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List of works by Sekar Kathiresan

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Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study

scientific article
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

scientific journal article
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

scientific article
Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations

scientific article
Distribution and medical impact of loss-of-function variants in the Finnish founder population

scientific article
Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium

scientific article
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci

scientific article
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

scientific article
Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials

scientific article
Inactivating mutations in NPC1L1 and protection from coronary heart disease

scientific article
Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia

scientific article
Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction

scientific article
Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study

scientific article published on March 2007
Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol

scientific article
Candidate gene association resource (CARe): design, methods, and proof of concept

scientific article
The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports

scientific article
Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease

scientific article published on April 2017
Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study

scientific article
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article
Exome-wide association study of plasma lipids in >300,000 individuals

scientific article published on 30 October 2017
Meta-analysis of gene-level tests for rare variant association

scientific article published on 15 December 2013
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

scientific article published on 11 September 2011
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data

scientific article
Increased small low-density lipoprotein particle number: a prominent feature of the metabolic syndrome in the Framingham Heart Study

scientific article published on 27 December 2005
Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study

scientific article published on 20 February 2014
Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity

scientific article published on April 2017
Contribution of Clinical Correlates and 13 C-Reactive Protein Gene Polymorphisms to Interindividual Variability in Serum C-Reactive Protein Level

article
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

scientific article published on 12 September 2016
Dysfunctional nitric oxide signalling increases risk of myocardial infarction

scientific article published on 10 November 2013
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

scientific article published on 12 September 2016
CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study

scientific article
Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease

scientific article
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism

scientific article
Genetically determined height and coronary artery disease

scientific article
Increased burden of cardiovascular disease in carriers of APOL1 genetic variants

scientific article published on 30 December 2013
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls

scientific article
Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis

scientific article published on 26 October 2015
Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans

scientific article
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scientific article published on 17 September 2018
Genetic determinants of plasma triglycerides

scientific article published on November 1, 2010
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

scientific article (publication date: 17 September 2013)
Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk

scientific article published on 03 September 2009
Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans

scientific article published on 16 March 2009
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 22 December 2017
Genome-wide association with select biomarker traits in the Framingham Heart Study

scientific article
Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample

scientific article published on 12 February 2007
Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study

scientific article published in January 2009
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

scientific article

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