List of works by Luke A. J. O'Neill

"Transflammation": when innate immunity meets induced pluripotency

scientific article published on 01 October 2012

'Fine tuning' TLR signaling

scientific article published in May 2008

100 NF-κB Activation by Mal/Tirap is Regulated by Caspase-1

scholarly article by Sinead M. Miggin et al published July 2007 in Cytokine

30

A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.

scientific article published on February 2016

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

scientific article published on 01 November 2018

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

scientific journal article

A Metabolic Roadblock in Inflammatory Macrophages

scientific article published in October 2016

A Potent Anti-Inflammatory Response in Bat Macrophages May Be Linked to Extended Longevity and Viral Tolerance

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

scientific article published on 5 February 2018

A broken krebs cycle in macrophages

scientific article published on 01 March 2015

A critical role for citrate metabolism in LPS signalling

scientific article published on 01 September 2011

A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins

scientific article

A feed-forward loop involving hyaluronic acid and toll-like receptor-4 as a treatment for colitis?

scientific article published on 29 October 2009

A gene for Crohn's disease is given the nod

scientific article published on 01 August 2001

A guide to immunometabolism for immunologists.

scientific article

A guiding map for inflammation

scientific article published on July 2017

A long noncoding RNA mediates both activation and repression of immune response genes

scientific journal article

A method to predict residues conferring functional differences between related proteins: application to MAP kinase pathways.

scientific article published on April 2000

A novel function of InIB from Listeria monocytogenes: activation of NF-kappaB in J774 macrophages.

scientific article

A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins

scientific article

A role for leptin in autoimmunity?

scientific article published on 01 July 2001

A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?

scientific article published on 19 March 2012

A roll-call of monocytic gene induction

scientific article published on 01 April 2001

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

scientific article

A trio of microRNAs that control Toll-like receptor signalling

scientific article

A vaccine for colorectral cancer

scientific article published on 01 July 2001

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.

scientific article published on August 2000

Activation of NF-kappa B and induction of vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 expression in human glial cells by IL-1. Modulation by antioxidants

scientific article published on 01 September 1994

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

scientific article

Adaptor usage and Toll-like receptor signaling specificity

scientific article

Adding fuel to fire: microRNAs as a new class of mediators of inflammation.

scientific article

An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation

scientific article published on 20 February 2018

Annotating genes with potential roles in the immune system: six new members of the IL-1 family

scientific journal article

Application of disposable plastic microfluidic device arrays with customized chemistries to multiplexed biochemical assays

scientific article published in April 2002

Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?

scientific article published on 18 March 2008

Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes

scientific article published in 2021

BCG-induced trained immunity: can it offer protection against COVID-19?

scientific article published on 11 May 2020

Bacteria fight back against Toll-like receptors

scientific article published on 01 April 2008

Biochemical regulation of the inflammasome

scientific article published on 11 June 2012

Biochemistry: succinate strikes.

scientific article

Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures

scientific article published on 23 February 2011

Boosting the brain's ability to block inflammation via microRNA-132.

scientific article published in December 2009

Both TLR2 and TRIF contribute to interferon-β production during Listeria infection

scientific article

Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling?

scientific article published on March 2004

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

scientific article published on 30 April 2003

Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide

scientific article

Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin

scientific article

Building an immune system from nine domains.

scientific article published on December 2007

Building unique bonds to fight misplaced DNA

scientific article published on 18 June 2013

Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus virulence

scientific article

Cardiolipin and the Nlrp3 inflammasome.

scientific article

Caspase-11 promotes allergic airway inflammation

scientific article published on 26 February 2020

Caspase-4: A Therapeutic Target for Peptic Ulcer Disease

scientific article published on 12 October 2020

Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction.

scientific article

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

article published in the Proceedings of the National Academy of Sciences of the United States of America

Circadian clock proteins and immunity

scientific article published on February 2014

Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1.

scientific article published on 20 May 2015

Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14.

scientific article published on 15 August 2012

Correction: The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes

scientific article (publication date: 27 February 2013)

Correction: The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes

scientific article (publication date: 9 July 2013)

Counter-regulation in the IKK family.

scientific article

Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL.

scientific article

Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication

scientific article

Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production

scientific article

Cytokine release inhibitor drug, CRID3, inhibits the NLRP3 inflammasome in glia

Cytokine-like Roles for Metabolites in Immunity

scientific article published on 22 April 2020

DNA makes RNA makes innate immunity

scientific article published in August 2009

Daily variation in macrophage phagocytosis is clock-independent and dispensable for cytokine production

scientific article published on 16 April 2019

Depolarising levels of KCl inhibit endothelin-1-mediated release of arachidonic acid in rat C6 glioma cells ⬇️

scientific article published on May 1, 1995

Detecting microRNA activity from gene expression data

scientific article

Dimethyl fumarate: targeting glycolysis to treat MS

scientific article published on 01 June 2018

DisSARMing Toll-like receptor signaling

scientific article published on 01 October 2006

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

scientific article published on 02 March 2011

Distinct mechanisms for induction and tolerance regulate the immediate early genes encoding interleukin 1β and tumor necrosis factor α.

scientific article

Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1

scientific article published on 01 March 2000

Diversity and regulation in the NF-kappaB system

scientific article published on 11 June 2007

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy.

scientific article

Endothelin antagonism: physiology or pharmacology?

scientific article published in June 2002

Erratum: IL-1 family nomenclature

scholarly article by Charles A. Dinarello et al published March 2011 in Nature Immunology

Evidence against a role for NLRP3-driven islet inflammation in db/db mice.

scientific article published on 7 February 2018

Evidence for a redox-sensitive protein tyrosine kinase in nuclear factor kappa B activation and interleukin 2 production in EL4.NOB1 cells

scientific article published on November 1993

Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock

scholarly article

GOTcha: lncRNA-ACOD1 targets metabolism during viral infection.

scientific article

GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway.

scientific article published on 23 April 2015

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.

scientific article published on 19 December 2017

Genetic variation in Toll-like receptor signalling and the risk of inflammatory and immune diseases.

scientific article published on 11 February 2009

Genetic variation in Toll-like receptors and disease susceptibility

scientific article

Genetic variation of innate immune genes in HIV-infected african patients with or without oropharyngeal candidiasis.

scientific article

Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation

scientific article published on 20 March 2008

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

scientific article published on 16 November 2016

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation

scientific article published on 01 October 2019

Glutathione and Glutathione Transferase Omega 1 as Key Posttranslational Regulators in Macrophages.

scientific article published on January 2017

Glutathione transferase omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages

scientific article

Glycolytic reprogramming by TLRs in dendritic cells

scientific article published on 01 April 2014

Gob genes, mucus and asthma.

scientific article published in July 2001

HIF1α and metabolic reprogramming in inflammation.

scientific article published on 29 August 2016

Hartmann's solution and Ringer's lactate: targeting the fourth space.

scientific article published in January 2003

High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity

scientific article published in September 2003

How Low Cholesterol Is Good for Anti-viral Immunity

scientific article published on December 2015

How NOD-ing off leads to Crohn disease

scientific article published on 01 August 2004

How Toll-like receptors signal: what we know and what we don't know

scientific article

How important are Toll-like receptors for antimicrobial responses?

scientific article published on 23 May 2007

How metabolism generates signals during innate immunity and inflammation.

scientific article published on 24 June 2013

How should we talk about metabolism?

scientific article published on 14 May 2020

Human tribbles, a protein family controlling mitogen-activated protein kinase cascades

scientific article

IL-1 family nomenclature

scientific article

IL-10 inhibits miR-155 induction by toll-like receptors

scientific article

IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8

scientific article published on 18 February 2008

IRAK-4: a new drug target in inflammation, sepsis, and autoimmunity

scientific article published in July 2002

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).

scientific article published on 16 April 2010

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).

scientific article published on November 2016

IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65

scientific article published on 26 September 2006

Immunity's early-warning system

scientific article published on 01 January 2005

Immunology. After the toll rush

scientific article published in March 2004

Immunology. How frustration leads to inflammation

scientific article published on 01 May 2008

Immunology. Sensing the dark side of DNA.

scientific article published in February 2013

Immunometabolism and the land of milk and honey.

scientific article

Immunometabolism governs dendritic cell and macrophage function

scientific article

Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-Curie innovative training network

scientific article published on 27 July 2020

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

scientific article published on 01 October 2018

Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs.

scientific article published on 06 September 2007

Inflammasomes in the lung.

scientific article published on 24 January 2017

Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice

scientific article published on 21 September 2020

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.

scientific article published on 18 December 2016

Inhibition of NF kappa B activity by oxidative processes in intact cells mechanism of action of pyrolidine dithiocarbamate and diamide

scientific article published on February 1996

Inhibition of nuclear factor kappaB by direct modification in whole cells--mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers

scientific article published in April 1998

Inhibition of tissue factor activity reduces the density of cellular network formation in an in vitro model of angiogenesis

scientific article published in April 2002

Innate immune memory: a paradigm shift in understanding host defense.

scientific article published in June 2015

Innate immunity and Toll-like receptors

scientific article published on 13 September 2004

Innate immunity: squelching anti-viral signalling with NLRX1.

scientific article

Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa.

scientific article published on 13 October 2003

Interleukin-1 activates transcription factor NF kappa B in glial cells

scientific article published on September 1993

Interleukin-1 and phorbol myristate acetate modulate the peripheral-type benzodiazepine receptor in lymphocytes and glial cells

scientific article published on September 1993

Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction

scientific article published on 30 August 2014

Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt.

scientific article

Irish say no to Nice but yes to immunology

scientific article published on 01 August 2001

Is circulating nitrite a directly acting vasodilator?

article published in 2002

Is there a novel brain interleukin 1 receptor that signals ischaemic brain damage?

scientific article published in March 2002

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

scientific article published on 28 March 2018

Itaconate: the poster child of metabolic reprogramming in macrophage function

scientific article published on 01 May 2019

Krebs Cycle Reborn in Macrophage Immunometabolism

scientific article published on 27 January 2020

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

scientific article published on 01 August 2018

Krebs cycle rewired for macrophage and dendritic cell effector functions.

scientific article

LPS induces the degradation of programmed cell death protein 4 (PDCD4) to release Twist2, activating c-Maf transcription to promote interleukin-10 production

scientific article

Lipid peroxidation is involved in the activation of NF-kappaB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304. Lack of involvement of H2O2 in NF-kappaB activation by either cytokine in both primary and transf

scientific article published on October 1997

Listeria monocytogenes infection in the face of innate immunity.

scientific article published on 02 February 2009

Localisation and trafficking of Toll-like receptors: an important mode of regulation.

scientific article published on 07 January 2010

Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis

scientific article published on 01 June 2018

Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease.

scientific article published on 12 December 2017

Low pH and Helicobacter pylori increase nuclear factor kappa B binding in gastric epithelial cells: a common pathway for epithelial cell injury?

scientific article published on 01 October 2005

Macrophage Immunometabolism: Where Are We (Going)?

scientific article published on 07 April 2017

Macrophages Remember Cheeseburgers and Promote Inflammation via NLRP3.

scientific article published on 23 February 2018

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

scientific article

Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors

scientific article

Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4.

scientific article published on 9 July 2004

Mal mediates TLR-induced activation of CREB and expression of IL-10.

scientific article published on 11 March 2011

Mal, more than a bridge to MyD88.

scientific article published on September 2013

Malonylation of GAPDH is an inflammatory signal in macrophages

scientific article published in Nature Communications

Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components

scientific article published on 15 May 2007

Mechanism of NF kappa B activation by interleukin-1 and tumour necrosis factor in endothelial cells

scientific article published on February 1996

Metabolic regulation of NLRP3.

scientific article published in January 2018

Metabolic reprograming in macrophage polarization.

scientific article

Metabolism of inflammation limited by AMPK and pseudo-starvation

scientific article published on January 2013

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages.

scientific article published on 7 July 2015

MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection

scientific article published on 23 May 2017

MicroRNAs and the resolution phase of inflammation in macrophages

scientific article

MicroRNAs: the fine-tuners of Toll-like receptor signalling

scientific article published on 18 February 2011

Mitochondria are the powerhouses of immunity.

scientific article

Modification of Proteins by Metabolites in Immunity

scientific article published on 17 November 2020

Modulation of toll-like receptor signalling as a new therapeutic principle

scientific article published on January 2010

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments

scientific article

Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity.

scientific article published on 27 January 2015

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction

scientific article published on 26 January 2006

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction

scientific article published on December 2016

MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C.

scientific article published on 24 April 2013

MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice

scientific article published on 06 March 2014

MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.

scientific article published on 28 August 2009

MyD88 is an essential component of retinoic acid-induced differentiation in human pluripotent embryonal carcinoma cells

scientific article published on 8 September 2017

Mycobacterial PIMs inhibit host inflammatory responses through CD14-dependent and CD14-independent mechanisms

scientific article

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.

scientific article published on 9 May 2017

Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody

scientific article published on 21 December 2009

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

scholarly article

NLRP3 and IL-1β in macrophages as critical regulators of metabolic diseases

scientific article published on September 2013

NLRP3 at the interface of metabolism and inflammation.

scientific article published on May 2015

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

scientific article

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

scientific journal article

Negative regulation of toll-like receptor-mediated immune responses

scientific article (publication date: June 2005)

New developments in Toll-like receptor targeted therapeutics.

scientific article published on 28 June 2012

New insights into the post-translational modification of Toll-like receptor signaling molecules

scientific article

New insights into the regulation of TLR signaling.

scientific article

New insights into the regulation of signalling by toll-like receptors and nod-like receptors.

scientific article published on 27 May 2010

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

scientific article published in Nature Communications

Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15

scientific article published on 19 July 2013

Outfoxing Foxo1 with miR-182 ⬇️

scientific article published on 01 November 2010

Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.

scientific article

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

scientific article published on 21 November 2019

Plant science. Innate immunity in plants goes to the PUB.

scientific article

Pre-eclampsia and the microcirculation: a novel explanation

scientific article published in April 2003

Preface

Primer: Toll-like receptor signaling pathways--what do rheumatologists need to know?

scientific article published on 29 April 2008

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation

scientific article

Protective role for caspase-11 during acute experimental murine colitis

scientific article

Pseudomonas Persists by Feeding off Itaconate

scientific article published on 01 June 2020

Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors.

scientific article published on 13 October 2017

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.

scientific article published on 3 February 2015

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages

scientific article published on January 2015

Questions and controversies in innate immune research: what is the physiological role of NLRP3?

scientific article

RAB39a binds caspase-1 and is required for caspase-1-dependent interleukin-1β secretion.

scientific article published on November 2016

Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion

scientific article published on 15 October 2009

Rac1 regulates interleukin 1-induced nuclear factor kappaB activation in an inhibitory protein kappaBalpha-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression

scientific article

Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1

scientific article (publication date: 8 March 2002)

Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells

scientific article published on 01 February 2000

Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins.

scientific article published on 29 July 2009

Regulation of signaling by non-degradative ubiquitination.

scientific article published on 13 November 2008

Regulators of TLR4 signaling by endotoxins.

scientific article published on January 2010

Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal

scientific article

Resolution of inflammation: state of the art, definitions and terms

scientific article

Retrospective. Jürg Tschopp (1951-2011).

scientific article

Rocking the world of innate immunity: an interview with Luke O'Neill

scientific article published on 29 November 2018

Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma.

scientific article published on 02 March 2017

SIGIRR puts the brakes on Toll-like receptors

scientific article published on 01 September 2003

ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance

scientific article

Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1

scientific journal article

Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1.

scientific article published on November 2016

Sensing and signaling in antiviral innate immunity

scientific article published on April 2010

Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4

scientific article

Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily

scientific article

Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase

scientific article

Signalling adaptors used by Toll-like receptors: an update.

scientific article published on 15 August 2008

Signalling of toll-like receptors.

scientific article published on January 2008

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.

scientific article published on 24 July 2017

Spatial Properties of Reactive Oxygen Species Govern Pathogen-Specific Immune System Responses

scientific article published on 06 March 2020

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

scientific article

Specificity in the innate response: pathogen recognition by Toll-like receptor combinations

scientific article published on 01 February 2001

Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β

scientific article published on 29 April 2019

Spotlight on new anti-inflammatory drug targets in the immune system

scientific article published on 01 August 2003

Spurs in the hunt for new immunomodulatory drug targets.

scientific article

Stopping sepsis by targeting sphingosine kinase 1.

scientific article published in June 2010

Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

scientific article

Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins

scientific article published on 31 July 2007

Studies into the mechanism of NF kappa B activation by IL1, TNF and H2O2 in primary and transformed endothelial cells

scientific article published on February 1997

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

scientific article published on 21 September 2016

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

scientific article

Succinate: a metabolic signal in inflammation

scientific article

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

scientific article published on 15 January 2006

Synergism between NOD-like receptors and Toll-like receptors in human B lymphocytes

scientific article published on 01 February 2011

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.

scientific article

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway

scientific article

TAMpering with toll-like receptor signaling.

scientific article

TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB

scientific article

TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-κB.

scientific article published in June 2010

TIRAP Ser180Leu polymorphism is associated with Behcet's disease

scientific article published on 24 June 2011

TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia

scientific article published on 27 April 2012

TLRs play good cop, bad cop in the lung

scientific article published on 01 November 2005

TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity

scientific article published in August 2006

TLRs: Professor Mechnikov, sit on your hat.

scientific article

TRIL is involved in cytokine production in the brain following Escherichia coli infection.

scientific article

TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain

scientific article

Targeting Toll-like receptors: emerging therapeutics?

scientific article published on April 2010

Targeting immunometabolism as an anti-inflammatory strategy

scientific article published on 04 March 2020

Targeting macrophage immunometabolism to prevent atherosclerosis

scientific article published on 01 December 2019

Targeting signal transduction as a strategy to treat inflammatory diseases.

scientific article published on 9 June 2006

The Cellular and Molecular Basis of Translational Immunometabolism.

scientific article published on September 2015

The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling.

scientific article published on 14 January 2013

The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation

scientific article

The Hunger Games: Salmonella, Anorexia, and NLRP3.

scientific article published on February 2017

The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense

scientific article published on 01 May 2000

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

scientific article published on 04 August 2020

The Immunomodulatory Potential of the Metabolite Itaconate

scientific article published on 06 June 2019

The Induction of Pro-IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production.

scientific article published on 15 March 2017

The Inflammasome in Atherosclerosis and Type 2 Diabetes

scientific article published on 01 May 2011

The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to, or severity of, rheumatoid arthritis

scientific article published on 07 January 2008

The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer

scientific article

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype ⬇️

scientific article published on 13 October 2016

The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome.

scientific article

The Role of HIF in Immunity and Inflammation

scientific article published on 19 August 2020

The Toll-IL-1 receptor adaptor family grows to five members.

scientific article

The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling.

scientific article published on 20 April 2007

The Warburg effect then and now: from cancer to inflammatory diseases

scientific article published on 20 September 2013

The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibitory effect of IL-1 beta on long term potentiation. A role for JNK.

scientific article

The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma.

scientific article published on 23 March 2017

The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes

scientific article

The effects of the bacterial endotoxin lipopolysaccharide on synaptic transmission and plasticity in the CA1-subiculum pathway in vivo

scientific article published in January 2001

The effects of thiol modifiers on the activation of NF kappa B by interleukin-1.

scientific article published on November 1993

The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3.

scientific article published on 06 May 2011

The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction

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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

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The history of Toll-like receptors - redefining innate immunity.

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The human endothelial cell line ECY304 as a model of endothelial cell activation by interleukin-1.

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The impact of childhood obesity on inflammation, innate immune cell frequency, and metabolic microRNA expression

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The interferon in TLR signaling: more than just antiviral

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The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.

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The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products

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The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense

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The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense.

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The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome

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The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory

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The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

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The next decade of metabolism

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The potential of targeting Toll-like receptor 2 in autoimmune and inflammatory diseases.

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The powerstroke and camshaft of the RIG-I antiviral RNA detection machine

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The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense

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The production of a reactive oxygen intermediate during the induction of apoptosis by cytotoxic insult.

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The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10

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The role of MyD88-like adapters in Toll-like receptor signal transduction

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The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis.

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The role of microRNAs in the control and mechanism of action of IL-10.

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The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence

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The role of toll-like receptors in macrophages.

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The serine protease inhibitor antithrombin III inhibits LPS-mediated NF-kappaB activation by TLR-4.

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Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer.

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Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases.

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Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL).

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Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal?

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Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclin-dependent kinase 6.

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Toll-like receptors and NOD-like receptors in rheumatic diseases

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Toll-like receptors and chronic inflammation in rheumatic diseases: new developments

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Toll-like receptors in the spotlight

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Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity

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Toll-like receptors: key activators of leucocytes and regulator of haematopoiesis.

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Toll-like receptors: methods and protocols.Preface

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Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells.

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Trained immunity, tolerance, priming and differentiation: distinct immunological processes

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Trained immunity: A program of innate immune memory in health and disease.

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Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1

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Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene

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Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs

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Tribbles 3: a novel regulator of TLR2-mediated signaling in response to Helicobacter pylori lipopolysaccharide

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Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling

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Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.

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Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance

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Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

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Urotensin II: a new player in vascular and myocardial disease?

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Using immunotherapy to treat rheumatic diseases

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Vaccine safety concerns

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Vitamin C inhibits NF kappa B activation in endothelial cells

scientific article published on February 1997

Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase.

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Wanted: a molecular basis for specificity in toll-like receptor signal transduction.

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What the Myddosome structure tells us about the initiation of innate immunity

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When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction

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mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

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miR-107: a toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes

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miR-223: infection, inflammation and cancer

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miRNAs That Shape the Innate Immune System: Regulation through Toll-Like Receptor Signaling

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