List of works - Luke A. J. O'Neill

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

scientific article (publication date: May 2007)

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

scientific article

Negative regulation of toll-like receptor-mediated immune responses

scientific article (publication date: June 2005)

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

scientific article

The history of Toll-like receptors - redefining innate immunity.

scientific article published on 17 May 2013

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

scientific article

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

scientific journal article

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

scientific article

Resolution of inflammation: state of the art, definitions and terms

scientific article

Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4

scientific article

Metabolism of inflammation limited by AMPK and pseudo-starvation

scientific article published on January 2013

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

scientific article

MicroRNAs: the fine-tuners of Toll-like receptor signalling

scientific article published on 18 February 2011

Trained immunity: A program of innate immune memory in health and disease.

scientific article

A guide to immunometabolism for immunologists.

scientific article

A long noncoding RNA mediates both activation and repression of immune response genes

scientific journal article

Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.

scientific article

Immunometabolism governs dendritic cell and macrophage function

scientific article

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

scientific article published on 21 September 2016

Targeting Toll-like receptors: emerging therapeutics?

scientific article published on April 2010

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.

scientific article published on December 2008

TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity

scientific article published in August 2006

How Toll-like receptors signal: what we know and what we don't know

scientific article

Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity

scientific article

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

scientific journal article

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

scientific article published on 15 January 2006

ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance

scientific article

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.

scientific article published on August 2000

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages

scientific article published on January 2015

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

scholarly article

The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense

scientific article published on 25 February 2003

The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense

scientific article

Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer.

scientific article published on 27 May 2009

Metabolic Reprograming in Macrophage Polarization

scientific article published on September 2, 2014

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

scientific article

A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?

scientific article published on 19 March 2012

The Toll-IL-1 receptor adaptor family grows to five members.

scientific article

Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production

scientific article

When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction

scientific article published on July 2008

Circadian clock proteins and immunity

scientific article published on February 2014

Genetic variation in Toll-like receptors and disease susceptibility

scientific article

miR‐223: infection, inflammation and cancer

scientific article published on June 25, 2013

The Warburg effect then and now: from cancer to inflammatory diseases

scientific article published on 20 September 2013

Signalling adaptors used by Toll-like receptors: an update.

scientific article published on 15 August 2008

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

scientific article published on 28 March 2018

Human tribbles, a protein family controlling mitogen-activated protein kinase cascades

scientific article

Succinate: a metabolic signal in inflammation

scientific article

Localisation and trafficking of Toll-like receptors: an important mode of regulation.

scientific article published on 07 January 2010

A trio of microRNAs that control Toll-like receptor signalling

scientific article

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

scientific article published on 30 April 2003

List of works by Luke A. J. O'Neill

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

Negative regulation of toll-like receptor-mediated immune responses

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

The history of Toll-like receptors - redefining innate immunity.

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Resolution of inflammation: state of the art, definitions and terms

Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4

Metabolism of inflammation limited by AMPK and pseudo-starvation

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

MicroRNAs: the fine-tuners of Toll-like receptor signalling

Trained immunity: A program of innate immune memory in health and disease.

A guide to immunometabolism for immunologists.

A long noncoding RNA mediates both activation and repression of immune response genes

Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.

Immunometabolism governs dendritic cell and macrophage function

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Targeting Toll-like receptors: emerging therapeutics?

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.

TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity

How Toll-like receptors signal: what we know and what we don't know

Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense

The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense

Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer.

Metabolic Reprograming in Macrophage Polarization

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?

The Toll-IL-1 receptor adaptor family grows to five members.

Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production

When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction

Circadian clock proteins and immunity

Genetic variation in Toll-like receptors and disease susceptibility

miR‐223: infection, inflammation and cancer

The Warburg effect then and now: from cancer to inflammatory diseases

Signalling adaptors used by Toll-like receptors: an update.

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Human tribbles, a protein family controlling mitogen-activated protein kinase cascades

Succinate: a metabolic signal in inflammation

Localisation and trafficking of Toll-like receptors: an important mode of regulation.

A trio of microRNAs that control Toll-like receptor signalling

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.