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List of works by Tasuku Honjo

A memoir of AID, which engraves antibody memory on DNA.

scientific article

A novel gene, Btcl1, encoding CUB and LDLa domains is expressed in restricted areas of mouse brain

scientific article published in July 2003

A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

scientific article published on December 2013

A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression

scientific article

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

scientific article published on June 2002

AID is required for c-myc/IgH chromosome translocations in vivo

scientific article

AID is required for germinal center-derived lymphomagenesis

scientific article published on 9 December 2007

AID mutant analyses indicate requirement for class-switch-specific cofactors

scientific article published on 10 August 2003

AID to overcome the limitations of genomic information

scientific article

AID to overcome the limitations of genomic information by introducing somatic DNA alterations

scientific article

AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements

scientific article

AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination

scientific article

AID: how does it aid antibody diversity?

scientific article published on June 2004

APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination

scientific article

Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut

scientific journal article

Absence of Programmed Death Receptor 1 Alters Thymic Development and Enhances Generation of CD4/CD8 Double-Negative TCR-Transgenic T Cells ⬇️

scientific article published on November 1, 2003

Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes

scientific article published on 13 September 2017

Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation ⬇️

scientific article published on April 22, 2013

Activation and differentiation of autoreactive B-1 cells by interleukin 10 induce autoimmune hemolytic anemia in Fas-deficient antierythrocyte immunoglobulin transgenic mice

scientific article

Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice

scholarly article

Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age

scientific article (publication date: 2011)

Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models

scientific article published on 25 February 2014

Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers

scientific article published on 18 July 2008

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

scientific article

Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation

scientific article published on February 2002

Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice

scientific article

An Evolutionary View of the Mechanism for Immune and Genome Diversity ⬇️

scientific article published on April 15, 2012

Antibodies to myelin oligodendrocyte glycoprotein are not involved in the severity of chronic non-remitting experimental autoimmune encephalomyelitis

scientific article published on 29 September 2008

Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice

scientific article published on May 7, 1992

Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells

scientific article

Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

scientific article

B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers

scientific article published on 06 December 2009

B1b lymphocytes confer T cell-independent long-lasting immunity

scientific article

C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion

scientific article published on 27 January 2014

CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid.

scientific article

Cancer immunotherapies targeting the PD-1 signaling pathway

scientific article published on 04 April 2017

Carboxy-terminal domain of AID required for its mRNA complex formation in vivo

scholarly article

Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development

scientific article published on March 2012

Chromatin reader Brd4 functions in Ig class switching as a repair complex adaptor of nonhomologous end-joining

scientific article

Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

scientific article

Circulation of gut-preactivated naïve CD8+ T cells enhances antitumor immunity in B cell-defective mice

scientific article published on 09 September 2020

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

scientific article (publication date: September 2000)

Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter

scientific article

Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II.

scholarly article

Combination therapy strategies for improving PD-1 blockade efficacy: a new era in cancer immunotherapy.

scientific article published on 26 October 2017

Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis

scientific article

Constitutive expression of AID leads to tumorigenesis

scientific article published on May 2003

Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora

scientific article published in November 2002

DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase

scientific article

DNA double-strand breaks: prior to but not sufficient in targeting hypermutation

scientific article published on May 2002

De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination

scholarly article

De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

scholarly article

Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation ⬇️

scientific article published on November 11, 2011

Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome

scientific article published in Nature

Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination

scientific article published on 10 November 2017

Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues

scientific article

Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase

scientific article published on 03 March 2014

Discovery of activation-induced cytidine deaminase, the engraver of antibody memory

scientific article published on January 2007

Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants

scholarly article

Does AID need another aid?

scientific article published in September 2002

Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10-deficient mice

scientific article published in February 2003

Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjögren's syndrome

scientific article

Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes

scientific article

Estrogen promotes differentiation and survival of dopaminergic neurons derived from human neural stem cells

scientific article published in February 2005

Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID.

scientific article

Evolutionary Comparison of the Mechanism of DNA Cleavage with Respect to Immune Diversity and Genomic Instability ⬇️

scientific article published on June 19, 2012

Expression of Btcl2, a novel member of Btcl gene family, during development of the central nervous system

scientific article published on October 2004

Expression of functional interleukin-2 receptors in human light chain/Tac ransgenic mice

scientific article published in Nature

Expression of lymphocyte surface IgE does not require switch recombination

scientific article published in Nature

FACT and H3.3: new markers for the somatic hypermutation

scientific article published on 23 August 2013

Fibulin-5/DANCE is essential for elastogenesis in vivo

scientific article (publication date: 10 January 2002)

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

scientific article

Functional assessment of self-renewal activity of male germline stem cells following cytotoxic damage and serial transplantation

scientific article published on 11 December 2002

Functional requirements of AID's higher order structures and their interaction with RNA-binding proteins

scientific article published on 29 February 2016

Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination.

scientific article

Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP.

scientific article

Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

scientific journal article

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation

scientific article

Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination ⬇️

scientific article published on December 7, 2010

Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice

scientific article published on 13 December 2005

IFN-α Directly Promotes Programmed Cell Death-1 Transcription and Limits the Duration of T Cell-Mediated Immunity ⬇️

scientific article published on January 24, 2011

Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase

scientific article published on 20 April 2015

Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice

scientific article published on 4 March 2009

Identification of a specific domain required for dimerization of activation-induced cytidine deaminase

retracted paper

Identification of a specific domain required for dimerization of activation-induced cytidine deaminase. VOLUME 281 (2006) PAGES 19115-19123

retraction notice

In Vivo Analysis of Aicda Gene Regulation: A Critical Balance between Upstream Enhancers and Intronic Silencers Governs Appropriate Expression ⬇️

scientific article published on April 16, 2013

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death ⬇️

scientific article published on November 1, 1992

Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child

scientific article published on 28 June 2021

Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas

scientific article published on 8 November 2005

Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells

scientific article

Intestinal IgA synthesis: regulation of front-line body defences

scientific article

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

scientific article

Involvement of fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila

scientific article

Japanese wild mouse, Mus musculus molossinus, has duplicated immunoglobulin γ2a genes ⬇️

scientific article published on July 1, 1982

Learning and memory deficits in Notch mutant mice.

scientific article

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.

scientific article published on 15 February 2008

Low-affinity IgM antibodies lacking somatic hypermutations are produced in the secondary response of C57BL/6 mice to (4-hydroxy-3-nitrophenyl)acetyl hapten

scientific article

Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior

scientific article

Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense ⬇️

scientific article published on January 23, 2011

Microanatomical localization of PD-1 in human tonsils

scientific article (publication date: October 2002)

Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity

scientific article published on 17 January 2017

Molecular mechanism for generation of antibody memory

scientific article published on March 2009

Molecular mechanism of class switch recombination: linkage with somatic hypermutation

scientific article

Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction

scientific article

Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling

scholarly article

Negative regulation of activation-induced cytidine deaminase in B cells

scholarly article

Neural precursor cells derived from human embryonic brain retain regional specificity

scientific article published in March 2004

New regulatory co-receptors: inducible co-stimulator and PD-1.

scientific article

Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes

scientific article published on 30 January 2012

Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model

scientific article published on 07 July 2016

Notch receptor cleavage depends on but is not directly executed by presenilins

scientific article

Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells

scientific journal article

Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells

scientific article published in February 2003

OC29 is preferentially expressed in the presumptive sensory organ region of the otocyst

scientific article

Obituary: Yasutomi Nishizuka (1932-2004)

scientific article

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.

scientific article

Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination

scientific article

Ordering of mouse immunoglobulin heavy chain genes by molecular cloning

scientific article published in Nature

Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression

scientific article

Organization of the constant-region gene family of the mouse immunoglobulin heavy chain

scientific article

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

scientific article

PD-1 and PD-1 ligands: from discovery to clinical application

scientific article published on 2 July 2007

PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells

scientific article

PD-1 deficiency results in the development of fatal myocarditis in MRL mice

article

PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice

scientific article

PD-1 inhibits antiviral immunity at the effector phase in the liver

scientific article

PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo

scientific article

PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2

scientific article (publication date: March 2002)

PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells

scientific article (publication date: February 2004)

Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy

scientific article

Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway

scientific article

Pillars Article: Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme. . 2000. 102: 553-563

Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches

scientific article published in March 2009

Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity

scientific article published on 05 March 2010

Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response

scientific article published on 16 September 2013

Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer

scientific article

RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis

scientific article

RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development

scientific article

RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase

scientific article published on 22 January 2013

RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase

scientific article published on 08 May 2020

RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells ⬇️

scientific article published on October 14, 2003

Recombination signal sequence-binding protein Jkappa alters mesodermal cell fate decisions by suppressing cardiomyogenesis

scientific article

Regulation of AID function in vivo

scientific article published on January 2007

Regulation of B cell development by Notch/RBP-J signaling

scientific article

Regulation of IgA synthesis at mucosal surfaces

scientific article published on June 2004

Regulation of Trypanosoma cruzi-induced myocarditis by programmed death cell receptor 1.

scientific article published on 28 February 2011

Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

scientific article

Regulation of lymphocyte development by Notch signaling

scientific article published on May 2007

Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway

scientific article published in February 2003

Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination

scientific article published on 6 November 2006

Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4.

scientific article

Role of AID in tumorigenesis

scientific article published on January 2007

Role of PD-1 in Immunity and Diseases

scientific article published on 20 September 2017

SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination

scientific article published on 08 June 2020

Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer

scientific article published on 8 September 2015

Science and government. In search of the best grant system

scientific article

Separate domains of AID are required for somatic hypermutation and class-switch recombination

scientific article published on 13 June 2004

Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function

scientific article

Stem cell-derived neural stem/progenitor cell supporting factor is an autocrine/paracrine survival factor for adult neural stem/progenitor cells

scientific journal article

T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions

scientific article

TRIM28 prevents autoinflammatory T cell development in vivo.

scientific article published on 29 April 2012

The AID dilemma: infection, or cancer?

scientific article published on January 2012

The AID enzyme induces class switch recombination in fibroblasts

scientific article published on 3 March 2002

The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination

scholarly article

The DSIF Subunits Spt4 and Spt5 Have Distinct Roles at Various Phases of Immunoglobulin Class Switch Recombination ⬇️

scientific article published on April 26, 2012

The PD-1-PD-L pathway in immunological tolerance

scientific article

The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

scientific article

The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy

scientific article

The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation ⬇️

scientific article published on July 26, 2012

The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells

scientific article published in June 2006

The programmed death-1 and interleukin-10 pathways play a down-modulatory role in LP-BM5 retrovirus-induced murine immunodeficiency syndrome

scientific article

Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma

scientific article published in April 2010

Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy

scientific article published on 03 March 2020

Two Opposing Roles of RBP-J in Notch Signaling ⬇️

scientific article published on January 1, 2010

Two distinctive pathways for recruitment of naive and primed IgM+ B cells to the gut lamina propria

scientific article

Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase

scientific article (publication date: March 2003)

Unmutated immunoglobulin M can protect mice from death by influenza virus infection

scientific article published on 9 June 2003

Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch

scientific article

X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells

scientific article

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