List of works - Sadaf Farooqi

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

scientific article

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

scientific article

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

scientific article

Common variants near MC4R are associated with fat mass, weight and risk of obesity

scientific article

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

scientific article (publication date: 20 March 2003)

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

scientific article

A frameshift mutation in MC4R associated with dominantly inherited human obesity

scientific article published on October 1, 1998

Large, rare chromosomal deletions associated with severe early-onset obesity

scientific article

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.

scientific article

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

scientific article published in July 2000

The hormonal control of food intake

scientific article

Leptin regulates striatal regions and human eating behavior

scientific article published on 09 August 2007

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

scientific article

Modulation of blood pressure by central melanocortinergic pathways

scientific article

Obesity associated genetic variation in FTO is associated with diminished satiety

scientific article

A genome-wide association meta-analysis identifies new childhood obesity loci

scientific article

Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor

scientific article published on January 2007

The central melanocortin system directly controls peripheral lipid metabolism

scientific article

Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene

scientific article published on December 2006

Genetics of Obesity in Humans

scientific article

Monogenic obesity in humans

scientific article

Obesity and the brain: how convincing is the addiction model?

scientific article published on 14 March 2012

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.

scientific article

Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity

scientific journal article

Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations

scientific article published on 25 June 2009

Leptin mediates the increase in blood pressure associated with obesity

scientific article

Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome

scientific article published in January 2003

Leptin: a pivotal regulator of human energy homeostasis

scientific article

Partial leptin deficiency and human adiposity.

scientific article

Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

scientific article

A mutation in the thyroid hormone receptor alpha gene

scientific article published on 14 December 2011

A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism

scientific article

Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease?

scientific article published in October 2002

Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy

scientific article

Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism.

scientific article published on 14 December 2004

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms

article

Antidiabetic effects of IGFBP2, a leptin-regulated gene

scientific article published on January 2010

Early childhood infection and atopic disorder

scientific article published on November 1998

Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.

scientific article published on 16 June 2008

Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity

scientific article published on 09 September 2008

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

scientific article

Proopiomelanocortin and energy balance: insights from human and murine genetics

scientific article published on June 2004

The hunger genes: pathways to obesity

scientific article

Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline.

scientific article

Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects

scientific article

Minireview: human obesity-lessons from monogenic disorders

scientific article

Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.

scientific article

A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance

scientific article published in February 2006

The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals

scientific article published on 13 March 2007

Heterozygosity for aPOMC-Null Mutation and Increased Obesity Risk in Humans

scientific article published on 01 September 2006

List of works by Sadaf Farooqi

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

Common variants near MC4R are associated with fat mass, weight and risk of obesity

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

A frameshift mutation in MC4R associated with dominantly inherited human obesity

Large, rare chromosomal deletions associated with severe early-onset obesity

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

The hormonal control of food intake

Leptin regulates striatal regions and human eating behavior

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

Modulation of blood pressure by central melanocortinergic pathways

Obesity associated genetic variation in FTO is associated with diminished satiety

A genome-wide association meta-analysis identifies new childhood obesity loci

Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor

The central melanocortin system directly controls peripheral lipid metabolism

Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene

Genetics of Obesity in Humans

Monogenic obesity in humans

Obesity and the brain: how convincing is the addiction model?

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.

Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity

Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations

Leptin mediates the increase in blood pressure associated with obesity

Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome

Leptin: a pivotal regulator of human energy homeostasis

Partial leptin deficiency and human adiposity.

Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

A mutation in the thyroid hormone receptor alpha gene

A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism

Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease?

Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy

Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism.

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms

Antidiabetic effects of IGFBP2, a leptin-regulated gene

Early childhood infection and atopic disorder

Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.

Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

Proopiomelanocortin and energy balance: insights from human and murine genetics

The hunger genes: pathways to obesity

Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline.

Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects

Minireview: human obesity-lessons from monogenic disorders

Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.

A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance

The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals

Heterozygosity for aPOMC-Null Mutation and Increased Obesity Risk in Humans