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List of works by David Komander

A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation

scholarly article by Jonathan N Pruneda et al published 5 November 2018 in Nature Microbiology

A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.

scientific article published on 28 August 2017

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes

scientific article

A further case of Dop‐ing in bacterial pupylation ⬇️

scientific article published on September 17, 2010

Activation mechanism of PINK1

scientific article published on 21 December 2021

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

scientific article published on 28 August 2013

Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins

scientific article published on 27 August 2018

Active site alanine substitutions can convert deubiquitinating enzymes into avid ubiquitin-binding domains

An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling

scientific article

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains

scientific article

An essential role for the ATG8 ortholog LC3C in antibacterial autophagy

scientific article published on 22 February 2013

An invisible ubiquitin conformation is required for efficient phosphorylation by PINK1.

scientific article published on 13 November 2017

Analysis of the LKB1-STRAD-MO25 complex

scientific article

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

scientific article

Assembly and specific recognition of k29- and k33-linked polyubiquitin.

scientific article

Assembly, analysis and architecture of atypical ubiquitin chains

scientific article

Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages ⬇️

scientific article published on July 23, 2012

BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.

scientific article published on March 2011

Biochemistry. Details of destruction, one molecule at a time

scientific article published on 01 April 2015

Breaking the chains: deubiquitylating enzyme specificity begets function

scientific article published on 01 June 2019

Breaking the chains: structure and function of the deubiquitinases

scientific article (publication date: August 2009)

CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

scientific journal article

CYLD tidies up dishevelled signaling

scientific article published in March 2010

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner.

scientific article

Cezanne regulates E2F1-dependent HIF2α expression

scientific article

Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest).

scientific article published on 29 January 2015

Development of Diubiquitin-Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes

scientific article published on 21 March 2016

Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression

scientific article published on 15 July 2020

Dissection of USP catalytic domains reveals five common insertion points

scientific article

Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity

Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation

scientific article published on 19 December 2019

Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages

scientific article

Emerging roles for Lys11-linked polyubiquitin in cellular regulation.

scientific article published on 07 June 2011

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

scientific article

Enzymatic Assembly of Ubiquitin Chains

scientific article published on 01 January 2018

Erratum: Mechanism of phospho-ubiquitin-induced PARKIN activation

scientific article published on 23 September 2015

Evaluating enzyme activities and structures of DUBs

scientific article published on 22 February 2019

Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling

scientific article published on 01 March 2020

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.

scientific article published on 08 August 2016

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

scientific article

Identification and characterization of diverse OTU deubiquitinases in bacteria

scientific article published on 22 June 2020

Insights into ubiquitin chain architecture using Ub-clipping

scientific article published on 15 August 2019

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1

scientific article

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

scientific article published on 20 February 2018

LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy

scientific article

LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB.

scientific article published on 8 May 2017

Lining the pockets of kinases and phosphatases.

scientific article published on 2 November 2006

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

scientific article

Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase

scientific article

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

scientific article published on 26 August 2020

Mechanism and regulation of the Lys6-selective deubiquitinase USP30.

scientific article

Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure

scientific article

Mechanism of parkin activation by PINK1

scientific article published in Nature

Mechanism of phospho-ubiquitin-induced PARKIN activation

scientific article published on 10 July 2015

Mechanism, Specificity and Structure of the Deubiquitinases ⬇️

scientific article published on January 1, 2010

Mechanisms of Deubiquitinase Specificity and Regulation.

scientific article

Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential

scientific article published in April 2018

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

scientific article

Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

scientific article

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

scientific article

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

scientific article

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

scientific article

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

scientific article published in May 2009

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

scientific article

New tools for ubiquitin signaling

scientific article published on 27 February 2012

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

scientific article

Novel inositol phospholipid headgroup surrogate crystallized in the pleckstrin homology domain of protein kinase Balpha

scientific article

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

scientific article

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

scientific article

OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death

scientific article published on 01 March 2019

OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer

scientific article published on 30 March 2020

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

scientific article

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

scientific article

PDK1, the master regulator of AGC kinase signal transduction

scientific article

Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21

scientific article published in April 2011

Publisher Correction: Breaking the chains: deubiquitylating enzyme specificity begets function

scientific article published on 01 May 2019

Purification, crystallization and preliminary X-ray diffraction of a proteolytic fragment of PDK1 containing the pleckstrin homology domain.

scientific article published on 23 January 2004

Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T.

scientific article published on 15 May 2008

Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy

scientific article published on July 2016

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

scientific article

Regulation of A20 and other OTU deubiquitinases by reversible oxidation

scientific article

Regulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULIN

scientific article

Regulation of the endosomal SNX27-retromer by OTULIN

scientific article published on 20 September 2019

Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.

scientific article published on March 2005

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

scientific article

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

scientific article

Strange New World: Bacteria Catalyze Ubiquitylation via ADP Ribosylation

scientific article published in February 2017

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

scientific article

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

scientific article published on 30 September 2004

Structure of PINK1 in complex with its substrate ubiquitin.

scientific article published on 30 October 2017

Structure of the A20 OTU domain and mechanistic insights into deubiquitination

scientific article

Structure of the human Parkin ligase domain in an autoinhibited state

scientific article

Synthesis and Analysis of K11-Linked Ubiquitin Chains ⬇️

scientific article published on 01 January 2012

Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer.

scientific article published on 27 November 2017

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

scientific journal article

The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway

scientific article published on 30 September 2020

The JAMM in the proteasome

scientific article published on 01 April 2014

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases

scientific article published on 13 July 2016

The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence

scientific article published on 27 October 2016

The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules

scientific article published on 27 May 2020

The emerging complexity of protein ubiquitination

scientific article

The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module

scientific article

The tumour suppressor CYLD regulates the p53 DNA damage response

scientific article

The ubiquitin code

scientific article

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

scientific article

USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation

scientific article published on 07 July 2020

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling

scientific article published on 20 September 2017

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

scientific article

Ubiquitin chain conformation regulates recognition and activity of interacting proteins

scientific article

Ubiquitin modifications

scientific article

Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities

scientific article published on 07 January 2021

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.

scientific article published in February 2018

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