List of works - Gordon B. Mills

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

scientific article published on January 2009

Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases

scientific article

Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer

scientific article

PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer

scientific article

Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis

scientific article published on May 2004

Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer.

scientific article

Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

scientific article published on 2 March 2016

Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals

scientific article published on December 6, 2012

A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models

scientific article published on 04 June 2013

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

article

Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer

scientific article

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities

scientific article

Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors

scientific article published on May 8, 2003

HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

scientific article published in May 2003

Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer

scientific article

The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells

scientific article published on 20 November 2008

Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance

scientific article published on January 2009

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

scientific article

Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8.

scientific article published on 30 April 2013

The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis

scholarly article

A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer

scientific article

Lysophosphatidic acid is a bioactive mediator in ovarian cancer

scientific article

Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.

scientific article published on May 2008

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

scientific article published on November 1999

Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials

scientific article

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

scientific article

Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer

scientific article published on 2 August 2009

Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon

scientific article

Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels

scientific article

Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells

scientific article published in October 2004

A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity

scientific article published on January 2008

Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents

scientific article published on December 18, 2012

Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms

scientific article

A genetically defined model for human ovarian cancer

scientific article published on March 2004

MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition

scientific article published on 19 March 2012

AMPK: A Contextual Oncogene or Tumor Suppressor?

scientific article published on 03 May 2013

Determinants of rapamycin sensitivity in breast cancer cells

scientific article published on February 2004

Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer.

scientific article

ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer

scientific article

CA 125: the past and the future

scientific article

Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells

scientific article published on 12 March 2003

Targeting the Hepatocyte Growth Factor–cMET Axis in Cancer Therapy

scientific article published on August 6, 2012

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling

scientific article

Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma.

scientific article

NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas

scientific article

A new mutational AKTivation in the PI3K pathway

scientific article published on August 2007

Assessing the clinical utility of cancer genomic and proteomic data across tumor types.

scientific article

TCPA: a resource for cancer functional proteomics data

scientific article

Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy

scientific article

Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications

scientific article

List of works by Gordon B. Mills

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases

Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer

PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer

Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis

Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer.

Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals

A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities

Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors

HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer

The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells

Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8.

The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis

A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer

Lysophosphatidic acid is a bioactive mediator in ovarian cancer

Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer

Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon

Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels

Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells

A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity

Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents

Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms

A genetically defined model for human ovarian cancer

MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition

AMPK: A Contextual Oncogene or Tumor Suppressor?

Determinants of rapamycin sensitivity in breast cancer cells

Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer.

ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer

CA 125: the past and the future

Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells

Targeting the Hepatocyte Growth Factor–cMET Axis in Cancer Therapy

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling

Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma.

NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas

A new mutational AKTivation in the PI3K pathway

Assessing the clinical utility of cancer genomic and proteomic data across tumor types.

TCPA: a resource for cancer functional proteomics data

Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy

Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications