List of works - Jos Beijnen

"Effect of the drug transporters ABCB1, ABCC2, and ABCG2 on the disposition and brain accumulation of the taxane analog BMS-275,183".

scientific article

'Flooding' of the lungs and severe dyspnea in a patient with bronchoalveolar carcinoma

scientific article published on 01 March 2010

2',3'-dideoxyinosine (ddI): its chemical stability and cyclodextrin complexation in aqueous media

scientific article published on 01 June 1993

2-Hydroxypropyl-beta-cyclodextrin extracts 2-phenylphenol from silicone tubing

scientific article

32P-postlabeling assay for the quantification of the major platinum-DNA adducts

scientific article

A Phase 1 Dose-Escalation Study of Low-Dose Metronomic Treatment With Novel Oral Paclitaxel Formulations in Combination With Ritonavir in Patients With Advanced Solid Tumors

scientific article published on 05 October 2020

A Phase I Dose Escalation Study of Once-Weekly Oral Administration of Docetaxel as ModraDoc001 Capsule or ModraDoc006 Tablet in Combination with Ritonavir

scientific article published on 19 June 2019

A Phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors

scientific article published on 01 May 2004

A Phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent.

scientific article

A Population Pharmacokinetic Model of Oral Docetaxel Coadministered With Ritonavir to Support Early Clinical Development

scientific article published on 09 October 2019

A Semi-Mechanistic Population Pharmacokinetic/Pharmacodynamic Model of Bortezomib in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

scientific article published on 01 February 2020

A bead-based multiplexed immunoassay to evaluate breast cancer biomarkers for early detection in pre-diagnostic serum.

scientific article published on 22 October 2012

A comparison of limited sampling strategies for prediction of Ecteinascidin 743 clearance when administered as a 24-h infusion

scientific article published on December 2001

A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy

scientific article published on 11 December 2018

A cost analysis study of the implementation of fixed-dosing of monoclonal antibodies in the Netherlands Cancer Institute

scientific article published on 10 September 2020

A dose-dependent delayed hypersensitivity reaction to acetaminophen after repeated acetaminophen intoxications ⬇️

scientific article published on 01 July 1998

A dose-escalation study of bi-daily once weekly oral docetaxel either as ModraDoc001 or ModraDoc006 combined with ritonavir

scientific article published on 11 October 2017

A dose-escalation study of indisulam in combination with capecitabine (Xeloda) in patients with solid tumours

scientific article published on 15 April 2008

A kinetic study of the chemical stability of the antimetastatic ruthenium complex NAMI-A.

scientific article published in November 2002

A less sensitive detector does not necessarily result in a less sensitive method: fast quantification of 13 antiretroviral analytes in plasma with liquid chromatography coupled with tandem mass spectrometry

scientific article published in August 2010

A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide

scientific article published in June 2001

A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080

scientific article

A more sensitive MS detector does not obviously lead to a more sensitive assay: experiences with ES-285.

scientific article

A multi-gram-scale stereoselective synthesis of Z -endoxifen

scholarly article by Lech-Gustav Milroy published in May 2018

A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma

scientific article

A novel self-microemulsifying formulation of paclitaxel for oral administration to patients with advanced cancer

scientific article published on 22 August 2006

A phase 0 clinical trial of novel candidate extended-release formulations of capecitabine

scientific article

A phase 1 comparative pharmacokinetic and cardiac safety study of two intravenous formulations of CO-101 in patients with advanced solid tumors

scientific article published on 18 June 2013

A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin

scientific article published on September 2002

A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies

scientific article published in January 2002

A phase I study of E7080, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumours ⬇️

scientific article published on April 19, 2012

A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors

scientific article published on 01 December 2002

A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients

scientific article published on 01 June 2007

A poor-quality generic drug for the treatment of visceral leishmaniasis: a case report and appeal

scientific article

A population pharmacokinetic model for Cremophor EL using nonlinear mixed-effect modeling: model building and validation.

scientific article

A population pharmacokinetic model for paclitaxel in the presence of a novel P-gp modulator, Zosuquidar Trihydrochloride (LY335979)

scientific article published in July 2003

A prospective case series of women with estrogen receptor-positive breast cancer: levels of tamoxifen metabolites in controlled ovarian stimulation with high-dose tamoxifen ⬇️

scientific article published on January 18, 2013

A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer

scientific article published on October 2004

A rapid and simple HPLC-UV method for the determination of inhibition characteristics of farnesyl transferase inhibitors

scientific article published in February 2006

A review of the bioanalytical methods for the quantitative determination of capecitabine and its metabolites in biological matrices

scientific article published on 01 January 2020

A semi-physiological population pharmacokinetic model describing the non-linear disposition of indisulam

scientific article published in September 2006

A sensitive LC-MS/MS method for the quantitative analysis of the Echinacea purpurea constituent undeca-2-ene-8,10-diynoic acid isobutylamide in human plasma

scientific article published on 12 November 2010

A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry

scientific article published on 10 May 2008

A sensitive combined assay for the quantification of paclitaxel, docetaxel and ritonavir in human plasma using liquid chromatography coupled with tandem mass spectrometry

scientific article published on 31 August 2011

A simple and safe method for 131I radiolabeling of rituximab for myeloablative high-dose radioimmunotherapy

scientific article published in February 2009

A simple and sensitive assay for the quantitative analysis of paclitaxel and metabolites in human plasma using liquid chromatography/tandem mass spectrometry

scientific article published in January 2006

A simple and sensitive assay for the quantitative analysis of rivastigmine and its metabolite NAP 226-90 in human EDTA plasma using coupled liquid chromatography and tandem mass spectrometry

scientific article published on 01 January 2006

A systematic study on the chemical stability of mitomycin A and mitomycin B

scientific article published on 01 July 1986

A validated assay for the quantitative analysis of vatalanib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry

scientific article published on 6 September 2009

ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation

scientific article published on 30 January 2019

ABCB1 Attenuates the Brain Penetration of the PARP Inhibitor AZD2461

scientific article published on 05 October 2018

ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-Inhibitors.

scientific article

ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients

scientific article

ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy

scientific article published on 19 March 2014

ABCC2, ABCC3, and ABCB1, but not CYP3A, Protect against Trabectedin-Mediated Hepatotoxicity

scientific article

ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors

scientific article published on 17 November 2017

Abcc4 Together with Abcb1 and Abcg2 Form a Robust Cooperative Drug Efflux System That Restricts the Brain Entry of Camptothecin Analogues ⬇️

scientific article published on March 5, 2013

Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents

scientific article published on August 2010

Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity

scientific article published on 17 November 2009

Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry

scientific article published on 20 March 2006

Accuracy, feasibility, and clinical impact of prospective Bayesian pharmacokinetically guided dosing of cyclophosphamide, thiotepa, and carboplatin in high-dose chemotherapy

scientific article published in January 2005

Acute poisoning after oral intake of a toluene-containing paint thinner

scientific article published on 16 April 2002

Age-Associated Hematological Toxicity in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Docetaxel in Clinical Practice

scientific article published on 01 April 2019

Allometric scaling of pegylated liposomal anticancer drugs ⬇️

scientific article published on August 24, 2011

Altered cyclophosphamide and thiotepa pharmacokinetics in a patient with moderate renal insufficiency

scientific article published on 23 April 2008

Amyloid beta protein and tau in cerebrospinal fluid and plasma as biomarkers for dementia: a review of recent literature

scientific article published on May 2008

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential.

scientific article

An Antiestrogenic Activity Score for tamoxifen and its metabolites is associated with breast cancer outcome.

scientific article published on 22 December 2016

An Integrated Pharmacokinetic Model for the Influence of CYP3A4 Expression on the In Vivo Disposition of Lopinavir and Its Modulation by Ritonavir ⬇️

scientific article published on December 29, 2010

An LC-MS/MS method for quantification of the active abiraterone metabolite Δ(4)-abiraterone (D4A) in human plasma

scientific article

An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patients

scientific article published in September 2002

An overview of the relations between polymorphisms in drug metabolising enzymes and drug transporters and survival after cancer drug treatment

scientific article published on 03 September 2008

Analysis of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and Its Phase I and Phase II Metabolites in Mouse Urine Using LC–UV–MS–MS

Analysis of Ecteinascidin 743, a new potent marine-derived anticancer drug, in human plasma by high-performance liquid chromatography in combination with solid-phase extraction ⬇️

scientific article published on June 12, 1998

Analysis of diacetylmorphine, caffeine, and degradation products after volatilization of pharmaceutical heroin for inhalation

scientific article published on 01 January 2006

Analysis of ifosforamide mustard, the active metabolite of ifosfamide, in plasma

scientific article published on 01 November 1996

Analytical procedure for the determination of the new antitumour drug N-benzoylstaurosporine and three potential metabolites in human plasma by reversed-phase high-performance liquid chromatography ⬇️

scientific article published on May 19, 1995

Antidrug Antibody Formation in Oncology: Clinical Relevance and Challenges

scientific article

Antiviral activity of HIV type 1 protease inhibitors nelfinavir and indinavir in vivo is not influenced by P-glycoprotein activity on CD4+ T cells.

scientific article published in January 2007

Application of PET/CT in the development of novel anticancer drugs

scientific article published on January 2008

Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D.

scientific article published on 24 April 2009

Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820.

scientific article published on 20 August 2008

Approaching tumour therapy beyond platinum drugs: status of the art and perspectives of ruthenium drug candidates

scientific article

Aprepitant inhibits cyclophosphamide bioactivation and thiotepa metabolism

scientific article

Are adverse events of nevirapine and efavirenz related to plasma concentrations?

scientific article published in January 2005

Assessing safety and efficacy of directed P-glycoprotein inhibition to improve the pharmacokinetic properties of saquinavir coadministered with ritonavir

scientific article published in February 2003

Assessment of performance of manufacturing procedures in a unit for production of investigational anticancer agents, using a mixed effects analysis

scientific article published on March 2007

Automated synthesis and quality control of [99mTc]Tc-PSMA for radioguided surgery (in a [68Ga]Ga-PSMA workflow)

scientific article published on 01 May 2020

BRAF Mutations as Predictive Biomarker for Response to Anti-EGFR Monoclonal Antibodies

scientific article published on 2 June 2017

Baclofen overdose treated with continuous venovenous hemofiltration

scientific article published on 9 January 2015

Bayesian pharmacokinetically guided dosing of paclitaxel in patients with non-small cell lung cancer.

scientific article published in April 2004

Bayesian pharmacokinetics of lithium after an acute self-intoxication and subsequent haemodialysis: a case report

scientific article published in May 2002

Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.

scientific article

Bevacizumab

scientific article published on 5 August 2010

Bevacizumab combined with docetaxel, oxaliplatin, and capecitabine, followed by maintenance with capecitabine and bevacizumab, as first-line treatment of patients with advanced HER2-negative gastric cancer: A multicenter phase 2 study

scientific article published on 11 March 2016

Bio-analysis and preliminary pharmacokinetics of the experimental antitumour drug LL-D49194 alpha 1

scientific article published on 01 January 1989

Bio-analysis of N-(deacetyl-O-4-vinblastoyl-23)-L-ethyl isoleucinate, methane sulphonate (VileE) by high-performance liquid chromatography with fluorescence detection

scientific article published on 01 January 1990

Bio-analysis of docetaxel and hydroxylated metabolites in human plasma by high-performance liquid chromatography and automated solid-phase extraction ⬇️

scientific article published on August 15, 1997

Bio-analysis of vinorelbine by high-performance liquid chromatography with fluorescence detection

scientific article published on 01 January 1992

Bioanalysis of EGFRm inhibitor osimertinib, and its glutathione cycle- and desmethyl metabolites by liquid chromatography-tandem mass spectrometry

scientific article published on 10 September 2019

Bioanalysis of aplidine, a new marine antitumoral depsipeptide, in plasma by high-performance liquid chromatography after derivatization with trans-4-hydrazino-2-stilbazole

scientific article

Bioanalysis of ibrutinib, and its dihydrodiol- and glutathione cycle metabolites by liquid chromatography-tandem mass spectrometry

scientific article published on 11 May 2018

Bioanalysis of m-iodobenzylguanidine in plasma by high-performance liquid chromatography after derivatization with benzoin

scientific article published on 01 July 1999

Bioanalysis of the investigational anti-tumour drug 5,10-dideaza-5,6,7,8-tetrahydrofolic acid by high-performance liquid chromatography with ultraviolet detection

scientific article published on April 15, 1992

Bioanalysis of the novel peptide anticancer drug kahalalide F in human plasma by h.p.l.c. under basic conditions coupled with positive turbo-ionspray tandem mass spectrometry.

scientific article

Bioanalysis of thiocoraline, a new marine antitumoral depsipeptide, in plasma by high-performance liquid chromatography and fluorescence detection

scientific article published on 01 April 1999

Bioanalytical Aspects of Clinical Mass Balance Studies in Oncology ⬇️

scientific article published on December 1, 2011

Bioanalytical Issues in Patient-Friendly Sampling Methods for Therapeutic Drug Monitoring: Focus on Antiretroviral Drugs ⬇️

scientific article published on October 1, 2009

Bioanalytical LC-MS/MS validation of therapeutic drug monitoring assays in oncology

scientific article published on 27 November 2019

Bioanalytical assay for the new-generation ROS1/TRK/ALK inhibitor repotrectinib in mouse plasma and tissue homogenate using liquid chromatography-tandem mass spectrometry

scientific article published on 01 April 2020

Bioanalytical assay for the novel TRK inhibitor selitrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry

scientific article published on 27 May 2019

Bioanalytical assay for the quantification of the ALK inhibitor lorlatinib in mouse plasma using liquid chromatography-tandem mass spectrometry.

scientific article

Bioanalytical liquid chromatography-tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenates

scientific article published on 19 August 2018

Bioanalytical method for the simultaneous quantification of irinotecan and its active metabolite SN-38 in mouse plasma and tissue homogenates using HPLC-fluorescence

scientific article published on 19 May 2020

Bioanalytical methods for determination of tamoxifen and its phase I metabolites: A review ⬇️

scientific article published on October 15, 2010

Bioanalytical methods for the quantification of therapeutic monoclonal antibodies and their application in clinical pharmacokinetic studies

scientific article published on January 2009

Bioavailability of oral etoposide in gastric cancer

scientific article published on 01 January 1994

Biodetermination of N-(deacetyl-O-4-vinblastoyl-23)-L-tryptophan, a metabolite of vintriptol, by high-performance liquid chromatography with fluorescence detection

scientific article published on 01 February 1992

Bioequivalence of Liposome-Entrapped Paclitaxel Easy-To-Use (LEP-ETU) formulation and paclitaxel in polyethoxylated castor oil: a randomized, two-period crossover study in patients with advanced cancer.

scientific article

Biotransformation profiling of [(14)C]ixabepilone in human plasma, urine and feces samples using accelerator mass spectrometry (AMS).

scientific article published in January 2009

Blood-brain barrier and chemotherapeutic treatment of brain tumors

scientific article published on August 2006

Bottom-up sample preparation for the LC-MS/MS quantification of anti-cancer monoclonal antibodies in bio matrices

scientific article published on 25 September 2020

Brain Accumulation of Ponatinib and Its Active Metabolite, N-Desmethyl Ponatinib, Is Limited by P-Glycoprotein (P-GP/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2).

scientific article

Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment

scientific article published on 10 March 2009

Brain accumulation of osimertinib and its active metabolite AZ5104 is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein)

scientific article published on 05 June 2019

Brain accumulation of sunitinib is restricted by P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration ⬇️

scientific article published on April 7, 2011

Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2).

scientific article published on 8 September 2015

Brain accumulation of tivozanib is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein) in mice

scientific article published on 28 March 2020

Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1).

scientific article published on 8 January 2015

Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) restrict oral availability and brain accumulation of the PARP inhibitor rucaparib (AG-014699).

scientific article

Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-gp/ABCB1) transport afatinib and restrict its oral availability and brain accumulation

scientific article published on 10 March 2017

Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation

scientific article published on 26 January 2010

Buparlisib is a brain penetrable pan-PI3K inhibitor

scientific article published on 17 July 2018

CD20 antigen imaging with ¹²⁴I-rituximab PET/CT in patients with rheumatoid arthritis

scientific article published on 01 January 2011

CMET-12. TUMOR CELL DETECTION BY IMMUNOFLOW CYTOMETRY AND BRAF MUTATION ANALYSIS IN CEREBROSPINAL FLUID OF MELANOMA PATIENTS WITH SUSPECTED LEPTOMENINGEAL METASTASES.

scientific article published on 6 November 2017

CRC/EORTC/NCI Joint Formulation Working Party: experiences in the formulation of investigational cytotoxic drugs

scientific article

CYP2C9 and CYP2C19 polymorphic forms are related to increased indisulam exposure and higher risk of severe hematologic toxicity

scientific article published on 01 May 2007

Cannulation of the jugular vein in mice

scientific article published on 01 January 2005

Capecitabine induces severe angina-like chest pain

scientific article published in March 2004

Carbamazepine induces bioactivation of cyclophosphamide and thiotepa

scientific article published on 24 April 2008

Carboplatin dosing in overweight and obese patients with normal renal function, does weight matter?

scientific article

Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice

scientific article published on 12 April 2006

Case series of acute hepatitis in a non-selected group of HIV-infected patients on nevirapine-containing antiretroviral treatment ⬇️

scientific article published on October 17, 2003

Cellular and clinical pharmacology of the taxanes docetaxel and paclitaxel--a review

scientific article published on May 2014

Changes in under-treatment after comprehensive geriatric assessment: an observational study

scientific article published on 01 October 2010

Characterization and identification of suspected counterfeit miltefosine capsules

scientific article published on 18 January 2012

Characterization of the in vitro activity of AZD3409, a novel prenyl transferase inhibitor

scientific article published on 13 March 2010

Characterizing the non-linear pharmacokinetics of miltefosine in paediatric visceral leishmaniasis patients from Eastern Africa

scientific article published on 11 August 2020

Chemical and enzymatic stability of a cyclic depsipeptide, the novel, marine-derived, anti-cancer agent kahalalide F.

scientific article published in August 2001

Chemical stability of suramin in commonly used infusion fluids

Chemical stability of the new antitumour agent intoplicine in infusion fluids

scientific article published on 01 November 1993

Chemoradiotherapy with capecitabine for locally advanced anal carcinoma: an alternative treatment option

scientific article published on 28 August 2014

Chromatographic analysis of the enantiomers of ifosfamide and some of its metabolites in plasma and urine

scientific article published on 01 March 1997

Chromatographic bioanalytical assays for targeted covalent kinase inhibitors and their metabolites

scientific article published on 30 November 2020

Chronic hepatotoxicity after long-term antiretroviral treatment including nevirapine

scientific article

Ciprofloxacin strongly inhibits clozapine metabolism: two case reports

scientific article

Circulating epithelial tumor cell analysis in CSF in patients with leptomeningeal metastases

scientific article published on 06 January 2020

Circulating tumor cells as pharmacodynamic biomarker in early clinical oncological trials ⬇️

scientific article published on May 17, 2011

Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.

scientific article published on April 2001

Clinical Evaluation of The Determination of Plasma Concentrations of Darunavir, Etravirine, Raltegravir and Ritonavir in Dried Blood Spot Samples ⬇️

scientific article published on 01 May 2011

Clinical Pharmacokinetics and Pharmacodynamics of Pazopanib: Towards Optimized Dosing

scientific article

Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs.

scientific article

Clinical Pharmacokinetics of Vemurafenib in BRAF-Mutated Melanoma Patients

scientific article published on 29 July 2016

Clinical and pharmacologic study of the farnesyltransferase inhibitor tipifarnib in cancer patients with normal or mildly or moderately impaired hepatic function

scientific article published on 01 October 2006

Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors

scientific article

Clinical experience with aurora kinase inhibitors: a review

scientific article published on 14 August 2009

Clinical pharmacokinetics of an amorphous solid dispersion tablet of elacridar

scientific article published on 18 November 2016

Clinical pharmacokinetics of camptothecin topoisomerase I inhibitors

scientific article published on 01 August 1998

Clinical pharmacokinetics of cyclophosphamide

scientific article

Clinical pharmacokinetics of therapeutic monoclonal antibodies

scientific article published on August 2010

Clinical pharmacokinetics of topotecan

scientific article published on August 1996

Clinical pharmacokinetics, pharmacodynamics and metabolism of the novel matrix metalloproteinase inhibitor ABT-518

scientific article published on 25 October 2002

Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study

scientific article

Clinical proteomics in breast cancer: a review

scientific article

Clinical proteomics: searching for better tumour markers with SELDI-TOF mass spectrometry

scientific article published on 4 April 2006

Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data

scientific article

Clinical research on antiangiogenic therapy ⬇️

scientific article published on January 1, 1998

Clinical trial simulations in paediatric oncology: A feasibility study from the Innovative Therapies for Children with Cancer Consortium.

scientific article published on 8 September 2017

Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients

scientific article

Co-administration of cyclosporin enables oral therapy with paclitaxel

article by J M Meerum Terwogt et al published 1 July 1998 in The Lancet

Co-trimoxazole and stavudine interference in a high-performance liquid chromatographic analysis for didanosine in human plasma

scientific article published on 01 December 1998

Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel

scientific article

Coadministration of ritonavir strongly enhances the apparent oral bioavailability of docetaxel in patients with solid tumors.

scientific article

Combined action and regulation of phase II enzymes and multidrug resistance proteins in multidrug resistance in cancer

scientific article published on 14 April 2008

Combined dapsone and clofazimine intoxication

scientific article published in August 1996

Combined quantification of paclitaxel, docetaxel and ritonavir in human feces and urine using LC-MS/MS.

scientific article

Combining Isotopic Tracer Techniques to Increase Efficiency of Clinical Pharmacokinetic Trials in Oncology

scientific article published on 16 April 2020

Commentary: Substandard medicines are the priority for neglected tropical diseases

scientific article

Comparative pharmacokinetics of vinblastine after a 96-hour continuous infusion in wild-type mice and mice lacking mdr1a P-glycoprotein

scientific article

Comparing the old and new generation SELDI-TOF MS: implications for serum protein profiling

scientific article

Comparison of normalisation methods for surface-enhanced laser desorption and ionisation (SELDI) time-of-flight (TOF) mass spectrometry data

scientific article

Comparison of two immortalized human cell lines to study nuclear receptor-mediated CYP3A4 induction.

scientific article

Compatibility and stability of Imexon in infusion devices and its in vitro biocompatibility

scientific article published in August 2005

Compatibility and stability of aplidine, a novel marine-derived depsipeptide antitumor agent, in infusion devices, and its hemolytic and precipitation potential upon i.v. administration

scientific article published on 01 November 1999

Compatibility and stability of the novel anti-cancer agent C1311 in infusion devices and its in vitro biocompatibility

scientific article published in March 2005

Complement activation by PEGylated liposomes containing prednisolone ⬇️

scientific article published on March 22, 2013

Complexation study of the anticancer agent EO-9 with 2-hydroxypropyl-beta-cyclodextrin

scientific article published in October 2008

Concentrations of Erlotinib in Tumor Tissue and Plasma in Non-Small-Cell Lung Cancer Patients After Neoadjuvant Therapy

scientific article

Concise Drug Review: Azacitidine and Decitabine ⬇️

scientific article published on May 13, 2013

Concise Drug Review: Pazopanib and Axitinib ⬇️

scientific article published on June 25, 2012

Concise overview of the clinical pharmacokinetics of dideoxynucleoside antiretroviral agents

scientific article published on March 1995

Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein).

scientific article published on August 2007

Concomitant intake of abiraterone acetate and food to increase pharmacokinetic exposure: real life data from a therapeutic drug monitoring programme

scientific article published on 12 March 2020

Concomitant use of proton pump inhibitors and systemic corticosteroids

scientific article published on January 1, 2013

Contraindications for anticoagulation in older patients with atrial fibrillation; a narrative review

scientific article published on July 2010

Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.

scientific article

Correction of peripheral blood mononuclear cell cytosolic protein for hemoglobin contamination ⬇️

scientific article published on January 15, 2013

Correction to: Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a 14C-microtracer and therapeutic dose in cancer patients

scientific article published on 27 November 2017

Correction to: Exposure-survival analyses of pazopanib in renal cell carcinoma and soft tissue sarcoma patients: opportunities for dose optimization

scientific article published on 11 June 2020

Corrigendum to "Development and validation of LC-MS/MS assays for the quantification of bendamustine and its metabolites in human plasma and urine" [J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 893-894 (2012) 92-100]

scientific article published on 25 March 2016

Corrigendum to "Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy".

scientific article published on 30 March 2015

Cost-effectiveness of monitoring endoxifen levels in breast cancer patients adjuvantly treated with tamoxifen.

scientific article published on 13 July 2018

Covariate-based dose individualization of the cytotoxic drug indisulam to reduce the risk of severe myelosuppression

scientific article

Cremophor EL pharmacokinetics in a phase I study of paclitaxel (Taxol) and carboplatin in non-small cell lung cancer patients

scientific article published on 01 October 2000

Crizotinib-induced fatal fulminant liver failure

scientific article published on 30 December 2015

Current knowledge and future directions of the selective epidermal growth factor receptor inhibitors erlotinib (Tarceva) and gefitinib (Iressa).

scientific article

Cyclodextrin as membrane protectant in spray-drying and freeze-drying of PEGylated liposomes ⬇️

scientific article published on August 31, 2012

Cyclosporine-induced anaphylaxis

scientific article published on 01 July 2000

Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes

scientific article published on 15 July 2019

Cytoreductive surgery and intraoperative hyperthermic intraperitoneal chemotherapy with paclitaxel: a clinical and pharmacokinetic study

scientific article published in February 2008

Cytotoxicity of the organic ruthenium anticancer drug Nami-A is correlated with DNA binding in four different human tumor cell lines

scientific article published on 19 March 2004

DNA repair mechanisms involved in gemcitabine cytotoxicity and in the interaction between gemcitabine and cisplatin

scientific article published on January 2003

DNA tattoo vaccination: effect on plasmid purity and transfection efficiency of different topoisoforms

scientific article published on 04 July 2009

DNA vaccination in oncology: current status, opportunities and perspectives

scientific article published on August 2010

DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis

scientific article published on 19 October 2018

DPYD genotype-guided dose individualization to improve patient safety of fluoropyrimidine therapy: call for a drug label update

scientific article

Decitabine triphosphate levels in peripheral blood mononuclear cells from patients receiving prolonged low-dose decitabine administration: a pilot study ⬇️

scientific article published on March 1, 2012

Degradation kinetics of antagonist [Arg6, D-Trp7,9, MePhe8]-substance P [6-11] in aqueous solutions

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Degradation kinetics of aplidine, a new marine antitumoural cyclic peptide, in aqueous solution.

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Degradation kinetics of three gonadorelin analogues: developing a method for calculating epimerization parameters

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Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites?

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Design of a drug-drug interaction study of vincristine with azole antifungals in pediatric cancer patients using clinical trial simulation.

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Design of informative renal impairment studies: evaluation of the impact of design stratification on bias, precision and dose adjustment error

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Detection of Colorectal Cancer by Serum and Tissue Protein Profiling: A Prospective Study in a Population at Risk

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Detection of breast cancer by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry tissue and serum protein profiling

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Detection of single nucleotide polymorphisms in the ABCG2 gene in a Dutch population

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Determinants of the elimination of methotrexate and 7-hydroxy-methotrexate following high-dose infusional therapy to cancer patients.

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Determination of 3'-amino-3'-deoxythymidine, a cytotoxic metabolite of 3'-azido-3'-deoxythymidine, in human plasma by ion-pair high-performance liquid chromatography

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Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection

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Determination of N,N',N"-triethylenethiophosphoramide and its active metabolite N,N',N"-triethylenephosphoramide in plasma and urine using capillary gas chromatography

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Determination of NVP-BEZ235, a dual PI3K and mTOR inhibitor, in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography with fluorescence detection

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Determination of Platinum Originating from Carboplatin in Human Urine and Canine Excretion Products by Inductively Coupled Plasma Mass Spectrometry ⬇️

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Determination of Sunitinib and Its Active Metabolite N-Desethylsunitinib in Sweat of a Patient ⬇️

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Determination of chloroacetaldehyde, a metabolite of oxazaphosphorine cytostatic drugs, in plasma

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Determination of doxorubicin and metabolites in murine specimens by high-performance liquid chromatography ⬇️

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Determination of ifosfamide, 2- and 3-dechloroethyifosfamide using gas chromatography with nitrogen-phosphorus or mass spectrometry detection

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Determination of imatinib mesylate and its main metabolite (CGP74588) in human plasma and murine specimens by ion-pairing reversed-phase high-performance liquid chromatography

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Determination of intoplicine, a new antitumour drug, in human faeces by normal-phase high-performance liquid chromatography with fluorescence detection

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Determination of intoplicine, a new antitumour drug, in human whole blood and plasma by normal-phase high-performance liquid chromatography with fluorescence detection

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Determination of oxaliplatin in human plasma and plasma ultrafiltrate by graphite-furnace atomic-absorption spectrometry

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Determination of paclitaxel and metabolites in mouse plasma, tissues, urine and faeces by semi-automated reversed-phase high-performance liquid chromatography

scientific article published on 01 February 1995

Determination of pamidronate in urine by ion-pair liquid chromatography after derivatization with 1-naphthylisothiocyanate ⬇️

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Determination of platinum originating from carboplatin in canine sebum and cerumen by inductively coupled plasma mass spectrometry ⬇️

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Determination of platinum surface contamination in veterinary and human oncology centres using inductively coupled plasma mass spectrometry

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Determination of polyoxyethyleneglycerol triricinoleate 35 (Cremophor EL) in plasma by pre-column derivatization and reversed-phase high-performance liquid chromatography

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Determination of ruthenium originating from the investigational anti-cancer drug NAMI-A in human plasma ultrafiltrate, plasma, and urine by inductively coupled plasma mass spectrometry

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Determination of saquinavir in human plasma, saliva, and cerebrospinal fluid by ion-pair high-performance liquid chromatography with ultraviolet detection ⬇️

scientific article published on September 26, 1997

Determination of stavudine, a new antiretroviral agent, in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection

scientific article published on December 23, 1992

Determination of tamoxifen and endoxifen in dried blood spots using LC-MS/MS and the effect of coated DBS cards on recovery and matrix effects

scientific article published in January 2014

Determination of the absolute bioavailability of oral imatinib using a stable isotopically labeled intravenous imatinib-d8 microdose

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Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a 14C-microtracer and therapeutic dose in cancer patients.

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Determination of topotecan in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography

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Determination of total platinum in plasma and plasma ultrafiltrate, from subjects dosed with the platinum-containing N-(2-hydroxypropyl)methacrylamide copolymer AP5280, by use of graphite-furnace Zeeman atomic-absorption spectrometry

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Deuterodiacetylmorphine as a marker for use of illicit heroin by addicts in a heroin-assisted treatment program

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Development and Validation of an LC-MS/MS Method for the Simultaneous Quantification of Abiraterone, Enzalutamide, and Their Major Metabolites in Human Plasma

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Development and clinical validation of an LC-MS/MS method for the quantification of pazopanib in DBS

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Development and validation of LC-MS/MS assays for the quantification of E7080 and metabolites in various human biological matrices

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Development and validation of LC–MS/MS assays for the quantification of bendamustine and its metabolites in human plasma and urine ⬇️

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Development and validation of a LC‐MS/MS method for the in vitro analysis of 1‐hydroxymidazolam in human liver microsomes: application for determining CYP3A4 inhibition in complex matrix mixtures ⬇️

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Development and validation of a UPLC-MS/MS method with a broad linear dynamic range for the quantification of morphine, morphine-3-glucuronide and morphine-6-glucuronide in mouse plasma and tissue homogenates

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Development and validation of a bioanalytical method for the quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib in human and mouse matrices using liquid chromatography-tandem mass spectrometry

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Development and validation of a high-performance liquid chromatography-tandem mass spectrometry assay for the quantification of Dexamphetamine in human plasma.

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Development and validation of a high-performance liquid chromatography-tandem mass spectrometry assay quantifying olaparib in human plasma.

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Development and validation of a high-performance liquid chromatography-tandem mass spectrometry assay quantifying vemurafenib in human plasma.

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Development and validation of a liquid chromatography-tandem mass spectrometry analytical method for the therapeutic drug monitoring of eight novel anticancer drugs

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Development and validation of a liquid chromatography-tandem mass spectrometry assay for nine oral anticancer drugs in human plasma

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Development and validation of a liquid chromatography-tandem mass spectrometry assay for the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its metabolite 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in

scientific article published on 29 July 2010

Development and validation of a liquid chromatography-tandem mass spectrometry assay for the quantification of lurbinectedin in human plasma and urine

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Development and validation of a liquid chromatography-ultraviolet absorbance detection assay using derivatisation for the novel marine anticancer agent ES-285 x HCl [(2S,3R)-2-amino-3-octadecanol hydrochloride] and its pharmaceutical dosage form

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Development and validation of a method to determine the unbound paclitaxel fraction in human plasma

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Development and validation of a population pharmacokinetic model for ritonavir used as a booster or as an antiviral agent in HIV-1-infected patients

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Development and validation of a quantitative assay for the analysis of tamoxifen with its four main metabolites and the flavonoids daidzein, genistein and glycitein in human serum using liquid chromatography coupled with tandem mass spectrometry.

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Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry ⬇️

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Development and validation of a quantitative assay for the measurement of miltefosine in human plasma by liquid chromatography-tandem mass spectrometry.

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Development and validation of a quantitative assay for the measurement of two HIV-fusion inhibitors, enfuvirtide and tifuvirtide, and one metabolite of enfuvirtide (M-20) in human plasma by liquid chromatography-tandem mass spectrometry

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Development and validation of a quantitative method for thymidine phosphorylase activity in peripheral blood mononuclear cells

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Development and validation of a rapid and sensitive UPLC-MS/MS method for determination of uracil and dihydrouracil in human plasma

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Development and validation of an LC-MS/MS method for the quantification of imatinib and imatinib-d8 in human plasma for the support of an absolute bioavailability microdose trial

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Development and validation of an LC-MS/MS method for the quantitative analysis of milciclib in human and mouse plasma, mouse tissue homogenates and tissue culture medium

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Development and validation of an LC-MS/MS method with a broad linear dynamic range for the quantification of tivozanib in human and mouse plasma, mouse tissue homogenates, and culture medium

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Development and validation of an LC-UV method for the quantification and purity determination of the novel anticancer agent C1311 and its pharmaceutical dosage form

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Development and validation of an UPLC-MS/MS method for the therapeutic drug monitoring of oral anti-hormonal drugs in oncology

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Development and validation of an anion-exchange LC-UV method for the quantification and purity determination of the DNA plasmid pDERMATT.

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Development and validation of an assay for the quantitative determination of cladribine nucleotides in MDCKII cells and culture medium using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry

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Development and validation of an assay for the simultaneous determination of zidovudine, abacavir, emtricitabine, lamivudine, tenofovir and ribavirin in human plasma using liquid chromatography–tandem mass spectrometry ⬇️

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Development and validation of an enzyme-linked immunosorbent assay for the quantification of trastuzumab in human serum and plasma.

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Development and validation of an integrated LC-MS/MS assay for therapeutic drug monitoring of five PARP-inhibitors

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Development and validation of limited sampling strategies for prediction of the systemic exposure to the novel anticancer agent E7070 (N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide). ⬇️

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Development of a LC method for pharmaceutical quality control of the antimetastatic ruthenium complex NAMI-A.

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Development of a Pharmacokinetic Model to Describe the Complex Pharmacokinetics of Pazopanib in Cancer Patients

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Development of a Tumour Growth Inhibition Model to Elucidate the Effects of Ritonavir on Intratumoural Metabolism and Anti-tumour Effect of Docetaxel in a Mouse Model for Hereditary Breast Cancer

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Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil.

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Development of an extended-release formulation of capecitabine making use of in vitro-in vivo correlation modelling.

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Development of an optimal pharmacokinetic sampling schedule for rubitecan administered orally in a daily times five schedule

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Development of an oral solid dispersion formulation for use in low-dose metronomic chemotherapy of paclitaxel

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Development of farnesyl transferase inhibitors: a review

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Development of luciferase tagged brain tumour models in mice for chemotherapy intervention studies

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Development of pharmaceutical heroin preparations for medical co-prescription to opioid dependent patients

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Development, validation, and clinical application of a high-performance liquid chromatography-tandem mass spectrometry assay for the quantification of total intracellular β-decitabine nucleotides and genomic DNA incorporated β-decitabine and 5-meth

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Dexrazoxane in anthracycline induced cardiotoxicity and extravasation

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Dextromethorphan as a phenotyping test to predict endoxifen exposure in patients on tamoxifen treatment

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Differential Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) on Axitinib Brain Accumulation and Oral Plasma Pharmacokinetics ⬇️

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Discontinuation of rivastigmine in routine clinical practice

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Discrepancies in reported drug use in geriatric outpatients: relevance to adverse events and drug-drug interactions

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Disease Progression/Clinical Outcome Model for Castration-Resistant Prostate Cancer in Patients Treated With Eribulin

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Disposition and metabolism of 14C-dovitinib (TKI258), an inhibitor of FGFR and VEGFR, after oral administration in patients with advanced solid tumors ⬇️

scientific article published on August 22, 2012

Disposition and toxicity of trabectedin (ET-743) in wild-type and mdr1 gene (P-gp) knock-out mice.

scientific article published on 24 February 2009

Do geriatric outpatients adhere to medication changes advised after assessment? An exploratory pilot study

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Docetaxel in 253 previously treated patients with progressive locally advanced or metastatic breast cancer: results of a compassionate use program in The Netherlands

scientific article published in April 2000

Does Older Age Lead to Higher Risk for Neutropenia in Patients Treated with Paclitaxel?

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Dose-finding and pharmacokinetic study of orally administered indibulin (D-24851) to patients with advanced solid tumors.

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Dose-finding and pharmacological study of ifosfamide in combination with paclitaxel and carboplatin in resistant small-cell lung cancer

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Dose-finding phase I clinical and pharmacokinetic study of orally administered irinotecan in patients with advanced solid tumors

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Dried Blood Spot Self-Sampling at Home for the Individualization of Tamoxifen Treatment: A Feasibility Study

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Drug Interaction of Fluvoxamine and Fluoxetine with Nevirapine in HIV-1-Infected Individuals

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Drug interactions between antiretroviral drugs and comedicated agents

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Drug interactions in oncology

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Drug interactions with zidovudine

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Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis

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Drug-drug interactions in a geriatric outpatient cohort: prevalence and relevance

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Dual mTORC1 and mTORC2 inhibitor Palomid 529 penetrates the Blood–Brain Barrier without restriction by ABCB1 and ABCG2 ⬇️

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Dynamics of parasite clearance in cutaneous leishmaniasis patients treated with miltefosine

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E7070: a novel synthetic sulfonamide targeting the cell cycle progression for the treatment of cancer

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Early diagnostic protein biomarkers for breast cancer: how far have we come? ⬇️

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Effect of Chinese herbs on CYP3A4 activity and expression in vitro ⬇️

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Effect of cisplatin-containing chemotherapy on lithium serum concentrations ⬇️

scientific article published on 01 April 1992

Effect of cyclodextrins on the chemical stability of mitomycins in alkaline solution

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Effect of heat treatment of potentially infected blood samples on therapeutic drug monitoring of selected drugs

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Effect of inhibition of the FGFR–MAPK signaling pathway on the development of ocular toxicities ⬇️

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Effect of mycophenolate mofetil on the pharmacokinetics of antiretroviral drugs and on intracellular nucleoside triphosphate pools

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Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice

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Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA.

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Effectiveness and safety of reduced-dose fluoropyrimidine therapy in patients carrying the DPYD*2A variant: A matched pair analysis

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Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen

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Effects of co-medicated drugs on cyclophosphamide bioactivation in human liver microsomes

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Effects of cyclosporine a on single-dose pharmacokinetics of intravenous itraconazole in patients with hematologic malignancies

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Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir

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Efficacy and tolerability of a high loading dose (25,000 IU weekly) vitamin D3 supplementation in obese children with vitamin D insufficiency/deficiency

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Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice

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Efficacy, Tolerance, and Plasma Levels of Abiraterone and Its Main Metabolites in a Patient With Metastatic Castration-resistant Prostate Cancer With a Hepatic Transplant

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Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab.

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Encorafenib, binimetinib and cetuximab combined therapy for patients with BRAFV600E mutant metastatic colorectal cancer

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Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833 ⬇️

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Enhanced resolution triple-quadrupole mass spectrometry for ultra-sensitive and quantitative analysis of the investigational anticancer agent EO9 (apaziquone) and its metabolite EO5a in human and dog plasma to support (pre)-clinical studies of EOqui

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Enhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors

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Enrichment of Circulating Endothelial Cells by CD34 Microbeads Followed by Enumeration Using Flow Cytometry

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Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut.

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Enzymatic digestion as a tool for the LC-MS/MS quantification of large peptides in biological matrices: measurement of chymotryptic fragments from the HIV-1 fusion inhibitor enfuvirtide and its metabolite M-20 in human plasma

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Enzyme linked immunosorbent assay for the quantification of nivolumab and pembrolizumab in human serum and cerebrospinal fluid

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EpCAM-based assays for epithelial tumor cell detection in cerebrospinal fluid

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EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors

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Equilibrium kinetics of the new experimental anti-tumour compound SK&F 104864-A in aqueous solution

scientific article published on 01 January 1990

Eribulin mesylate pharmacokinetics in patients with solid tumors receiving repeated oral ketoconazole

scientific article published on May 5, 2012

Etoposide phosphate, the water soluble prodrug of etoposide

scientific article published on October 1996

Etoposide, leucovorin, 5-fluorouracil (ELF) combination chemotherapy for advanced gastric cancer: experience with two treatment schedules incorporating intravenous or oral etoposide

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Evaluation of a pharmacology-driven dosing algorithm of 3-weekly paclitaxel using therapeutic drug monitoring: a pharmacokinetic-pharmacodynamic simulation study

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Evaluation of formulas using the serum creatinine level to calculate the optimal dosage of carboplatin

scientific article published in January 1996

Evaluation of human neutrophil peptide-1, -2 and -3 as serum markers for colorectal cancer

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Evaluation of human plasma protein binding of trabectedin (Yondelis, ET-743).

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Evaluation of pharmacotherapy in geriatric patients after performing complete geriatric assessment at a diagnostic day clinic

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Evaluation of the autoinduction of ifosfamide metabolism by a population pharmacokinetic approach using NONMEM.

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Evaluation of the bioequivalence of tablets and capsules containing the novel anticancer agent R115777 (Zarnestra) in patients with advanced solid tumors

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Evaluation of α2-Integrin Expression as a Biomarker for Tumor Growth Inhibition for the Investigational Integrin Inhibitor E7820 in Preclinical and Clinical Studies ⬇️

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Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment.

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Exposure to Docetaxel in the Elderly Patient Population: a Population Pharmacokinetic Study

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Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer

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Exposure-response analyses of abiraterone and its metabolites in real-world patients with metastatic castration-resistant prostate cancer

scientific article published on 14 October 2019

Exposure-response analyses of anaplastic lymphoma kinase inhibitors crizotinib and alectinib in non-small-cell lung cancer patients

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Exposure-survival analyses of pazopanib in renal cell carcinoma and soft tissue sarcoma patients: opportunities for dose optimization

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Extensive metabolism and hepatic accumulation of gemcitabine after multiple oral and intravenous administration in mice

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Extrahepatic metabolism of ibrutinib

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Extremely high exposures in an obese patient receiving high-dose cyclophosphamide, thiotepa and carboplatin

scientific article published on 30 July 2002

Facile small scale synthesis of nucleoside 5'-phosphate mixtures

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Failure of miltefosine in visceral leishmaniasis is associated with low drug exposure

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Fast and Adequate Liquid Chromatography-Tandem Mass Spectrometric Determination of Z-endoxifen Serum Levels for Therapeutic Drug Monitoring

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Fast and simultaneous determination of darunavir and eleven other antiretroviral drugs for therapeutic drug monitoring: method development and validation for the determination of all currently approved HIV protease inhibitors and non-nucleoside reve

scientific article published on 01 January 2007

Fast and straightforward method for the quantification of pazopanib in human plasma using LC-MS/MS.

scientific article published on 18 December 2017

Fatal interstitial lung disease associated with high erlotinib and metabolite levels. A case report and a review of the literature ⬇️

scientific article published on November 17, 2011

Fixed Dosing of Monoclonal Antibodies in Oncology

scientific article published on 28 July 2017

Flat dosing of carboplatin is justified in adult patients with normal renal function

scientific article published in November 2006

Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers

scientific article published on 25 September 2018

From Mouse to Man: Predictions of Human Pharmacokinetics of Orally Administered Docetaxel From Preclinical Studies ⬇️

scientific article published on April 19, 2011

Fully automated high-performance liquid chromatographic method for the determination of carzelesin (U-80,244) and metabolites (U-76,073 and U-76,074) in human plasma

scientific article published on 01 January 1994

GMP production of pDERMATT for vaccination against melanoma in a phase I clinical trial

scientific article published on 17 May 2008

Gas chromatographic determination of 2- and 3-dechloroethylifosfamide in plasma and urine

scientific article published on 01 December 1992

Gas chromatographic determination of ifosfamide in microvolumes of urine and plasma ⬇️

scientific article published on November 15, 1991

Gastric bypass may promote weight loss in overweight partners

scientific article published in January 2015

Gemcitabine and paclitaxel: pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer

scientific article published on 01 July 1999

Gene polymorphisms, pharmacokinetics, and hematological toxicity in advanced non-small-cell lung cancer patients receiving cisplatin/gemcitabine ⬇️

scientific article published on May 18, 2011

Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer

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Genetically modified mouse models for oral drug absorption and disposition

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Germline TYMS genotype is highly predictive in patients with metastatic gastrointestinal malignancies receiving capecitabine-based chemotherapy

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Germline polymorphisms in patients with advanced nonsmall cell lung cancer receiving first‐line platinum‐gemcitabine chemotherapy ⬇️

scientific article published on September 28, 2011

HAART, or Just Mini-HAART? ⬇️

scientific article published on December 15, 2001

HPV-negative squamous cell carcinoma of the anal canal is unresponsive to standard treatment and frequently carries disruptive mutations in TP53

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Haptoglobin phenotype is not a predictor of recurrence free survival in high-risk primary breast cancer patients.

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Hepatic clearance of reactive glucuronide metabolites of diclofenac in the mouse is dependent on multiple ATP-binding cassette efflux transporters

scientific article published on 19 January 2010

Hepatotoxicity and metabolism of trabectedin: a literature review.

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Hepatotoxicity following nevirapine-containing regimens in HIV-1-infected individuals

scientific article published in September 2002

Herb-drug interactions in oncology

scientific article published on 01 April 2014

Herb-drug interactions in oncology: focus on mechanisms of induction

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Heroin-assisted treatment in the Netherlands: History, findings, and international context

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High exposures to bioactivated cyclophosphamide are related to the occurrence of veno-occlusive disease of the liver following high-dose chemotherapy

scientific article published on May 2006

High prevalence of vitamin D insufficiency/deficiency in Dutch multi-ethnic obese children

scientific article published in February 2015

High-Tech Drugs in Creaky Formulations

scientific article published on 30 May 2017

High-grade glioma mouse models and their applicability for preclinical testing

scientific article published on 19 September 2009

High-performance liquid chromatographic analysis for the determination of a novel polymer-bound camptothecin derivative (MAG-camptothecin) and free camptothecin in human plasma ⬇️

scientific article published on November 5, 2001

High-performance liquid chromatographic analysis of the anticancer drug irinotecan (CPT-11) and its active metabolite SN-38 in human plasma

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High-performance liquid chromatographic analysis of the antitumour drug camptothecin and its lactone ring-opened form in rat plasma

scientific article published on 01 July 1993

High-performance liquid chromatographic analysis of the investigational anticancer drug 9-aminocamptothecin, as the lactone form and as the total of the lactone and the hydroxycarboxylate forms, in micro-volumes of human plasma ⬇️

scientific article published on 01 September 1998

High-performance liquid chromatographic analysis of the new antitumour drug N-benzoylstaurosporine (CGP 41 251) and four potential metabolites in micro-volumes of plasma

scientific article published on 01 December 1995

High-performance liquid chromatographic analysis of the new antitumour drug SK&F 104864-A (NSC 609699) in plasma

scientific article published on 01 January 1990

High-performance liquid chromatographic bio-analysis and preliminary pharmacokinetics of the experimental antitumour drug vintriptol

scientific article published on 01 August 1990

High-performance liquid chromatographic bio-analysis of PSC 833 in human and murine plasma

scientific article published on 01 November 1998

High-performance liquid chromatographic bioanalysis of anthracycline cytostatic drugs

scientific article published on 01 January 1988

High-performance liquid chromatographic determination of m-iodobenzylguanidine in urine of cancer patients

scientific article published on 01 December 1993

High-performance liquid chromatographic determination of ritonavir in human plasma, cerebrospinal fluid and saliva ⬇️

scientific article published on January 23, 1998

High-performance liquid chromatographic determination of stabilized 4-hydroxyifosfamide in human plasma and erythrocytes

scientific article published on 01 September 1998

High-performance liquid chromatographic determination of vinblastine, 4-O-deacetylvinblastine and the potential metabolise 4-O-deacetylvinblastine-3-oic acid in biological fluids ⬇️

scientific article published on August 16, 1991

High-performance liquid chromatographic method for the analysis of 10-ethyl-10-deaza-aminopterin and metabolites in plasma

scientific article published on 01 July 1990

High-performance liquid chromatographic procedures for the quantitative determination of paclitaxel (Taxol) in human urine

scientific article published on 01 February 1995

High-performance liquid chromatography analysis of a novel small-molecule, anti-cancer drug, Palomid 529, in human and mouse plasma and in mouse tissue homogenates ⬇️

scientific article published on October 29, 2011

High-performance liquid chromatography coupled with mass spectrometry for the quantitative analysis of vinca-alkaloids in biological matrices: a concise survey from the literature

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Highly sensitive UPLC-MS/MS method for the quantification of paromomycin in human plasma

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Hot flashes are not predictive for serum concentrations of tamoxifen and its metabolites

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Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel

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Human mass balance study and metabolite profiling of 14C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer

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Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry.

scientific article published on 9 March 2007

Human metabolism of [(14)C]indisulam following i.v. infusion in cancer patients.

scientific article published in August 2005

Hypersensitivity reactions to etoposide

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Identification and profiling of circulating metabolites of atazanavir, a HIV protease inhibitor.

scientific article published on 22 June 2009

Identification of serum proteins as prognostic and predictive markers of colorectal cancer using surface enhanced laser desorption ionization-time of flight mass spectrometry

scientific article published in July 2010

Identification of serum proteins discriminating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-time of flight mass spectrometry

scientific article published in March 2006

Identification of two new serum protein profiles for renal cell carcinoma.

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Impact of Older Age on the Exposure of Paclitaxel: a Population Pharmacokinetic Study

scientific article published on 07 January 2019

Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Gene Dosage on Plasma Pharmacokinetics and Brain Accumulation of Dasatinib, Sorafenib, and Sunitinib ⬇️

scientific article published on July 10, 2013

Impact of age on exposure to oral antiandrogen therapies in clinical practice

scientific article published on 02 October 2018

Importance of highly selective LC–MS/MS analysis for the accurate quantification of tamoxifen and its metabolites: focus on endoxifen and 4-hydroxytamoxifen ⬇️

scientific article published on March 3, 2012

Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2.

scientific article published on 28 May 2018

Improved and simplified liquid chromatographic assay for adefovir, a novel antiviral drug, in human plasma using derivatization with chloroacetaldehyde

scientific article published on 01 December 1999

Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein

scientific article

Improved pharmacodynamic assay for dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells

scientific article published on 01 January 2015

Improvement of oral drug treatment by temporary inhibition of drug transporters and/or cytochrome P450 in the gastrointestinal tract and liver: an overview

scientific article

Improving colorectal cancer management: the potential of proteomics

scientific article published on 01 June 2008

Improving safety of fluoropyrimidine chemotherapy by individualizing treatment based on dihydropyrimidine dehydrogenase activity - Ready for clinical practice?

scientific article

Improving the solubility of nilotinib through novel spray-dried solid dispersions.

scientific article published on 6 July 2017

In vitro biocompatibility studies with the experimental anticancer agent BIBX1382BS

scientific article published on 01 January 2000

In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug

scientific article published on August 2004

In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug

scientific article published in January 2006

In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug

scientific article published on February 2007

In vitro hemolysis and buffer capacity studies with the novel marine anticancer agent kahalalide F and its reconstitution vehicle cremophor EL/ethanol

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In vitro pharmacokinetic study of the novel anticancer agent E7070: red blood cell and plasma protein binding in human blood

scientific article

In vitro transport of gimatecan (7-t-butoxyiminomethylcamptothecin) by breast cancer resistance protein, P-glycoprotein, and multidrug resistance protein 2.

scientific article published on December 2007

In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction

scientific article published on October 2005

In-vitro metabolism of anti-cancer drugs, methods and applications: paclitaxel, docetaxel, tamoxifen and ifosfamide

scientific article published on 01 October 1998

Incidence and risk factors for nevirapine-associated rash

scientific article published on 12 August 2003

Incidence of hematologic toxicity in older adults treated with gemcitabine or a gemcitabine-containing regimen in routine clinical practice: a multicenter retrospective cohort study

scientific article published in October 2014

Inclusion complexation of doxorubicin and daunorubicin with cyclodextrins

scientific article published on 01 January 1990

Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses

scientific article

Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar

scientific article published on 3 October 2013

Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.

scientific article published in July 2002

Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein.

scientific article

Increased risk of severe fluoropyrimidine-associated toxicity in patients carrying a G to C substitution in the first 28-bp tandem repeat of the thymidylate synthase 2R allele.

scientific article published on 18 July 2015

Increasing failure of miltefosine in the treatment of Kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncompliance

scientific article

Increasing thyroid-stimulating hormone is associated with impaired glucose metabolism in euthyroid obese children and adolescents ⬇️

scientific article published on January 1, 2013

Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel

scientific article published on December 2010

Individualised cancer chemotherapy: strategies and performance of prospective studies on therapeutic drug monitoring with dose adaptation: a review

scientific article

Individualized dosing of fluoropyrimidine-based chemotherapy to prevent severe fluoropyrimidine-related toxicity - What are the options?

scientific article published on 05 October 2020

Individualized dosing of oral targeted therapies in oncology is crucial in the era of precision medicine

scientific article published on 07 June 2019

Inducing synthetic lethality using PARP inhibitors

scientific article published on August 2010

Inductively coupled plasma mass spectrometric analysis of the total amount of platinum in DNA extracts from peripheral blood mononuclear cells and tissue from patients treated with cisplatin

scientific article published on 03 April 2008

Inductively coupled plasma mass‐spectrometric determination of platinum in excretion products of client‐owned pet dogs ⬇️

scientific article published on May 28, 2013

Influence of Cremophor EL on the quantification of paclitaxel in plasma using high-performance liquid chromatography with solid-phase extraction as sample pretreatment ⬇️

scientific article published on 01 May 1998

Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide

scientific article

Influence of sample storage duration on serum protein profiles assessed by surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI-TOF MS).

scientific article

Influence of variations in sample handling on SELDI-TOF MS serum protein profiles for colorectal cancer

scientific article published on 01 June 2008

Inherent formulation issues of kinase inhibitors

scientific article published on 28 August 2016

Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam

scientific article published on 14 September 2009

Inhibitors of mTOR.

scientific article published on 08 December 2010

Integrated Population Pharmacokinetic Model of both cyclophosphamide and thiotepa suggesting a mutual drug-drug interaction

scientific article published in April 2004

Integrated Simulation Framework for Toxicity, Dose Intensity, Disease Progression, and Cost Effectiveness for Castration-Resistant Prostate Cancer Treatment With Eribulin

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Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662.

scientific article published on May 2015

Interactions of serum albumin, valproic acid and carbamazepine with the pharmacokinetics of phenytoin in cancer patients

scientific article published in August 2006

Intermittent fasting during Ramadan causes a transient increase in total, LDL, and HDL cholesterols and hs-CRP in ethnic obese adolescents.

scientific article published on 13 February 2014

Intoxication with trazodone caused by dirty facsimile machine

scientific article published in September 2009

Intracellular Pharmacokinetics of Pyrimidine Analogues used in Oncology and the Correlation with Drug Action

scientific article published on 16 October 2020

Intracellular and plasma steady-state pharmacokinetics of raltegravir, darunavir, etravirine and ritonavir in heavily pre-treated HIV-infected patients

scientific article

Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides

scientific article published on 16 February 2018

Intracranial antitumor responses of nivolumab and ipilimumab: a pharmacodynamic and pharmacokinetic perspective, a scoping systematic review.

scientific article published on 30 May 2019

Intraperitoneal chemotherapy with taxanes for ovarian cancer with peritoneal dissemination

scientific article

Intraperitoneal-administered carboplatin in patients with ovarian cancer; influence of a dwell-time on toxicity and response

scientific article published on 01 February 1994

Intravenous-to-oral switch in anticancer chemotherapy: a focus on docetaxel and paclitaxel

scientific article

Inventory of oral anticancer agents: Pharmaceutical formulation aspects with focus on the solid dispersion technique

scientific article

Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques.

scientific article published on 18 February 2011

Is Bodyweight-Based Dosing Truly Better Than Flat Dosing for Panitumumab? [Letter]

scientific article published on 30 October 2020

Is combination therapy the next step to overcome resistance and reduce toxicities in melanoma? ⬇️

scientific article published on December 1, 2012

Is fluorouracil-induced severe toxicity in DPYD*2A individuals related to sex or to treatment regimen?

scientific article published on 22 September 2008

Isocratic ion-exchange chromatographic assay for the nucleotide gemcitabine triphosphate in human white blood cells

scientific article published in November 2002

Isolation, purification and biological activity of major docetaxel metabolites from human feces.

scientific article published on June 1996

Isolation, purification, and biological activity of mono- and dihydroxylated paclitaxel metabolites from human feces

scientific article published on 01 January 1995

Itraconazole as an alternative for ritonavir liquid formulation when combined with saquinavir

scientific article published on 01 January 2000

Itraconazole solution: summary of pharmacokinetic features and review of activity in the treatment of fluconazole-resistant oral candidosis in HIV-infected persons

scientific article

Kinetics and mechanism of the degradation of 1a-acetylmitomycin C in aqueous solution.

scientific article

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism

scientific article

LC-MS/MS assay for the quantification of testosterone, dihydrotestosterone, androstenedione, cortisol and prednisone in plasma from castrated prostate cancer patients treated with abiraterone acetate or enzalutamide

scientific article published on 20 March 2019

LC-UV method development and validation for the investigational anticancer agent imexon and identification of its degradation products

scientific article published on 19 March 2005

Lack of tumor uptake of 131-I labeled rituximab in a patient with a CD20 positive lymphoma lesion ⬇️

scientific article published on 06 January 2012

Lapatinib for advanced or metastatic breast cancer

scientific article published on 3 April 2012

Lethal morphine intoxication in a patient with a sickle cell crisis and renal impairment: case report and a review of the literature

scientific article

Lethal toxicity of uracil/tegafur in the treatment of sigmoid carcinoma

scientific article published on 14 December 2006

Letter to the editor regarding "A prospective, controlled study of the botanical compound mixture LCS101 for chemotherapy-induced hematological complications in breast cancer" by Yaal-Hahoshen et al. (The Oncologist 2011;16:1197-1202).

scientific article published on 17 April 2012

Limited sampling models for topotecan pharmacokinetics

scientific article published on March 1994

Limited-sampling models for anticancer agents

scientific article published on January 1994

Lipopolysaccharide contamination in intradermal DNA vaccination: toxic impurity or adjuvant?

scientific article published on 02 July 2009

Liposomal drug formulations in the treatment of rheumatoid arthritis

scientific article published on 17 June 2011

Liquid chromatographic assay for simultaneous determination of abacavir and mycophenolic acid in human plasma using dual spectrophotometric detection

scientific article

Liquid chromatographic assay for the antiviral nucleotide analogue tenofovir in plasma using derivatization with chloroacetaldehyde

scientific article

Liquid chromatographic assay for the cyclic depsipeptide aplidine, a new marine antitumor drug, in whole blood using derivatization with trans-4'-hydrazino-2-stilbazole.

scientific article published in January 2004

Liquid chromatographic assay for the non-peptidic protease inhibitor tipranavir in plasma

scientific article

Liquid chromatographic assay for the protease inhibitor atazanavir in plasma

scientific article published in January 2006

Liquid chromatographic assay with fluorescence detection to determine ajmaline in serum from patients with suspected Brugada syndrome

scientific article published on 25 June 2010

Liquid chromatographic-mass spectrometric determination of the novel, recently identified thioTEPA metabolite, thioTEPA-mercapturate, in urine

scientific article published on 01 September 1999

Liquid chromatography-mass spectrometry for the quantitative bioanalysis of anticancer drugs

scientific article

Liquid chromatography-tandem mass spectrometric assay for clobetasol propionate in human serum from patients with atopic dermatitis

scientific article published on 19 June 2010

Liquid chromatography-tandem mass spectrometric assay for diclofenac and three primary metabolites in mouse plasma

scientific article published on 18 July 2008

Liquid chromatography-tandem mass spectrometric assay for ponatinib and N-desmethyl ponatinib in mouse plasma

scientific article published on 2 May 2016

Liquid chromatography-tandem mass spectrometric assay for pravastatin and two isomeric metabolites in mouse plasma and tissue homogenates ⬇️

scientific article published on August 21, 2010

Liquid chromatography-tandem mass spectrometric assay for sorafenib and sorafenib-glucuronide in mouse plasma and liver homogenate and identification of the glucuronide metabolite

scientific article

Liquid chromatography-tandem mass spectrometric assay for the JAK2 inhibitor CYT387 in plasma

scientific article published on 23 March 2012

Liquid chromatography-tandem mass spectrometric assay for the PARP inhibitor rucaparib in plasma

scientific article published on 23 October 2013

Liquid chromatography-tandem mass spectrometric assay for the PI3K/mTOR inhibitor GSK2126458 in mouse plasma and tumor homogenate.

scientific article published on 19 January 2015

Liquid chromatography-tandem mass spectrometric assay for the T790M mutant EGFR inhibitor osimertinib (AZD9291) in human plasma

scientific article published on 18 July 2016

Liquid chromatography-tandem mass spectrometric assay for the VEGFR inhibitor cediranib and its primary human metabolite cediranib-N⁺-glucuronide in plasma

scientific article published on 23 March 2012

Liquid chromatography-tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes

scientific article published on 28 February 2006

Liquid chromatography-tandem mass spectrometric assay for the cyclin-dependent kinase inhibitor AT7519 in mouse plasma

scientific article published on 12 September 2013

Liquid chromatography-tandem mass spectrometric assay for the light sensitive survivin suppressant sepantronium bromide (YM155) in mouse plasma

scientific article published on 21 January 2014

Liquid chromatography-tandem mass spectrometric assay for the light sensitive tyrosine kinase inhibitor axitinib in human plasma

scientific article published on 30 October 2009

Liquid chromatography-tandem mass spectrometric assay for the multikinase inhibitor regorafenib in plasma

scientific article

Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor dabrafenib in mouse plasma.

scientific article published on 27 February 2013

Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor vemurafenib in human and mouse plasma.

scientific article

Liquid chromatography-tandem mass spectrometric assay for the nucleoside reverse transcriptase inhibitor emtricitabine in human plasma

scientific article

Liquid chromatography-tandem mass spectrometric assay for the quantification of galunisertib in human plasma and the application in a pre-clinical study

scientific article published on 21 May 2019

Liquid chromatography-tandem mass spectrometric assay for the quantitative determination of the tyrosine kinase inhibitor quizartinib in mouse plasma using salting-out liquid-liquid extraction

scientific article published on 23 July 2017

Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies.

scientific article published on 27 October 2015

Liquid chromatography-tandem mass spectrometric assay for the tyrosine kinase inhibitor afatinib in mouse plasma using salting-out liquid-liquid extraction

scientific article published on 21 January 2016

Liquid chromatography-tandem mass spectrometric assay for therapeutic drug monitoring of the B-Raf inhibitor encorafenib, the EGFR inhibitors afatinib, erlotinib and gefitinib and the O-desmethyl metabolites of erlotinib and gefitinib in human plasm

scientific article published on 11 September 2016

Liquid chromatography-tandem mass spectrometric assays for salinomycin in mouse plasma, liver, brain and small intestinal contents and in OptiMEM cell culture medium

scientific article

Liquid chromatography-tandem mass spectrometry assay for the EGFR inhibitor pelitinib in plasma.

scientific article published on 4 July 2013

Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine

scientific article published on 19 November 2016

Liquid chromatography-tandem mass spectrometry assay to quantify plitidepsin in human plasma, whole blood and urine

scientific article published on 21 June 2017

Liquid chromatography/tandem mass spectrometric method for the quantification of eight proteolytic fragments of ITIH4 with biomarker potential in human plasma and serum

scientific article

Liquid chromatography–tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasma ⬇️

scientific article published on August 21, 2012

Liquid chromatography–tandem mass spectrometric assay for the PARP-1 inhibitor olaparib in combination with the nitrogen mustard melphalan in human plasma ⬇️

scientific article published on 07 May 2011

Liquid chromatography–tandem mass spectrometric assay for therapeutic drug monitoring of the tyrosine kinase inhibitor pazopanib in human plasma ⬇️

scientific article published on August 10, 2012

Lithium pharmacokinetics during cisplatin-based chemotherapy: a case report

scientific article published on 01 January 1994

Long term stability of lyophilized plasmid DNA pDERMATT ⬇️

scientific article published on June 19, 2013

Long-term platinum retention after treatment with cisplatin and oxaliplatin

scientific article

Long-term safety and anti-tumour activity of olaparib monotherapy after combination with carboplatin and paclitaxel in patients with advanced breast, ovarian or fallopian tube cancer.

scientific article published on 16 July 2015

Low nevirapine plasma concentrations predict virological failure in an unselected HIV-1-infected population

scientific article

Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir

scientific article published in November 2002

Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response

scientific article published in Nature Communications

MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid

scientific article

Macrophage Activation Marker Neopterin: A Candidate Biomarker for Treatment Response and Relapse in Visceral Leishmaniasis.

scientific article

Malignant effusions contain lysophosphatidic acid (LPA)-like activity ⬇️

scientific article published on April 1, 1998

Malnourished Malawian patients presenting with large Wilms tumours have a decreased vincristine clearance rate

scientific article published on 09 April 2010

Management of Hot Flashes in Patients Who Have Breast Cancer With Venlafaxine and Clonidine: A Randomized, Double-Blind, Placebo-Controlled Trial ⬇️

scientific article published on September 12, 2011

Manufacture of gene-modified human T-cells with a memory stem/central memory phenotype.

scientific article

Mass Balance Study of [14C]Eribulin in Patients with Advanced Solid Tumors ⬇️

scientific article published on October 31, 2011

Mass balance and metabolite profiling of 14C-guadecitabine in patients with advanced cancer

scientific article published on 11 October 2019

Mass balance studies, with a focus on anticancer drugs.

scientific article

Mass spectrometry in the quantitative analysis of therapeutic intracellular nucleotide analogs

scientific article published on 08 July 2010

Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions

scientific article published on August 2004

Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids

scientific article published on 01 September 2011

Metabolism and disposition of the anticancer quinolone derivative vosaroxin, a novel inhibitor of topoisomerase II.

scientific article published on 31 January 2017

Metabolism and excretion of paclitaxel after oral administration in combination with cyclosporin A and after i.v. administration

scientific article published on 01 November 2000

Metabolism of docetaxel in mice

scientific article published on 30 April 2005

Metabolism of paclitaxel in mice

scientific article published in March 2003

Metabolism of trabectedin (ET-743, Yondelis) in patients with advanced cancer

scientific article

Metabolite Profiling of Bendamustine in Urine of Cancer Patients after Administration of [14C]Bendamustine ⬇️

scientific article published on 04 April 2012

Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison

scientific article published on 28 March 2016

Metabolite profiling of the novel anti-cancer agent, plitidepsin, in urine and faeces in cancer patients after administration of 14C-plitidepsin

scientific article published on 04 July 2018

Method development and validation for the quantification of dasatinib, erlotinib, gefitinib, imatinib, lapatinib, nilotinib, sorafenib and sunitinib in human plasma by liquid chromatography coupled with tandem mass spectrometry ⬇️

scientific article published on September 17, 2012

Methylnaltrexone

scientific article published on 15 July 2009

Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4.

scientific article published on 21 April 2005

Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes

scientific article published on 21 December 2007

Milk Thistle’s Active Components Silybin and Isosilybin: Novel Inhibitors of PXR-Mediated CYP3A4 Induction ⬇️

scientific article published on May 14, 2013

Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis ⬇️

scientific article published on July 24, 2012

Model-based evaluation and optimization of cardiac monitoring protocols for adjuvant treatment of breast cancer with trastuzumab

scientific article published on 21 August 2012

Model‐Based Evaluation of Similarity in Pharmacokinetics of Two Formulations of the Blood‐Derived Plasma Product C1 Esterase Inhibitor ⬇️

scientific article published on February 1, 2012

Model‐based treatment optimization of a novel VEGFR inhibitor ⬇️

scientific article published on August 1, 2012

Modulation of oral drug bioavailability: from preclinical mechanism to therapeutic application

scientific article

Modulation of the blood-brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours?

scientific article

Modulation of the cytochrome P450-mediated metabolism of ifosfamide by ketoconazole and rifampin

scientific article

Molecular Imaging of ABCB1/ABCG2 Inhibition at the Human Blood Brain Barrier using Elacridar and 11C-Erlotinib PET.

scientific article

Monitoring of platinum surface contamination in seven Dutch hospital pharmacies using inductively coupled plasma mass spectrometry

scientific article published on 22 March 2007

Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs

scientific article published on November 2002

Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics

scientific article published on 01 October 2006

Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides

scientific article published on 7 May 2007

Multiparameter Flow Cytometry Assay for Quantification of Immune Cell Subsets, PD-1 Expression Levels and PD-1 Receptor Occupancy by Nivolumab and Pembrolizumab

scientific article published on 12 August 2019

Neoadjuvant Systemic Treatment of Primary Angiosarcoma

scientific article published on 12 August 2020

Nevirapine and efavirenz pharmacokinetics and covariate analysis in the 2NN study.

scientific article published in January 2005

Nevirapine plus didanosine: once or twice daily combination?

scientific article published on 01 September 2000

New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine

scientific article

No pharmacokinetic drug-drug interaction between nevirapine and paclitaxel

scientific article published in July 2005

No relation between docetaxel administration route and high-grade diarrhea incidence

scientific article published on 01 August 2020

Novel clinical trial designs for innovative therapies

scientific article published on 24 December 2008

Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers

scientific article published on 24 June 2006

Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor

scientific article published on 7 October 2008

O-glucuronidation, a newly identified metabolic pathway for topotecan and N-desmethyl topotecan ⬇️

scientific article published on 01 August 1998

OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation

scientific article published on 22 February 2020

Ocular complications of the acquired immunodeficiency syndrome. Focus on the treatment of cytomegalovirus retinitis with ganciclovir and foscarnet

scientific article published on April 1993

Optimal Dosing of Miltefosine in Children and Adults with Visceral Leishmaniasis ⬇️

scientific article published on May 14, 2012

Optimization of intradermal vaccination by DNA tattooing in human skin

scientific article

Optimizing anticancer drug treatment in pregnant cancer patients: pharmacokinetic analysis of gestation-induced changes for doxorubicin, epirubicin, docetaxel and paclitaxel

scientific article published on 8 April 2014

Optimizing drug development of anti‐cancer drugs in children using modelling and simulation ⬇️

scientific article published on July 1, 2013

Optimizing the therapeutic index of liposomal glucocorticoids in experimental arthritis ⬇️

scientific article published on April 2, 2011

Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study

scientific article published in June 2008

Oral anticancer drugs: mechanisms of low bioavailability and strategies for improvement.

scientific article published on June 2013

Oral availability and brain penetration of the B-RAFV600E inhibitor vemurafenib can be enhanced by the P-GLYCOprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar

scientific article

Oral bioavailability of docetaxel in combination with OC144-093 (ONT-093).

scientific article

Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation

scientific article published on 29 April 2014

Oral coadministration of elacridar and ritonavir enhances brain accumulation and oral availability of the novel ALK/ROS1 inhibitor lorlatinib

scientific article published on 17 January 2019

Oral delivery of taxanes

scientific article

Organic Anion-Transporting Polypeptides 1a/1b Control the Hepatic Uptake of Pravastatin in Mice ⬇️

scientific article published on 03 August 2012

Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors

scientific article

P glycoprotein in human immunodeficiency virus type 1 infection and therapy

scientific article published on April 2004

P-Glycoprotein (ABCB1) Transports the Primary Active Tamoxifen Metabolites Endoxifen and 4-Hydroxytamoxifen and Restricts Their Brain Penetration ⬇️

scientific article published on 04 March 2011

P-Glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib, While Cytochrome P450-3A (CYP3A) Limits Its Oral Bioavailability

scientific article published on 10 October 2018

P-Glycoprotein, Multidrug-Resistance Associated Protein 2, Cyp3a, and Carboxylesterase Affect the Oral Availability and Metabolism of Vinorelbine ⬇️

scientific article published on July 5, 2012

P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib

scientific article published on 11 January 2012

P-glycoprotein (ABCB1/MDR1) limits brain accumulation and Cytochrome P450-3A (CYP3A) restricts oral availability of the novel FGFR4 inhibitor fisogatinib (BLU-554)

scientific article published on 20 November 2019

P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) affect brain accumulation and intestinal disposition of encorafenib in mice

scientific article published on 14 November 2017

P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) limit brain accumulation of the FLT3 inhibitor quizartinib in mice

scientific article published on 12 December 2018

P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387.

scientific article published on July 2013

P-glycoprotein (MDR1/ABCB1) controls brain accumulation and intestinal disposition of the novel TGF-β signaling pathway inhibitor galunisertib

scientific article published on 15 July 2019

P-glycoprotein (MDR1/ABCB1) restricts brain accumulation and Cytochrome P450-3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib.

scientific article

P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 determine the pharmacokinetics of etoposide

scientific article published on 22 December 2009

P-glycoprotein Limits Ribociclib Brain Exposure and CYP3A4 Restricts Its Oral Bioavailability

scientific article published on 05 August 2019

P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo.

scientific article

P-glycoprotein and breast cancer resistance protein restrict brigatinib brain accumulation and toxicity, and, alongside CYP3A, limit its oral availability

scientific article published on 22 September 2018

P-glycoprotein and breast cancer resistance protein restrict the brain penetration of the CDK4/6 inhibitor palbociclib.

scientific article

P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan

scientific article published in November 2007

P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin

scientific article published on 14 January 2008

P-glycoprotein system as a determinant of drug interactions: the case of digoxin-verapamil

scientific article

P-glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice

scientific article published on 28 August 2015

P-glycoprotein, CYP3A, and plasma carboxylesterase determine brain and blood disposition of the mTOR Inhibitor everolimus (Afinitor) in mice.

scientific article published on 11 April 2014

P-gp and taxanes

scientific article published on 19 June 2014

P04.91 ABC-drug efflux transporters at the blood-brain barrier limit the efficacy of treatment against primary and secondary brain tumors

PARP Inhibitors in the Treatment of Triple-Negative Breast Cancer

scientific article

PI3K-mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models.

scientific article published on 23 August 2016

PK/PD model of indisulam and capecitabine: interaction causes excessive myelosuppression

scientific article published on 12 September 2007

PXR-mediated P-glycoprotein induction by small molecule tyrosine kinase inhibitors ⬇️

scientific article published on December 28, 2012

PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line

scientific article

Paclitaxel in self-micro emulsifying formulations: oral bioavailability study in mice

scientific article

Palliative effect of metaiodobenzylguanidine in metastatic carcinoid tumors

scientific article published on June 1996

Part 1: background, methodology, and clinical adoption of pharmacogenetics

scientific article published on 31 May 2011

Part 2: Pharmacogenetic Variability in Drug Transport and Phase I Anticancer Drug Metabolism ⬇️

scientific article published on May 31, 2011

Part 3: Pharmacogenetic Variability in Phase II Anticancer Drug Metabolism ⬇️

scientific article published on 09 June 2011

Part 4: Pharmacogenetic Variability in Anticancer Pharmacodynamic Drug Effects ⬇️

scientific article published on June 9, 2011

Patients homozygous for DPYD c.1129-5923C>G/haplotype B3 have partial DPD deficiency and require a dose reduction when treated with fluoropyrimidines

scientific article published on 20 August 2016

Pemetrexed pathway-associated germline polymorphisms: a useful tool for treatment individualization?

scientific article published on 6 July 2010

Penetration of 3'-Amino-3'-Deoxythymidine, a Cytotoxic Metabolite of Zidovudine, Into the Cerebrospinal Fluid of HIV-1-Infected Patients ⬇️

scientific article published on 01 June 1997

Penetration of idarubicin into malignant brain tumor tissue.

scientific article published in August 1999

Penetration of zidovudine into the cerebrospinal fluid of patients infected with HIV

scientific article published on 01 December 1993

Performance of Methods for Handling Missing Categorical Covariate Data in Population Pharmacokinetic Analyses ⬇️

scientific article published on May 31, 2012

Persistent neuropathy after treatment with cisplatin and oxaliplatin

scientific article published in January 2009

Personalized medicine in oncology: a personal view with myths and facts

scientific article published on August 2010

Pharmaceutical development and preliminary clinical testing of an oral solid dispersion formulation of docetaxel (ModraDoc001)

scientific article published on 02 September 2011

Pharmaceutical development of a lyophilised dosage form for the investigational anticancer agent Imexon using dimethyl sulfoxide as solubilising and stabilising agent

scientific article published in May 2005

Pharmaceutical development of a parenteral formulation of the investigational anticancer drug clanfenur

scientific article published on 01 March 1997

Pharmaceutical development of a parenteral formulation of the novel anti-tumor agent carzelesin (U-80,244)

scientific article published on 01 January 1994

Pharmaceutical development of a parenteral lyophilised dosage form for the novel anticancer agent C1311.

scientific article published in September 2005

Pharmaceutical development of a parenteral lyophilised formulation of the investigational anticancer agent ES-285.HCl.

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Pharmaceutical development of a parenteral lyophilized formulation of the novel antitumor agent aplidine.

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Pharmaceutical development of an amorphous solid dispersion formulation of elacridar hydrochloride for proof-of-concept clinical studies

scientific article published on 23 December 2016

Pharmaceutical development of an intravenous dosage form of diacetylmorphine hydrochloride.

scientific article published in November 2004

Pharmaceutical development of an oral tablet formulation containing a spray dried amorphous solid dispersion of docetaxel or paclitaxel

scientific article published on 29 July 2016

Pharmaceutical heroin for inhalation: thermal analysis and recovery experiments after volatilisation

scientific article published on 21 July 2005

Pharmaceutical quality control of the investigational polymer-conjugated platinum anticancer agent AP 5280

scientific article published on 01 May 2003

Pharmacodynamic assay of thymidylate synthase activity in peripheral blood mononuclear cells ⬇️

scientific article published on January 12, 2013

Pharmacodynamic biomarkers in model-based drug development in oncology

scientific article published on February 2011

Pharmacodynamic modeling of adverse effects of anti-cancer drug treatment

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Pharmacodynamics and pharmacokinetics of oral topotecan in patients with advanced solid tumours and impaired renal function

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Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population

scientific article published on 01 January 2006

Pharmacogenetic screening of CYP3A and ABCB1 in relation to population pharmacokinetics of docetaxel

scientific article published on 01 October 2006

Pharmacogenetic screening of the gene deletion and duplications of CYP2D6.

scientific article published on January 2007

Pharmacogenetic variants associated with outcome in patients with advanced gastric cancer treated with fluoropyrimidine and platinum-based triplet combinations: a pooled analysis of three prospective studies

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Pharmacokinetic Optimization of Everolimus Dosing in Oncology: A Randomized Crossover Trial

scientific article published on 31 July 2017

Pharmacokinetic Parameters of Nevirapine and Efavirenz in Relation to Antiretroviral Efficacy

scientific article published in March 2006

Pharmacokinetic Targets for Therapeutic Drug Monitoring of Small Molecule Kinase Inhibitors in Pediatric Oncology

scientific article published on 05 February 2020

Pharmacokinetic comparison of two methods of heroin smoking: 'chasing the dragon' versus the use of a heating device

scientific article published in May 2005

Pharmacokinetic drug-drug interaction of the novel anticancer agent E7070 and acenocoumarol

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Pharmacokinetic evaluation of three oral formulations of docetaxel boosted with ritonavir: two single-drug formulations vs. a fixed-dose combination tablet

scientific article published on June 2013

Pharmacokinetic individualisation of zidovudine therapy. Current state of pharmacokinetic-pharmacodynamic relationships

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Pharmacokinetic study of docetaxel in intraoperative hyperthermic i.p. chemotherapy for ovarian cancer

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Pharmacokinetic variability of zidovudine in HIV-infected individuals: subgroup analysis and drug interactions

scientific article published on 01 December 1994

Pharmacokinetically guided sunitinib dosing: a feasibility study in patients with advanced solid tumours

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Pharmacokinetics and Excretion of 14C-Bendamustine in Patients with Relapsed or Refractory Malignancy ⬇️

scientific article published on March 1, 2013

Pharmacokinetics and excretion of (14)C-lenvatinib in patients with advanced solid tumors or lymphomas.

scientific article published on 8 November 2014

Pharmacokinetics and excretion of (14)C-omacetaxine in patients with advanced solid tumors

scientific article published on 25 May 2016

Pharmacokinetics and excretion of 14C-Plitidepsin in patients with advanced cancer.

scientific article published on 23 January 2017

Pharmacokinetics and metabolism of docetaxel administered as a 1-h intravenous infusion

scientific article published on 01 January 2000

Pharmacokinetics and metabolism of the staurosporine analogue CGP 41 251 in mice

scientific article published on 01 January 1999

Pharmacokinetics and pharmacodynamics of high doses of pharmaceutically prepared heroin, by intravenous or by inhalation route in opioid-dependent patients

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Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.

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Pharmacokinetics and pharmacodynamics of topotecan administered daily for 5 days every 3 weeks

scientific article published on 01 January 1995

Pharmacokinetics and pharmacokinetic variability of heroin and its metabolites: review of the literature

scientific article published on January 2006

Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis

scientific article published on 20 November 2019

Pharmacokinetics of Selected Anticancer Drugs in Elderly Cancer Patients: Focus on Breast Cancer

scientific article published on 2 January 2016

Pharmacokinetics of Sustained-Release Oral Dexamphetamine Sulfate in Cocaine and Heroin-Dependent Patients.

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Pharmacokinetics of cyclophosphamide and thiotepa in a conventional fractionated high-dose regimen compared with a novel simplified unfractionated regimen

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Pharmacokinetics of eribulin mesylate in patients with solid tumors and hepatic impairment

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Pharmacokinetics of eribulin mesylate in patients with solid tumours receiving repeated oral rifampicin ⬇️

scientific article published on February 1, 2013

Pharmacokinetics of gemcitabine and metabolites in a patient with double-sided nephrectomy: a case report and review of the literature

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Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients.

scientific article published on 2 June 2008

Pharmacokinetics of nevirapine: once-daily versus twice-daily dosing in the 2NN study.

scientific article published in September 2005

Pharmacokinetics of oral cyclosporin A when co-administered to enhance the absorption of orally administered docetaxel

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Pharmacokinetics of oseltamivir carboxylate in critically ill patients: each patient is unique

scientific article published on 27 February 2013

Pharmacokinetics of paclitaxel administered as a 3-hour or 96-hour infusion

scientific article published on 01 July 1999

Pharmacokinetics of paclitaxel and carboplatin in a dose-escalating and dose-sequencing study in patients with non-small-cell lung cancer. The European Cancer Centre

scientific article published on 01 January 1997

Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients

scientific article published on 01 November 1993

Pharmacokinetics of paclitaxel and three major metabolites in patients with advanced breast carcinoma refractory to anthracycline therapy treated with a 3-hour paclitaxel infusion: a European Cancer Centre (ECC) trial.

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Pharmacokinetics of sunitinib in an obese patient with a GIST.

scientific article published on 19 January 2009

Pharmacokinetics of zidovudine and acetaminophen in a patient on chronic acetaminophen therapy

scientific article published in March 1994

Pharmacologic study of 3-hour 135 mg M-2 paclitaxel in platinum pretreated patients with advanced ovarian cancer

scientific article published on 01 September 1998

Pharmacology of the paclitaxel-cisplatin, gemcitabine-cisplatin, and paclitaxel-gemcitabine combinations in patients with advanced non-small cell lung cancer.

scientific article published on 7 March 2006

Pharmacotherapy of Hospitalised HIV-Infected Patients in a General Hospital during 1990, 1997 and 2001 ⬇️

scientific article published on January 1, 2003

Phase 1 study of combination treatment with PTK 787/ZK 222584 and cetuximab for patients with advanced solid tumors: safety, pharmacokinetics, pharmacodynamics analysis

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Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer

scientific article published on 09 March 2020

Phase 1a/1b and pharmacogenetic study of docetaxel, oxaliplatin and capecitabine in patients with advanced cancer of the stomach or the gastroesophageal junction

scientific article published on 23 October 2015

Phase I Study of Afatinib and Selumetinib in Patients with KRAS-Mutated Colorectal, Non-Small Cell Lung, and Pancreatic Cancer

scientific article published on 09 December 2020

Phase I and pharmacokinetic study of E7070, a novel chloroindolyl sulfonamide cell-cycle inhibitor, administered as a one-hour infusion every three weeks in patients with advanced cancer

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Phase I and pharmacokinetic study of SPI-77, a liposomal encapsulated dosage form of cisplatin

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Phase I and pharmacokinetic study of Yondelis (Ecteinascidin-743; ET-743) administered as an infusion over 1 h or 3 h every 21 days in patients with solid tumours

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Phase I and pharmacokinetic study of a daily times 5 short intravenous infusion schedule of 9-aminocamptothecin in a colloidal dispersion formulation in patients with advanced solid tumors

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Phase I and pharmacokinetic study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced solid malignancies ⬇️

scientific article published on August 2, 2011

Phase I and pharmacokinetic study of combined treatment with perifosine and radiation in patients with advanced solid tumours

scientific article published on 17 August 2006

Phase I and pharmacokinetic study of irinotecan administered as a low-dose, continuous intravenous infusion over 14 days in patients with malignant solid tumors

scientific article published on 01 June 1999

Phase I and pharmacokinetic study of oral paclitaxel

scientific article published on 01 June 2000

Phase I and pharmacokinetic study of the combination of topotecan and ifosfamide administered intravenously every 3 weeks

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Phase I and pharmacokinetic trial of AP5346, a DACH-platinum-polymer conjugate, administered weekly for three out of every 4 weeks to advanced solid tumor patients

scientific article published on 17 February 2007

Phase I and pharmacokinetics study of topotecan, a new topoisomerase I inhibitor

scientific article published on 01 September 1993

Phase I and pharmacologic study of the combination of paclitaxel, cisplatin, and topotecan administered intravenously every 21 days as first-line therapy in patients with advanced ovarian cancer

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Phase I and pharmacologic study of the combination paclitaxel and carboplatin as first-line chemotherapy in stage III and IV ovarian cancer

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Phase I and pharmacologic study of weekly doxorubicin and 1 h infusional paclitaxel in patients with advanced breast cancer

scientific article published on 01 September 1998

Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra, R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumours

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Phase I and pharmacological trial of lapatinib in combination with gemcitabine in patients with advanced breast cancer

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Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel

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Phase I clinical and pharmacokinetic study of kahalalide F in patients with advanced androgen refractory prostate cancer.

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Phase I clinical and pharmacokinetic study of topotecan administered by a 24-hour continuous infusion ⬇️

scientific article published on July 1, 1995

Phase I clinical and pharmacologic study of a 2-weekly administration of cisplatin and gemcitabine in patients with advanced non-small cell lung cancer

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Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer

scientific article published in June 2002

Phase I dose-escalation study and population pharmacokinetic analysis of fixed dose rate gemcitabine plus carboplatin as second-line therapy in patients with ovarian cancer.

scientific article

Phase I pharmacokinetic and pharmacodynamic study of Carboplatin and topotecan administered intravenously every 28 days to patients with malignant solid tumors

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Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer

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Phase I pharmacokinetic and pharmacodynamic study of the prenyl transferase inhibitor AZD3409 in patients with advanced cancer.

scientific article published on 27 May 2008

Phase I pharmacokinetic study of the safety and tolerability of lapatinib (GW572016) in combination with oxaliplatin/fluorouracil/leucovorin (FOLFOX4) in patients with solid tumors

scientific article published on 01 August 2007

Phase I pharmacological study of continuous chronomodulated capecitabine treatment

scientific article published on 07 May 2020

Phase I study of Oral gemcitabine prodrug (LY2334737) alone and in combination with erlotinib in patients with advanced solid tumors

scientific article published on 13 July 2011

Phase I study of an oral formulation of irinotecan administered daily for 14 days every 3 weeks in patients with advanced solid tumours

scientific article published on 16 November 2004

Phase I study of continuous olaparib capsule dosing in combination with carboplatin and/or paclitaxel (Part 1)

scientific article published on 30 October 2019

Phase I study of intermittent olaparib capsule or tablet dosing in combination with carboplatin and paclitaxel (part 2)

scientific article published on 21 October 2019

Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer

scientific article published on 09 April 2020

Phase I study of lonafarnib (SCH66336) in combination with trastuzumab plus paclitaxel in Her2/neu overexpressing breast cancer: EORTC study 16023 ⬇️

scientific article published on September 29, 2012

Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

scientific article published on 25 October 2014

Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With TP53-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months

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Phase II and pharmacologic study of weekly oral paclitaxel plus cyclosporine in patients with advanced non-small-cell lung cancer

scientific article published on 01 December 2002

Phase II and pharmacological study of oral docetaxel plus cyclosporin A in anthracycline pre-treated metastatic breast cancer

scientific article published on 01 May 2014

Phase II and pharmacological study of oral paclitaxel (Paxoral) plus ciclosporin in anthracycline-pretreated metastatic breast cancer

scientific article published on 12 September 2006

Phase II study of the combination carboplatin and paclitaxel in patients with ovarian cancer ⬇️

scientific article published on April 1, 1997

Phenytoin alters the disposition of topotecan and N-desmethyl topotecan in a patient with medulloblastoma ⬇️

scientific article published on March 1, 1998

Photophobia in a patient with high indinavir plasma concentrations

scientific article published in December 2003

Photostability profiles of the experimental antimetastatic ruthenium complex NAMI-A.

scientific article published in November 2002

Pilot Study to Predict Pharmacokinetics of a Therapeutic Gemcitabine Dose From a Microdose

scientific article published on 22 January 2020

Piraña and PCluster: a modeling environment and cluster infrastructure for NONMEM.

scientific article published on 02 June 2010

Plasma Levels of Enzalutamide and Its Main Metabolites in a Patient With Metastatic Castration-resistant Prostate Cancer Undergoing Hemodialysis

scientific article published on 19 December 2018

Plasma concentrations of tyrosine kinase inhibitors imatinib, erlotinib, and sunitinib in routine clinical outpatient cancer care

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Plasma pharmacokinetics, tissue disposition, excretion and metabolism of vinleucinol in mice as determined by high-performance liquid chromatography

scientific article published on 01 January 1994

Plasma pharmacokinetics, tissue disposition, excretion and metabolism of vinorelbine in mice as determined by high performance liquid chromatography

scientific article published on 01 May 1993

Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa

scientific article

Population PKPD of paclitaxel and carboplatin in ovarian cancer patients: A study by the EORTC-PAMM-NDDG.

scientific article published in April 2007

Population Pharmacokinetic-Pharmacodynamic Analysis of Trastuzumab-Associated Cardiotoxicity

scientific article published on June 1, 2011

Population Pharmacokinetics of Intracellular 5-Fluorouridine 5'-Triphosphate and its Relationship with Hand-and-Foot Syndrome in Patients Treated with Capecitabine

scientific article published on 08 January 2021

Population Pharmacokinetics of MCLA-128, a HER2/HER3 Bispecific Monoclonal Antibody, in Patients with Solid Tumors

scientific article published on 31 January 2020

Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors.

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Population pharmacokinetic and pharmacodynamic analysis to support treatment optimization of combination chemotherapy with indisulam and carboplatin

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Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen

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Population pharmacokinetics and pharmacodynamics for treatment optimization in clinical oncology

scientific article published on January 2008

Population pharmacokinetics and pharmacodynamics of doxorubicin and cyclophosphamide in breast cancer patients: a study by the EORTC-PAMM-NDDG.

scientific article published in January 2007

Population pharmacokinetics and pharmacodynamics of mitomycin during intraoperative hyperthermic intraperitoneal chemotherapy

scientific article published on 01 January 2004

Population pharmacokinetics and pharmacodynamics of paclitaxel and carboplatin in ovarian cancer patients: a study by the European organization for research and treatment of cancer-pharmacology and molecular mechanisms group and new drug development

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Population pharmacokinetics and pharmacokinetic-pharmacodynamic relationships of the novel anticancer agent E7070 in four phase I studies

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Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine

scientific article published in January 2005

Population pharmacokinetics of cyclophosphamide and its metabolites 4-hydroxycyclophosphamide, 2-dechloroethylcyclophosphamide, and phosphoramide mustard in a high-dose combination with Thiotepa and Carboplatin

scientific article published in December 2005

Population pharmacokinetics of efavirenz in an unselected cohort of HIV-1-infected individuals

scientific article published in January 2005

Population pharmacokinetics of heroin and its major metabolites

scientific article published in January 2006

Population pharmacokinetics of ifosfamide and its dechloroethylated and hydroxylated metabolites in children with malignant disease: a sparse sampling approach

scientific article published in January 2001

Population pharmacokinetics of indinavir alone and in combination with ritonavir in HIV-1-infected patients

scientific article published in September 2005

Population pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer

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Population pharmacokinetics of itraconazole in Thai HIV-1-infected persons

scientific article published on April 2003

Population pharmacokinetics of lopinavir in combination with ritonavir in HIV-1-infected patients

scientific article published in October 2005

Population pharmacokinetics of nevirapine in an unselected cohort of HIV-1-infected individuals

scientific article published on October 2002

Population pharmacokinetics of nevirapine in an unselected cohort of HIV-1-infected individuals.

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Population pharmacokinetics of orally administered paclitaxel formulated in Cremophor EL

scientific article published on March 2005

Population pharmacokinetics of the novel anticancer agent E7070 during four phase I studies: model building and validation

scientific article published in October 2002

Population pharmacokinetics of the novel anticancer agent KRN7000.

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Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy

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Population pharmacokinetic–pharmacodynamic analysis for eribulin mesilate‐associated neutropenia ⬇️

scientific article published on September 1, 2013

Postoperative serum proteomic profiles may predict recurrence-free survival in high-risk primary breast cancer

scientific article

Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology

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Practical guidelines for therapeutic drug monitoring of anticancer tyrosine kinase inhibitors: focus on the pharmacokinetic targets

scientific article published on April 2014

Practical guidelines to interpret plasma concentrations of antiretroviral drugs

scientific article published in January 2004

Preclinical pharmacokinetics of paclitaxel and docetaxel ⬇️

scientific article published on January 1, 1998

Predictive Value of Microdose Pharmacokinetics

scientific article published on 01 October 2019

Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies.

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Preparation and stability testing of a hydrogel for topical analgesia

scientific article published in November 1995

Prescription error resulting in valproic acid intoxication

scientific article published in December 2004

Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity

scientific article published on 20 April 2017

Prevalence of xerostomia and its relationship with underlying diseases, medication, and nutrition: a descriptive observational study.

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Prevention of severe toxicity from capecitabine, 5-fluorouracil and tegafur by screening for DPD-deficiency

scientific article published on 01 January 2012

Procedures and practices for the validation of bioanalytical methods using dried blood spots: a review

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Process characterisation, optimisation and validation of production of diacetylmorphine/caffeine sachets: a design of experiments approach

scientific article published in November 2004

Prognostic factors for the clinical effectiveness of fluconazole in the treatment of oral candidiasis in HIV-1-infected individuals

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Progress in the development of alternative pharmaceutical formulations of taxanes

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Prolonged exposure to tenofovir monotherapy 1 month after treatment discontinuation because of tenofovir-related renal failure

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Prolonged versus standard gemcitabine infusion: translation of molecular pharmacology to new treatment strategy

scientific article published on March 2008

Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers

scientific article published on 10 May 2016

PropAngio study protocol: a neoadjuvant trial on the efficacy of propranolol monotherapy in cutaneous angiosarcoma-a proof of principle study

scientific article published on 10 September 2020

Propofol extravasation in a breast cancer patient

scientific article published on 27 August 2008

Protein versus DNA as a marker for peripheral blood mononuclear cell counting

scientific article published on 16 August 2009

Purity determinations in the bulk drug of the novel indoloquinone antitumor agent EO9

scientific article published on 01 January 1996

P‐glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel ⬇️

article by Jeroen J M A Hendrikx et al published 14 November 2012 in International Journal of Cancer

Qualitative aspects of the degradation of mitomycins in alkaline solution

scientific article published on 01 January 1985

Quantification of 11 Therapeutic Kinase Inhibitors in Human Plasma for Therapeutic Drug Monitoring Using Liquid Chromatography Coupled With Tandem Mass Spectrometry

scientific article published on 5 October 2016

Quantification of FGFR4 inhibitor BLU-554 in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry

scientific article published on 16 February 2019

Quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cell lysate using liquid chromatography coupled with tandem mass spectrometry

scientific article published on 14 January 2009

Quantification of cabazitaxel, its metabolite docetaxel and the determination of the demethylated metabolites RPR112698 and RPR123142 as docetaxel equivalents in human plasma by liquid chromatography–tandem mass spectrometry ⬇️

scientific article published on March 5, 2013

Quantification of docetaxel and its metabolites in human plasma by liquid chromatography/tandem mass spectrometry

scientific article published in September 2013

Quantification of etravirine (TMC125) in plasma, dried blood spots and peripheral blood mononuclear cell lysate by liquid chromatography tandem mass spectrometry

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Quantification of farnesylmethylcysteine in lysates of peripheral blood mononuclear cells using liquid chromatography coupled with electrospray tandem mass spectrometry: pharmacodynamic assay for farnesyl transferase inhibitors

scientific article published on 01 April 2006

Quantification of miltefosine in peripheral blood mononuclear cells by high-performance liquid chromatography-tandem mass spectrometry

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Quantification of paclitaxel metabolites in human plasma by high-performance liquid chromatography

scientific article published on 01 December 1995

Quantification of protease inhibitors and non-nucleoside reverse transcriptase inhibitors in dried blood spots by liquid chromatography-triple quadrupole mass spectrometry

scientific article published on 8 April 2008

Quantification of sunitinib and N-desethyl sunitinib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry: validation and application in routine therapeutic drug monitoring

scientific article published in April 2013

Quantification of taxanes in biological matrices: a review of bioanalytical assays and recommendations for development of new assays

scientific article published on April 2014

Quantification of the HIV-integrase inhibitor raltegravir and detection of its main metabolite in human plasma, dried blood spots and peripheral blood mononuclear cell lysate by means of high-performance liquid chromatography tandem mass spectrometr

scientific article published on 27 November 2008

Quantification of the pharmacokinetic-toxicodynamic relationship of oral docetaxel co-administered with ritonavir

scientific article published on 19 April 2020

Quantification of topotecan and its metabolite N-desmethyltopotecan in human plasma, urine and faeces by high-performance liquid chromatographic methods

scientific article published on 01 April 1999

Quantification of vosaroxin and its metabolites N-desmethylvosaroxin and O-desmethylvosaroxin in human plasma and urine using high-performance liquid chromatography-tandem mass spectrometry.

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Quantifying vemurafenib in dried blood spots using high-performance LC-MS/MS

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Quantitative Determination of Erlotinib And O -Desmethyl Erlotinib in Human Edta Plasma And Lung Tumor Tissue ⬇️

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Quantitative LC-MS/MS analysis of 5-hydroxymethyl-2'-deoxyuridine to monitor the biological activity of J-binding protein

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Quantitative analysis of D-24851, a novel anticancer agent, in human plasma and urine by liquid chromatography coupled with tandem mass spectrometry

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Quantitative analysis of EO9 (apaziquone) and its metabolite EO5a in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray tandem mass spectrometry

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Quantitative analysis of docetaxel in human plasma using liquid chromatography coupled with tandem mass spectrometry

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Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry

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Quantitative analysis of the P-glycoprotein inhibitor Elacridar (GF120918) in human and dog plasma using liquid chromatography with tandem mass spectrometric detection

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Quantitative analysis of the farnesyl transferase inhibitor lonafarnib (Sarasartrade mark, SCH66336) in human plasma using high-performance liquid chromatography coupled with tandem mass spectrometry

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Quantitative and selective assay of 5-methylindirubine, an inhibitor of cyclin-dependent kinases, in murine plasma using coupled liquid chromatography and electrospray tandem mass spectrometry

scientific article published on 22 June 2007

Quantitative aspects of the analysis of the monoclonal antibody trastuzumab using high-performance liquid chromatography coupled with electrospray mass spectrometry

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Quantitative assay for six potential breast cancer biomarker peptides in human serum by liquid chromatography coupled to tandem mass spectrometry

scientific article published on 18 January 2010

Quantitative bioanalysis of peptides by liquid chromatography coupled to (tandem) mass spectrometry

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Quantitative bioanalytical assay for the selective RET inhibitors selpercatinib and pralsetinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry

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Quantitative bioanalytical assay for the tropomyosin receptor kinase inhibitor larotrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry

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Quantitative determination of (−)-2′-deoxy-3′-thiacytidine (lamivudine) in human plasma, saliva and cerebrospinal fluid by high-performance liquid chromatography with ultraviolet detection ⬇️

scientific article published on August 25, 1998

Quantitative determination of Ecteinascidin 743 in human plasma by miniaturized high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry

scientific article published on 01 November 1998

Quantitative determination of abacavir (1592U89), a novel nucleoside reverse transcriptase inhibitor, in human plasma using isocratic reversed-phase high-performance liquid chromatography with ultraviolet detection

scientific article published on 01 December 1999

Quantitative determination of azacitidine triphosphate in peripheral blood mononuclear cells using liquid chromatography coupled with high-resolution mass spectrometry.

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Quantitative determination of capecitabine and its six metabolites in human plasma using liquid chromatography coupled to electrospray tandem mass spectrometry ⬇️

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Quantitative determination of efavirenz (DMP 266), a novel non-nucleoside reverse transcriptase inhibitor, in human plasma using isocratic reversed-phase high-performance liquid chromatography with ultraviolet detection

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Quantitative determination of oseltamivir and oseltamivir carboxylate in human fluoride EDTA plasma including the ex vivo stability using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry ⬇️

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Quantitative determination of the novel anticancer drug E7070 (indisulam) and its metabolite (1,4-benzenedisulphonamide) in human plasma, urine and faeces by high-performance liquid chromatography coupled with electrospray ionization tandem mass spe

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Quantitative effect of gender, age, liver function, and body size on the population pharmacokinetics of Paclitaxel in patients with solid tumors

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RNA-Sequencing of Tumor-Educated Platelets, a Novel Biomarker for Blood-Based Sarcoma Diagnostics

scientific article published on 27 May 2020

RT-PCR detection of respiratory pathogens in newborn children admitted to a neonatal medium care unit

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Race is not associated with nevirapine pharmacokinetics

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Radiochemical purity of iodine-131 labelled metaiodobenzylguanidine infusion fluids: a report from clinical practice

scientific article published on 01 July 1993

Radiochemical stability during infusion of 131I-labelled metaiodobenzylguanidine for therapeutic use

scientific article published on 01 September 1993

Randomized phase I and pharmacological study of weekly or 2-weekly gemcitabine and cisplatin in advanced non-small cell lung cancer

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Randomized phase I clinical and pharmacologic study of weekly versus twice-weekly dose-intensive cisplatin and gemcitabine in patients with advanced non-small cell lung cancer ⬇️

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Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies

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Rapid detection of the DPYD IVS14+1G>A mutation for screening patients to prevent fluorouracil-related toxicity

scientific article published on 01 January 2007

Rapid determination of nevirapine in human plasma by ion-pair reversed-phase high-performance liquid chromatography with ultraviolet detection ⬇️

scientific article published on August 25, 1998

Rapid esterase-sensitive breakdown of polysorbate 80 and its impact on the plasma pharmacokinetics of docetaxel and metabolites in mice

scientific article published on 01 October 1999

Rapid quantification of delavirdine, a novel non-nucleoside reverse transcriptase inhibitor, in human plasma using isocratic reversed-phase high-performance liquid chromatography with fluorescence detection

scientific article published on 01 April 1999

Reasons for undertreatment with oral anticoagulants in frail geriatric outpatients with atrial fibrillation: a prospective, descriptive study

scientific article published on January 2010

Recent developments in the chromatographic bioanalysis of approved kinase inhibitor drugs in oncology.

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Reconstitution of recombinant interleukin-2 (rIL-2): a comparative study of various rIL-2 muteins

scientific article published on 01 January 1993

Reduced liver uptake of arterially infused melphalan during retrograde rat liver perfusion with unaffected liver tumor uptake

scientific article published on November 2002

Regulatory aspects of human radiolabeled mass balance studies in oncology: concise review

scientific article published on 17 May 2016

Relations between polymorphisms in drug-metabolising enzymes and toxicity of chemotherapy with cyclophosphamide, thiotepa and carboplatin

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Relationship between cisplatin administration and the development of ototoxicity

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Relationship between exposure and toxicity in high-dose chemotherapy with cyclophosphamide, thiotepa and carboplatin

scientific article

Relationship between single nucleotide polymorphisms and haplotypes in DPYD and toxicity and efficacy of capecitabine in advanced colorectal cancer

scientific article published on 15 April 2011

Relevance of Endoxifen Concentrations: Absence of Evidence Is Not Evidence of Absence

scientific article published on 18 June 2019

Relevance of in vitro and clinical data for predicting CYP3A4-mediated herb-drug interactions in cancer patients.

scientific article

Renal excretion of iodine-131 labelled meta-iodobenzylguanidine and metabolites after therapeutic doses in patients suffering from different neural crest-derived tumours

scientific article published on 01 May 1997

Renal excretion of meta-iodobenzylguanidine after therapeutic doses in cancer patients and its relation to dose and creatinine clearance

scientific article published on 01 September 1995

Renal function, body surface area, and age are associated with risk of early-onset fluoropyrimidine-associated toxicity in patients treated with capecitabine-based anticancer regimens in daily clinical care

scientific article published on 4 January 2016

Reply to Arya and Agarwal

scientific article published on 11 June 2013

Reply to T. Magnes et al.

scientific article

Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP.

scientific article

Retention studies of 2'-2'-difluorodeoxycytidine and 2'-2'-difluorodeoxyuridine nucleosides and nucleotides on porous graphitic carbon: development of a liquid chromatography-tandem mass spectrometry method

scientific article published on 10 February 2009

Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment

scientific article published on 23 July 2018

Review of therapeutic drug monitoring of anticancer drugs part 1--cytotoxics

scientific article

Review of therapeutic drug monitoring of anticancer drugs part two--targeted therapies

scientific article

Review on the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and its phase I and phase II metabolites in biological matrices, foodstuff and beverages

scientific article published on 26 October 2010

Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model

scientific article published on 21 August 2015

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan

scientific article published on 01 October 2000

Rs895819 in MIR27A improves the predictive value of DPYD variants to identify patients at risk of severe fluoropyrimidine-associated toxicity

scientific article

SELDI-TOF MS serum protein profiles in breast cancer: assessment of robustness and validity

scientific article

Safety and pharmacology of gemcitabine and capecitabine in patients with advanced pancreatico-biliary cancer and hepatic dysfunction.

scientific article published on 29 October 2013

Safety and pharmacology of paclitaxel in patients with impaired liver function: a population pharmacokinetic-pharmacodynamic study

scientific article

Sampling technique from central venous catheters proves critical for pharmacokinetic studies

scientific article published on 01 February 1999

Saturable binding of indisulam to plasma proteins and distribution to human erythrocytes

scientific article published on 24 March 2006

Screening for illicit heroin use in patients in a heroin-assisted treatment program

scientific article published in July 2006

Screening for polymorphisms in the PXR gene in a Dutch population

scientific article published on 28 March 2006

Search for breast cancer biomarkers in fractionated serum samples by protein profiling with SELDI-TOF MS.

scientific article

Search for metabolites of ecteinascidin 743, a novel, marine-derived, anti-cancer agent, in man.

scientific article

Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study

scientific article

Selected new developments in oncology

scientific article published on 01 August 2010

Selective high-performance liquid chromatographic assay for itraconazole and hydroxyitraconazole in plasma from human immunodeficiency virus-infected patients

scientific article published in February 2002

Semi-automatic liquid chromatographic analysis of olpadronate in urine and serum using derivatization with (9-fluorenylmethyl)chloroformate

scientific article published on 01 February 2000

Semi-automatic liquid chromatographic analysis of pamidronate in serum and citrate plasma after derivatization with 1-naphthylisothiocyanate ⬇️

scientific article published on February 13, 1998

Semi-automatic liquid chromatographic analysis of pamidronate in urine after derivatization with 1-naphthylisothiocyanate

scientific article published on 01 June 1999

Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam

scientific article

Semiphysiological versus empirical modelling of the population pharmacokinetics of free and total cefazolin during pregnancy

scientific article published on 3 February 2014

Sensitive isocratic high-performance liquid chromatographic determination of a novel indoloquinone cytotoxic drug (EO9) in human plasma and urine

scientific article published on 01 June 1993

Sensitive liquid chromatography/tandem mass spectrometry assay for absolute quantification of ITIH4-derived putative biomarker peptides in clinical serum samples

scientific article published in July 2010

Sensitive method for plasma and tumor Ko143 quantification using reversed-phase high-performance liquid chromatography and fluorescence detection ⬇️

scientific article published on 06 December 2012

Serum degradome markers for the detection of breast cancer

scientific article published on 01 August 2010

Serum protein profiling for diagnosis of breast cancer using SELDI-TOF MS.

scientific article

Serum proteomics and disease-specific biomarkers of patients with advanced gastric cancer

scientific article

Serum β-HCG and CA-125 as Tumor Markers in a Patient with Osteosarcoma: Case Report ⬇️

scientific article published on January 1, 2011

Severe cannabinoid intoxication in a patient with non-small-cell lung cancer

scientific article published on 01 January 2012

Severe encephalopathy and polyneuropathy induced by dichloroacetate.

scientific article published on 15 July 2010

Severe lactic acidosis in a diabetic patient after ethanol abuse and floor cleaner intake.

scientific article

Shielding the cationic charge of nanoparticle-formulated dermal DNA vaccines is essential for antigen expression and immunogenicity

scientific article published on 12 September 2009

Should non-nucleoside reverse transcriptase inhibitors be combined?

scientific article

Significant induction of cyclophosphamide and thiotepa metabolism by phenytoin

scientific article

Sildenafil is not a useful modulator of ABCB1 and ABCG2 mediated drug resistance in vivo ⬇️

scientific article published on February 17, 2013

Simple and rapid method for the simultaneous determination of the non-nucleoside reverse transcriptase inhibitors efavirenz and nevirapine in human plasma using liquid chromatography

scientific article

Simple and selective determination of the cyclophosphamide metabolite phosphoramide mustard in human plasma using high-performance liquid chromatography

scientific article published on 01 August 2000

Simple and sensitive liquid chromatographic quantitative analysis of the novel marine anticancer drug Yondelis (ET-743, trabectedin) in human plasma using column switching and tandem mass spectrometric detection

scientific article published in April 2004

Simple high‐performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue ⬇️

scientific article published on October 1, 2003

Simultaneous Integrated Boost–Intensity Modulated Radiation Therapy With Concomitant Capecitabine and Mitomycin C for Locally Advanced Anal Carcinoma: A Phase 1 Study ⬇️

scientific article published on April 1, 2013

Simultaneous determination of AZD1152 (prodrug) and AZD1152-hydroxyquinazoline pyrazol anilide by reversed phase liquid chromatography

scientific article published on 28 August 2009

Simultaneous determination of N,N',N"-triethylenethiophosphoramide, cyclophosphamide and some of their metabolites in plasma using capillary gas chromatography

scientific article published on 01 September 1998

Simultaneous population pharmacokinetic modelling of plasma and intracellular PBMC miltefosine concentrations in New World cutaneous leishmaniasis and exploration of exposure-response relationships

scientific article published on 01 August 2018

Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry

scientific article published in October 2009

Simultaneous quantification of cyclophosphamide and its active metabolite 4-hydroxycyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-MS/MS)

scientific article published on 25 April 2007

Simultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in human plasma by high-performance liquid chromatography coupled with electrospr

scientific article published in March 2004

Simultaneous quantification of dabrafenib and trametinib in human plasma using high-performance liquid chromatography-tandem mass spectrometry

scientific article published on 25 March 2016

Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry

scientific article published on 14 January 2010

Simultaneous quantification of the new HIV protease inhibitors atazanavir and tipranavir in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry

scientific article published in May 2004

Simultaneous quantitative determination of the HIV protease inhibitors amprenavir, indinavir, nelfinavir, ritonavir and saquinavir in human plasma by ion-pair high-performance liquid chromatography with ultraviolet detection

scientific article published on 01 November 1998

Skin tissue sample collection, sample homogenization, and analyte extraction strategies for liquid chromatographic mass spectrometry quantification of pharmaceutical compounds

scientific article published on 28 August 2020

Slow dissolution behaviour of amorphous capecitabine ⬇️

scientific article published on 05 December 2012

Solubility and bioavailability improvement of pazopanib hydrochloride

scientific article published on 19 April 2018

Sorption of thiotepa to polyurethane catheter causes falsely elevated plasma levels

scientific article published on 01 June 2003

Sparse sampling design for therapeutic drug monitoring of sequentially administered cyclophosphamide, thiotepa, and carboplatin (CTC).

scientific article published in June 2005

Specific Investigation of Sample Handling Effects on Protease Activities and Absolute Serum Concentrations of Various Putative Peptidome Cancer Biomarkers ⬇️

scientific article published on September 30, 2010

Stability experiments in human urine with EO9 (apaziquone): a novel anticancer agent for the intravesical treatment of bladder cancer

scientific article published on 22 August 2006

Stability of oxaliplatin in chloride-containing carrier solutions used in hyperthermic intraperitoneal chemotherapy.

scientific article published on 20 December 2014

Stable Isotopically Labeled Intravenous Microdose Pharmacokinetic Trials as a Tool to Assess Absolute Bioavailability: Feasibility and Paradigm to Apply for Protein Kinase Inhibitors in Oncology

scientific article published on 22 June 2020

Stable and sensitive method for the simultaneous determination of N5-methyltetrahydrofolate, leucovorin, methotrexate and 7-hydroxymethotrexate in biological fluids

scientific article published on 01 March 1989

Stable isotopically labeled internal standards in quantitative bioanalysis using liquid chromatography/mass spectrometry: necessity or not?

scientific article published in January 2005

Standard-dose tegafur-uracil (UFT) is not a safe alternative in partial dihydropyrimidine dehydrogenase-deficient patients ⬇️

scientific article published on January 1, 2013

Strategies to target drugs to gliomas and CNS metastases of solid tumors

scientific article published on 17 October 2015

Structure elucidation of aplidine metabolites formed in vitro by human liver microsomes using triple quadrupole mass spectrometry

scientific article published in June 2005

Study on didanosine concentrations in cerebrospinal fluid. Implications for the treatment and prevention of AIDS dementia complex

scientific article published on November 1995

Subtherapeutic antiretroviral plasma concentrations in routine clinical outpatient HIV care

scientific article

Successful intraperitoneal suramin treatment of peritoneal mesothelioma ⬇️

scientific article published on 01 August 1997

Survival after massive ecstasy overdose

scientific article published on 01 January 1998

Symptoms and treatment in cancer therapy-induced early menopause

scientific article published on June 2006

Synthetic vehicles for DNA vaccination

scientific article published on January 2010

Systematic Review of Host-Mediated Activity of Miltefosine in Leishmaniasis through Immunomodulation.

scientific article published on 24 June 2019

Systematic review of biomarkers to monitor therapeutic response in leishmaniasis

scientific article

Tailored Tamoxifen Treatment for Breast Cancer Patients: A Perspective

scientific article published on 23 April 2015

Tamoxifen dose and serum concentrations of tamoxifen and six of its metabolites in routine clinical outpatient care

scientific article published on 05 January 2014

Tandem mass spectrometry of small-molecule signal transduction inhibitors: Accurate-m/z data to adapt structure proposals of product ions

scientific article published on 24 December 2020

Targeting core (mutated) pathways of high-grade gliomas: challenges of intrinsic resistance and drug efflux.

scientific article

Taxanes: Old drugs, new oral formulations ⬇️

scientific article published on 07 May 2013

Taxanes: a new class of antitumor agents.

scientific article published on January 1995

The G2 checkpoint-a node-based molecular switch

scientific article published on 4 March 2017

The Use of Dried Blood Spots for Pharmacokinetic Monitoring of Vemurafenib Treatment in Melanoma Patients

scientific article published on 26 February 2016

The absolute quantification of eight inter‐α‐trypsin inhibitor heavy chain 4 (ITIH4)‐derived peptides in serum from breast cancer patients ⬇️

scientific article published on 01 December 2010

The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research

scientific article published on March 2008

The bioanalysis of the major Echinacea purpurea constituents dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides in human plasma using LC-MS/MS

scientific article published on 26 June 2012

The bioanalysis of the monoclonal antibody trastuzumab by high-performance liquid chromatography with fluorescence detection after immuno-affinity purification from human serum.

scientific article published on 7 May 2009

The bioanalysis of trastuzumab in human serum using precipitate-enhanced ellipsometry.

scientific article

The bioanalysis of vinorelbine and 4-O-deacetylvinorelbine in human and mouse plasma using high-performance liquid chromatography coupled with heated electrospray ionization tandem mass-spectrometry

scientific article

The biological and clinical role of drug transporters at the intestinal barrier

scientific article

The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients ⬇️

scientific article published on November 16, 2001

The domain architecture of the protozoan protein J-DNA-binding protein 1 suggests synergy between base J DNA binding and thymidine hydroxylase activity

scientific article published on 10 July 2019

The effect of Echinacea purpurea on the pharmacokinetics of docetaxel ⬇️

scientific article published on September 1, 2013

The effect of P-glycoprotein and cytochrome P450 3a on the oral bioavailability of vinorelbine in mice

scientific article

The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib

scientific article published in May 2008

The effect of St John's wort on the pharmacokinetics of docetaxel

scientific article published on 01 January 2014

The effect of complementary and alternative medicines on CYP3A4-mediated metabolism of three different substrates: 7-benzyloxy-4-trifluoromethyl-coumarin, midazolam and docetaxel

scientific article published on 7 January 2014

The effect of fluconazole on ritonavir and saquinavir pharmacokinetics in HIV-1-infected individuals

scientific article

The effect of food on the pharmacokinetics of S-1 after single oral administration to patients with solid tumors

scientific article

The effect of grape seed extract on the pharmacokinetics of dextromethorphan in healthy volunteers.

scientific article published on 24 July 2013

The effect of hydroxyurea on P-glycoprotein/BCRP-mediated transport and CYP3A metabolism of imatinib mesylate

scientific article published on 16 December 2006

The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models

scientific article published on 10 October 2006

The effect of seasonal variation and secretion of sunitinib in sweat on the development of hand-foot syndrome

scientific article published on 31 August 2013

The effects of sulfur-containing compounds and gemcitabine on the binding of cisplatin to plasma proteins and DNA determined by inductively coupled plasma mass spectrometry and high performance liquid chromatography-inductively coupled plasma mass s

scientific article published in July 2008

The impact of P-glycoprotein and breast cancer resistance protein on the brain pharmacokinetics and pharmacodynamics of a panel of MEK inhibitors

scientific article published on 16 September 2017

The impact of column temperature in the high performance liquid chromatographic analysis of topotecan in rat and dog plasma

scientific article published on 01 November 1996

The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases

scientific article published on 11 February 2018

The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity.

scientific article published on 15 April 2014

The influence of P170-glycoprotein modulators on the efficacy and the distribution of vincristine as well as on MDR1 expression in BRO/mdr1.1 human melanoma xenografts

scientific article published on 01 May 1999

The influence of formulation excipients on the stability of the novel antitumor agent carzelesin (U-80,244)

scientific article published on 01 November 1995

The influence of the P-glycoprotein inhibitor zosuquidar trihydrochloride (LY335979) on the brain penetration of paclitaxel in mice ⬇️

scientific article published on November 7, 2003

The intravenous to oral switch of taxanes: strategies and current clinical developments

scientific article published on 24 December 2020

The performance of model-based versus rule-based phase I clinical trials in oncology : A quantitative comparison of the performance of model-based versus rule-based phase I trials with molecularly targeted anticancer drugs over the last 2 years.

scientific article published on 10 March 2016

The pharmacokinetics of nelfinavir in HIV-1-infected children

scientific article

The pharmacokinetics of reduced folates after intraperitoneal and intravenous administration of racemic [6S,R]-folinic acid

scientific article published on 01 January 1994

The pharmacokinetics of topotecan and its carboxylate form following separate intravenous administration to the dog

scientific article published on October 1, 1997

The pharmacokinetics of ¹²⁴I-rituximab in patients with rheumatoid arthritis

scientific article published on 01 January 2011

The pharmacokinetics of ¹³¹I-rituximab in a patient with CD20 positive non-Hodgkin Lymphoma: evaluation of the effect of radioiodination on the biological properties of rituximab

scientific article published on 01 January 2011

The pharmacological role of P-glycoprotein in the intestinal epithelium ⬇️

scientific article published on June 1, 1998

The plasma and intracellular steady-state pharmacokinetics of lopinavir/ritonavir in HIV-1-infected patients

scientific article

The preparation of radiolabeled monoclonal antibodies for human use.

scientific article published on January 2009

The quantitative analysis of heroin, methadone and their metabolites and the simultaneous detection of cocaine, acetylcodeine and their metabolites in human plasma by high-performance liquid chromatography coupled with tandem mass spectrometry

scientific article

The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice

scientific article published on 01 March 2000

The steady-state plasma pharmacokinetics of indinavir alone and in combination with a low dose of ritonavir in twice daily dosing regimens in HIV-1-infected individuals

scientific article published on 01 October 1999

The toxicity of radiotherapy following high-dose chemotherapy with peripheral blood stem cell support in high-risk breast cancer: a preliminary analysis

scientific article published on 01 August 1996

The use of combinations of monoclonal antibodies in clinical oncology

scientific article published on 30 October 2015

The use of the Calvert formula to determine the optimal carboplatin dosage ⬇️

scientific article published on January 1, 1995

Therapeutic Drug Monitoring of Oral Anti-Hormonal Drugs in Oncology

scientific article published on 01 March 2019

Therapeutic Drug Monitoring of endoxifen as an alternative for CYP2D6 genotyping in individualizing tamoxifen therapy

scientific article published on 22 August 2018

Therapeutic drug monitoring in cancer--are we missing a trick?

scientific article

Therapeutic drug monitoring of antiretroviral drugs at home using dried blood spots: a proof-of-concept study

scientific article published on 12 December 2012

Therapeutic drug monitoring of imatinib in patients with gastrointestinal stromal tumours - Results from daily clinical practice

scientific article published on 17 July 2020

Therapeutic drug monitoring of non-anticancer drugs in cancer patients.

scientific article

Therapeutic drug monitoring of phenytoin in patients with the acquired immunodeficiency syndrome

scientific article published on 01 December 1994

Therapeutic drug monitoring of small molecule kinase inhibitors in oncology in a real-world cohort study: does age matter?

scientific article published on 26 September 2018

Thermal stability study of crystalline and novel spray-dried amorphous nilotinib hydrochloride

scientific article published on 12 October 2017

Three spectroscopic techniques evaluated as a tool to study the effects of iodination of monoclonal antibodies, exemplified by rituximab ⬇️

scientific article published on May 20, 2011

Tissue disposition, excretion and metabolism of vinblastine in mice as determined by high-performance liquid chromatography

scientific article published on 01 January 1993

Tissue distribution, metabolism and excretion of paclitaxel in mice

scientific article published on 01 January 1996

Topoisomerase I inhibitors in the treatment of gastrointestinal cancer: from intravenous to oral administration

scientific article published in September 2004

Topoisomerase I levels in white blood cells of patients with ovarian cancer treated with paclitaxel-cisplatin-topotecan in a phase I study

scientific article published on January 2002

Topoisomerase I/II inhibitor intoplicine administered as a 24 h infusion: phase I and pharmacologic study

scientific article published on 01 January 1999

Toxicokinetics of a dipyridamole (Persantin) intoxication: case report

scientific article

Toxicological analysis of azide and cyanide for azide intoxications using gas chromatography

scientific article published on 22 October 2020

Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype

scientific article

Trabectedin (Yondelis, formerly ET-743), a mass balance study in patients with advanced cancer.

scientific article

Translational PK-PD modeling analysis of MCLA-128, a HER2/HER3 bispecific monoclonal antibody, to predict clinical efficacious exposure and dose

scientific article published on 05 May 2018

Translational pharmacokinetic modelling and simulation for the assessment of duration of contraceptive use after treatment with miltefosine.

scientific article published on 10 May 2012

Transplacental transfer of anthracyclines, vinblastine, and 4-hydroxy-cyclophosphamide in a baboon model ⬇️

scientific article published on September 17, 2010

Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone

scientific article published on 9 October 2008

Transport of topoisomerase I inhibitors by the breast cancer resistance protein. Potential clinical implications

scientific article

Transposon leads to contamination of clinical pDNA vaccine.

scientific article published on 23 May 2013

Trastuzumab

scientific article published on 31 May 2011

Trastuzumab and bevacizumab combined with docetaxel, oxaliplatin and capecitabine as first-line treatment of advanced HER2-positive gastric cancer: a multicenter phase II study

scientific article published on 8 December 2015

Treatment Individualization in Colorectal Cancer

scientific article

Treatment of hypertension in an elderly outpatient population in the Netherlands

scientific article published in August 2009

Treatment of older patients with immune checkpoint inhibitors in routine clinical care as compared to inclusion in pivotal registration trials

Treatment of ovarian cancer using intraperitoneal chemotherapy with taxanes: from laboratory bench to bedside

scientific article published on 30 August 2006

Tubuline, BRCA1, ERCC1, Abraxas, RAP80 mRNA expression, p53/p21 immunohistochemistry and clinical outcome in patients with advanced non small-cell lung cancer receiving first-line platinum–gemcitabine chemotherapy ⬇️

scientific article published on April 29, 2011

Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: boosting of neoantigen-specific T cell reactivity and long-term follow-up

scientific article published on 01 August 2020

Two-protein signature of novel serological markers apolipoprotein-A2 and serum amyloid alpha predicts prognosis in patients with metastatic renal cell cancer and improves the currently used prognostic survival models

scientific article

Two-stage model-based clinical trial design to optimize phase I development of novel anticancer agents

scientific article

Two-stage model-based design of cancer phase I dose escalation trials: evaluation using the phase I program of barasertib (AZD1152) ⬇️

scientific article published on May 28, 2011

Ultra-sensitive LC-MS/MS method for the quantification of gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma for a microdose clinical trial

scientific article published on 26 December 2017

Universal access to quality medicines: prioritisation of a-priori solutions

scientific article published on 01 November 2012

Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis

scientific article published on 16 November 2015

Urinary and fecal excretion of topotecan in patients with malignant solid tumours

scientific article

Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs

scientific article

Use of chloroquine in reducing mother to child transmission of HIV-1 during breastfeeding

article

Use of dried blood spots for the determination of plasma concentrations of nevirapine and efavirenz ⬇️

scientific article published on February 1, 2012

Use of dried blood spots for the determination of serum concentrations of tamoxifen and endoxifen

scientific article published on 25 May 2014

Use of leftovers of monoclonal antibody products after partial extraction - A microbiological safety study

scientific article published on 02 June 2019

Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry

scientific article published on 01 January 2007

Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tan

scientific article

Validated method for the determination of platinum from a liposomal source (SPI-77) in human plasma using graphite furnace Zeeman atomic absorption spectrometry

scientific article published on 01 February 2000

Validation and Clinical Evaluation of a Novel Method To Measure Miltefosine in Leishmaniasis Patients Using Dried Blood Spot Sample Collection.

scientific article published on 19 January 2016

Validation and clinical application of an LC-MS/MS method for the quantification of everolimus using volumetric absorptive microsampling

scientific article published on 30 November 2018

Validation of SELDI-TOF MS serum protein profiles for renal cell carcinoma in new populations

scientific article

Validation of a limited sampling model for carboplatin in a high-dose chemotherapy combination

scientific article

Validation of a liquid chromatographic method for the pharmaceutical quality control of products containing elacridar

scientific article published on 23 April 2016

Validation of a multiparameter flow cytometry method for the determination of phosphorylated extracellular‐signal‐regulated kinase and DNA in circulating tumor cells ⬇️

scientific article published on April 12, 2012

Validation of a quantitative assay for human neutrophil peptide-1, -2, and -3 in human plasma and serum by liquid chromatography coupled to tandem mass spectrometry

scientific article published on 15 March 2010

Validation of high-performance liquid chromatography-tandem mass spectrometry assays quantifying omacetaxine mepesuccinate and its 4'‑des-methyl and cephalotaxine metabolites in human plasma and urine.

scientific article

Validation of high-performance liquid chromatography–tandem mass spectrometry assays for the quantification of eribulin (E7389) in various biological matrices ⬇️

scientific article published on March 17, 2011

Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo

scientific article published on 21 June 2005

Validation of previously identified serum biomarkers for breast cancer with SELDI-TOF MS: a case control study

scientific article

Validation of serum amyloid α as an independent biomarker for progression-free and overall survival in metastatic renal cell cancer patients.

scientific article published on 23 January 2012

Variability in bioavailability of small molecular tyrosine kinase inhibitors

scientific article published on 20 March 2015

Vemurafenib plus cobimetinib in unresectable stage IIIc or stage IV melanoma: response monitoring and resistance prediction with positron emission tomography and tumor characteristics (REPOSIT): study protocol of a phase II, open-label, multicenter s

scientific article published on 15 September 2017

Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study.

scientific article published on 6 September 2017

Volumetric absorptive microsampling (VAMS) as an alternative to conventional dried blood spots in the quantification of miltefosine in dried blood samples.

scientific article published on 9 December 2016

Vorinostat in patients with resistant BRAFV600E mutated advanced melanoma: a proof of concept study

scientific article published on 03 March 2020

Weekly oral paclitaxel as first-line treatment in patients with advanced gastric cancer

scientific article

Yondelis (trabectedin, ET-743): the development of an anticancer agent of marine origin

scientific article

[Demethylating medication in myelodysplastic syndrome]

scientific article published on 01 January 2012

[Hyperglycaemia during treatment with everolimus].

scientific article published in January 2014

List of works by Jos Beijnen

"Effect of the drug transporters ABCB1, ABCC2, and ABCG2 on the disposition and brain accumulation of the taxane analog BMS-275,183".

'Flooding' of the lungs and severe dyspnea in a patient with bronchoalveolar carcinoma

2',3'-dideoxyinosine (ddI): its chemical stability and cyclodextrin complexation in aqueous media

2-Hydroxypropyl-beta-cyclodextrin extracts 2-phenylphenol from silicone tubing

32P-postlabeling assay for the quantification of the major platinum-DNA adducts

A Phase 1 Dose-Escalation Study of Low-Dose Metronomic Treatment With Novel Oral Paclitaxel Formulations in Combination With Ritonavir in Patients With Advanced Solid Tumors

A Phase I Dose Escalation Study of Once-Weekly Oral Administration of Docetaxel as ModraDoc001 Capsule or ModraDoc006 Tablet in Combination with Ritonavir

A Phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors

A Phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent.

A Population Pharmacokinetic Model of Oral Docetaxel Coadministered With Ritonavir to Support Early Clinical Development

A Semi-Mechanistic Population Pharmacokinetic/Pharmacodynamic Model of Bortezomib in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

A bead-based multiplexed immunoassay to evaluate breast cancer biomarkers for early detection in pre-diagnostic serum.

A comparison of limited sampling strategies for prediction of Ecteinascidin 743 clearance when administered as a 24-h infusion

A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy

A cost analysis study of the implementation of fixed-dosing of monoclonal antibodies in the Netherlands Cancer Institute

A dose-dependent delayed hypersensitivity reaction to acetaminophen after repeated acetaminophen intoxications ⬇️

A dose-escalation study of bi-daily once weekly oral docetaxel either as ModraDoc001 or ModraDoc006 combined with ritonavir

A dose-escalation study of indisulam in combination with capecitabine (Xeloda) in patients with solid tumours

A kinetic study of the chemical stability of the antimetastatic ruthenium complex NAMI-A.

A less sensitive detector does not necessarily result in a less sensitive method: fast quantification of 13 antiretroviral analytes in plasma with liquid chromatography coupled with tandem mass spectrometry

A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide

A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080

A more sensitive MS detector does not obviously lead to a more sensitive assay: experiences with ES-285.

A multi-gram-scale stereoselective synthesis of Z -endoxifen

A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma

A novel self-microemulsifying formulation of paclitaxel for oral administration to patients with advanced cancer

A phase 0 clinical trial of novel candidate extended-release formulations of capecitabine

A phase 1 comparative pharmacokinetic and cardiac safety study of two intravenous formulations of CO-101 in patients with advanced solid tumors

A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin

A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies

A phase I study of E7080, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumours ⬇️

A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors

A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients

A poor-quality generic drug for the treatment of visceral leishmaniasis: a case report and appeal

A population pharmacokinetic model for Cremophor EL using nonlinear mixed-effect modeling: model building and validation.

A population pharmacokinetic model for paclitaxel in the presence of a novel P-gp modulator, Zosuquidar Trihydrochloride (LY335979)

A prospective case series of women with estrogen receptor-positive breast cancer: levels of tamoxifen metabolites in controlled ovarian stimulation with high-dose tamoxifen ⬇️

A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer

A rapid and simple HPLC-UV method for the determination of inhibition characteristics of farnesyl transferase inhibitors

A review of the bioanalytical methods for the quantitative determination of capecitabine and its metabolites in biological matrices

A semi-physiological population pharmacokinetic model describing the non-linear disposition of indisulam

A sensitive LC-MS/MS method for the quantitative analysis of the Echinacea purpurea constituent undeca-2-ene-8,10-diynoic acid isobutylamide in human plasma

A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry

A sensitive combined assay for the quantification of paclitaxel, docetaxel and ritonavir in human plasma using liquid chromatography coupled with tandem mass spectrometry

A simple and safe method for 131I radiolabeling of rituximab for myeloablative high-dose radioimmunotherapy

A simple and sensitive assay for the quantitative analysis of paclitaxel and metabolites in human plasma using liquid chromatography/tandem mass spectrometry

A simple and sensitive assay for the quantitative analysis of rivastigmine and its metabolite NAP 226-90 in human EDTA plasma using coupled liquid chromatography and tandem mass spectrometry

A systematic study on the chemical stability of mitomycin A and mitomycin B

A validated assay for the quantitative analysis of vatalanib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry

ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation

ABCB1 Attenuates the Brain Penetration of the PARP Inhibitor AZD2461

ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-Inhibitors.

ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients

ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy

ABCC2, ABCC3, and ABCB1, but not CYP3A, Protect against Trabectedin-Mediated Hepatotoxicity

ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors

Abcc4 Together with Abcb1 and Abcg2 Form a Robust Cooperative Drug Efflux System That Restricts the Brain Entry of Camptothecin Analogues ⬇️

Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents

Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity

Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry

Accuracy, feasibility, and clinical impact of prospective Bayesian pharmacokinetically guided dosing of cyclophosphamide, thiotepa, and carboplatin in high-dose chemotherapy

Acute poisoning after oral intake of a toluene-containing paint thinner

Age-Associated Hematological Toxicity in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Docetaxel in Clinical Practice

Allometric scaling of pegylated liposomal anticancer drugs ⬇️

Altered cyclophosphamide and thiotepa pharmacokinetics in a patient with moderate renal insufficiency

Amyloid beta protein and tau in cerebrospinal fluid and plasma as biomarkers for dementia: a review of recent literature

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential.

An Antiestrogenic Activity Score for tamoxifen and its metabolites is associated with breast cancer outcome.

An Integrated Pharmacokinetic Model for the Influence of CYP3A4 Expression on the In Vivo Disposition of Lopinavir and Its Modulation by Ritonavir ⬇️

An LC-MS/MS method for quantification of the active abiraterone metabolite Δ(4)-abiraterone (D4A) in human plasma

An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patients

An overview of the relations between polymorphisms in drug metabolising enzymes and drug transporters and survival after cancer drug treatment

Analysis of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and Its Phase I and Phase II Metabolites in Mouse Urine Using LC–UV–MS–MS

Analysis of Ecteinascidin 743, a new potent marine-derived anticancer drug, in human plasma by high-performance liquid chromatography in combination with solid-phase extraction ⬇️

Analysis of diacetylmorphine, caffeine, and degradation products after volatilization of pharmaceutical heroin for inhalation

Analysis of ifosforamide mustard, the active metabolite of ifosfamide, in plasma

Analytical procedure for the determination of the new antitumour drug N-benzoylstaurosporine and three potential metabolites in human plasma by reversed-phase high-performance liquid chromatography ⬇️

Antidrug Antibody Formation in Oncology: Clinical Relevance and Challenges

Antiviral activity of HIV type 1 protease inhibitors nelfinavir and indinavir in vivo is not influenced by P-glycoprotein activity on CD4+ T cells.