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List of works by David Komander

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The ubiquitin code

scientific article
Breaking the chains: structure and function of the deubiquitinases

scientific article (publication date: August 2009)
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

scientific article
PDK1, the master regulator of AGC kinase signal transduction

scientific article
Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

scientific article
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

scientific article
The emerging complexity of protein ubiquitination

scientific article
Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

scientific article published on July 23, 2012
Ubiquitin modifications

scientific article
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

scientific article
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

scientific article
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

scientific article
Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

scientific article published on 28 August 2013
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

scientific article
Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

scientific article
Structure of the human Parkin ligase domain in an autoinhibited state

scientific article
The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module

scientific article
Mechanism of phospho-ubiquitin-induced PARKIN activation

scientific article published on 10 July 2015
Mechanisms of Deubiquitinase Specificity and Regulation.

scientific article
LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy

scientific article
Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

scientific article
On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

scientific article
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

scientific article
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

scientific article
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

scientific article published on 30 September 2004
Structure of the A20 OTU domain and mechanistic insights into deubiquitination

scientific article
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

scientific journal article
Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

scientific article
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

scientific article
Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21

scientific article published in April 2011
Molecular Basis and Regulation of OTULIN-LUBAC Interaction

scientific article
Ubiquitin chain conformation regulates recognition and activity of interacting proteins

scientific article
Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

scientific article
Analysis of the LKB1-STRAD-MO25 complex

scientific article
Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest)

scientific article published on January 29, 2015
Dissection of USP catalytic domains reveals five common insertion points

scientific article
Assembly, analysis and architecture of atypical ubiquitin chains

scientific article
Molecular basis of USP7 inhibition by selective small-molecule inhibitors

scientific article
Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin

scientific article published on March 5, 2015
Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase

scientific article
Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T.

scientific article published on 15 May 2008
Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

scientific article
An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling

scientific article
An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains

scientific article
Regulation of A20 and other OTU deubiquitinases by reversible oxidation

scientific article
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

scientific journal article
Breaking the chains: deubiquitylating enzyme specificity begets function

scientific article published on 01 June 2019
Mechanism, Specificity and Structure of the Deubiquitinases

scientific article published on January 1, 2010
Mechanism of parkin activation by PINK1

scientific article published in Nature
BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.

scientific article published on March 2011

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