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List of works by Kristel Sleegers

A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42.

scientific article published on 15 June 2015

A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study

scientific article

A comprehensive study of the genetic impact of rare variants in SORL1 in European early-onset Alzheimer's disease

scientific article published on 30 March 2016

A deletion in DJ-1 and the risk of dementia--a population-based survey

scientific article published in December 2004

A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population

scientific article

A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort

scientific article published on 18 December 2019

A novel locus for dementia with Lewy bodies: a clinically and genetically heterogeneous disorder

scientific article

A pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability, and intermediate repeats

scientific article published on 4 January 2013

A study of the SORL1 gene in Alzheimer's disease and cognitive function

scientific article published in January 2009

APOE and Lipid Level Synergy Effects on Declarative Memory Functioning in Adulthood

APOE ε4 is associated with longer telomeres, and longer telomeres among ε4 carriers predicts worse episodic memory

scientific article

APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease.

scientific article

APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy

scientific article

Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family

scientific article published in October 2007

Amyloid pathology influences aβ1-42 cerebrospinal fluid levels in dementia with lewy bodies

scientific article published in January 2013

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation

scientific article

An intronic VNTR affects splicing of ABCA7 and increases risk of Alzheimer's disease

scientific article published on 27 March 2018

Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population

scientific article published in October 2006

Association study of cholesterol-related genes in Alzheimer's disease

scientific article published on 27 March 2007

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

scientific article published on 16 January 2012

Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease

scientific article published in January 2013

C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease

scientific article published on 16 June 2015

C9orf72 G4C2 repeat expansions in Alzheimer's disease and mild cognitive impairment.

scientific article published on 24 January 2013

CMT-associated mutations in glycyl- and tyrosyl-tRNA synthetases exhibit similar pattern of toxicity and share common genetic modifiers in Drosophila

scientific article

Cerebrospinal fluid Aβ1-40 improves differential dementia diagnosis in patients with intermediate P-tau181P levels

scientific article

Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

scientific article published on 08 March 2019

Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer's disease

scientific article published on 03 November 2020

Cholesterol and triglycerides moderate the effect of apolipoprotein E on memory functioning in older adults

scientific article published on March 2007

Clinical Evidence of Disease Anticipation in Families Segregating a C9orf72 Repeat Expansion

scientific article published on 13 February 2017

Clinical variability and onset age modifiers in an extended Belgian GRN founder family.

scientific article

Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort

scientific article published on 25 October 2017

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

scientific article (publication date: May 2011)

Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia

scientific article published in February 2009

Complement receptor 1 coding variant p.Ser1610Thr in Alzheimer's disease and related endophenotypes

scientific article published on 10 April 2013

Contribution of TARDBP to Alzheimer's disease genetic etiology

scientific article

Current status on Alzheimer disease molecular genetics: from past, to present, to future

scientific article

DNMBP is genetically associated with Alzheimer dementia in the Belgian population.

scientific article

Deleterious ABCA7 mutations and transcript rescue mechanisms in early onset Alzheimer's disease

scientific article published on 27 April 2017

Diagnostic Accuracy of Cerebrospinal Fluid Amyloid-β Isoforms for Early and Differential Dementia Diagnosis

scientific article published in January 2015

Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology

scientific article published on 20 August 2020

Diffusion Kurtosis Imaging: A Possible MRI Biomarker for AD Diagnosis?

scientific article published on 22 September 2015

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

scientific article published on 05 September 2019

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

scholarly article published in Nature Genetics

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

article

Expression of ABCA7 in Alzheimer's disease

scientific article published on 28 February 2020

Follow-up study of susceptibility loci for Alzheimer's disease and onset age identified by genome-wide association

scientific article published in January 2010

Functional Changes in the Language Network in Response to Increased Amyloid β Deposition in Cognitively Intact Older Adults

scientific article published on December 2014

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

scientific article

Genetic insights in Alzheimer's disease

scientific article published on January 2013

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease

scientific article published on 24 August 2006

Genetic variability in SQSTM1 and risk of early-onset Alzheimer dementia: a European early-onset dementia consortium study

scientific article published on 19 February 2015

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

scientific article published on 16 December 2007

Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond

scientific article published on July 2016

Genome-wide association interaction analysis for Alzheimer's disease

scientific article

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

scientific article (publication date: October 2009)

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

scientific article

Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset

scientific article published on 22 November 2020

Global investigation and meta-analysis of the C9orf72 (G4C2)n repeat in Parkinson disease

scientific article

Guanosine triphosphate cyclohydrolase 1 promoter deletion causes dopa-responsive dystonia

scientific article published on 13 September 2012

ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study

scientific journal article

Identification and description of three families with familial Alzheimer disease that segregate variants in the SORL1 gene

scientific article

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia

scientific article published on 9 October 2013

Invited article: the Alzheimer disease-frontotemporal lobar degeneration spectrum

scientific article published on October 2008

Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease

scientific article (publication date: 15 August 2005)

Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample

scientific article

Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects

scientific article

Longitudinal stability of cerebrospinal fluid biomarker levels: fulfilled requirement for pharmacodynamic markers in Alzheimer's disease

scientific article published in January 2013

Lymphoblast-derived integration-free iPS cell line from a 65-year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant

scientific article published on 28 December 2015

Lymphoblast-derived integration-free iPS cell line from a 69-year-old male

scientific article published on December 2015

Lymphoblast-derived integration-free iPS cell line from a female 67-year-old Alzheimer's disease patient with TREM2 (R47H) missense mutation

scientific article published on 20 October 2016

Lymphoblast-derived integration-free iPSC lines from a female and male Alzheimer's disease patient expressing different copy numbers of a coding CNV in the Alzheimer risk gene CR1.

scientific article published on 19 October 2016

Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease

article

Meta-analysis of the association between variants in SORL1 and Alzheimer disease

scientific article

Microglial upregulation of progranulin as a marker of motor neuron degeneration

scientific article published in December 2010

Molecular genetics of Alzheimer's disease: an update

scientific article published on January 2008

Molecular genetics of early-onset Alzheimer's disease revisited

scientific article

Molecular pathogenesis of frontotemporal lobar degeneration: basic science seminar in neurology

scientific article published on June 2008

Molecular pathways of frontotemporal lobar degeneration

scientific article published on January 2010

Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study

scientific article

Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia

scientific article published in April 2007

NanoSatellite: accurate characterization of expanded tandem repeat length and sequence through whole genome long-read sequencing on PromethION

scientific article published on 14 November 2019

Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS

No allelic association or interaction of three known functional polymorphisms with bipolar disorder in a northern Swedish isolated population

scientific article published in October 2006

No association between CALHM1 and risk for Alzheimer dementia in a Belgian population

scientific article

No association of CSF biomarkers with APOEepsilon4, plaque and tangle burden in definite Alzheimer's disease

scientific article published on 22 June 2007

No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration

scientific article published on 14 May 2009

Novel Alzheimer's disease risk genes: exhaustive investigation is paramount

scientific article published on 12 July 2019

Parietal cortex activation predicts memory decline in apolipoprotein E-epsilon4 carriers

scientific article published in November 2006

Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation

scientific article published on April 2016

Polymorphism of brain derived neurotrophic factor influences β amyloid load in cognitively intact apolipoprotein E ε4 carriers

scientific article published on 11 April 2013

Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis

scientific article

Potent amyloidogenicity and pathogenicity of Aβ43.

scientific article published on 3 July 2011

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

scientific article published on 08 May 2019

Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease

scientific article

Rare Variants in PLD3 Do Not Affect Risk for Early-Onset Alzheimer Disease in a European Consortium Cohort

scientific article published on 28 September 2015

Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration

scientific article

Reduced hippocampal volume in non-demented carriers of the apolipoprotein E epsilon4: relation to chronological age and recognition memory

scientific article published on 6 January 2006

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations

scientific article published on 16 July 2015

Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin

scientific article published on 29 December 2015

Role of progranulin as a biomarker for Alzheimer's disease

scientific article published on February 2010

SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population

scientific article

Serum biomarker for progranulin-associated frontotemporal lobar degeneration

scientific article published in May 2009

Structural variants identified by Oxford Nanopore PromethION sequencing of the human genome

Structural variants identified by Oxford Nanopore PromethION sequencing of the human genome

scientific article published on 11 June 2019

TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

scientific article published on 23 December 2016

TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort

scientific article

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

scientific article

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study

scientific article

The Cerebrospinal Fluid Aβ1-42/Aβ1-40 Ratio Improves Concordance with Amyloid-PET for Diagnosing Alzheimer's Disease in a Clinical Setting

scientific article published on September 2017

The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics.

scientific article published on 6 July 2018

The UBQLN1 polymorphism, UBQ-8i, at 9q22 is not associated with Alzheimer's disease with onset before 70 years

scientific article published on 6 October 2005

The apolipoprotein E gene and its age-specific effects on cognitive function

scientific article

The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample

scientific article

The genetic landscape of Alzheimer disease: clinical implications and perspectives

scientific article

The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects

scientific article published on 18 January 2010

The role of ABCA7 in Alzheimer's disease: evidence from genomics, transcriptomics and methylomics

scientific article published on 22 March 2019

Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort

scientific article published on 01 January 2020

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers

scientific article

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