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List of works by Gordon B. Mills

"Personalized Cancer Therapy": A Publicly Available Precision Oncology Resource.

scientific article

10th Biennial Helene Harris Memorial Trust Meeting

scientific article published on 01 March 2006

3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma

scientific article published on 14 July 2009

A Bayesian hierarchical model for inference across related reverse phase protein arrays experiments

scientific article published on January 2014

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

scientific article published in April 2018

A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma

scientific article published in November 2017

A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas

scientific article published on 30 September 2021

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.

scientific article published on 8 May 2017

A Population of Heterogeneous Breast Cancer Patient-Derived Xenografts Demonstrate Broad Activity of PARP Inhibitor in BRCA1/2 Wild-Type Tumors

scientific article published in November 2017

A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells

scientific article published in August 2005

A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers

scientific article

A Time‐Series DDP for Functional Proteomics Profiles ⬇️

scientific article published on January 5, 2012

A comprehensive comparison of normalization methods for loading control and variance stabilization of reverse-phase protein array data

scientific article

A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance mechanisms in head and neck squamous cell carcinoma

scientific article

A curated census of autophagy-modulating proteins and small molecules: candidate targets for cancer therapy.

scientific article

A decision support framework for genomically informed investigational cancer therapy

scientific article

A feasibility study of neoadjuvant talazoparib for operable breast cancer patients with a germline BRCA mutation demonstrates marked activity

scientific article published on 6 December 2017

A feasibility study of returning clinically actionable somatic genomic alterations identified in a research laboratory.

scientific article published on 8 March 2017

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

scientific article

A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer

scientific article

A functional genomic approach to actionable gene fusions for precision oncology

scientific article published on 09 February 2022

A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation

scientific article

A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance

scientific article published on 23 February 2011

A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition

scientific article published on 09 December 2013

A genetically defined model for human ovarian cancer

scientific article published on March 2004

A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer

scientific article published on 9 September 2011

A module of negative feedback regulators defines growth factor signaling

scientific article published on 25 February 2007

A multi-encoder variational autoencoder controls multiple transformational features in single-cell image analysis

scientific article published on 23 March 2022

A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses

scientific article published in 2022

A murine preclinical syngeneic transplantation model for breast cancer precision medicine.

scientific article

A network-based, integrative study to identify core biological pathways that drive breast cancer clinical subtypes

scientific article published on 16 February 2012

A new mutational AKTivation in the PI3K pathway

scientific article published on August 2007

A novel AKT3 mutation in melanoma tumours and cell lines

scientific article published on 23 September 2008

A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy

scientific article published on December 2008

A pan-cancer proteomic perspective on The Cancer Genome Atlas.

scientific article

A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers

scientific article published on 12 January 2017

A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase

scientific article published on 10 August 2007

A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway.

scientific article

A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models

scientific article published on 04 June 2013

A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners

scholarly article

A sequence-based survey of the complex structural organization of tumor genomes

scientific article

A systems approach to analysis of molecular complexity in breast cancer

scientific article published on January 2009

A unified approach to targeting the lysosome's degradative and growth signaling roles.

scientific article published on 12 September 2017

A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity

scientific article published on January 2008

A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer

scientific article published on 26 April 2018

A-to-I-edited miRNA-379-5p inhibits cancer cell proliferation through CD97-induced apoptosis

scientific article published on 01 December 2019

AKT isoform-specific expression and activation across cancer lineages

scientific article published on 16 July 2018

AKT pathway genes define 5 prognostic subgroups in glioblastoma

scientific article

AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis

scientific article

AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53stability and cell apoptosis.

scientific article published on 3 September 2014

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

scientific article

ALK: a tyrosine kinase target for cancer therapy

scientific article published on January 2017

AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27.

scientific article

AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability

scientific article

AMPK: A Contextual Oncogene or Tumor Suppressor? ⬇️

scientific article published on 03 May 2013

ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers

scientific article

ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

scientific article published on 11 June 2015

ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade

scientific article published on 07 May 2018

ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma

scientific article

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

scientific article

ATX-LPA receptor axis in inflammation and cancer

scientific article

AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies

scientific article published on 29 August 2016

Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer

scientific article

Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes

scientific article published on September 2015

Abortive autophagy induces endoplasmic reticulum stress and cell death in cancer cells.

scientific article

Abstract 3299: Maternal embryonic leucine zipper kinase is critical for the growth and migration of triple negative breast cancer cells

Abstract 4265: Derivation and characterization of endometrial cancer cells resistant to phosphatidylinositol-3-kinase (PI3K) pathway inhibitors

Abstract 82: Novel role of DAPK-1 in growth regulation of ER-negative breast cancer

Abstract LB010: SMMART Program: A multi-omics tumor board with a focus on breast cancer

scientific article published in 2021

Abstract OT3-05-01: Adaptive Multi-Drug Treatment of Evolving Cancers (AMTEC): A Phase II, Open-Label, Study of Olaparib in Combination with either Durvalumab, Selumetinib or Capivasertib, or Ceralasertib Monotherapy in Patients with Metastatic TNBC

scientific article published in 2023

Acquired Uniparental Disomy Regions Are Associated with Disease Outcome in Patients with Oral Cavity and Oropharynx But Not Larynx Cancers

scientific article published on 15 April 2020

Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt.

scientific article

Activated SRC protein tyrosine kinase is overexpressed in late-stage human ovarian cancers

scientific article

Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer

scientific article

Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells

scientific article published in January 2007

Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis.

scientific article

Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis

scientific article

Activation of the ras-mitogen-activated protein kinase pathway and phosphorylation of ets-2 at position threonine 72 in human ovarian cancer cell lines ⬇️

scientific article published on May 15, 1998

Active Disclosure of Secondary Germline Findings to Deceased Research Participants' Personal Representatives: Process and Outcomes

scientific article published on 31 October 2017

Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates

scientific article

Adaptive responses in a PARP inhibitor window of opportunity trial illustrate limited functional interlesional heterogeneity and potential combination therapy options

scientific article published on 28 May 2019

Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.

scientific article published in December 1998

Adenovirus-mediated p53 growth inhibition of ovarian cancer cells is independent of endogenous p53 status

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

scientific article

Advancing Drug Development in Gynecologic Malignancies

scientific article published on 24 May 2019

Agents That Stabilize Mutated von Hippel–Lindau (VHL) Protein: Results of a High-Throughput Screen to Identify Compounds That Modulate VHL Proteostasis ⬇️

scientific article published on February 21, 2012

Akt and ERK Control the Proliferative Response of Mammary Epithelial Cells to the Growth Factors IGF-1 and EGF Through the Cell Cycle Inhibitor p57 Kip2 ⬇️

scientific article published on March 6, 2012

Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy

scientific article published on October 2007

Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression

scientific article

Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells

scientific article published on 10 March 2009

Alkoxymethylenephosphonate analogues of (Lyso) phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor

scientific article published on December 2007

Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer

scientific article published on April 2007

Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer.

scientific article

An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2.

scientific article published on 15 April 2015

An efficient procedure for protein extraction from formalin-fixed, paraffin-embedded tissues for reverse phase protein arrays

scientific article published on 24 September 2012

An emerging toolkit for targeted cancer therapies

scientific article published on February 2012

An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance

scientific article published on 22 October 2012

An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation.

scientific article published on 2 December 2013

An inherent role of integrin-linked kinase-estrogen receptor alpha interaction in cell migration.

scientific article published on November 2006

An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

scientific article published on August 2008

An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer

scientific article published on 15 February 2022

Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade-specific epigenome and transcriptome landscapes

scientific article published on 03 August 2020

Analysis of molecular aberrations in ovarian cancer allows novel target identification

scientific article published on May 2004

Analysis of mutational and proteomic heterogeneity of gastric cancer suggests an effective pipeline to monitor post-treatment tumor burden using circulating tumor DNA

scientific article published on 07 October 2020

Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion

scientific article published on 08 July 2016

Analysis of the EDG2 receptor based on the structure/activity relationship of LPA.

scientific article published on April 2000

Androgen Regulation of 5α-Reductase Isoenzymes in Prostate Cancer: Implications for Prostate Cancer Prevention ⬇️

scientific article published on December 14, 2011

Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer

scientific article published on 10 March 2009

Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer.

scientific article published on April 2007

Are oncogenes sufficient to cause human cancer? ⬇️

scientific article published on November 17, 2010

Assay of Rab25 function in ovarian and breast cancers

scientific article published on January 2005

Assessing BRCA carrier probabilities in extended families

scientific article

Assessing the clinical utility of cancer genomic and proteomic data across tumor types.

scientific article

Association between germline single nucleotide polymorphisms in the PI3K-AKT-mTOR pathway, obesity, and breast cancer disease-free survival

scientific article

Association of Somatic Mutations of ADAMTS Genes With Chemotherapy Sensitivity and Survival in High-Grade Serous Ovarian Carcinoma

scientific article

Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy

scientific article

Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.

scientific article

Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2.

scientific article

Author Correction: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer

scientific article published in Nature Communications

Author Correction: Loss of Phd2 cooperates with BRAF to drive melanomagenesis

scientific article published on 11 March 2019

Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas

scientific article published on 01 January 2019

Author Correction: Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin

scientific article published on 19 September 2018

Author response

Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis.

scientific article

Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model.

scientific article published on October 2008

Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity

scientific article published on 20 March 2006

Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice

scientific article published on 3 April 2012

Autotaxin exacerbates tumor progression by enhancing MEK1 and overriding the function of miR-489-3p

scientific article published on 31 May 2018

Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis

scientific article published on 9 April 2012

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

scientific article

Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate ⬇️

scientific article published on September 1, 2003

Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression

scientific article

Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis

scientific article published on 12 January 2009

Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis.

scientific article

BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators

scientific article published on 03 September 2021

BRAF Mutation Testing in Cell-Free DNA from the Plasma of Patients with Advanced Cancers Using a Rapid, Automated Molecular Diagnostics System

scientific article published on 20 May 2016

BRCA1 promoter methylation and clinical outcomes in ovarian cancer: an individual patient data meta-analysis

scientific article published on 15 May 2020

BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation

scientific article

BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency

scientific article published on 01 March 2018

BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors

scientific article published on 23 July 2018

BRD4 facilitates replication stress-induced DNA damage response.

scientific article published on 11 April 2018

BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

scientific article

BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation

scientific article

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

scientific article published on January 2009

Bayesian inference of signaling network topology in a cancer cell line

scientific article

Bayesian models based on test statistics for multiple hypothesis testing problems

scientific article published in February 2008

Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity

scientific article

Beta-arrestin/Ral signaling regulates lysophosphatidic acid-mediated migration and invasion of human breast tumor cells.

scientific article published in July 2009

Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma

scientific article

Bias from removing read duplication in ultra-deep sequencing experiments

scientific article

Bioinformatics and systems biology

scientific article

Biomarkers of Response to Akt Inhibitor MK-2206 in Breast Cancer ⬇️

scientific article published on August 29, 2012

Breast cancer quantitative proteome and proteogenomic landscape

Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR ⬇️

scientific article published on January 9, 2012

Building a Personalized Medicine Infrastructure at a Major Cancer Center ⬇️

scientific article published on April 15, 2013

CA 125: the past and the future

scientific article

COTI-2, A Novel Thiosemicarbazone Derivative, Exhibits Antitumor Activity in HNSCC through p53-dependent and -independent Mechanisms

scientific article published on 15 July 2019

CSIG-08NITROSOUREAS IMPROVE SURVIVAL IN THE SECONDARY-LIKE AKT SUBTYPE OF GLIOBLASTOMA.

scientific article

CTNNB1 (beta-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence.

scientific article published on 10 March 2017

CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis

scientific article

CanDrA: cancer-specific driver missense mutation annotation with optimized features

scientific article

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

scientific article published on 24 May 2018

Cancer Systems Biology: a peek into the future of patient care?

scientific article published on 04 February 2014

Cancer driver mutation prediction through Bayesian integration of multi-omic data.

scientific article

Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.

scientific article published on May 2008

Candidate biomarker assessment for pharmacological response

scientific article published on 08 July 2020

Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis

scientific article

Cardiac glycosides display selective efficacy for STK11 mutant lung cancer.

scientific article published on 19 July 2016

Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors ⬇️

scientific article

Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity.

scientific article published on 10 March 2009

Characteristics of percutaneous core biopsies adequate for next generation genomic sequencing.

scientific article published on 27 December 2017

Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays

scientific article

Characterization of Hypoxia-associated Molecular Features to Aid Hypoxia-Targeted Therapy

scientific article published on 18 March 2019

Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics

scientific article (publication date: 15 May 2009)

Characterization of the role Rab25 in energy metabolism and cancer using extracellular flux analysis and material balance

scientific article

Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours

scientific article published on 17 June 2015

Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer

scientific article published on March 2017

Clinical Use of Precision Oncology Decision Support

scientific article published on 13 September 2017

Clinical actionability enhanced through deep targeted sequencing of solid tumors

scientific article published on 27 January 2015

Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype.

scientific article published on 3 May 2018

Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing

scientific article published on 3 February 2012

Clinical investigation of receptor and non-receptor tyrosine kinase inhibitors for the treatment of epithelial ovarian cancer

scientific article

Clinical next generation sequencing to identify actionable aberrations in a phase I program

scientific article

Clinical outcomes based on multigene profiling in metastatic breast cancer patients

scientific article published on 28 October 2016

Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers

scientific article published on 29 November 2019

Clinical significance of CTNNB1 mutation and Wnt pathway activation in endometrioid endometrial carcinoma

scientific article

Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma

scientific article

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities

scientific article

Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma

scientific article published on 12 April 2018

Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness

scientific article published on 24 January 2019

Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors

scientific article

Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models

scientific article published on 24 July 2020

Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas

scientific article published on 4 May 2017

Comparison of Real-Time Fluorescence Confocal Digital Microscopy With Hematoxylin-Eosin-Stained Sections of Core-Needle Biopsy Specimens

scientific article published on 02 March 2020

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

article

Comprehensive Characterization of Alternative Polyadenylation in Human Cancer

scientific article published on 2 November 2017

Comprehensive Characterization of Cancer Driver Genes and Mutations

scientific article published in April 2018

Comprehensive Characterization of Cancer Driver Genes and Mutations

article

Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients

scientific article published on May 2016

Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.

scientific article published on October 2015

Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer

scientific article

Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer

scientific article published on 01 August 2018

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma

scientific article published on 4 November 2015

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

scientific article published on 01 October 2018

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

scientific article

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

article

Comprehensive assessment of computational algorithms in predicting cancer driver mutations

scientific article published on 20 February 2020

Comprehensive characterization of circular RNAs in ~ 1000 human cancer cell lines

scientific article published on 26 August 2019

Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer

scientific article

Concordance of genomic alterations between primary and recurrent breast cancer.

scientific article

Confocal Fluorescence Microscopy Platform Suitable for Rapid Evaluation of Small Fragments of Tissue in Surgical Pathology Practice

scientific article published on 30 October 2018

Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2.

scientific article published on June 2000

Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling.

scientific article published on 19 December 2016

Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway

scientific article

Cooperative Effect of Oncogenic MET and PIK3CA in an HGF-Dominant Environment in Breast Cancer

scientific article published on 05 December 2018

Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules ⬇️

scientific article published on 05 August 2013

Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.

scientific article

Correction: A feasibility study of returning clinically actionable somatic genomic alterations identified in a research laboratory

scientific article published on 27 August 2019

Correction: Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes

scientific article published on 8 March 2016

Correction: Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer

scientific article published on 11 October 2017

Correction: Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer

scientific article published on 01 May 2019

Correction: RCP induces Slug expression and cancer cell invasion by stabilizing β1 integrin

scientific article published on 01 May 2019

Correction: Systematic Identification of Combinatorial Drivers and Targets in Cancer Cell Lines

Correction: Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis

scientific article published on 01 January 2020

Corrigendum: A pan-cancer proteomic perspective on The Cancer Genome Atlas

scientific article published on 28 January 2015

Credentialing Individual Samples for Proteogenomic Analysis

scientific article published on 01 May 2018

Critical Role of Lysophospholipids in the Pathophysiology, Diagnosis, and Management of Ovarian Cancer ⬇️

scientific article published on January 1, 2002

Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference

article

Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis

scientific article

Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks.

scientific article

Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells.

scientific article published on 29 February 2016

Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma

scientific article

Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers

scientific article published on 01 November 2006

DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance.

scientific article published on November 2011

Data integration gets 'Sloppy'

scientific article

Death-associated protein kinase 1 promotes growth of p53-mutant cancers

scientific article

Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis

scientific article

Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer

scientific article published on 16 July 2015

Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype

scientific article published on 01 May 2018

Definition of PKC-α, CDK6, and MET as therapeutic targets in triple-negative breast cancer

scientific article

Derailed endocytosis: an emerging feature of cancer

scientific article

Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer

scientific article published in Nature Communications

Detection algorithm for the validation of human cell lines

scientific article published on 12 April 2012

Detection of breast cancer stem cell gene mutations in circulating free DNA during the evolution of metastases

scientific article published on 06 August 2019

Determinants of rapamycin sensitivity in breast cancer cells

scientific article published on February 2004

Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression.

scientific article published on 19 December 2011

Development and Validation of a Prognostic Gene-Expression Signature for Lung Adenocarcinoma ⬇️

scientific article published on September 7, 2012

Development and validation of an ultra-deep next-generation sequencing assay for testing of plasma cell-free DNA from patients with advanced cancer

scientific article

Development of a robust classifier for quality control of reverse-phase protein arrays

scientific article

Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma

scientific article published on 10 February 2020

Differences in gene and protein expression and the effects of race/ethnicity on breast cancer subtypes

scientific article published on 02 December 2013

Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression

scientific article published on 09 April 2020

Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine

scientific article published on 16 June 2006

Differential signaling by an anti-p185(HER2) antibody and heregulin

scientific article published on 01 July 2000

Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer

scientific article published on 04 May 2016

Dissecting "PI3Kness": the complexity of personalized therapy for ovarian cancer

scientific article

Distinct histone modifications denote early stress-induced drug tolerance in cancer

scientific article published on 24 December 2017

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells

scientific article

Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival.

scientific article

Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors

scientific article published on 27 April 2020

Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells

scientific article published on 29 June 2018

Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models

scientific article published on 12 October 2011

Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor

scientific article published on 5 May 2009

Dynamic clonal remodelling in breast cancer metastases is associated with subtype conversion

scientific article published on 04 September 2019

EGFR mediates LPA-induced proteolytic enzyme expression and ovarian cancer invasion: inhibition by resveratrol

scientific article

EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation.

scientific article published in April 2018

EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF.

scientific article published on 23 December 2011

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.

scientific article published on 20 October 2016

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

scientific article published on 20 January 2008

ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer

scientific article

EVI1 splice variants modulate functional responses in ovarian cancer cells

scientific article published on 05 March 2013

Early Detection of Ovarian Cancer: Promise and Reality ⬇️

scientific article published on January 1, 2002

Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck

scientific article published on January 2007

Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK ⬇️

scientific article published on March 15, 1998

Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors.

scientific article

Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer

scientific article published on 15 January 2013

Emerging role of RAB GTPases in cancer and human disease

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Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity

scientific article published on December 2003

Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts

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Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer.

scientific article

Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab

scientific article published on 01 September 2007

Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.

scientific article published on 7 April 2017

Erratum to: Modeling precision treatment of breast cancer

scientific article published on 12 May 2015

Erratum: Corrigendum: Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer

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Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo

scientific article published on 22 September 2017

Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.

scientific article published on 29 August 2016

Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer.

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Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2.

scientific article published in February 2002

Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival

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Ex Vivo Confocal Fluorescence Microscopy for Rapid Evaluation of Tissues in Surgical Pathology Practice

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Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

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Expanded analysis of secondary germline findings from matched tumor/normal sequencing identifies additional clinically significant mutations

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Exploratory analysis of the copy number alterations in glioblastoma multiforme

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Explore, Visualize, and Analyze Functional Cancer Proteomic Data Using the Cancer Proteome Atlas.

scientific article published in November 2017

Exposing the cancer genome atlas as a SPARQL endpoint

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Expression of Concern: Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer

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Expression of TTK, a novel human protein kinase, is associated with cell proliferation

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Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases

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Expression of endogenous granzyme B in a subset of human primary breast carcinomas

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Expression of p16 induces transcriptional downregulation of the RB gene

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Expression of p53 in cisplatin-resistant ovarian cancer cell lines: modulation with the novel platinum analogue (1R, 2R-diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV)

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Extracellular lactate cooperates with limited glucose and glutamine to sustain breast cancer cell survival by providing ATP, NADPH, amino acids, and glutathione

Favorable modulation of benign breast tissue and serum risk biomarkers is associated with > 10 % weight loss in postmenopausal women

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Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials

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Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways

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Frequency of mesenchymal-epithelial transition factor gene (MET) and the catalytic subunit of phosphoinositide-3-kinase (PIK3CA) copy number elevation and correlation with outcome in patients with early stage breast cancer

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Frequency of mutations and polymorphisms in borderline ovarian tumors of known cancer genes.

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Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals ⬇️

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Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer

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Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers

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Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance

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Functional annotation of rare gene aberration drivers of pancreatic cancer

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Functional consequence of the MET-T1010I polymorphism in breast cancer

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Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer

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Functional proteomic analysis of advanced serous ovarian cancer using reverse phase protein array: TGF-beta pathway signaling indicates response to primary chemotherapy

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Functional proteomic characterization of cancer cell lines

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Functional proteomic profiling of AML predicts response and survival

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Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer

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Functional proteomics characterization of residual breast cancer after neoadjuvant systemic chemotherapy.

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Functional proteomics characterization of residual triple-negative breast cancer after standard neoadjuvant chemotherapy

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Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer

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Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer.

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Functional variomics and network perturbation: connecting genotype to phenotype in cancer.

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Future for ovarian cancer screening: novel markers from emerging technologies of transcriptional profiling and proteomics

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Future of personalized medicine in oncology: a systems biology approach

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G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth

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GENE-29. DEEP PANEL SEQUENCING OF A PROSPECTIVELY COLLECTED GLIOMA COHORT

GPNMB augments Wnt-1 mediated breast tumor initiation and growth by enhancing PI3K/AKT/mTOR pathway signaling and β-catenin activity

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Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.

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Gene Expression, Molecular Class Changes, and Pathway Analysis after Neoadjuvant Systemic Therapy for Breast Cancer ⬇️

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Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation

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Gene and protein expression markers of response to combined antiangiogenic and epidermal growth factor targeted therapy in renal cell carcinoma

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Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer

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General keynote: molecular therapeutics and pharmocogenomics

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General keynote: proteomic patterns in sera serve as biomarkers of ovarian cancer

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Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling

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Genetic alterations and expression characteristics of ARID1A impact tumor immune contexture and survival in early-onset gastric cancer

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Genetic alterations in the PI3K/AKT pathway and baseline AKT activity define AKT inhibitor sensitivity in breast cancer patient-derived xenografts

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Genetic analysis of early- versus late-stage ovarian tumors.

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Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein

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Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer

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Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer

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Genome-Wide Analysis of Head and Neck Squamous Cell Carcinomas Reveals HPV, TP53, Smoking and Alcohol-Related Allele-Based Acquired Uniparental Disomy Genomic Alterations

Genome-Wide Profiling of Acquired Uniparental Disomy Reveals Prognostic Factors in Head and Neck Squamous Cell Carcinoma

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Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

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Genome-wide perturbations by miRNAs map onto functional cellular pathways, identifying regulators of chromatin modifiers

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Genome-wide transcriptome profiling of homologous recombination DNA repair

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Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma

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Genomic amplicons target vesicle recycling in breast cancer

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Genomic analysis of exceptional responder to regorafenib in treatment-refractory metastatic rectal cancer: a case report and review of the literature

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Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

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Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer

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Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines

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Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models

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Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase

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Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer ⬇️

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Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8.

scientific article published on 30 April 2013

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

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HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.

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HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

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HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors

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Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis

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Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity

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High Intratumoral Stromal Content Defines Reactive Breast Cancer as a Low-risk Breast Cancer Subtype

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High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

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High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays

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High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients

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Homeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect.

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Homeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect.

scientific article published on 15 March 2015

Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer.

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Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts

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Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types

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Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer

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Identification and validation of a prognostic proteomic signature for cervical cancer

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Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations

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Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor

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Identification of biomarkers of response to preoperative talazoparib monotherapy in treatment naïve gBRCA+ breast cancers

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Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis

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Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer

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Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling

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Identification of tissue- and cancer-selective promoters for the introduction of genes into human ovarian cancer cells.

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Identifying Abundant Immunotherapy and Other Targets in Solid Tumors: Integrating RNA-seq and Mass Spectrometry Proteomics Data Sets

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Immuno-genomic landscape of osteosarcoma

scientific article published on 21 February 2020

Impact of Cold Ischemic Time and Freeze-Thaw Cycles on RNA, DNA and Protein Quality in Colorectal Cancer Tissues Biobanking

scientific article published on 27 August 2019

Implementation of a Multiplex and Quantitative Proteomics Platform for Assessing Protein Lysates Using DNA-Barcoded Antibodies.

scientific article published on 12 March 2018

Implementation of biomarker-driven cancer therapy: existing tools and remaining gaps

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Implementing a comprehensive translational oncology platform: from molecular testing to actionability

scientific article published on 14 December 2018

Improved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm

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In silico prediction of physical protein interactions and characterization of interactome orphans

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In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002).

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In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer

scientific article published in Nature Communications

Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer

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Incidental germline variants in 1000 advanced cancers on a prospective somatic genomic profiling protocol

scientific article published on 19 January 2016

Individualized molecular medicine: linking functional proteomics to select therapeutics targeting the PI3K pathway for specific patients

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Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma

scientific article published on 21 March 2018

Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling

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Induction of papillary carcinoma in human ovarian surface epithelial cells using combined genetic elements and peritoneal microenvironment

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Inferring causal molecular networks: empirical assessment through a community-based effort

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Inferring tumour purity and stromal and immune cell admixture from expression data

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Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins

scientific article published on 19 March 2013

Influence of biospecimen variables on proteomic biomarkers in breast cancer

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Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma

scientific article published on March 2006

Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells

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Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells

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Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1α and oxidative phosphorylation in melanoma

scientific article published on 8 October 2014

Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.

scientific article published on February 2002

Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors

scientific article published on 05 October 2020

Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo

scientific article published in October 2002

Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma

scientific article published on February 2006

Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity i

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Integrated Genomic Characterization of the Human Immunome in Cancer

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Integrated Molecular Characterization of Uterine Carcinosarcoma

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Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma

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Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer

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Integrated analysis of transcriptomes of cancer cell lines and patient samples reveals STK11/LKB1-driven regulation of cAMP phosphodiesterase-4D.

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Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer

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Integrated genomic characterization of endometrial carcinoma ⬇️

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Integrated transcriptomic-genomic tool Texomer profiles cancer tissues

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Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma

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Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma

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Integrative Protein-Based Prognostic Model for Early-Stage Endometrioid Endometrial Cancer

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Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer

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Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set

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Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome

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Integrative epidemiology: from risk assessment to outcome prediction

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Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.

scientific article published on 22 March 2010

Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer.

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Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells

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Interactions between tumor cells and microenvironment in breast cancer: a new opportunity for targeted therapy

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Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms

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Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells.

scientific article published on July 2001

Involvement of the SHP-1 tyrosine phosphatase in regulating B lymphocyte antigen receptor signaling, proliferation and transformation

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Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels

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Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling

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Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells

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LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer

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LMW-E/CDK2 Deregulates Acinar Morphogenesis, Induces Tumorigenesis, and Associates with the Activated b-Raf-ERK1/2-mTOR Pathway in Breast Cancer Patients ⬇️

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LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer

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Lactate Dehydrogenase B: A Metabolic Marker of Response to Neoadjuvant Chemotherapy in Breast Cancer ⬇️

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Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

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Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines

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Large-Scale Drug Screens Support Precision Medicine

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Levels of soluble interleukin-2 receptor-α are elevated in serum and ascitic fluid from epithelial ovarian cancer patients

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Lineage infidelity of MDA-MB-435 cells: expression of melanocyte proteins in a breast cancer cell line

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Linking molecular diagnostics to molecular therapeutics: targeting the PI3K pathway in breast cancer

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Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo

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Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis

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Location, location, location: a crystal-clear view of autotaxin saturating LPA receptors ⬇️

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Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis

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Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance.

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Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors ⬇️

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Loss of Phd2 cooperates with BRAF to drive melanomagenesis

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Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer

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Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions.

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Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers

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Loss-of-function screens of druggable targetome against cancer stem-like cells.

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Lysophosphatidic Acid Induces Lymphangiogenesis and IL-8 Production in Vitro in Human Lymphatic Endothelial Cells ⬇️

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Lysophosphatidic Acid Signaling Protects Pulmonary Vasculature From Hypoxia-Induced Remodeling ⬇️

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Lysophosphatidic acid (LPA)-induced vasodilator-stimulated phosphoprotein mediates lamellipodia formation to initiate motility in PC-3 prostate cancer cells

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Lysophosphatidic acid and ovarian cancer: a paradigm for tumorogenesis and patient management.

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Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression

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Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells

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Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway.

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Lysophosphatidic acid is a bioactive mediator in ovarian cancer

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Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer

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Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase

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Lysophosphatidic acid production and action: validated targets in cancer?

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Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells

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Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis

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Lysophosphatidylcholine Stimulates Activator Protein 1 and the c-Jun N-terminal Kinase Activity

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Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer.

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MAPK Activation Predicts Poor Outcome and the MEK Inhibitor, Selumetinib, Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian Cancer

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MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling

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MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis

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MEK Inhibition Remodels the Immune Landscape of Mutant <i>KRAS</i> Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors

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MERIT: Systematic Analysis and Characterization of Mutational Effect on RNA Interactome Topology

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MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition ⬇️

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MODULATION OF AUTOPHAGY AND ITS POTENTIAL FOR CANCER THERAPY.

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MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition

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Mammalian target of rapamycin

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Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis

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Mask is required for the activity of the Hippo pathway effector Yki/YAP.

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Mechanical Stress Signaling in Pancreatic Cancer Cells Triggers p38 MAPK- and JNK-Dependent Cytoskeleton Remodeling and Promotes Cell Migration via Rac1/cdc42/Myosin II

scientific article published on 01 March 2022

Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells

scientific article published on 11 December 2003

Mechanisms underlying chemoprevention of ovarian cancer

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Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer.

scientific article published on 12 February 2008

Mechanistic basis for overcoming platinum resistance using copper chelating agents

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Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance

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Messenger RNA expression and methylation of candidate tumor-suppressor genes and risk of ovarian cancer-a case-control analysis ⬇️

scientific article published on January 1, 2010

Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes

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Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer

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Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes.

scientific article published on 14 March 2018

Mig-6 suppresses endometrial cancer associated with Pten deficiency and ERK activation

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Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance

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Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance

Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling.

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Modeling precision treatment of breast cancer

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Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Postmenopausal Women

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Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Premenopausal Women

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Modulation of the Hippo pathway and organ growth by RNA processing proteins

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Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer

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Molecular characterization of gallbladder cancer using somatic mutation profiling

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Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation

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Molecular determinants of post-mastectomy breast cancer recurrence

scientific article published on 12 October 2018

Molecular heterogeneity at the network level: high-dimensional testing, clustering and a TCGA case study

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Molecular mechanisms and pathobiology of oncogenic fusion transcripts in epithelial tumors

Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients

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Molecular screening for breast cancer prevention, early detection, and treatment planning: combining biomarkers from DNA, RNA, and protein

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Molecular therapeutics: promise and challenges

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Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3.

scientific article published on 4 February 2008

Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity

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Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy

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Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo

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Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers.

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Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy

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Multigene clinical mutational profiling of breast carcinoma using next-generation sequencing

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Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

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Multiomics analysis of serial PARP inhibitor treated metastatic TNBC inform on rational combination therapies

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Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

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Multiplatform-based molecular subtypes of non-small-cell lung cancer

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Multiplex digital spatial profiling of proteins and RNA in fixed tissue

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Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer.

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Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1

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Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications

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Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance

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Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance

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NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas

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Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors

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Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

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Neomorphic mutations create therapeutic challenges in cancer.

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Network Analysis of the Focal Adhesion to Invadopodia Transition Identifies a PI3K-PKCα Invasive Signaling Axis ⬇️

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Network inference using steady-state data and Goldbeter–Koshland kinetics

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Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R.

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New era of integrated cancer biomarker discovery using reverse-phase protein arrays

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Next generation sequencing analysis of platinum refractory advanced germ cell tumor sensitive to Sunitinib (Sutent®) a VEGFR2/PDGFRβ/c-kit/ FLT3/RET/CSF1R inhibitor in a phase II trial

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Next-Generation Sequencing and Result Interpretation in Clinical Oncology: Challenges of Personalized Cancer Therapy.

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Next-generation characterization of the Cancer Cell Line Encyclopedia

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Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.

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Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study

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Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models

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Non-parametric quantification of protein lysate arrays

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Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set.

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Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer

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Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer

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Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial

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Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms

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Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer

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OvMark: a user-friendly system for the identification of prognostic biomarkers in publically available ovarian cancer gene expression datasets.

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Ovarian cancer: linking genomics to new target discovery and molecular markers--the way ahead

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Overcoming implementation challenges of personalized cancer therapy

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Overexpression of kallikrein 10 in epithelial ovarian carcinomas

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PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas

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PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness

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PIK3CA Amplification Associates with Aggressive Phenotype but Not Markers of AKT-MTOR Signaling in Endometrial Carcinoma

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PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer

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PIK3CA is implicated as an oncogene in ovarian cancer.

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PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer

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PIK3CA/PTEN Mutations and Akt Activation As Markers of Sensitivity to Allosteric mTOR Inhibitors ⬇️

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PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth

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Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway

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Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer

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Perifosine plus docetaxel in patients with platinum and taxane resistant or refractory high-grade epithelial ovarian cancer

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Peritoneal Spread of Ovarian Cancer harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling

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Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer

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Personalized Integrated Network Modeling of the Cancer Proteome Atlas

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Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies

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Phosphorylated 4E-BP1 is associated with poor survival in melanoma

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Point mutations of protein kinases and individualised cancer therapy

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Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro.

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Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency.

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Predicting Cancer Cell Line Dependencies From the Protein Expression Data of Reverse-Phase Protein Arrays

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Predicting time to ovarian carcinoma recurrence using protein markers.

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Predicting time to ovarian carcinoma recurrence using protein markers.

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Pretest prediction of BRCA1 or BRCA2 mutation by risk counselors and the computer model BRCAPRO

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Prospective Clinical Sequencing of Adult Glioma

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Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer

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Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer

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Proteomic Characterization of Head and Neck Cancer Patient-Derived Xenografts

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Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival.

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Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response

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Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer

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Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer

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Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

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Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence

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Proteomic profiling of endometrioid endometrial cancer reveals differential expression of hormone receptors and MAPK signaling proteins in obese versus non-obese patients

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Proteomics advances for precision therapy in ovarian cancer

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Quantitative proteomic analysis in breast cancer

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RADical response puts an exceptional responder in CHKmate: a synthetic lethal curative response to DNA-damaging chemotherapy?

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RCP induces Slug expression and cancer cell invasion by stabilizing β1 integrin

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RET fusion as a novel driver of medullary thyroid carcinoma

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RNA editing derived epitopes function as cancer antigens to elicit immune responses

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RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC

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RPPAML/RIMS: a metadata format and an information management system for reverse phase protein arrays

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Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression

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Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT.

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Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments

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Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin.

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Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress

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Rak functions as a tumor suppressor by regulating PTEN protein stability and function

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Randomized, placebo-controlled window trial of EGFR, Src, or combined blockade in head and neck cancer

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Ras-superfamily GTP-ases in ovarian cancer

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Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers.

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Realizing the promise of reverse phase protein arrays for clinical, translational, and basic research: a workshop report: the RPPA (Reverse Phase Protein Array) society

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Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer

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Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation

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Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer

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Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition

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Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

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Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies

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Regulation of mRNA expression in breast cancer - a cis-tematic trans-action ⬇️

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Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

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Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium

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Relationship Between Response and Dose in Published, Contemporary Phase I Oncology Trials

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Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils

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Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents ⬇️

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Results of an abbreviated phase II study of AKT inhibitor MK-2206 in the treatment of recurrent platinum-resistant high grade serous ovarian, fallopian tube, or primary peritoneal carcinoma (NCT 01283035)

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Rethinking ovarian cancer: recommendations for improving outcomes

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Retrospective Review of MET Gene Mutations

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Reverse phase protein array identifies novel anti-invasion mechanisms of YC-1.

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Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

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Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations in HPV-associated head and neck cancer

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Robust Selection Algorithm (RSA) for Multi-Omic Biomarker Discovery; Integration with Functional Network Analysis to Identify miRNA Regulated Pathways in Multiple Cancers

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Role of RPL39 in Metaplastic Breast Cancer.

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Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer ⬇️

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Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity

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Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes.

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SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity

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SU2C phase Ib study of paclitaxel and MK-2206 in advanced solid tumors and metastatic breast cancer

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Safety lead-in of the MEK inhibitor trametinib in combination with GSK2141795, an AKT inhibitor, in patients with recurrent endometrial cancer: An NRG Oncology/GOG study

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Sarcomatoid renal cell carcinoma has a distinct molecular pathogenesis, driver mutation profile and transcriptional landscape

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Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis

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Selective Genomic Copy Number Imbalances and Probability of Recurrence in Early-Stage Breast Cancer ⬇️

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Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer ⬇️

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Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy

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Serial dilution curve: a new method for analysis of reverse phase protein array data

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Sex-associated molecular differences for cancer immunotherapy

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Sharpening the edges of understanding the structure/function of the LPA1 receptor: expression in cancer and mechanisms of regulation

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Shrewd AKT regulation to survive

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Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia

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Site-specific activation of AKT protects cells from death induced by glucose deprivation ⬇️

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Small Molecule ErbB Inhibitors Decrease Proliferative Signaling and Promote Apoptosis in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia ⬇️

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Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha

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Soft tissue sarcoma subtypes exhibit distinct patterns of acquired uniparental disomy ⬇️

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Soluble interleukin-2 receptor alpha is elevated in sera of patients with benign ovarian neoplasms and epithelial ovarian cancer

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Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer

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Somatic mutations of PIK3R1 promote gliomagenesis

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Sparse Bayesian Graphical Models for RPPA Time Course Data

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Spatial normalization of reverse phase protein array data

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Spatially Interacting Phosphorylation Sites and Mutations in Cancer

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Spatially interacting phosphorylation sites and mutations in cancer

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Specific keynote: genome copy number abnormalities in ovarian cancer

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Specific keynote: molecular therapeutics in ovarian cancer

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Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo

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Src Kinase Activity Is Regulated by the SHP-1 Protein-tyrosine Phosphatase ⬇️

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Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades

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Src promotes estrogen-dependent estrogen receptor alpha proteolysis in human breast cancer

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Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer.

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State-of-the-art strategies for targeting the DNA damage response in cancer

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Stem cell-ness: a "magic marker" for cancer

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Stem cell-ness: a “magic marker” for cancer.

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Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation

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Subtype and pathway specific responses to anticancer compounds in breast cancer

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Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

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Survival Outcomes by TP53 Mutation Status in Metastatic Breast Cancer

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Survival of cancer stem-like cells under metabolic stress via CaMK2α-mediated upregulation of sarco/endoplasmic reticulum calcium ATPase expression

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Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML

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Surviving ovarian cancer: an affair between defective DNA repair and RB1.

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Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells

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Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.

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Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid ⬇️

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Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis

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Systematic Functional Annotation of Somatic Mutations in Cancer.

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Systematic Identification of Combinatorial Drivers and Targets in Cancer Cell Lines ⬇️

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Systematic analysis of genotype-specific drug responses in cancer

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Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers

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Systems Biology Approaches to Decoding the Genome of Liver Cancer ⬇️

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Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response.

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Systems approach to rational combination therapy: PARP inhibitors

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Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery

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TCPA v3.0: An Integrative Platform to Explore the Pan-Cancer Analysis of Functional Proteomic Data

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TCPA: a resource for cancer functional proteomics data

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Targeting Extracellular Matrix Remodeling restores BRAF Inhibitor Sensitivity in BRAFi Resistant Melanoma

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Targeting KRas-dependent tumour growth, circulating tumour cells and metastasis in vivo by clinically significant miR-193a-3p

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Targeting PI3K-AKT pathway for cancer therapy

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Targeting gamma secretase: has progress moved up a Notch?

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Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma

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Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells

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Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid

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Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity

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Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors

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Targeting ncRNAs in the 3q26.2 amplicon

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Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis

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Targeting the Hepatocyte Growth Factor–cMET Axis in Cancer Therapy ⬇️

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Targeting the epidermal growth factor receptor in epithelial ovarian cancer: current knowledge and future challenges.

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Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression

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Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy

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Targeting therapeutic liabilities engendered by PIK3R1 mutations for cancer treatment.

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Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer

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Tat-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520.

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Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells

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The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck.

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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

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The Cancer Genome Atlas Pan-Cancer analysis project

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The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer

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The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment

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The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

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The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy.

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The Impact of Tumor Heterogeneity on Patient Treatment Decisions ⬇️

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The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

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The PI3K/AKT Pathway and Renal Cell Carcinoma

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The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

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The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers

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The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF

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The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis

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The emerging role of the RAB25 small GTPase in cancer

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The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.

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The outcome of heregulin-induced activation of ovarian cancer cells depends on the relative levels of HER-2 and HER-3 expression

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The phosphatase PPM1A inhibits triple negative breast cancer growth by blocking cell cycle progression

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The right drugs at the right time for the right patient: the MD Anderson precision oncology decision support platform

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The tyrosine kinase activity of the C-erbB-2 gene product (p185) is required for growth inhibition by anti-p185 antibodies but not for the cytotoxicity of an anti-p185-ricin-A chain immunotoxin

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TransVar: a multilevel variant annotator for precision genomics

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Transfection of human ovarian cancer cells with the HER-2/neu receptor tyrosine kinase induces a selective increase in PTP-H1, PTP-1B, PTP-alpha expression

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Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development

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Transient commensal clonal interactions can drive tumor metastasis

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Trastuzumab has preferential activity against breast cancers driven by HER2 homodimers

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Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals

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Ultra-deep next-generation sequencing of plasma cell-free DNA in patients with advanced lung cancers: results from the Actionable Genome Consortium

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Upregulation of Cell Surface GD3 Ganglioside Phenotype is Associated with Human Melanoma Brain Metastasis

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Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer

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Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma.

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Using Reverse Phase Protein Array (RPPA) to Identify and Target Adaptive Resistance

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Using reverse-phase protein arrays as pharmacodynamic assays for functional proteomics, biomarker discovery, and drug development in cancer

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Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

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Validation of reverse phase protein array for practical screening of potential biomarkers in serum and plasma: accurate detection of CA19-9 levels in pancreatic cancer

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Verteporfin inhibits PD-L1 through autophagy and the STAT1-IRF1-TRIM28 signaling axis, exerting antitumor efficacy

scientific article published on 07 April 2020

Verteporfin inhibits YAP function through up-regulating 14-3-3σ sequestering YAP in the cytoplasm

scientific article published on 15 December 2015

Vimentin is a novel AKT1 target mediating motility and invasion

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WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome

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Which path to follow? Utilizing proteomics to improve therapy choices for breast cancer patients

scientific article published on 20 April 2020

Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.

scientific article

YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor-Induced Activation of the PI3K Pathway

scientific article published on 15 February 2017

YB-1 transforms human mammary epithelial cells through chromatin remodeling leading to the development of basal-like breast cancer

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Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma

scientific article published on 21 September 2015

ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction

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ZNF668 Functions as a Tumor Suppressor by Regulating p53 Stability and Function in Breast Cancer ⬇️

scientific article published on August 18, 2011

cMET Activation and EGFR-Directed Therapy Resistance in Triple-Negative Breast Cancer

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cMET and phospho-cMET protein levels in breast cancers and survival outcomes

scientific article published on 28 February 2012

hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness

scientific article published on 25 August 2014

mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer

scientific article published on 6 November 2015

miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer

scientific article published on 01 December 2019

p202 self-associates through a sequence conserved among the members of the 200-family proteins

scientific article published on 01 October 1998

p85α neomorphic mutants: splitting away from the canonical path.

scientific article published on 27 May 2015

p85β regulates autophagic degradation of AXL to activate oncogenic signaling

scientific article published on 08 May 2020

α-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration

scientific article

β-catenin/TCF activity regulates IGF-1R tyrosine kinase inhibitor sensitivity in colon cancer

scientific article published on 12 June 2018

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