List of works - Frank von Delft

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

scientific article

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

scientific article

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

scientific article

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

scientific article

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation

scientific article

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

scientific article

Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases

scientific article

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva

scientific article

The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity

scientific article

CCP4i2: the new graphical user interface to the CCP4 program suite.

scientific article published in February 2018

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

scientific article

Ribosomal oxygenases are structurally conserved from prokaryotes to humans

scientific article

Crystal structures of the catalytic domain of human soluble guanylate cyclase

scientific article

Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A

scientific article

Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing

scientific article

The structural basis of ZMPSTE24-dependent laminopathies

scientific article

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

scientific article (publication date: 24 April 2017)

The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily

scientific article published in May 2001

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

scientific article

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

scientific article

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

scientific article

Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor

scientific article

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation

scientific article

Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis

scientific article

Crystal Structure of Escherichia coli Ketopantoate Reductase at 1.7 Å Resolution and Insight into the Enzyme Mechanism

scientific article published on December 4, 2001

A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03115j.

scientific article published on 22 December 2015

On the need for an international effort to capture, share and use crystallization screening data

scientific article (publication date: March 2012)

Insight into S -adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits

scientific article

Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima

scientific article

Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function

scientific article

The XChemExplorer graphical workflow tool for routine or large-scale protein-ligand structure determination.

scientific article

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures

scientific article

Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 A resolution

scientific article

Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases

scientific article

The Cryptosporidium parvum Kinome

scientific article

Gentle, fast and effective crystal soaking by acoustic dispensing.

scientific article

Structural Insights into Functional Overlapping and Differentiation among Myosin V Motors

scientific article

Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family

scientific article

Where is crystallography going?

scientific article published in February 2018

Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 A resolution

scientific article

Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites

scientific article

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

scientific article published on 07 June 2018

Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design

scientific journal article

Synthesis and Demonstration of the Biological Relevance of sp3 -rich Scaffolds Distantly Related to Natural Product Frameworks.

scientific article published on 6 October 2017

Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).

scientific article published on 20 August 2015

Proper modelling of ligand binding requires an ensemble of bound and unbound states

scientific article published on 06 March 2017

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

scientific article

An overview of heavy-atom derivatization of protein crystals

scientific article

Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation.

scientific article

Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens

scientific article published on 28 July 2015

List of works by Frank von Delft

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva

The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity

CCP4i2: the new graphical user interface to the CCP4 program suite.

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

Ribosomal oxygenases are structurally conserved from prokaryotes to humans

Crystal structures of the catalytic domain of human soluble guanylate cyclase

Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A

Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing

The structural basis of ZMPSTE24-dependent laminopathies

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation

Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis

Crystal Structure of Escherichia coli Ketopantoate Reductase at 1.7 Å Resolution and Insight into the Enzyme Mechanism

A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03115j.

On the need for an international effort to capture, share and use crystallization screening data

Insight into S -adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits

Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima

Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function

The XChemExplorer graphical workflow tool for routine or large-scale protein-ligand structure determination.

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures

Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 A resolution

Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases

The Cryptosporidium parvum Kinome

Gentle, fast and effective crystal soaking by acoustic dispensing.

Structural Insights into Functional Overlapping and Differentiation among Myosin V Motors

Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family

Where is crystallography going?

Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 A resolution

Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design

Synthesis and Demonstration of the Biological Relevance of sp3 -rich Scaffolds Distantly Related to Natural Product Frameworks.

Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).

Proper modelling of ligand binding requires an ensemble of bound and unbound states

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

An overview of heavy-atom derivatization of protein crystals

Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation.

Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens