List of works - Tobias Krojer

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

scientific article published on August 2013

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

scientific article

A Multi-Crystal Method for Extracting Obscured Signal from Crystallographic Electron Density

article published in 2016

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

scientific article (publication date: 24 April 2017)

A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03115j.

scientific article published on 22 December 2015

Achieving a Good Crystal System for Crystallographic X-Ray Fragment Screening

scientific article published on 15 October 2018

Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control

scientific article published in January 2008

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

scientific article published on 28 October 2019

Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects

scientific article published on 9 April 2011

Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii

scientific article

Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6

scientific article

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

scientific article

Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

scientific article

Crystal structure of the protease domain of DegQ from Escherichia coli

scholarly article published 27 July 2011

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

scientific article published on 07 October 2020

Experiences From Developing Software for Large X-Ray Crystallography-Driven Protein-Ligand Studies

publication published on 11 April 2022

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking

scientific article published on 24 November 2020

Gentle, fast and effective crystal soaking by acoustic dispensing

article published in 2016

Gentle, fast and effective crystal soaking by acoustic dispensing.

scientific article

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

scientific article

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation

scientific article

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

scholarly article

Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor

scientific article

Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization

scientific article

Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell Envelope

scientific article

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor

scientific article published in December 2014

Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop

scientific article

Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites

scientific article published on 28 February 2017

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

scientific article

Proper modelling of ligand binding requires an ensemble of bound and unbound states

scientific article published on 06 March 2017

Regulation of the E stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress

scientific article

Ribosomal oxygenases are structurally conserved from prokaryotes to humans

scientific article

Selectivity profiling of DegP substrates and inhibitors

scientific article published on 5 February 2009

Squeezing the most from every crystal: the fine details of data collection.

scientific article

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

scientific article

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

scientific article

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases

scientific article published on 27 September 2013

Structural basis for the regulated protease and chaperone function of DegP

scientific article

Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.

scientific article

Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function

scientific article

Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli

scientific article published on 18 August 2009

Substrate-induced remodeling of the active site regulates human HTRA1 activity

scientific article

The XChemExplorer graphical workflow tool for routine or large-scale protein-ligand structure determination.

scientific article

The low-cost Shifter microscope stage transforms the speed and robustness of protein crystal harvesting

scientific article published on 01 January 2021

List of works by Tobias Krojer

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

A Multi-Crystal Method for Extracting Obscured Signal from Crystallographic Electron Density

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03115j.

Achieving a Good Crystal System for Crystallographic X-Ray Fragment Screening

Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects

Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii

Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

Crystal structure of the protease domain of DegQ from Escherichia coli

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

Experiences From Developing Software for Large X-Ray Crystallography-Driven Protein-Ligand Studies

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking

Gentle, fast and effective crystal soaking by acoustic dispensing

Gentle, fast and effective crystal soaking by acoustic dispensing.

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor

Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization

Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell Envelope

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor

Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop

Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

Proper modelling of ligand binding requires an ensemble of bound and unbound states

Regulation of the E stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress

Ribosomal oxygenases are structurally conserved from prokaryotes to humans

Selectivity profiling of DegP substrates and inhibitors

Squeezing the most from every crystal: the fine details of data collection.

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases

Structural basis for the regulated protease and chaperone function of DegP

Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.

Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function

Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli

Substrate-induced remodeling of the active site regulates human HTRA1 activity

The XChemExplorer graphical workflow tool for routine or large-scale protein-ligand structure determination.

The low-cost Shifter microscope stage transforms the speed and robustness of protein crystal harvesting

When protein crystal dehydration helps