List of works - Frédéric Calon

A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer's Disease.

scientific article published on 10 August 2017

A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model.

scientific article

ABCG2- and ABCG4-mediated efflux of amyloid-β peptide 1-40 at the mouse blood-brain barrier

scientific article

Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer's Disease.

scientific article published on 26 August 2015

Accumulation of amyloid-β in the cerebellar cortex of essential tremor patients

scientific article published on 4 August 2015

Accumulation of dietary docosahexaenoic acid in the brain attenuates acute immune response and development of postischemic neuronal damage.

scientific article published on 18 August 2011

Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease

scientific article

Age-Dependent Regulation of the Blood-Brain Barrier Influx/Efflux Equilibrium of Amyloid-β Peptide in a Mouse Model of Alzheimer's Disease (3xTg-AD).

scientific article published on 09 October 2015

Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage

scientific article published on 09 November 2018

Alteration of glutamate receptors in the striatum of dyskinetic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys following dopamine agonist treatment

scientific article published in January 2002

Altered cerebral insulin response in transgenic mice expressing the epsilon-4 allele of the human apolipoprotein E gene

scientific article published on 30 November 2016

Altered cerebral vascular volumes and solute transport at the blood-brain barriers of two transgenic mouse models of Alzheimer's disease

scientific article published on 12 March 2014

Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function

scientific article

Apolipoprotein E isoforms disrupt long-chain fatty acid distribution in the plasma, the liver and the adipose tissue of mice.

scientific article published on 28 September 2014

Association of Neuropathological Markers in the Parietal Cortex With Antemortem Cognitive Function in Persons With Mild Cognitive Impairment and Alzheimer Disease

scientific article published on 31 January 2017

Beta-amyloid pathology in human brain microvessel extracts from the parietal cortex: relation with cerebral amyloid angiopathy and Alzheimer's disease

scientific article published on 07 February 2019

Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease.

scientific article

Brain bioavailability of human intravenous immunoglobulin and its transport through the murine blood-brain barrier.

scientific article published on 18 September 2013

Brain mural cell loss in the parietal cortex in Alzheimer's disease correlates with cognitive decline and TDP-43 pathology

scientific article published on 22 January 2020

Brain uptake of a fluorescent vector targeting the transferrin receptor: a novel application of in situ brain perfusion.

scientific article published on 22 November 2013

Can iPCSK9-induced hypocholesterolemia starve cancer cells?

scientific article published on 21 April 2017

Can insulin signaling pathways be targeted to transport Aβ out of the brain?

scientific article published on 16 June 2015

Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology

scientific article

Changes of GABA receptors and dopamine turnover in the postmortem brains of parkinsonians with levodopa-induced motor complications

scientific article published in March 2003

Characterization of a 3xTg-AD mouse model of Alzheimer's disease with the senescence accelerated mouse prone 8 (SAMP8) background

scientific article published on 17 January 2018

Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons

scientific article published on 19 August 2011

Cognitive-Enhancing Effects of a Polyphenols-Rich Extract from Fruits without Changes in Neuropathology in an Animal Model of Alzheimer's Disease

scientific article published on 20 September 2016

Cystamine metabolism and brain transport properties: clinical implications for neurodegenerative diseases.

scientific article published on 19 August 2010

DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice

scientific article

Decreased drebrin mRNA expression in Alzheimer disease: correlation with tau pathology.

scientific article published in August 2008

Defective dentate nucleus GABA receptors in essential tremor

scientific article

Deficient striatal adaptation in aminergic and glutamatergic neurotransmission is associated with tardive dyskinesia in non-human primates exposed to antipsychotic drugs.

scientific article published on 5 August 2017

Dietary intake of unsaturated fatty acids modulates physiological properties of entorhinal cortex neurons in mice

scientific article published on 23 May 2012

Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease

scientific article published in August 2005

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study.

scientific article published on 13 May 2009

Direct evidence of abca1-mediated efflux of cholesterol at the mouse blood–brain barrier

article

Docosahexaenoic acid prevents cognitive deficits in human apolipoprotein E epsilon 4-targeted replacement mice

scientific article published on 10 May 2017

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

scientific article

Dopamine-receptor stimulation: biobehavioral and biochemical consequences

scientific article published on 01 October 2000

Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease

scientific article published in January 2011

High dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-beta and tau pathologies in the 3xTg-AD model of Alzheimer's disease.

scientific article

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

scientific article

High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology.

scientific article published on 29 July 2016

Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in mice

scientific article

Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice.

scientific article published on 9 January 2016

IVIg protects the 3xTg-AD mouse model of Alzheimer’s disease from memory deficit and Aβ pathology

scientific article (publication date: 22 March 2014)

Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17β-hydroxysteroid dehydrogenase type 10

scientific article published on 26 September 2018

Immunotherapies in Alzheimer's disease: Too much, too little, too late or off-target?

scientific article published on 21 December 2015

Impact of DHA intake in a mouse model of synucleinopathy

scientific article published on 8 December 2017

Impact of intravenous immunoglobulin on the dopaminergic system and immune response in the acute MPTP mouse model of Parkinson's disease

scientific article

Impact of ω-3 fatty acids in Parkinson's disease

scientific article published on 23 March 2011

Impaired thermoregulation and beneficial effects of thermoneutrality in the 3×Tg-AD model of Alzheimer's disease.

scientific article

In vivo labeling of brain capillary endothelial cells after intravenous injection of monoclonal antibodies targeting the transferrin receptor

scientific article

Increase of preproenkephalin mRNA levels in the putamen of Parkinson disease patients with levodopa-induced dyskinesias

scientific article published in February 2002

Increased LINGO1 in the cerebellum of essential tremor patients

scientific article

Increased adenosine A2A receptors in the brain of Parkinson's disease patients with dyskinesias

scientific article published on 19 March 2004

Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease

scientific article

Internalization of targeted quantum dots by brain capillary endothelial cells in vivo

scientific article published on 6 October 2015

Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism.

scientific article

L-Dopa treatment abolishes the numerical increase in striatal dopaminergic neurons in parkinsonian monkeys

scientific article published on 17 July 2007

Levodopa or D2 agonist induced dyskinesia in MPTP monkeys: correlation with changes in dopamine and GABAA, receptors in the striatopallidal complex ⬇️

scientific article published on May 22, 1995

Levodopa response motor complications--GABA receptors and preproenkephalin expression in human brain

scientific article

Levodopa-induced motor complications are associated with alterations of glutamate receptors in Parkinson's disease

scientific article published in December 2003

Malassezia and Parkinson's Disease

scientific article published on 24 July 2019

Metabotropic glutamate receptor II in the brains of Parkinsonian patients

scientific article published in April 2009

Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies

scientific article

New highly sensitive rodent and human tests for soluble amyloid precursor protein alpha quantification: preclinical and clinical applications in Alzheimer's disease

scientific article

Nonpatentable drugs and the cost of our ignorance

scientific article published on February 2006

Novel liposomal formulation for targeted gene delivery

scientific article published on 24 March 2007

Novel pharmacological targets for the treatment of Parkinson's disease

scientific article published on October 2006

Old age potentiates cold-induced tau phosphorylation: linking thermoregulatory deficit with Alzheimer's disease

scientific article published on 12 October 2016

Omega-3 polyunsaturated fatty acids in Alzheimer's disease: key questions and partial answers.

scientific article published on August 2011

PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Aβ

scientific article

Partial neurorescue effects of DHA following a 6-OHDA lesion of the mouse dopaminergic system.

scientific article

Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer's disease

scholarly article by Isabelle St-Amour et al published 5 January 2019 in Journal of Neuroinflammation

Polyphenol-rich extract from grape and blueberry attenuates cognitive decline and improves neuronal function in aged mice.

scientific article

Postmortem brain fatty acid profile of levodopa-treated Parkinson disease patients and parkinsonian monkeys

scientific article published on 26 January 2006

Potentiation of the bioavailability of blueberry phenolic compounds by co-ingested grape phenolic compounds in mice, revealed by targeted metabolomic profiling in plasma and feces.

scientific article

Prevention of dyskinesia by an NMDA receptor antagonist in MPTP monkeys: effect on adenosine A2A receptors

scientific article

Prevention of levodopa-induced dyskinesias by a selective NR1A/2B N-methyl-D-aspartate receptor antagonist in parkinsonian monkeys: implication of preproenkephalin

scientific article

Rapid beta-oxidation of eicosapentaenoic acid in mouse brain: an in situ study

scientific article published on 23 February 2009

Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2

scientific article

Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease

scientific article published in March 2009

Relevance of the MPTP primate model in the study of dyskinesia priming mechanisms

scientific article

Repeated cold exposures protect a mouse model of Alzheimer's disease against cold-induced tau phosphorylation

scholarly article by Marine Tournissac et al published April 2019 in Molecular Metabolism

Response to Comment on Vandal et al. Insulin Reverses the High-Fat Diet-Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease. Diabetes 2014;63:4291-4301.

scientific article

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

scientific article published on 15 January 2006

Sex-dependent alterations in social behaviour and cortical synaptic activity coincide at different ages in a model of Alzheimer's disease

scientific article

Sex-dependent alterations in the physiology of entorhinal cortex neurons in old heterozygous 3xTg-AD mice

scientific article published on 16 November 2020

Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease

scientific article

Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions

scientific article

Tau hyperphosphorylation in the brain of ob/ob mice is due to hypothermia: Importance of thermoregulation in linking diabetes and Alzheimer's disease.

scientific article published on 25 October 2016

The benefit of docosahexaenoic acid for the adult brain in aging and dementia

scientific article

The effect of striatal pre-enkephalin overexpression in the basal ganglia of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

scientific article published on 21 April 2014

The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration

scientific article

Transferrin Receptor-Mediated Uptake at the Blood-Brain Barrier Is Not Impaired by Alzheimer's Disease Neuropathology

scientific article published on 17 January 2019

Transgenic autoinhibition of p21-activated kinase exacerbates synaptic impairments and fronto-dependent behavioral deficits in an animal model of Alzheimer's disease

scientific article

Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease ⬇️

scientific article published on November 29, 2010

Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease

scientific article published on 19 August 2010

eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response.

scientific article published on 17 October 2016

miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo.

scientific article

microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice

scientific article published on 3 August 2016

n-3 LCPUFA improves cognition: the young, the old and the sick

scientific article

p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis

scientific journal article

List of works by Frédéric Calon

A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer's Disease.

A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model.

ABCG2- and ABCG4-mediated efflux of amyloid-β peptide 1-40 at the mouse blood-brain barrier

Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer's Disease.

Accumulation of amyloid-β in the cerebellar cortex of essential tremor patients

Accumulation of dietary docosahexaenoic acid in the brain attenuates acute immune response and development of postischemic neuronal damage.

Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease

Age-Dependent Regulation of the Blood-Brain Barrier Influx/Efflux Equilibrium of Amyloid-β Peptide in a Mouse Model of Alzheimer's Disease (3xTg-AD).

Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage

Alteration of glutamate receptors in the striatum of dyskinetic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys following dopamine agonist treatment

Altered cerebral insulin response in transgenic mice expressing the epsilon-4 allele of the human apolipoprotein E gene

Altered cerebral vascular volumes and solute transport at the blood-brain barriers of two transgenic mouse models of Alzheimer's disease

Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function

Apolipoprotein E isoforms disrupt long-chain fatty acid distribution in the plasma, the liver and the adipose tissue of mice.

Association of Neuropathological Markers in the Parietal Cortex With Antemortem Cognitive Function in Persons With Mild Cognitive Impairment and Alzheimer Disease

Beta-amyloid pathology in human brain microvessel extracts from the parietal cortex: relation with cerebral amyloid angiopathy and Alzheimer's disease

Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease.

Brain bioavailability of human intravenous immunoglobulin and its transport through the murine blood-brain barrier.

Brain mural cell loss in the parietal cortex in Alzheimer's disease correlates with cognitive decline and TDP-43 pathology

Brain uptake of a fluorescent vector targeting the transferrin receptor: a novel application of in situ brain perfusion.

Can iPCSK9-induced hypocholesterolemia starve cancer cells?

Can insulin signaling pathways be targeted to transport Aβ out of the brain?

Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology

Changes of GABA receptors and dopamine turnover in the postmortem brains of parkinsonians with levodopa-induced motor complications

Characterization of a 3xTg-AD mouse model of Alzheimer's disease with the senescence accelerated mouse prone 8 (SAMP8) background

Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons

Cognitive-Enhancing Effects of a Polyphenols-Rich Extract from Fruits without Changes in Neuropathology in an Animal Model of Alzheimer's Disease

Cystamine metabolism and brain transport properties: clinical implications for neurodegenerative diseases.

DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice

Decreased drebrin mRNA expression in Alzheimer disease: correlation with tau pathology.

Defective dentate nucleus GABA receptors in essential tremor

Deficient striatal adaptation in aminergic and glutamatergic neurotransmission is associated with tardive dyskinesia in non-human primates exposed to antipsychotic drugs.

Dietary intake of unsaturated fatty acids modulates physiological properties of entorhinal cortex neurons in mice

Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study.

Direct evidence of abca1-mediated efflux of cholesterol at the mouse blood–brain barrier

Docosahexaenoic acid prevents cognitive deficits in human apolipoprotein E epsilon 4-targeted replacement mice

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

Dopamine-receptor stimulation: biobehavioral and biochemical consequences

Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease

High dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-beta and tau pathologies in the 3xTg-AD model of Alzheimer's disease.

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology.

Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in mice

Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice.

IVIg protects the 3xTg-AD mouse model of Alzheimer’s disease from memory deficit and Aβ pathology

Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17β-hydroxysteroid dehydrogenase type 10

Immunotherapies in Alzheimer's disease: Too much, too little, too late or off-target?

Impact of DHA intake in a mouse model of synucleinopathy

Impact of intravenous immunoglobulin on the dopaminergic system and immune response in the acute MPTP mouse model of Parkinson's disease

Impact of ω-3 fatty acids in Parkinson's disease

Impaired thermoregulation and beneficial effects of thermoneutrality in the 3×Tg-AD model of Alzheimer's disease.

In vivo labeling of brain capillary endothelial cells after intravenous injection of monoclonal antibodies targeting the transferrin receptor

Increase of preproenkephalin mRNA levels in the putamen of Parkinson disease patients with levodopa-induced dyskinesias

Increased LINGO1 in the cerebellum of essential tremor patients

Increased adenosine A2A receptors in the brain of Parkinson's disease patients with dyskinesias

Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease

Internalization of targeted quantum dots by brain capillary endothelial cells in vivo

Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism.

L-Dopa treatment abolishes the numerical increase in striatal dopaminergic neurons in parkinsonian monkeys

Levodopa or D2 agonist induced dyskinesia in MPTP monkeys: correlation with changes in dopamine and GABAA, receptors in the striatopallidal complex ⬇️

Levodopa response motor complications--GABA receptors and preproenkephalin expression in human brain

Levodopa-induced motor complications are associated with alterations of glutamate receptors in Parkinson's disease

Malassezia and Parkinson's Disease

Metabotropic glutamate receptor II in the brains of Parkinsonian patients

Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies

New highly sensitive rodent and human tests for soluble amyloid precursor protein alpha quantification: preclinical and clinical applications in Alzheimer's disease

Nonpatentable drugs and the cost of our ignorance

Novel liposomal formulation for targeted gene delivery

Novel pharmacological targets for the treatment of Parkinson's disease

Old age potentiates cold-induced tau phosphorylation: linking thermoregulatory deficit with Alzheimer's disease

Omega-3 polyunsaturated fatty acids in Alzheimer's disease: key questions and partial answers.

PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Aβ

Partial neurorescue effects of DHA following a 6-OHDA lesion of the mouse dopaminergic system.

Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer's disease

Polyphenol-rich extract from grape and blueberry attenuates cognitive decline and improves neuronal function in aged mice.

Postmortem brain fatty acid profile of levodopa-treated Parkinson disease patients and parkinsonian monkeys

Potentiation of the bioavailability of blueberry phenolic compounds by co-ingested grape phenolic compounds in mice, revealed by targeted metabolomic profiling in plasma and feces.

Prevention of dyskinesia by an NMDA receptor antagonist in MPTP monkeys: effect on adenosine A2A receptors