List of works - Benedikt M. Kessler

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

scientific article

Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation.

scientific article published on 22 May 2014

A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14

scientific article

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

scientific article

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

scientific article published in March 2004

Arginine methylation regulates the p53 response

scientific journal article

A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance

scientific article

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

scientific article

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

scientific journal article

Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

scientific article

A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae

scientific article

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.

scientific article

New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes

scientific article published on 17 June 2010

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

scientific article published on 28 March 2018

Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes

scientific article

A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L

scientific journal article

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

scientific article

Neuronal loss and brain atrophy in mice lacking cathepsins B and L

scientific article

Structural basis and specificity of human otubain 1-mediated deubiquitination

scientific article

Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins

scientific article

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

scientific article

Identification of the target self-antigens in reperfusion injury

scientific article

Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

scientific article

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

scientific article

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl

scientific article

Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells

scholarly article

Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication

article

Arginine methylation controls growth regulation by E2F-1

scientific article

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

scientific article

Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach

scientific article published on 02 July 2008

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

scientific article

Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway

scientific article

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits

scientific article published in September 2001

Identification of proteins associated with murine cytomegalovirus virions

scientific article

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

scientific article

Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury.

scientific article published in October 2006

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase

scientific article published on 13 September 2004

QuaNCAT: quantitating proteome dynamics in primary cells.

scientific article published on 10 March 2013

Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP

scientific article

Comparative evaluation of label-free SINQ normalized spectral index quantitation in the central proteomics facilities pipeline

scientific article published on 8 June 2011

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair

scientific article

CPFP: a central proteomics facilities pipeline

scientific article

Control of cross-presentation during dendritic cell maturation

scientific article published in February 2004

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

scientific article published on 20 October 2008

ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage

scientific article published on 21 February 2012

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

scientific article

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

scientific article

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein

scientific article

Ancient proteins resolve the evolutionary history of Darwin’s South American ungulates

scientific article (publication date: 18 March 2015)

Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency

scientific article published on 14 March 2013

List of works by Benedikt M. Kessler

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation.

A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

Arginine methylation regulates the p53 response

A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.

New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes

A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

Neuronal loss and brain atrophy in mice lacking cathepsins B and L

Structural basis and specificity of human otubain 1-mediated deubiquitination

Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

Identification of the target self-antigens in reperfusion injury

Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl

Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells

Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication

Arginine methylation controls growth regulation by E2F-1

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits

Identification of proteins associated with murine cytomegalovirus virions

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury.

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase

QuaNCAT: quantitating proteome dynamics in primary cells.

Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP

Comparative evaluation of label-free SINQ normalized spectral index quantitation in the central proteomics facilities pipeline

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair

CPFP: a central proteomics facilities pipeline

Control of cross-presentation during dendritic cell maturation

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein

Ancient proteins resolve the evolutionary history of Darwin’s South American ungulates

Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency