cycloSaligenyl-pronucleotides - 5,5'-Bis-(cycloSaligenyl-2',3'-dideoxy-2',3'-didehydrothymidine monophosphates).

scientific article

E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: a topographical study of some novel potent cytotoxins

scientific article

E,E-2-Benzylidene-6-(nitrobenzylidene)cyclohexanones: syntheses, cytotoxicity and an examination of some of their electronic, steric, and hydrophobic properties

scientific article

Efficacy and adverse effects of the antiviral compound plerixafor in feline immunodeficiency virus-infected cats

scientific article published on 30 March 2012

Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus

scientific article published in February 1998

Efficient conversion of tetrapeptide-based TSAO prodrugs to the parent drug by dipeptidyl-peptidase IV (DPPIV/CD26).

scientific article published on August 2007

Efficient synthesis of exomethylene- and keto-exomethylene-d-glucopyranosyl nucleoside analogs as potential cytotoxic agents ⬇️

scientific article published on October 30, 2010

Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis

scientific article

Enantioselective syntheses of carbocyclic nucleosides 5′-homocarbovir, epi-4′-homocarbovir, and their cyclopropylamine analogs using facially selective Pd-mediated allylations ⬇️

scientific article published on February 4, 2011

Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation

scientific article published on 15 May 2006

Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.

scientific article published on November 1998

Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates.

scientific article

Entry of hepatitis C virus and human immunodeficiency virus is selectively inhibited by carbohydrate-binding agents but not by polyanions

scientific article

Enzymatically activated cycloSal-d4T-monophosphates: The third generation of cycloSal-pronucleotides

scientific article

Erratum: Modification of the antibiotic olivomycin I at the 2′-keto group of the side chain. Novel derivatives, antitumor and topoisomerase I-poisoning activity

scholarly article published in The Journal of Antibiotics

Establishment of a bioassay to determine serum levels of dextran sulfate and pentosan polysulfate, two potent inhibitors of human immunodeficiency virus

scientific article published in January 1990

Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study

scientific article published on 14 March 2013

Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity

scientific article published on 19 October 2007

Evaluating Clinical Isolates for Their Phenotypic and Genotypic Resistance Against Anti-HIV Drugs.

scientific article

Evaluation of in vitro biological activity of O-alkylated hydroxamic derivatives of some nonsteroidal anti-inflammatory drugs

scientific article published on October 1, 2010

Evidence for distinction of the differentiation-inducing activities and cytostatic properties of 9-(2-phosphonylmethoxyethyl)adenine and a variety of differentiation-inducing agents in human erythroleukemia K562 cells.

scientific article published on November 1996

Evidence for the Involvement of the Small Subunit of HIV-1 Reverse Transcriptase (RT) in the TSAO-Resistance

article

Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV.

scientific article published on July 2001

Exploring the purine core of 3'-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics

scientific article published on 03 March 2016

Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates

scientific article published on 27 January 2016

Exposure of HIV-1 to a combination of two carbohydrate-binding agents markedly delays drug resistance development and selects for virus strains with compromised fitness

scientific article published on 21 October 2013

Expression analysis of the nucleocytoplasmic lectin 'Orysata' from rice in Pichia pastoris

scientific article

FV100 as a new approach for the possible treatment of varicella-zoster virus infection

scientific article

Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products

scientific article published on 5 January 2017

First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication

scientific article published on June 2005

Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues.

scientific article published on March 2005

From norbornane-based nucleotide analogs locked in South conformation to novel inhibitors of feline herpes virus

scientific article published on 13 April 2014

From β-Amino-γ-Sultone to New Bicyclic Pyridine and Pyrazine Heterocyclic Systems: Discovery of a Novel Class of HIV-1 Non-nucleoside Inhibitors

article

From β-Amino-γ-sultone to Unusual Bicyclic Pyridine and Pyrazine Heterocyclic Systems: Synthesis and Cytostatic and Antiviral Activities

article

Furano pyrimidines as novel potent and selective anti-VZV agents

scientific article

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches

scientific article

Glycan deletions in the HIV-1 gp120 V1/V2 domain compromise viral infectivity, sensitize the mutant virus strains to carbohydrate-binding agents and represent a specific target for therapeutic intervention

scientific article

Glycine-amide is an active metabolite of the antiretroviral tripeptide glycyl-prolyl-glycine-amide

scientific article

Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses

scientific article published on 5 April 2017

HIV-1 envelope trimer has similar binding characteristics for carbohydrate-binding agents as monomeric gp120.

scientific article

Halophenyl furanopyrimidines as potent and selective anti-VZV agents

scientific article published in May 2003

High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300.

scientific article

High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations

scientific article

Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

scientific article

Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain

scientific article

Highly stereoselective synthesis and biological properties of nucleoside analogues bearing a spiro inserted oxirane ring

scientific article

Hiv-1 Specific Reverse Transcriptase Inhibitors: why are Tsao-Nucleosides so Unique?

article

How a modification (8-aza-3-deaza-2'-deoxyguanosine) influences the quadruplex structure of Hotoda's 6-mer TGGGAG with 5'- and 3'-end modifications

scientific article published in January 2004

Human glutaredoxin-1 catalyzes the reduction of HIV-1 gp120 and CD4 disulfides and its inhibition reduces HIV-1 replication

scientific article published on 6 November 2008

Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C-->C181I)RT HIV-1 mutants

scientific article published on 5 July 1994

Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[Spiro[4"-amino-2",2" -dioxo-1",2" -oxathiole-5",3'-[2', 5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]]]-3-ethylthy mine

scientific article

Human mitochondrial thymidine kinase is selectively inhibited by 3'-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity

scientific article published on 20 February 2009

Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation

scientific article published on 12 February 2009

Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy

scientific article published on 4 June 2010

Hybrids of [TSAO-T]-[foscarnet]: The first conjugate of foscarnet with a non-nucleoside reverse transcriptase inhibitor through a labile covalent ester bond

scientific article published on June 2004

Hydantoin derivatives of L- and D-amino acids: synthesis and evaluation of their antiviral and antitumoral activity

scientific article published on November 2006

Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase

scientific article published in December 2001

Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase.

scientific article published in June 2001

Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor

scientific article

Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59).

scientific article published on 21 April 2009

Identification of novel thiocarboxanilide derivatives that suppress a variety of drug-resistant mutant human immunodeficiency virus type 1 strains at a potency similar to that for wild-type virus

scientific article

Imidazothiadiazine dioxides: synthesis and antiviral activity

scientific article

Immunomodulatory activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA), a potent anti-HIV nucleotide analogue, on in vivo murine models

scientific article

Improving the antiviral efficacy and selectivity of HIV-1 reverse transcriptase inhibitor TSAO-T by the introduction of functional groups at the N-3 position

scientific article published on October 2005

Improving the selectivity of acyclic nucleoside analogues as inhibitors of human mitochondrial thymidine kinase: replacement of a triphenylmethoxy moiety with substituted amines and carboxamides

scientific article published in September 2003

In Vitro -Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs ⬇️

scientific article published on December 21, 2011

In search of specific inhibitors of retrovirus replication.

scientific article published in January 1985

In vitro activity of polyhydroxycarboxylates against herpesviruses and HIV.

scientific article

In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides

scientific article

In vitro synergistic activity against CCR5-tropic HIV-1 with combinations of potential candidate microbicide molecules HHA, KRV2110 and enfuvirtide (T20).

scientific article published on 29 October 2009

Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase

scientific article published on March 2004

Increased mitochondrial DNA copy-number in CEM cells resistant to delayed toxicity of 2',3'-dideoxycytidine

scientific article published on 15 December 2007

Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide

scientific article

Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus

scientific article published on April 2009

Influence of 2-substituent on the activity of imidazo[1,2-a] pyridine derivatives against human cytomegalovirus

scientific article published on April 2002

Influence of Fluorination of the Sugar Moiety on the Anti-HIV-1 Activity of 2',3'-Dideoxynucleosides

article

Inhibition of cell-to-cell transmission of human T-cell lymphotropic virus type 1 in vitro by carbohydrate-binding agents

scientific article published on 27 May 2008

Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics

scientific article published on 6 April 2006

Inhibition of human immunodeficiency virus by a new class of pyridine oxide derivatives

scientific article published on September 2003

Inhibition of human immunodeficiency virus type 1 transcription by N-aminoimidazole derivatives

scientific article published on 24 April 2007

Inhibition of pyrimidine and purine nucleoside phosphorylases by a 3,5-dichlorobenzoyl-substituted 2-deoxy-D-ribose-1-phosphate derivative

scientific article

Inhibition of the in vitro growth of Plasmodium falciparum by acyclic nucleoside phosphonates

scientific article published on June 1999

Inhibitory effect of 9-(2-phosphonylmethoxyethyl)-adenine (PMEA) on human and duck hepatitis B virus infection

scientific article published on June 1993

Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine on visna virus infection in lambs: a model for in vivo testing of candidate anti-human immunodeficiency virus drugs

scientific article

Inhibitory effects of 9-(2-phosphonylmethoxyethyl)adenine and 3'-azido-2',3'-dideoxythymidine on tumor development in mice inoculated intracerebrally with Moloney murine sarcoma virus

scientific article published in March 1990

Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture

scientific article

Inhibitory effects of potent inhibitors of human immunodeficiency virus and cytomegalovirus on the growth of human granulocyte-macrophage progenitor cells in vitro

scientific article published in August 1990

Initial studies on the cellular pharmacology of 2',3-dideoxycytidine, an inhibitor of HTLV-III infectivity.

scientific article published in July 1986

Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship

scientific article

Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound

scientific article

Intracellular trapping of cycloSal-pronucleotides: modification of prodrugs with amino acid esters

scientific article published on October 2008

Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway

scientific article published on 24 June 2012

Introduction to the Special Issue dedicated to Prof. Erik De Clercq for reaching the Professor Emeritus status at the Katholieke Universiteit Leuven

scientific article published in 2006

Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors

scientific article

KAY-2-41, a novel nucleoside analogue inhibitor of orthopoxviruses in vitro and in vivo

scientific article published on 14 October 2013

Kinetic analysis of novel multisubstrate analogue inhibitors of thymidine phosphorylase.

scientific article

Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-di

scientific article (publication date: 15 June 1992)

Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus.

scientific article published on October 1993

Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase

scientific article published in May 2002

Lead optimization of diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase

scientific article published on June 2010

Lectin-Like Molecules of Lactobacillus rhamnosus GG Inhibit Pathogenic Escherichia coli and Salmonella Biofilm Formation

scientific article

Limited development and progression of resistance of HIV-1 to the nucleoside analogue reverse transcriptase inhibitor lamivudine in human primary macrophages

scientific article published on 21 April 2005

Lipophilic prodrugs of nucleoside triphosphates as biochemical probes and potential antivirals

scientific article published on 27 October 2015

Long-lasting enfuvirtide carrier pentasaccharide conjugates with potent anti-human immunodeficiency virus type 1 activity

scientific article

Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors

scientific article

Macrophages and HIV infection: therapeutical approaches toward this strategic virus reservoir

scientific article

Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection

scientific article published on October 2004

Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis.

scientific article published on 17 February 2005

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent

scientific article

Measuring cooperative Rev protein-protein interactions on Rev responsive RNA by fluorescence resonance energy transfer

scientific article

Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives

scientific article

Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents

scientific article (publication date: December 1992)

Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro

scientific article

Mechanism of the potentiating effect of ribavirin on the activity of 2',3'-dideoxyinosine against human immunodeficiency virus

scientific article (publication date: 15 November 1991)

Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase

scientific article published on 09 June 2009

Mechanisms underlying activity of antiretroviral drugs in HIV-1-infected macrophages: new therapeutic strategies

scientific article published on 24 August 2006

Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues

scientific article published on 23 March 2016

Meningoradiculoneuritis due to acyclovir-resistant varicella-zoster virus in a patient with AIDS.

scientific article published in November 1993

Metabolic activation of nucleoside and nucleotide reverse transcriptase inhibitors in dendritic and Langerhans cells

scientific article published on November 2002

Metabolic and pharmacological characteristics of the bicyclic nucleoside analogues (BCNAs) as highly selective inhibitors of varicella-zoster virus (VZV).

scientific article published in May 2003

Metabolism and anti-HIV activity of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety

scientific article published on January 1998

Methyl-2-arylidene hydrazinecarbodithioates: synthesis and biological activity

article

Microvirin, a novel alpha(1,2)-mannose-specific lectin isolated from Microcystis aeruginosa, has anti-HIV-1 activity comparable with that of cyanovirin-N but a much higher safety profile

scientific article

Mitochondrial expression of the Drosophila melanogaster multisubstrate deoxyribonucleoside kinase

scientific article published on 12 September 2007

Mitochondrial thymidine kinase inhibitors

scientific article

Modification of the antibiotic olivomycin I at the 2'-keto group of the side chain. Novel derivatives, antitumor and topoisomerase I-poisoning activity

scientific article

Molecular modifications of 2-arylidene-1-indanones leading to increased cytotoxic potencies

scientific article published on February 2007

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

scientific article

Mutational analysis of trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime target for the rational design of new non-nucleoside RT inhibitors

scientific article

Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopes

scientific article

Mutations at amino acid positions 63, 189, and 396 of human immunodeficiency virus type 1 reverse transcriptase (RT) partially restore the DNA polymerase activity of a Trp229Tyr mutant RT.

scientific article

Mutations distal to the substrate site can affect varicella zoster virus thymidine kinase activity: implications for drug design

scientific article published on 23 March 2006

Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs

scientific article published on 3 August 2015

Mycoplasma hyorhinis-encoded purine nucleoside phosphorylase: kinetic properties and its effect on the cytostatic potential of purine-based anticancer drugs

scientific article published on 25 September 2013

Mycoplasmas and cancer: focus on nucleoside metabolism

scientific article published on 27 March 2014

N(4)-Acyl derivatives as lipophilic prodrugs of cidofovir and its 5-azacytosine analogue, (S)-HPMP-5-azaC: chemistry and antiviral activity

scientific article published on 26 March 2014

N-3 substituted TSAO derivatives as a probe to explore the dimeric interface of HIV-1 reverse transcriptase

scientific article published in May 2003

N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action

scientific article published on April 2003

NICTABA and UDA, two GlcNAc-binding lectins with unique antiviral activity profiles

scientific article published on 19 February 2015

Nebrodeolysin, a novel hemolytic protein from mushroom Pleurotus nebrodensis with apoptosis-inducing and anti-HIV-1 effects

scientific article

New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity

scientific article

New developments of the "lock-in" modified cycloSal-d4TMPs

scientific article published on January 2007

New neplanocin analogues. 1. Synthesis of 6'-modified neplanocin A derivatives as broad-spectrum antiviral agents

scientific article

New neplanocin analogues. 7. Synthesis and antiviral activity of 2-halo derivatives of neplanocin A.

scientific article published on September 1996

New prodrugs of Adefovir and Cidofovir

scientific article published on 22 April 2011

New sorafenib derivatives: synthesis, antiproliferative activity against tumour cell lines and antimetabolic evaluation

scientific article published on 23 January 2012

Niacin esters of chalcones with tumor-selective properties

scientific article published on 2 June 2016

Non-Nucleoside HIV-1 Reverse-Transcriptase Inhibitors. Part 10

article

Non-nucleoside HIV reverse transcriptase inhibitors, Part 6[1]: synthesis and anti-HIV activity of novel 2-[(arylcarbonylmethyl)thio]-6-arylthio DABO analogues

scientific article published on October 2005

Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues

scientific article published on September 2006

Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity

scientific article published on 11 August 2007

Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 13: synthesis of fluorine-containing diaryltriazine derivatives for in vitro anti-HIV evaluation against wild-type strain

scientific article published on April 2009

Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase

scientific article published in February 2003

Non-nucleoside structures retain full anti-HCMV potency of the dideoxy furanopyrimidine family.

scientific article

Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors, Part 4[1]. Synthesis and Anti-HIV Activity of N-1-β-Carbonyl-6-naphthyl-methyl Analogues of HEPT

article

Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues

scientific article published on July 2003

Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones

scientific article

Nonnucleoside HIV-1 reverse-transcriptase inhibitors, part 5. Synthesis and anti-HIV-1 activity of novel 6-naphthylthio HEPT analogues

scientific article published in August 2005

Novel 1,2,4-triazole and Purine Acyclic Cyclopropane Nucleoside Analogues: Synthesis, Antiviral and Cytostatic Activity Evaluations ⬇️

scientific article published on July 4, 2011

Novel 1,2,4-triazole and imidazole derivatives of L-ascorbic and imino-ascorbic acid: synthesis, anti-HCV and antitumor activity evaluations

scientific article published on 15 February 2012

Novel 1-acyl-4-substituted semicarbazide derivatives of primaquine - synthesis, cytostatic, antiviral and antioxidative studies

scientific article

Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity

scientific article

Novel 5-arylcarbamoyl-2-methylisoxazolidin-3-yl-3-phosphonates as nucleotide analogues

scientific article

Novel 6-azapyrimidine-2'-deoxy-4'-thionucleosides: synthesis, biological evaluation and conformational analysis

scientific article

Novel 9-Arylpurines, as Selective Inhibitors of In Vitro Enterovirus Replication

scientific article published in 2009

Novel Analogues of the Anti-HIV-1 Agent TSAO-T Modified at the 3′-Spiro Moiety

article

Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations

scientific article published on June 2007

Novel Carbocyclic Nucleosides Containing a Cyclopentyl Ring. Adenosine and Uridine Analogues

scientific article published on 01 August 1997

Novel Tsao Derivatives. Synthesis and Anti-HIV-1 Activity of Allofuranosyl-TSAO-T Analogues

article

Novel [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2" -dioxide) derivatives with anti-HIV-1 and anti-human-cytomegalovirus activity.

scientific article published on February 2005

Novel acyclic phosphonylated 1,2,3-triazolonucleosides with an acetamidomethyl linker: synthesis and biological activity

scientific article published on 25 March 2014

Novel adamantylated pyrimidines and their preliminary biological evaluations.

scientific article

Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates

scientific article

Novel aryl substituted bicyclic furo nucleosides as extremely potent and selective anti-VZV agents

scientific article published in April 2001

Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity

scientific article

Novel bicyclic sugar modified nucleosides: synthesis, conformational analysis and antiviral evaluation

scientific article published on June 2004

Novel conjugated unsaturated ketones with submicromolar potencies towards some leukemic and colon cancer cells

scientific article published on 01 January 2019

Novel human immunodeficiency virus (HIV) inhibitors that have a dual mode of anti-HIV action

scientific article

Novel imidazo[1,2-c]pyrimidine base-modified nucleosides: synthesis and antiviral evaluation

scientific article published in August 2004

Novel in vivo model for the study of human immunodeficiency virus type 1 transcription inhibitors: evaluation of new 6-desfluoroquinolone derivatives

scientific article published on 22 January 2007

Novel isoxazolidine analogues of homonucleosides and homonucleotides

scientific article published on 02 November 2016

Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation

scientific article

Novel lipophilic hydroxyurea derivatives: synthesis, cytostatic and antiviral activity evaluations

scientific article

Novel multi-targeting anthra[2,3-b]thiophene-5,10-diones with guanidine-containing side chains: interaction with telomeric G-quadruplex, inhibition of telomerase and topoisomerase I and cytotoxic properties

scientific article published on 8 August 2014

Novel non-nucleoside human cytomegalovirus inhibitors based upon TSAO nucleoside derivatives: structure-activity relationships

scientific article published in January 2007

Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article published on November 2013

Novel potential agents for human cytomegalovirus infection: synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides

scientific article

Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2

scientific article

Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity

scientific article

Novel series of TSAO-T derivatives. Synthesis and anti-HIV-1 activity of 4-, 5-, and 6-substituted pyrimidine analogues.

scientific article published on February 1994

Novel series of [ddN]-[TSAO-T] heterodimers as potential bi-functional inhibitors of HIV-1 RT. Studies in the linker and ddN region

scientific article

Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme

scientific article published on 9 October 2013

Nucleoside Diphosphate Prodrugs: Nonsymmetric DiPPro-Nucleotides

scientific article

Nucleoside diphosphate prodrugs

scientific article

Nucleoside mono- and diphosphate prodrugs of 2',3'-dideoxyuridine and 2',3'-dideoxy-2',3'-didehydrouridine

scientific article published on 10 September 2014

Nucleoside-catabolizing enzymes in mycoplasma-infected tumor cell cultures compromise the cytostatic activity of the anticancer drug gemcitabine

scientific article

Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)).

scientific article

One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole: a unique, highly active antimicrotubule agent

scientific article published on 15 October 2011

Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies

scientific article

PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer

scientific article published on 17 March 2014

Palladium-Catalyzed Aryl Amination Reactions of 6-Bromo- and 6-Chloropurine Nucleosides

scientific article

Palladium-catalyzed synthesis of (E)-5-(2-acylvinyl)-2′-deoxyuridines and their antiviral and cytotoxic activities

scientific article published in 1995

Particular characteristics of the anti-human cytomegalovirus activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in vitro

scientific article (publication date: July 1991)

Pharmacokinetics in mice of the anti-retrovirus agent 9-(2-phosphonylmethoxyethyl)adenine ⬇️

scientific article published on September 1, 1992

Phenylboronic-Acid-Based Carbohydrate Binders as Antiviral Therapeutics: Bisphenylboronic Acids ⬇️

scientific article published on January 1, 2011

Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: monophenylboronic acids

scientific article

Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

scientific article

Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside

scientific article

Phosphoramidate derivatives of 2′,3′-didehydro-2′,3′-dideoxyadenosine [d4A] have markedly improved anti-HIV potency and selectivity

article

Phosphoramidate derivatives of d4T with improved anti-HIV efficacy retain full activity in thymidine kinase-deficient cells

article

Phosphoramidate derivatives of stavudine as inhibitors of HIV: unnatural amino acids may substitute for alanine

scientific article

Phosphoramidates of 2'-beta-D-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism

scientific article published on March 2010

Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets

scientific article

Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase

scientific article published on 23 July 2009

Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle

scientific article

Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate ⬇️

scientific article published on February 1, 1990

Potent and selective anti-HTLV-III/LAV activity of 2',3'-dideoxycytidinene, the 2',3'-unsaturated derivative of 2',3'-dideoxycytidine.

scientific article published in October 1986

Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event

scientific article (publication date: 15 June 1992)

Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base

scientific article

Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines

scientific article published on August 1996

Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region

scientific article

Potential prodrug derivatives of 2',3'-didehydro-2',3'-dideoxynucleosides. Preparations and antiviral activities

scientific article (publication date: 24 July 1992)

Potentiating effect of ribavirin on the anti-retrovirus activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside in vitro and in vivo

scientific article (publication date: 1989)

Potentiating effect of ribavirin on the in vitro and in vivo antiretrovirus activities of 2',3'-dideoxyinosine and 2',3'-dideoxy-2,6-diaminopurine riboside

scientific article

Pradimicin A, a carbohydrate-binding nonpeptidic lead compound for treatment of infections with viruses with highly glycosylated envelopes, such as human immunodeficiency virus

scientific article published on 18 October 2006

Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.

scientific article

Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus

scientific article published on 22 October 2007

Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET.

scientific article

Preparation of Chloro and Sulfanyl Derivatives of 1-(2-Deoxy-4-C-hydroxymethyl-α-L-threo-Pentofuranosyl)uracil

Pridine Oxide Derivatives: Structure‐Activity Relationship for Inhibition of Human Immunodeficiency Virus and Cytomegalovirus Replication in Cell Culture

scientific article

ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites

scientific article published on 27 October 2016

Prodrugs of Antiviral Nucleosides Cleavable by Dipeptidyl-Peptidase-IV (CD26)

scientific article published in 2008

Profile of resistance of human immunodeficiency virus to mannose-specific plant lectins

scientific article published on October 2004

Prognostic value of pretransplantation positron emission tomography using fluorine 18-fluorodeoxyglucose in patients with aggressive lymphoma treated with high-dose chemotherapy and stem cell transplantation

scientific article published on 27 February 2003

Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates

scientific article published on 09 October 2015

Pronounced anti-proliferative activity and tumor cell selectivity of 5-alkyl-2-amino-3-methylcarboxylate thiophenes

scientific article

Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines

scientific article published on 22 November 2006

Pyridine N-oxide derivatives are inhibitory to the human SARS and feline infectious peritonitis coronavirus in cell culture

scientific article published on 30 December 2005

Pyridine N-oxide derivatives inhibit viral transactivation by interfering with NF-kappaB binding

scientific article published on 24 January 2006

Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action

scientific article

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

scientific article (publication date: August 1988)

Rational Development of Nucleoside Diphosphate Prodrugs: DiPPro-Compounds

scientific article published on 25 August 2015

Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth

scientific article published on 2 October 2007

Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.

scientific article

Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications

scientific article published on January 2012

Red blood cells mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to primary macrophages: efficiency metabolism and activity against human immunodeficiency virus or herpes simplex virus

scientific article published in February 1997

Reduced levels of mitochondrial DNA increases the toxicity of 9-beta-D-arabinofuranosylguanine (araG).

scientific article published in June 2008

Regiospecific synthesis and anti-human immunodeficiency virus activity of novel 5-substituted N-alkylcarbamoyl and N,N-dialkylcarbamoyl 1,2,3-triazole-TSAO analogues

scientific article published on November 1998

Related lectins from snowdrop and maize differ in their carbohydrate-binding specificity

scientific article

Resistance of HIV-1 to the broadly HIV-1-neutralizing, anti-carbohydrate antibody 2G12.

scientific article published on 21 November 2006

Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720

scientific article

Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1

scientific article published on 25 January 2016

Retained sensitivity to cytotoxic pyrimidine nucleoside analogs in thymidine kinase 2 deficient human fibroblasts

scientific article published on January 2010

Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro

scientific article

Ribavirin inhibits in vitro hepatitis E virus replication through depletion of cellular GTP pools and is moderately synergistic with alpha interferon

scientific article published on 21 October 2013

Role of MRP4 and MRP5 in biology and chemotherapy

scientific article

Role of cations in the interaction of pradimicins with HIV-1 envelope gp120.

scientific article published on August 2013

Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations.

scientific article published on January 2004

Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir)

scientific article

Role of the carbohydrate-binding sites of griffithsin in the prevention of DC-SIGN-mediated capture and transmission of HIV-1.

scientific article

S-Adenosyl-L-homocysteine Hydrolase Inhibitors as Anti-Viral Agents: 5′-Deoxyaristeromycin

article

SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus

scientific article

Safety concerns for the potential use of cyanovirin-N as a microbicidal anti-HIV agent

article

Screening Platform toward New Anti-HIV Aptamers Set on Molecular Docking and Fluorescence Quenching Techniques

scientific article published on 25 January 2016

Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).

scientific article published on March 1998

Selective inhibition of Human Immunodeficiency Virus type 1 (HIV-1) by a novel family of tricyclic nucleosides

scientific article published on 12 May 2011

Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG).

scientific article published on November 1990

Several N-Glycans on the HIV Envelope Glycoprotein gp120 Preferentially Locate Near Disulphide Bridges and Are Required for Efficient Infectivity and Virus Transmission

scientific article published on 29 June 2015

Side-chain derivatives of biologically active nucleosides. 1. Side-chain analogs of 3'-azido-3'-deoxythymidine (AZT)

scientific article

Simian immunodeficiency virus is susceptible to inhibition by carbohydrate-binding agents in a manner similar to that of HIV: implications for further preclinical drug development

scientific article published on 12 May 2008

Single-Crystal Neutron Diffraction Study of Diammonium Hexaaquacopper Disulfate at 15 and 293 K. Investigation of Anharmonic Thermal Motion

Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo

scientific article

Sodium and potassium benzeneazophosphonate complexes with crown ethers: Solid-state microwave synthesis, characterization and biological activity

Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase

scientific article published in February 2002

Spirobipyridopyrans, spirobinaphthopyrans, indolinospiropyridopyrans, indolinospironaphthopyrans and indolinospironaphtho-1,4-oxazines: synthesis, study of X-ray crystal structure, antitumoral and antiviral evaluation.

scientific article published on March 2004

Stereocontrolled Facile Synthesis and Biological Evaluation of (3′S) and (3′R)-3′-Amino (and Azido)-3′-Deoxy Pyranonucleosides ⬇️

scientific article published on January 1, 2012

Stereoselective Synthesis and Antiviral Activity of Methyl-SubstitutedcycloSal-Pronucleotides ⬇️

scientific article published on August 3, 2012

Stereospecific Synthesis and NMR Conformational Studies of .gamma.-Butyrolactones of Nucleosides as Chiral Synthons for the Preparation of 2'-C- and 3'-C-Branched-Chain Nucleosides

Stereospecific synthesis and antiviral activities of beta-L-2',3'-dideoxy-5-chloropyrimidine nucleoside derivatives

scientific article

Structural basis for the specificity of thymidylate kinases from human pathogens: implications for nucleotide analogues activation

scientific article published in January 2009

Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors

Structural modifications of DAPY analogues with potent anti-HIV-1 activity

scientific article

Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design

scientific article

Structure-activity relationship of brominated 3-alkyl-5-methylene-2(5H)-furanones and alkylmaleic anhydrides as inhibitors of Salmonella biofilm formation and quorum sensing regulated bioluminescence in Vibrio harveyi

scientific article

Structure-activity relationship of tumor-selective 5-substituted 2-amino-3-carboxymethylthiophene derivatives

scientific article published on 18 September 2014

Structure-activity relationship studies of a series of antiviral and antibacterial aglycon derivatives of the glycopeptide antibiotics vancomycin, eremomycin, and dechloroeremomycin

scientific article

Structure-activity relationship studies on a novel family of specific HIV-1 reverse transcriptase inhibitors.

scientific article published on September 2003

Structure-activity relationship study on anti-HIV 6-desfluoroquinolones

scientific article published on 19 August 2008

Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base

scientific article

Studies on enzyme-cleavable dialkoxymethyl-cyclosaligenyl-2',3'-dideoxy-2',3'-didehydrothymidine monophosphates

scientific article published on 4 October 2008

Substituted naphthalen-1-yl-acetic acid hydrazides: synthesis, antimicrobial evaluation and QSAR analysis

scientific article

Substrate specificity of feline and canine herpesvirus thymidine kinase

scientific article

Substrate specificity of vaccinia virus thymidylate kinase

scientific article

Successful kinase bypass with new acyclovir phosphoramidate prodrugs

scientific article published on 24 June 2008

Successful treatment of progressive mucocutaneous infection due to acyclovir- and foscarnet-resistant herpes simplex virus with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC).

scientific article published in April 1994

Sugar and Base-Modified 2',3'-Dideoxynucleosides as Potential Anti-Aids Drugs

article

Sugar-binding proteins potently inhibit dendritic cell human immunodeficiency virus type 1 (HIV-1) infection and dendritic-cell-directed HIV-1 transfer

scientific article

Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine

scientific article published on April 1990

Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives)

scientific article

Susceptibilities of several clinical varicella-zoster virus (VZV) isolates and drug-resistant VZV strains to bicyclic furano pyrimidine nucleosides

scientific article published on March 2005

Susceptibility of feline immunodeficiency virus/human immunodeficiency virus type 1 reverse transcriptase chimeras to non-nucleoside RT inhibitors

scientific article

Synergistic in vitro anti-HIV type 1 activity of tenofovir with carbohydrate-binding agents (CBAs).

scientific article published on 8 April 2011

Syntheses and anti-HIV activities of (+/-)-norcarbovir and (+/-)-norabacavir

scientific article published on March 2007

Syntheses et Activites Biologiques de Nouvelles (E)-Alcenyl-5 Desoxy-2′ Uridines

Synthesis and Anti-HIV Evaluation of Novel 1,2,4-triazole Derivatives as Potential Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

article

Synthesis and Anti-HIV-1 Activity of 4- and 5-Substituted 1,2,3-Triazole-TSAO Derivatives

article

Synthesis and Antiviral Activities of Some New 5-Heteroaromatic Substituted Derivatives of 2'-Deoxyuridine

Synthesis and Antiviral Activities of Some Novel Carbocyclic Nucleosides

Synthesis and Antiviral Activity of Acyclic Nucleotide Analogues Derived from 6-(Aminomethyl)purines and Purine-6-carboxamidines

Synthesis and Antiviral Activity of Various N4-Acyl Derivatives of Cidofovir and its 5-Azacytosine Counterpart, 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine

scientific article published in 2008

Synthesis and Antiviral Evaluation of 3'-Substituted Thymidine Analogues Derived from 3'-Amino-3'-deoxythymidine

Synthesis and Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclobutane Ring

scientific article published in October 1999

Synthesis and Biological Activity of the Mono- and Diamino Analogues of 2′-Deoxyadenosine, Cordycepin, 9-(3-Deoxy-α-D-Threo-Pentofuranosyl)-Adenine (A Structural Component of Agrocin 84) and 9-(2-Deoxy-α-D-Threo-Pentofuranosyl)Adenine

Synthesis and Biological Evaluation of 1,2-Disubstituted Carbonucleosides of 6-Substituted Purine and 8-Azapurine

scientific article published on 01 April 1999

Synthesis and Biological Evaluation of Acyclic Nucleotide Analogues of Bicyclic Pyrimidine Bases

scientific article published in 2009

Synthesis and Biological Evaluation of Novel 1,2,3‐Triazolonucleotides ⬇️

scientific article published on February 21, 2013

Synthesis and Evaluation of Antiviral Activity of 3'-C-Cyano-3'-Deoxynucleosides

Synthesis and Evaluation of Novel Acyclovir Phosphoramidates as Anti-HIV Agents

article

Synthesis and NMR conformational studies of stable analogues of 2-deoxy-α-D-ribose-1-phosphate

Synthesis and SAR of 2',3'-bis-O-substituted N(6), 5'-bis-ureidoadenosine derivatives: implications for prodrug delivery and mechanism of action

scientific article published on 21 August 2012

Synthesis and SAR studies on azetidine-containing dipeptides as HCMV inhibitors

article

Synthesis and an antiviral activity evaluation of nucleoside 5´-O-(N-acyl) phosphoramidates.

scientific article

Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof

scientific article published on 16 May 2013

Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article published on 13 November 2006

Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors

scientific article

Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors

scientific article published on 20 May 2010

Synthesis and anti-HIV activity of 4'-C-ethynyl-2'-deoxy-4'-thio-nucleosides

scientific article published in January 2009

Synthesis and anti-HIV activity of 4-(naphthalen-1-yl)-1,2,5-thiadiazol-3-hydroxyl derivatives

scientific article published on 30 June 2014

Synthesis and anti-HIV activity of aryl-2-[(4-cyanophenyl)amino]-4-pyrimidinone hydrazones as potent non-nucleoside reverse transcriptase inhibitors

scientific article published on 8 September 2011

Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency

scientific article published on March 1998

Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides

scientific article (publication date: June 1990)

Synthesis and anti-HIV studies of 2- and 3-adamantyl-substituted thiazolidin-4-ones

scientific article published on 10 March 2008

Synthesis and anti-HIV studies of 2-adamantyl-substituted thiazolidin-4-ones

scientific article published on 20 January 2007

Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article published on 24 March 2007

Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives

scientific article published in March 2006

Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds

scientific article published on 13 February 2008

Synthesis and anti-herpetic activity of phosphoramidate ProTides

scientific article published on 18 April 2013

Synthesis and anti-varicella-zoster virus activity of some novel bicyclic nucleoside inhibitors: effect of enhanced aqueous solubility

scientific article

Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.

scientific article published on July 1993

Synthesis and antiretrovirus properties of 5'-isocyano-5'-deoxythymidine, 5'-isocyano-2',5'-dideoxyuridine, 3'-azido-5'-isocyano-3',5'-dideoxythymidine, and 3'-azido-5'-isocyano-2',3',5'-trideoxyuridine

scientific article (publication date: April 1991)

Synthesis and antitumor molecular mechanism of agents based on amino 2-(3',4',5'-trimethoxybenzoyl)benzo[b]furan: inhibition of tubulin and induction of apoptosis

scientific article

Synthesis and antiviral activities of 1,2,3-triazole functionalized thymidines: 1,3-dipolar cycloaddition for efficient regioselective diversity generation

scientific article

Synthesis and antiviral activities of 3-aralkylthiomethylimidazo[1,2-b]pyridazine derivatives

scientific article published on July 2003

Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety

scientific article

Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analogues

scientific article

Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain.

scientific article published on 3 May 2009

Synthesis and antiviral activity of 1,3-disubstituted uracils against HIV-1 and HCMV.

scientific article published in September 2003

Synthesis and antiviral activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil against HIV-1.

scientific article

Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds

scientific article published on June 2004

Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines

scientific article

Synthesis and antiviral activity of 6-benzoyl-benzoxazolin-2-one and 6-benzoyl-benzothiazolin-2-one derivatives

scientific article

Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines

scientific article published on 4 March 2011

Synthesis and antiviral activity of boranophosphonate isosteres of AZT and d4T monophosphates

scientific article

Synthesis and antiviral activity of highly water-soluble polycarboxylic derivatives of [70]fullerene ⬇️

scientific article published on June 10, 2011

Synthesis and antiviral activity of imidazo[1,2-a]pyridines

Synthesis and antiviral activity of monofluorinated cyclopropanoid nucleosides

scientific article published on 28 November 2003

Synthesis and antiviral activity of new pyrazole and thiazole derivatives.

scientific article published on 5 April 2009

Synthesis and antiviral activity of phosphonate derivatives of enantiomeric dihydro-2H-pyranyl nucleosides

scientific article published in 1995

Synthesis and antiviral activity of some 5'-N-phthaloyl-3'-azido-2',3'-dideoxythymidine analogues

scientific article published in May 2003

Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives

scientific article

Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines

scientific article published on 6 December 2007

Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine

scientific article (publication date: August 1989)

Synthesis and antiviral activity of three pyrazole analogues of distamycin A.

scientific article published on June 1994

Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives

scientific article published on 2 August 2007

Synthesis and antiviral and cytostatic properties of 3'-deoxy-3'-fluoro- and 2'-azido-3'-fluoro-2',3'-dideoxy-D-ribofuranosides of natural heterocyclic bases

scientific article

Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives

scientific article

Synthesis and antiviral evaluation of 3′-substituted thymidine analogues derived from 3′-amino-3′-deoxythymidine

Synthesis and antiviral evaluation of 4'-alkoxy analogues of 9-(beta-D-xylofuranosyl)adenine

scientific article

Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core

scientific article

Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4′-phosphono-but-2′-en-1′-yl]purine nucleosides

article

Synthesis and antiviral evaluation of cis-substituted cyclohexenyl and cyclohexanyl nucleosides.

scientific article published on January 2005

Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives

scientific article

Synthesis and antiviral evaluation of phosphoramidate derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine

scientific article published on September 2001

Synthesis and antiviral evaluation of some 3'-fluoro bicyclic nucleoside analogues

scientific article published in January 2004

Synthesis and antiviral evaluation of some beta-L-2', 3'-dideoxy-5-chloropyrimidine nucleosides and pronucleotides

scientific article

Synthesis and antiviral evaluation of α-L-2'-deoxythreofuranosyl nucleosides

scientific article published on 20 May 2011

Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design

scientific article

Synthesis and biological activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles: non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors

scientific article

Synthesis and biological activity of strongly fluorescent tricyclic analogues of acyclovir and ganciclovir

scientific article published in November 2002

Synthesis and biological activity of tricyclic analogues of 9-[[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine

scientific article published on 2 February 2006

Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors

scientific article published on 9 February 2008

Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors

scientific article published on October 2006

Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization

scientific article published on 06 August 2008

Synthesis and biological evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a new class of antitubulin agents

scientific article

Synthesis and biological evaluation of 3,3-difluoropyridine-2,4(1H,3H)-dione and 3-deaza-3-fluorouracil base and nucleoside derivatives

scientific article

Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV.

scientific article published on 9 March 2010

Synthesis and biological evaluation of 5-(alkyn-1-yl)-1-(p-toluenesulfonyl)uracil derivatives

article

Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivatives

scientific article published on January 2006

Synthesis and biological evaluation of N- and O-alkylated bicyclic furanopyrimidines as non-nucleosidic inhibitors of human cytomegalovirus.

scientific article published on January 2005

Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2'-deoxy nucleoside analogues

scientific article published on 12 March 2012

Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides

scientific article published on July 2005

Synthesis and biological evaluation of acyclic nucleotide analogues with a furo[2,3-d]pyrimidin-2(3H)-one base

Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging

scientific article published on 30 March 2007

Synthesis and biological evaluation of dinucleoside methylphosphonates of 3'-azido-3'-deoxythymidine and 2', 3'-dideoxycytidine

scientific article (publication date: July 1990)

Synthesis and biological evaluation of iodinated and fluorinated 9-(2-hydroxypropyl) and 9-(2-hydroxyethoxy)methyl purine nucleoside analogues

scientific article published on December 2003

Synthesis and biological evaluation of isonucleosides derived from methyl 3,5-anhydro-2-O-(2-fluorobenzyl)-D-xylofuranosides

scientific article

Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase

article

Synthesis and biological evaluation of novel 1'-branched and spironucleoside analogues.

scientific article

Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article published on 30 January 2008

Synthesis and biological evaluation of phosphoramidate prodrugs of two analogues of 2-deoxy-d-ribose-1-phosphate directed to the discovery of two carbasugars as new potential anti-HIV leads

scientific article

Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article

Synthesis and biological evaluation of prodrugs of 2-fluoro-2-deoxyribose-1-phosphate and 2,2-difluoro-2-deoxyribose-1-phosphate ⬇️

scientific article published on March 14, 2013

Synthesis and biological evaluation of purine 2'-fluoro-2'-deoxyriboside ProTides as anti-influenza virus agents

scientific article

Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs

scientific article published on 9 January 2013

Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus ⬇️

scientific article published on January 28, 2012

Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase

scientific article published on 22 January 2011

Synthesis and biological properties of C-2 triazolylinosine derivatives

scientific article

Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides

scientific article published on 4 July 2013

Synthesis and cellular pharmacology studies of a series of 2-amino-3-aroyl-4-substituted thiophene derivatives

scientific article published on November 2010

Synthesis and cytostatic and antiviral activities of 1-beta-D-ribofuranosyl-5-alkylcytosine (5-alkylcytidine) cyclic 3',5'-monophosphates

scientific article (publication date: 1989)

Synthesis and cytostatic evaluation of 4-N-alkanoyl and 4-N-alkyl gemcitabine analogues

scientific article published on 30 December 2013

Synthesis and cytotoxic evaluation of some styryl ketones and related compounds

Synthesis and cytotoxic properties of 4,11-bis[(aminoethyl)amino]anthra[2,3-b]thiophene-5,10-diones, novel analogues of antitumor anthracene-9,10-diones

scientific article

Synthesis and evaluation of a (99m)Tc-MAMA-propyl-thymidine complex as a potential probe for in vivo visualization of tumor cell proliferation with SPECT.

scientific article

Synthesis and evaluation of new antitumor 3-aminomethyl-4,11-dihydroxynaphtho[2,3-f]indole-5,10-diones

scientific article published on 8 September 2014

Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.

scientific article published in April 2001

Synthesis and evaluation of thymine-derived carboxamides against mitochondrial thymidine kinase (TK-2) and related enzymes

scientific article published in October 2004

Synthesis and fluorescent properties of 6-(4-biphenylyl)-3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purine analogues of acyclovir and ganciclovir

scientific article published on May 2003

Synthesis and fluorescent properties of the tricyclic analogues of acyclovir linked with nitrogen hetbrocyclic units

scientific article

Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV.

scientific article

Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article

Synthesis and in vitro cytotoxic and antiviral activities of 1-(2,5,6-trideoxy-6-halogenohept-5-enofuranurononitrile)thymine and derivatives

scientific article

Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles

scientific article published on September 2005

Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography

scientific article published on 14 February 2007

Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs

scientific article

Synthesis of 2?-Deoxy-5-(isothiazol-5-yl)uridine and Its Interaction with the HSV-1 Thymidine Kinase

article

Synthesis of 3' '-substituted TSAO derivatives with anti-HIV-1 and anti-HIV-2 activity through an efficient palladium-catalyzed cross-coupling approach

scientific article published on August 2002

Synthesis of 3',4'-difluoro-3'-deoxyribonucleosides and its evaluation of the biological activities: discovery of a novel type of anti-HCV agent 3',4'-difluorocordycepin

scientific article published on 17 September 2014

Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents

scientific article published on March 2003

Synthesis of 3'-Fluoro-3'-Deoxyribonucleosides; Anti-HIV-1 and Cytostatic Properties

article

Synthesis of 3-fluoro-6-S-(2-S-pyridyl) nucleosides as potential lead cytostatic agents ⬇️

scientific article published on August 17, 2010

Synthesis of 4,6-dideoxy-3-fluoro-2-keto-beta-D-glucopyranosyl analogues of 5-fluorouracil, N6-benzoyl adenine, uracil, thymine, N4-benzoyl cytosine and evaluation of their antitumor activities

scientific article

Synthesis of 5-substituted 2'-deoxyuridine-5'- phosphonate analogues and evaluation of their antiviral activity

scientific article published in January 2012

Synthesis of O2- and N3-(2-Phosphonomethoxy)ethyl Derivatives of 6-Phenyl- and 6-Pyridinyl-5-azacytosine

article

Synthesis of [1-[2',5'-bis-O-(t-Butyldimethylsilyl)-β- L-ribofuranosyl] thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (L-TSAO-T)

article published in 1995

Synthesis of [1-[3′,5′-Bis-O-(tert-butyldimethylsilyl)-β-d-arabino- and β-d-ribofuranosyl]cytosine]-2′-spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide). Analogues of the highly specific anti-HIV-1 agent TSAO-T

article

Synthesis of adamantane spiro sultones as potential antiviral agents

scientific article published in 1992

Synthesis of an apionucleoside family and discovery of a prodrug with anti-HIV activity

scientific article published on 20 May 2014

Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents

scientific article published on October 2010

Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents

scientific article published in January 2004

Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation

scientific article published on 21 December 2010

Synthesis of novel 6-azapyrimidine acyclic nucleoside analogues and antiviral evaluation

scientific article published on July 2010

Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives

scientific article

Synthesis of novel carbocyclic nucleosides with a modified cyclopentane ring and evaluation of their antiviral activity

scientific article

Synthesis of purine and 7-deazapurine nucleoside analogues of 6-N-(4-Nitrobenzyl)adenosine; inhibition of nucleoside transport and proliferation of cancer cells

scientific article published on 30 April 2014

Synthesis of unusual bicyclic nucleosides bearing an unsaturated side-chain, as potential inhibitors of varicella-zoster virus (VZV).

scientific article published on May 2003

Synthesis, Biological Evaluation, and Structure Analysis of a Series of New 1,5-Anhydrohexitol Nucleosides

article

Synthesis, Characterization and Antiviral Properties of Pd(II) Complexes With Penciclovir

scientific article published on January 2001

Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin

scientific article (publication date: May 1989)

Synthesis, SAR, and preliminary mechanistic evaluation of novel antiproliferative N6,5′-bis-ureido- and 5′-carbamoyl-N6-ureidoadenosine derivatives ⬇️

scientific article published on December 2, 2011

Synthesis, X-ray crystal structural study, antiviral and cytostatic evaluations of the novel unsaturated acyclic and epoxide nucleoside analogues

scientific article published on 2 August 2006

Synthesis, X-ray crystal structure study, and cytostatic and antiviral evaluation of the novel cycloalkyl-N-aryl-hydroxamic acids.

scientific article published on February 2005

Synthesis, anti-HIV and cytostatic evaluation of 3'-deoxy-3'-fluorothymidine (FLT) pro-nucleotides

scientific article published on 5 April 2014

Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound

scientific article published on 7 March 2008

Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T).

scientific article published on November 1998

Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid

scientific article published on 19 January 2010

Synthesis, anticancer and cytostatic activity of some 6H-indolo[2,3-b]quinoxalines

scientific article

Synthesis, anticancer, and cytotoxic activities of some mononuclear Ru(II) compounds

scientific article published on 19 August 2007

Synthesis, antimicrobial and antiviral activity of substituted benzimidazoles

scientific article published in October 2009

Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives

scientific article published on 11 September 2008

Synthesis, antimycobacterial, antiviral, antimicrobial activity and QSAR studies of N(2)-acyl isonicotinic acid hydrazide derivatives

scientific article published in February 2013

Synthesis, antineoplastic and cytotoxic activities of some mononuclear Ru(II) complexes

scientific article

Synthesis, antiretrovirus effects, and phosphorylation kinetics of 3'-isocyano-3'-deoxythymidine and 3'-isocyano-2',3'-dideoxyuridine

scientific article

Synthesis, antiviral and cytostatic activities, of carbocyclic nucleosides incorporating a modified cyclopentane ring. IV. Adenosine and uridine analogues

scientific article

Synthesis, biological activity, pharmacokinetic properties and molecular modelling studies of novel 1H,3H-oxazolo[3,4-a]benzimidazoles: non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article published on May 2001

Synthesis, conformational analysis and antiviral and antitumoral activity of new 1,2-disubstituted carbocyclic nucleosides.

scientific article published in September 2002

Synthesis, modeling and evaluation of 3'-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3'-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors

scientific article published on 2 December 2010

Synthesis, solution conformation and anti-HIV activity of novel 3'-substituted-2',3'-dideoxy-5-hydroxymethyluridines and their 4,5-substituted analogues

scientific article published on May 2003

Synthesis, structural studies, and biological evaluation of some purine substituted 1-aminocyclopropane-1-carboxylic acids and 1-amino-1-hydroxymethylcyclopropanes.

scientific article published in April 2003

TSAO Derivatives: Highly Specific Inhibitors of Human Immunodeficiency Virus Type-1 (HIV-1) Replication

article

TSAO analogues. 3. Synthesis and anti-HIV-1 activity of 2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl 3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) purine and purine-modified nucleosides.

scientific article published on October 1993

TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro -5''- (4''-amino-1'',2''-oxathiole 2'',2''-dioxide) pyrimidine and pyrimidine-modified nucleosides

scientific article (publication date: 7 August 1992)

TSAO compounds: the comprehensive story of a unique family of HIV-1 specific inhibitors of reverse transcriptase

scientific article published on January 2004

TSAO-T analogues bearing amino acids at position N-3 of thymine: synthesis and anti-human immunodeficiency virus activity

scientific article

Targeting HIV entry through interaction with envelope glycoprotein 120 (gp120): synthesis and antiviral evaluation of 1,3,5-triazines with aromatic amino acids

scientific article published on 13 July 2011

Targeting platelet-derived endothelial cell growth factor/thymidine phosphorylase for cancer therapy

scientific article published on 16 May 2007

The 2',3'-dideoxyriboside of 2,6-diaminopurine and its 2',3'-didehydro derivative inhibit the deamination of 2',3'-dideoxyadenosine, an inhibitor of human immunodeficiency virus (HIV) replication

scientific article

The 2',3'-dideoxyriboside of 2,6-diaminopurine selectively inhibits human immunodeficiency virus (HIV) replication in vitro

scientific article published on May 1987

The A167Y mutation converts the herpes simplex virus type 1 thymidine kinase into a guanosine analogue kinase

scientific article

The Application of Phosphoramidate Protide Technology to Acyclovir confers Novel Anti-HIV Inhibition

article

The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition

scientific article

The DiPPro approach: synthesis, hydrolysis, and antiviral activity of lipophilic d4T diphosphate prodrugs

scientific article published on 11 March 2014

The Highly Conserved Glycan at Asparagine 260 of HIV-1 gp120 Is Indispensable for Viral Entry ⬇️

scientific article published on October 17, 2011

The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs

scientific article

The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization

scientific article

The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors

scientific article published on 15 April 2005

The antiretroviral and cytostatic activity, and metabolism of 3'-azido-2',3'-dideoxythymidine, 3'-fluoro-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly cell type-dependent.

scientific article published in January 1989

The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2'-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes

scientific article published on 31 May 2011

The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones

scientific article published on 29 March 2008

The design, synthesis and antiviral evaluation of a series of 5-trimethylsilyl-1-beta-D-(arabinofuranosyl)uracil phosphoramidate ProTides

scientific article published on 9 March 2010

The dual role of thymidine phosphorylase in cancer development and chemotherapy

scientific article

The effect of a methyl or 2-fluoroethyl substituent at the N-3 position of thymidine, 3'-fluoro-3'-deoxythymidine and 1-beta-D-arabinosylthymine on their antiviral and cytostatic activity in cell culture

scientific article

The first series of 4,11-bis[(2-aminoethyl)amino]anthra[2,3-b]furan-5,10-diones: Synthesis and anti-proliferative characteristics

scientific article published on 19 November 2010

The griffithsin dimer is required for high-potency inhibition of HIV-1: evidence for manipulation of the structure of gp120 as part of the griffithsin dimer mechanism

scientific article published on 10 June 2013

The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines

scientific article

The journey towards elucidating the anti-HCMV activity of alkylated bicyclic furano pyrimidines.

scientific article published on January 2005

The lantibiotic peptide labyrinthopeptin A1 demonstrates broad anti-HIV and anti-HSV activity with potential for microbicidal applications

scientific article

The molecular basis of resilience to the effect of the Lys103Asn mutation in non-nucleoside HIV-1 reverse transcriptase inhibitors studied by targeted molecular dynamics simulations

scientific article

The monomeric and dimeric mannose-binding proteins from the Orchidaceae species Listera ovata and Epipactis helleborine: sequence homologies and differences in biological activities

scientific article published in August 1994

The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations

scientific article published on 25 October 2006

The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations.

scientific article published on January 2005

The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations

scientific article

The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: synthesis, cytostatic and antiviral activity evaluations.

scientific article published on 15 September 2007

The novel pyrimidine and purine derivatives of l-ascorbic acid: synthesis, one- and two-dimensional 1H and 13C NMR study, cytostatic and antiviral evaluation

scientific article

The nucleoside derivative 5'-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action

scientific article

The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT.

scientific article

The phthalocyanine prototype derivative Alcian Blue is the first synthetic agent with selective anti-human immunodeficiency virus activity due to its gp120 glycan-binding potential

scientific article

The potential of acyclic nucleoside phosphonates as broad-spectrum antiviral agents.

scientific article published on January 1995

The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase

scientific article published on February 2005

The pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis and how it may affect nucleoside-based therapy

scientific article

The rare HIV-1 gp41 mutations 43T and 50V elevate enfuvirtide resistance levels of common enfuvirtide resistance mutations that did not impact susceptibility to sifuvirtide

scientific article published on 21 March 2010

The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention

scientific article

The role of N-glycans of HIV-1 gp41 in virus infectivity and susceptibility to the suppressive effects of carbohydrate-binding agents

scientific article published on 11 December 2014

The role of Thr139 in the human immunodeficiency virus type 1 reverse transcriptase sensitivity to (+)-calanolide A.

scientific article

The role of individual carbohydrate-binding sites in the function of the potent anti-HIV lectin griffithsin

scientific article

The synthesis, antiviral, cytostatic and cytotoxic evaluation of a new series of acyclonucleotide analogues with a 1,2,3-triazole linker

scientific article published on 30 October 2013

The thymidine phosphorylase inhibitor 5'-O-tritylinosine (KIN59) is an antiangiogenic multitarget fibroblast growth factor-2 antagonist

scientific article published on February 2012

Therapeutic strategies towards HIV-1 infection in macrophages

scientific article published on 9 June 2006

Thermal characterization of the antiviral drug UC-781 and stability of its glass

Thienothiadiazine 2,2-dioxide acyclonucleosides: synthesis and antiviral activity

scientific article published in May 2000

Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120.

scientific article published on 3 January 2012

Thiosugars. X. Novel nucleoside analogues derived from 4-thio-L-lyxofuranose

scientific article published in October 2003

Thiosugars. XII. Synthesis of new 3'-O-substituted 2',5'-anhydro-2'-thio-alpha-D-pentofuranosyl nucleoside analogues.

scientific article

Thymidine analogs as potential antiviral agents

scientific article published on January 2008

Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications

scientific article

Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: synthesis, biological investigation and molecular modeling studies

scientific article published on 30 August 2013

Treatment of visna virus infection in lambs with the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)adenine (PMEA).

scientific article published in May 1998

Tumour-specific cytotoxicity and structure-activity relationships of novel 1-[3-(2-methoxyethylthio)propionyl]-3,5-bis(benzylidene)-4-piperidones

scientific article published on 30 March 2016

Unusual lability of 5'-O-tert-butyldimethylsilyl group on 4''-acyl TSAO derivatives

scientific article published in May 2003

Vaginal microbiota and its role in HIV transmission and infection

scientific article

Virtual screening of acyclovir derivatives as potential antiviral agents: design, synthesis and biological evaluation of new acyclic nucleoside ProTides

scientific article

Viruses as key regulators of angiogenesis ⬇️

scientific article published on May 1, 2011

[(18)F]FDG PET monitoring of tumour response to chemotherapy: does [(18)F]FDG uptake correlate with the viable tumour cell fraction?

scientific article published on 25 February 2003

[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1

scientific article (publication date: May 1992)

cycloSal-PMEA and cycloAmb-PMEA: potentially new phosphonate prodrugs based on the cycloSal-pronucleotide approach

scientific article published on December 2005

cycloSal-Pronucleotides of 2',3'-dideoxyadenosine and 2', 3'-dideoxy-2',3'-didehydroadenosine: synthesis and antiviral evaluation of a highly efficient nucleotide delivery system

scientific article

cycloSal-Pronucleotides of 2'-fluoro-ara- and 2'-fluoro-ribo-2',3'- dideoxyadenosine as a strategy to bypass a metabolic blockade

scientific article

cycloSal-d4TMP pronucleotides structural variations, mechanistic insights and antiviral activity.

scientific article

Paulina is supported by:

About Paulina

Help