Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway
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| Description | scientific article published on 24 June 2012 |
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author: Federico Gago Jan Balzarini Anna Karlsson |
| Publication date | June 24, 2012 |
| Language | English |
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